BG62430B1 - Първичен и вторичен неврозащитен ефект на флупиртина приневродегенеративни заболявания - Google Patents

Първичен и вторичен неврозащитен ефект на флупиртина приневродегенеративни заболявания Download PDF

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Publication number
BG62430B1
BG62430B1 BG100356A BG10035696A BG62430B1 BG 62430 B1 BG62430 B1 BG 62430B1 BG 100356 A BG100356 A BG 100356A BG 10035696 A BG10035696 A BG 10035696A BG 62430 B1 BG62430 B1 BG 62430B1
Authority
BG
Bulgaria
Prior art keywords
flupirtine
preparation
medicament
treatment
active substance
Prior art date
Application number
BG100356A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG100356A (bg
Inventor
Michael Schwarz
Gabriela Pergande
Juergen Engel
Bernd Nickel
Heinz Ulrich
Stefan Szelenyi
Original Assignee
Asta Medica Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asta Medica Aktiengesellschaft filed Critical Asta Medica Aktiengesellschaft
Publication of BG100356A publication Critical patent/BG100356A/bg
Publication of BG62430B1 publication Critical patent/BG62430B1/bg

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Confectionery (AREA)
BG100356A 1993-08-17 1996-02-14 Първичен и вторичен неврозащитен ефект на флупиртина приневродегенеративни заболявания BG62430B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4327516A DE4327516A1 (de) 1993-08-17 1993-08-17 Primäre und sekundäre neuroprotektive Wirkung bei neurodegenerativen Erkrankungen von Flupirtin
PCT/EP1994/002649 WO1995005175A1 (en) 1993-08-17 1994-08-10 The primary and secondary neuroprotective effect of flupirtine in neurodegenerative diseases

Publications (2)

Publication Number Publication Date
BG100356A BG100356A (bg) 1996-07-31
BG62430B1 true BG62430B1 (bg) 1999-11-30

Family

ID=6495312

Family Applications (1)

Application Number Title Priority Date Filing Date
BG100356A BG62430B1 (bg) 1993-08-17 1996-02-14 Първичен и вторичен неврозащитен ефект на флупиртина приневродегенеративни заболявания

Country Status (27)

Country Link
US (1) US5721258A (es)
EP (1) EP0716602B1 (es)
JP (1) JPH09501664A (es)
KR (1) KR100341952B1 (es)
CN (1) CN1086291C (es)
AT (1) ATE210442T1 (es)
AU (1) AU694447B2 (es)
BG (1) BG62430B1 (es)
BR (1) BR9407293A (es)
CA (1) CA2169718C (es)
CZ (1) CZ289040B6 (es)
DE (2) DE4327516A1 (es)
DK (1) DK0716602T3 (es)
EE (1) EE03204B1 (es)
ES (1) ES2168309T3 (es)
HR (1) HRP940464A2 (es)
HU (1) HU227765B1 (es)
IL (1) IL110681A (es)
NO (1) NO309842B1 (es)
NZ (1) NZ273292A (es)
PT (1) PT716602E (es)
RU (1) RU2166318C2 (es)
SK (1) SK283330B6 (es)
UA (1) UA43351C2 (es)
WO (1) WO1995005175A1 (es)
YU (1) YU49215B (es)
ZA (1) ZA946176B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19539861A1 (de) * 1995-10-26 1997-04-30 Asta Medica Ag Verwendung von 4-Amino-4-(4-fluorbenzylamino)-1-ethoxy-carbonylaminobenzen zur Prophylaxe und Behandlung der Folgen der akuten und chronischen zerebralen Minderdurchblutung sowie neurodegenerativer Erkrankungen
DE19541405A1 (de) * 1995-11-07 1997-05-15 Asta Medica Ag Verwendung von Flupirtin zur Prophylaxe und Therapie von Erkrankungen, die mit einer Beeinträchtigung des hämatopoetischen Zellsystems einhergehen
DE19625582A1 (de) * 1996-06-27 1998-01-02 Asta Medica Ag Verwendung von Flupirtin zur Prophylaxe und Therapie von Erkrankungen die mit einer unphysiologisch hohen Zellsterberate einhergehen
ES2235368T3 (es) * 1997-10-27 2005-07-01 Sumitomo Pharmaceuticals Company, Limited Derivados de amida para tratar alteraciones neurodegenerativas de la retina.
AU1359801A (en) * 1999-11-05 2001-06-06 Vela Pharmaceuticals Inc. Methods and compositions for treating reward deficiency syndrome
US6821995B1 (en) 1999-12-01 2004-11-23 Duke University Method of treating batten disease
AU1353901A (en) * 1999-12-01 2001-06-12 Duke University Method of treating batten disease
DE10327674A1 (de) 2003-06-20 2005-01-05 Awd.Pharma Gmbh & Co. Kg Injizierbare Darreichungsform von Flupirtin
DE10328260A1 (de) * 2003-06-23 2005-01-27 Schmidt, K.-G., Dr. med. Flupirtine-Präparat
CN1917876A (zh) * 2003-12-16 2007-02-21 Cns生物有限公司 方法和组合物
WO2006065204A1 (en) * 2004-12-14 2006-06-22 Astrazeneca Ab Substituted aminopyridines and uses thereof
EP1688141A1 (en) 2005-01-31 2006-08-09 elbion AG The use of flupirtine for the treatment of overactive bladder and associated diseases, and for the treatment of irritable bowel syndrome
US20060258708A1 (en) * 2005-05-16 2006-11-16 Andrulis Peter J Jr Method for treating Parkinson's disease and other neurological diseases
US20080279930A1 (en) * 2007-05-07 2008-11-13 Bernd Terhaag Controlled-Release Flupirtine Compositions, Compacts, Kits and Methods of Making and Use Thereof
DE102011006425A1 (de) 2010-03-31 2011-10-06 Awd.Pharma Gmbh & Co. Kg Pharmazeutische Zubereitung und deren Verwendung
DE102010030053A1 (de) 2010-06-14 2011-12-15 Awd.Pharma Gmbh & Co.Kg Injizierbare Darreichungsform von Flupirtin
EP3027188A4 (en) * 2013-07-31 2017-03-01 Teva Pharmaceutical Industries Ltd. Treatment of multiple sclerosis with combination of laquinimod and flupirtine
WO2019014547A1 (en) * 2017-07-14 2019-01-17 Texas Tech University System FUNCTIONALIZED PYRIDINE CARBAMATES HAVING ENHANCED NEUROPROTECTOR ACTIVITY
DE102017007385A1 (de) 2017-08-02 2019-02-07 Christoph Hoock Maleatfreie feste Arzneimittelformen

