HUP9801835A2 - Biciklusos tachikinin antagonisták, eljárás előállításukra és alkalmazásuk - Google Patents

Biciklusos tachikinin antagonisták, eljárás előállításukra és alkalmazásuk

Info

Publication number
HUP9801835A2
HUP9801835A2 HU9801835A HUP9801835A HUP9801835A2 HU P9801835 A2 HUP9801835 A2 HU P9801835A2 HU 9801835 A HU9801835 A HU 9801835A HU P9801835 A HUP9801835 A HU P9801835A HU P9801835 A2 HUP9801835 A2 HU P9801835A2
Authority
HU
Hungary
Prior art keywords
compounds
general formula
antagonists
different
atom
Prior art date
Application number
HU9801835A
Other languages
English (en)
Inventor
Federico Arcamone
Danilo Giannotti
Carlo Alberto Maggi
Laura Quartara
Original Assignee
A. Menarini Industrie Farmaceutiche Riunite S.R.L.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11351134&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUP9801835(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by A. Menarini Industrie Farmaceutiche Riunite S.R.L. filed Critical A. Menarini Industrie Farmaceutiche Riunite S.R.L.
Publication of HUP9801835A2 publication Critical patent/HUP9801835A2/hu
Publication of HUP9801835A3 publication Critical patent/HUP9801835A3/hu
Publication of HU222051B1 publication Critical patent/HU222051B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/22—Tachykinins, e.g. Eledoisins, Substance P; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Virology (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

A talál mány új, (I) általánős képletű vegyületekre, ezekelőállítására és e vegyületeket tartalmazó gyógyászati készítményekrevőnatkőzik. Az (I) képletben X1, X2, X3, X4, X5 és X6 azőnősak vagy különbözők, és jelentésük -NR'CO- vagy -CONR'- általánős képletű csőpőrt, ahől R' hidrőgénatőmőtvagy 1-3 szénatőmős alkilcsőpőrtőt jelent, Y jelentése -NRCO, CONR vagy -SS- általánős képletű csőpőrt, ahől Rhidrőgénatőmőt vagy 1-3 szénatőmős alkilcsőpőrtőt jelent, R1, R2, R3 és R4 csőpőrtők azőnősak vagy különbözők, és legalábbegyikük hidrőfil, míg a többi csőpőrtők hidrőfóbők, m és n értéke azőnős vagy különböző, és jelentésük 1, 2, 3 vagy 4. A találmány szerinti vegyületek a neűrőkinin A (NKA) receptőrralagőnistaként vagy antagőnistaként, főként antagőnistaként lépnekkölcsönhatásba. A simaizőmzat túlzőtt összehúzódását gátló hatásőkalapján a találmány szerinti hatóanyagők (illetve a találmány szerintivegyületeket hatóanyagként taralmazó gyógyászati készítmények),izületi gyűlladás, asztma, daganatnövekedés, a győmőr-bélcsatőrnatúlzőtt mőzgékőnysága, ideggyűlladás, idegfájdalmak, félőldalifejfájásők (migrén), magas vérnyőmás, vizelet-visszatartáselégtelensége, csalánkiütés, inflűenza és nátha kezelésébenalkalmazhatók. ŕ
HU9801835A 1995-03-13 1996-03-11 Biciklusos tachikinin antagonisták, eljárás előállításukra és alkalmazásuk HU222051B1 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT95FI000044A IT1277835B1 (it) 1995-03-13 1995-03-13 Composti biciclici, loro preparazione ed uso in composizioni farmaceutiche
PCT/EP1996/001028 WO1996028467A1 (en) 1995-03-13 1996-03-11 Bicyclic tachykinins antagonists, preparation thereof and their use in pharmaceutical composition

Publications (3)

Publication Number Publication Date
HUP9801835A2 true HUP9801835A2 (hu) 1999-01-28
HUP9801835A3 HUP9801835A3 (en) 2000-05-29
HU222051B1 HU222051B1 (hu) 2003-04-28

Family

ID=11351134

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9801835A HU222051B1 (hu) 1995-03-13 1996-03-11 Biciklusos tachikinin antagonisták, eljárás előállításukra és alkalmazásuk

Country Status (33)

