BG62053B1 - (-)-бета-l-2-хидроксиметил-5-(5-флуороцитозин-1-ил)-1,3-оксатиолан, методиза получаването му, фармацевтичен състав на негова база иприложението му като антивирусно средство - Google Patents
(-)-бета-l-2-хидроксиметил-5-(5-флуороцитозин-1-ил)-1,3-оксатиолан, методиза получаването му, фармацевтичен състав на негова база иприложението му като антивирусно средство Download PDFInfo
- Publication number
- BG62053B1 BG62053B1 BG98062A BG9806293A BG62053B1 BG 62053 B1 BG62053 B1 BG 62053B1 BG 98062 A BG98062 A BG 98062A BG 9806293 A BG9806293 A BG 9806293A BG 62053 B1 BG62053 B1 BG 62053B1
- Authority
- BG
- Bulgaria
- Prior art keywords
- ftc
- oxathiolane
- hydroxymethyl
- compound
- fluorocytosin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Genetics & Genomics (AREA)
- Communicable Diseases (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/659,760 US5210085A (en) | 1990-02-01 | 1991-02-22 | Method for the synthesis, compositions and use of 2'-deoxy-5-fluoro-3'-thiacytidine and related compounds |
US73608991A | 1991-07-26 | 1991-07-26 | |
US83115392A | 1992-02-12 | 1992-02-12 | |
PCT/US1992/001339 WO1992014743A2 (en) | 1991-02-22 | 1992-02-20 | Antiviral activity and resolution of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane |
Publications (2)
Publication Number | Publication Date |
---|---|
BG98062A BG98062A (bg) | 1994-04-29 |
BG62053B1 true BG62053B1 (bg) | 1999-01-29 |
Family
ID=35276919
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BG98062A BG62053B1 (bg) | 1991-02-22 | 1993-08-20 | (-)-бета-l-2-хидроксиметил-5-(5-флуороцитозин-1-ил)-1,3-оксатиолан, методиза получаването му, фармацевтичен състав на негова база иприложението му като антивирусно средство |
Country Status (25)
Country | Link |
---|---|
EP (3) | EP1439177B1 (ja) |
JP (2) | JP2901160B2 (ja) |
KR (1) | KR0172590B1 (ja) |
CN (4) | CN1037682C (ja) |
AT (2) | ATE469147T1 (ja) |
AU (2) | AU679649B2 (ja) |
BG (1) | BG62053B1 (ja) |
BR (1) | BR9205661A (ja) |
CA (2) | CA2513440C (ja) |
CZ (1) | CZ295074B6 (ja) |
DE (2) | DE69233379T2 (ja) |
DK (2) | DK1439177T3 (ja) |
ES (2) | ES2345102T3 (ja) |
FI (2) | FI114915B (ja) |
HK (1) | HK1026419A1 (ja) |
HU (2) | HU227823B1 (ja) |
IE (1) | IE920545A1 (ja) |
IL (1) | IL100965A (ja) |
MX (1) | MX9200747A (ja) |
MY (1) | MY114350A (ja) |
NO (3) | NO312399B1 (ja) |
NZ (2) | NZ250842A (ja) |
PT (1) | PT100151B (ja) |
RO (2) | RO119365B1 (ja) |
WO (1) | WO1992014743A2 (ja) |
Families Citing this family (75)
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US6175008B1 (en) | 1988-04-11 | 2001-01-16 | Biochem Pharma Inc. | Processes for preparing substituted 1,3-oxathiolanes with antiviral properties |
US5466806A (en) * | 1989-02-08 | 1995-11-14 | Biochem Pharma Inc. | Processes for preparing substituted 1,3-oxathiolanes with antiviral properties |
HU226137B1 (en) * | 1989-02-08 | 2008-05-28 | Shire Canada Inc | Process for preparing substituted 1,3-oxathiolanes with antiviral properties |
US6703396B1 (en) | 1990-02-01 | 2004-03-09 | Emory University | Method of resolution and antiviral activity of 1,3-oxathiolane nuclesoside enantiomers |