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4481205A (en) * 1980-09-13 1984-11-06 Degussa Aktiengesellschaft 2-Amino-3-carbethoxyamino-6-(p-fluoro-benzylamino)-pyridine-maleate
DE3369315D1 (en) * 1982-10-27 1987-02-26 Degussa Derivatives of 2-amino-3-acylamino-6-benzylamino pyridine with an anti-epileptic activity
DE3337593A1 (de) * 1982-10-27 1984-05-03 Degussa Ag, 6000 Frankfurt 2-amino-3-acylamino-6-benzylamino-pyridin-derivate mit antiepileptischer wirkung
NO860825L (no) * 1985-03-23 1986-09-24 Degussa Fremgangsmaate til fremstilling av 2-amino-3-nitro-6-(4-fluor-benzylamino)-pyridin samt 2-amino-3-karbetoksyamino-6-(4-fluor-benzylamino)-pyridin.
IN172468B (es) * 1990-07-14 1993-08-14 Asta Medica Ag

Also Published As

Publication number Publication date
RU2166318C2 (ru) 2001-05-10
NZ273292A (en) 1999-09-29
CN1129399A (zh) 1996-08-21
HUT75650A (en) 1997-05-28
DE4327516A1 (de) 1995-02-23
CA2169718A1 (en) 1995-02-23
EE03204B1 (et) 1999-08-16
BG100356A (bg) 1996-07-31
ES2168309T3 (es) 2002-06-16
AU7652894A (en) 1995-03-14
SK283330B6 (sk) 2003-06-03
YU49215B (sh) 2004-11-25
HU227765B1 (en) 2012-02-28
KR960703591A (ko) 1996-08-31
ZA946176B (en) 1995-03-20
BR9407293A (pt) 1996-10-01
JPH09501664A (ja) 1997-02-18
CZ46596A3 (en) 1996-05-15
DK0716602T3 (da) 2002-03-25
SK21496A3 (en) 1997-01-08
HU9600355D0 (en) 1996-04-29
PT716602E (pt) 2002-05-31
CA2169718C (en) 2002-11-12
US5721258A (en) 1998-02-24
IL110681A (en) 1999-08-17
KR100341952B1 (ko) 2003-04-11
NO960607L (no) 1996-02-15
UA43351C2 (uk) 2001-12-17
EP0716602A1 (en) 1996-06-19
DE69429435D1 (de) 2002-01-24
IL110681A0 (en) 1994-11-11
CZ289040B6 (cs) 2001-10-17
WO1995005175A1 (en) 1995-02-23
YU51294A (sh) 1998-05-15
HRP940464A2 (en) 1997-06-30
DE69429435T2 (de) 2002-06-13
NO309842B1 (no) 2001-04-09
CN1086291C (zh) 2002-06-19
AU694447B2 (en) 1998-07-23
ATE210442T1 (de) 2001-12-15
NO960607D0 (no) 1996-02-15
EP0716602B1 (en) 2001-12-12

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