Country Link
US (1) US6150325A (hu)
EP (1) EP0815126B1 (hu)
JP (1) JP4618821B2 (hu)
KR (1) KR100405009B1 (hu)
CN (1) CN1189477C (hu)
AR (1) AR004476A1 (hu)
AT (1) ATE198481T1 (hu)
AU (1) AU696528B2 (hu)
BG (1) BG63208B1 (hu)
BR (1) BR9607348A (hu)
CZ (1) CZ287372B6 (hu)
DE (1) DE69611438T2 (hu)
DK (1) DK0815126T3 (hu)
EA (1) EA000697B1 (hu)
EE (1) EE03618B1 (hu)
ES (1) ES2155187T3 (hu)
GE (1) GEP20002271B (hu)
GR (1) GR3035676T3 (hu)
HR (1) HRP960117B1 (hu)
HU (1) HU222051B1 (hu)
IL (1) IL117395A (hu)
IT (1) IT1277835B1 (hu)
MX (1) MX9706927A (hu)
NO (1) NO319290B1 (hu)
NZ (1) NZ303982A (hu)
PL (1) PL184147B1 (hu)
PT (1) PT815126E (hu)
RO (1) RO118297B1 (hu)
SK (1) SK281899B6 (hu)
TW (1) TW565572B (hu)
UA (1) UA48962C2 (hu)
WO (1) WO1996028467A1 (hu)
ZA (1) ZA961983B (hu)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6017705A (en) * 1995-03-14 2000-01-25 Ludwig Institute For Cancer Research Isolated nucleic acid molecules which are members of the MAGE-B family and uses thereof
IT1291776B1 (it) * 1997-02-07 1999-01-21 Menarini Ricerche Spa Composti monociclici a quattro residui bifunzionali, aventi azione nk-2 antagonista
IT1304888B1 (it) * 1998-08-05 2001-04-05 Menarini Ricerche Spa Composti monociclici ad azione nk-2 antagonista e formulazioni che licontengono
WO2001095904A1 (en) * 2000-06-12 2001-12-20 University Of Rochester Method of treating symptoms of hormonal variation, including hot flashes, using tachykinin receptor antagonist
EP1297826A1 (en) * 2001-09-27 2003-04-02 Menarini Ricerche S.p.A. Nasal pharmaceutical compositions containing a NK-2 antagonist
ITFI20020239A1 (it) * 2002-12-06 2004-06-07 Menarini Ricerche Spa Processo per la preparazione di composti peptidici biciclici.
ITFI20040221A1 (it) * 2004-10-27 2005-01-27 Guidotti & C Spa Composizioni farmaceutiche a base di nk2 antagonisti per uso pediatrico
ITRM20120331A1 (it) 2012-07-12 2014-01-13 Guidotti & C Spa Labor Composizioni pediatriche orali liquide contenenti nepadutant.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1262902B (it) * 1992-04-15 1996-07-22 Menarini Farma Ind Composti triciclici antagonisti delle tachichinine, loro preparazione e loro uso in composizioni farmaceutiche.

Also Published As

Publication number Publication date
PL322105A1 (en) 1998-01-05
ZA961983B (en) 1997-09-29
CZ287372B6 (en) 2000-11-15
GEP20002271B (en) 2000-10-25
JPH11501643A (ja) 1999-02-09
AU696528B2 (en) 1998-09-10
PT815126E (pt) 2001-06-29
DK0815126T3 (da) 2001-05-07
EP0815126B1 (en) 2001-01-03
SK121297A3 (en) 1998-02-04
IL117395A (en) 1999-12-31
IL117395A0 (en) 1996-07-23
IT1277835B1 (it) 1997-11-12
EA199700223A1 (ru) 1998-04-30
CN1183786A (zh) 1998-06-03
NO974057L (no) 1997-11-07
TW565572B (en) 2003-12-11
SK281899B6 (sk) 2001-09-11
US6150325A (en) 2000-11-21
BG101849A (en) 1998-04-30
ATE198481T1 (de) 2001-01-15
WO1996028467A1 (en) 1996-09-19
KR19980703011A (ko) 1998-09-05
UA48962C2 (uk) 2002-09-16
HRP960117A2 (en) 1997-08-31
AU5105996A (en) 1996-10-02
NO974057D0 (no) 1997-09-03
ITFI950044A1 (it) 1996-09-13
EE03618B1 (et) 2002-02-15
ITFI950044A0 (it) 1995-03-13
CZ286297A3 (cs) 1998-02-18
EE9700230A (et) 1998-04-15
EA000697B1 (ru) 2000-02-28
GR3035676T3 (en) 2001-06-29
NO319290B1 (no) 2005-07-11
HRP960117B1 (en) 2001-06-30
DE69611438D1 (de) 2001-02-08
HU222051B1 (hu) 2003-04-28
AR004476A1 (es) 1998-12-16
BG63208B1 (bg) 2001-06-29
JP4618821B2 (ja) 2011-01-26
PL184147B1 (pl) 2002-09-30
KR100405009B1 (ko) 2004-05-20
EP0815126A1 (en) 1998-01-07
BR9607348A (pt) 1997-12-30
MX9706927A (es) 1997-11-29
RO118297B1 (ro) 2003-04-30
CN1189477C (zh) 2005-02-16
DE69611438T2 (de) 2001-06-13
ES2155187T3 (es) 2001-05-01
NZ303982A (en) 1998-04-27
HUP9801835A3 (en) 2000-05-29

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Legal Events

Date Code Title Description
HFG4 Patent granted, date of granting

Effective date: 20030122