US5204466A (en) * | 1990-02-01 | 1993-04-20 | Emory University | Method and compositions for the synthesis of bch-189 and related compounds |
US5728575A (en) | 1990-02-01 | 1998-03-17 | Emory University | Method of resolution of 1,3-oxathiolane nucleoside enantiomers |
US6642245B1 (en) | 1990-02-01 | 2003-11-04 | Emory University | Antiviral activity and resolution of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane |
US5276151A (en) * | 1990-02-01 | 1994-01-04 | Emory University | Method of synthesis of 1,3-dioxolane nucleosides |
US5444063A (en) * | 1990-12-05 | 1995-08-22 | Emory University | Enantiomerically pure β-D-dioxolane nucleosides with selective anti-Hepatitis B virus activity |
IL100502A (en) * | 1991-01-03 | 1995-12-08 | Iaf Biochem Int | PHARMACEUTICAL PREPARATIONS CONTAINING CIS-4-AMINO-1-) 2-HYDROXIMETHIL-1,3-OXETYOLEN-5-IL (- |
US6812233B1 (en) | 1991-03-06 | 2004-11-02 | Emory University | Therapeutic nucleosides |
AU662130B2 (en) * | 1991-03-06 | 1995-08-24 | Emory University | Use of 5-fluoro-2'-deoxy-3'-thiacytidine for the treatment of hepatitis B |
US5817667A (en) * | 1991-04-17 | 1998-10-06 | University Of Georgia Research Foudation | Compounds and methods for the treatment of cancer |
GB9110874D0 (en) * | 1991-05-20 | 1991-07-10 | Iaf Biochem Int | Medicaments |
ZA923640B (en) * | 1991-05-21 | 1993-02-24 | Iaf Biochem Int | Processes for the diastereoselective synthesis of nucleosides |
GB9116601D0 (en) * | 1991-08-01 | 1991-09-18 | Iaf Biochem Int | 1,3-oxathiolane nucleoside analogues |
WO1993023021A2 (en) * | 1992-05-13 | 1993-11-25 | The Wellcome Foundation Limited | Therapeutic combinations |
US6177435B1 (en) | 1992-05-13 | 2001-01-23 | Glaxo Wellcome Inc. | Therapeutic combinations |
GB9226927D0 (en) * | 1992-12-24 | 1993-02-17 | Iaf Biochem Int | Dideoxy nucleoside analogues |
TW374087B (en) * | 1993-05-25 | 1999-11-11 | Univ Yale | L-2',3'-dideoxy nucleotide analogs as anti-hepatitis B(HBV) and anti-HIV agents |
US5627160A (en) * | 1993-05-25 | 1997-05-06 | Yale University | L-2',3'-dideoxy nucleoside analogs as anti-hepatitis B (HBV) and anti-HIV agents |
US20020120130A1 (en) | 1993-09-10 | 2002-08-29 | Gilles Gosselin | 2' or 3' -deoxy and 2', 3' -dideoxy-beta-L-pentofuranonucleo-side compounds, method of preparation and application in therapy, especially as anti- viral agents |
CA2171550C (en) | 1993-09-10 | 2008-08-26 | Raymond F. Schinazi | Nucleosides with anti-hepatitis b virus activity |
GB9320316D0 (en) * | 1993-10-01 | 1993-11-17 | Smithkline Beecham Plc | Pharmaceuticals |
US5587362A (en) * | 1994-01-28 | 1996-12-24 | Univ. Of Ga Research Foundation | L-nucleosides |
IL115156A (en) | 1994-09-06 | 2000-07-16 | Univ Georgia | Pharmaceutical compositions for the treatment of cancer comprising 1-(2-hydroxymethyl-1,3-dioxolan-4-yl) cytosines |
US5703058A (en) * | 1995-01-27 | 1997-12-30 | Emory University | Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent |
US6391859B1 (en) | 1995-01-27 | 2002-05-21 | Emory University | [5-Carboxamido or 5-fluoro]-[2′,3′-unsaturated or 3′-modified]-pyrimidine nucleosides |
US5808040A (en) * | 1995-01-30 | 1998-09-15 | Yale University | L-nucleosides incorporated into polymeric structure for stabilization of oligonucleotides |
US5869461A (en) * | 1995-03-16 | 1999-02-09 | Yale University | Reducing toxicity of L-nucleosides with D-nucleosides |
ES2276404T3 (es) * | 1995-06-07 | 2007-06-16 | Emory University | Nucleosidos con actividad antivirus de la hepatitis-b. |
ID19490A (id) | 1996-06-25 | 1998-07-16 | Glaxo Group Ltd | Kombinasi-kombinasi antiviral |
US5753789A (en) * | 1996-07-26 | 1998-05-19 | Yale University | Oligonucleotides containing L-nucleosides |
WO1998041522A1 (en) | 1997-03-19 | 1998-09-24 | Emory University | Synthesis, anti-human immunodeficiency virus and anti-hepatitis b virus activities of 1,3-oxaselenolane nucleosides |
IT1290447B1 (it) | 1997-03-28 | 1998-12-03 | Zambon Spa | Derivati 1,3-ossatiolanici ad attivita' antivirale |
AU6898498A (en) | 1997-04-07 | 1998-10-30 | Triangle Pharmaceuticals, Inc. | Use of mkc-442 in combination with other antiviral agents |
JP2002500881A (ja) | 1998-01-26 | 2002-01-15 | フアーム−エコ・ラボラトリーズ・インコーポレーテツド | 鏡像異性体分離のための酵素活性化担体 |
EA008609B1 (ru) | 1998-02-25 | 2007-06-29 | Эмори Юниверсити | 2'-фторнуклеозиды |
ES2232169T3 (es) | 1998-08-12 | 2005-05-16 | Gilead Sciences, Inc. | Procedimiento de fabricacion de nucleosidos de 1,3-oxatiolano. |
US6979561B1 (en) | 1998-10-09 | 2005-12-27 | Gilead Sciences, Inc. | Non-homogeneous systems for the resolution of enantiomeric mixtures |
ATE254126T1 (de) | 1998-12-23 | 2003-11-15 | Shire Biochem Inc | Antivirale nukleosidanaloga |
KR100339786B1 (ko) * | 1999-04-02 | 2002-06-07 | 안용현 | 라세미 혼합물 상태로 존재하는 뉴클레오시드로부터 거울상 이성질체의 분리 방법 |
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US6436948B1 (en) | 2000-03-03 | 2002-08-20 | University Of Georgia Research Foundation Inc. | Method for the treatment of psoriasis and genital warts |
CA2308559C (en) | 2000-05-16 | 2005-07-26 | Brantford Chemicals Inc. | 1,3-oxathiolan-5-ones useful in the production of antiviral nucleoside analogues |
PT1411954E (pt) | 2000-10-18 | 2011-03-16 | Pharmasset Inc | Nucleosídeos modificados para o tratamento de infecções virais e proliferação celular anormal |
US6828119B2 (en) * | 2001-01-04 | 2004-12-07 | Bristol Myers Squibb Company | Enzymatic deprotection of amines and hydroxides |
DE10104231A1 (de) | 2001-01-31 | 2002-08-08 | Consortium Elektrochem Ind | Verfahren zur enzymatischen Herstellung von enantiomerenreinen 1,3-Dioxolan-4-on-Derivaten |
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KR20050005442A (ko) | 2002-04-12 | 2005-01-13 | 아칠리온 파르마세우티칼스 인코포레이티드 | β-L-플루오로-2',3'-디데히드로사이티딘(β-L-FD4C)의합성 방법 |
JP4501135B2 (ja) * | 2002-11-18 | 2010-07-14 | シェア カナダ インコーポレーテッド | ジオキソランヌクレオシド類似体の立体選択的製造方法 |
DE602004014470D1 (de) | 2003-01-14 | 2008-07-31 | Gilead Sciences Inc | Zusammensetzungen und verfahren zur antiviralen kombinationstherapie |
ITMI20030578A1 (it) * | 2003-03-24 | 2004-09-25 | Clariant Lsm Italia Spa | Processo ed intermedi per la preparazione di emtricitabina |
WO2006096954A1 (en) * | 2005-03-14 | 2006-09-21 | Shire Biochem Inc. | Process and methods for the preparation of optically active cis-2-hydroxymethyl-4-(cytosin-1´-yl)-1,3-oxathiolane or pharmaceutically acceptable salts thereof |
TWI471145B (zh) | 2005-06-13 | 2015-02-01 | Bristol Myers Squibb & Gilead Sciences Llc | 單一式藥學劑量型 |
TWI375560B (en) | 2005-06-13 | 2012-11-01 | Gilead Sciences Inc | Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same |
AU2008219622A1 (en) | 2007-02-28 | 2008-09-04 | Conatus Pharmaceuticals, Inc. | Methods for the treatment of liver diseases using specified matrix metalloproteinase (MMP) inhibitors |
PT2159224E (pt) | 2007-06-18 | 2012-10-24 | Sunshine Lake Pharma Co Ltd | Tiazolil dihidropirimidinas substituídas com bromo-fenilo |
US8350030B2 (en) | 2007-12-07 | 2013-01-08 | Matrix Laboratories Limited | Process for producing 5-fluoro-1-(2R, 5S)-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine |
JPWO2009107692A1 (ja) * | 2008-02-29 | 2011-07-07 | 株式会社カネカ | 2’−水酸基が保護されたリボヌクレオシド誘導体およびその製造方法 |
NZ593647A (en) | 2008-12-23 | 2013-08-30 | Gilead Pharmasset Llc | Synthesis of purine nucleosides |
EP2376514A2 (en) | 2008-12-23 | 2011-10-19 | Pharmasset, Inc. | Nucleoside analogs |
MX2011006891A (es) | 2008-12-23 | 2011-10-06 | Pharmasset Inc | Fosforamidatos de nucleosidos. |
EP2377862A1 (en) | 2010-03-29 | 2011-10-19 | Esteve Química, S.A. | Process for obtaining emtricitabine |
AU2011235112B2 (en) | 2010-03-31 | 2015-07-09 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
TWI556840B (zh) | 2010-11-19 | 2016-11-11 | 吉李德科學股份有限公司 | 治療用組成物 |
AU2013257951A1 (en) | 2012-05-11 | 2015-01-22 | Akron Molecules Ag | Use of compounds for the treatment of pain |
AU2013340559B2 (en) | 2012-10-29 | 2018-03-15 | Cipla Limited | Antiviral phosphonate analogues and process for preparation thereof |
CN102911167B (zh) * | 2012-11-09 | 2014-06-25 | 合肥工业大学 | 一种高光学纯度的核苷类中间体的制备方法 |
CN104059057A (zh) * | 2014-01-03 | 2014-09-24 | 石家庄龙泽制药有限公司 | 拉米夫定杂质3-tu的制备方法 |
CN108285895B (zh) * | 2018-01-26 | 2020-06-23 | 中国科学院南海海洋研究所 | 一种酯酶EstC11及其编码基因和应用 |
KR102069443B1 (ko) | 2018-08-31 | 2020-01-22 | (주)대한뷰티산업진흥원 | 울금, 비트 및 무 추출물을 포함하는 바이오셀룰로오스 및 이의 제조방법 |
WO2021209563A1 (en) | 2020-04-16 | 2021-10-21 | Som Innovation Biotech, S.A. | Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus |
WO2022011554A1 (zh) * | 2020-07-14 | 2022-01-20 | 四川大学 | 3-去氧-2-酮糖酸含氮衍生物及其制备方法和用途 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4914028A (en) * | 1988-02-10 | 1990-04-03 | Eli Lilly And Company | Method of preparing beta-2',2'-difluoronucleosides |
US5047407A (en) * | 1989-02-08 | 1991-09-10 | Iaf Biochem International, Inc. | 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties |
US5204466A (en) * | 1990-02-01 | 1993-04-20 | Emory University | Method and compositions for the synthesis of bch-189 and related compounds |
ATE143016T1 (de) * | 1990-11-13 | 1996-10-15 | Iaf Biochem Int | Substituierte 1,3-oxathiolane mit antiviralen eigenschaften |
AU662130B2 (en) | 1991-03-06 | 1995-08-24 | Emory University | Use of 5-fluoro-2'-deoxy-3'-thiacytidine for the treatment of hepatitis B |
-
1992
- 1992-02-17 IL IL10096592A patent/IL100965A/en not_active IP Right Cessation
- 1992-02-17 NZ NZ250842A patent/NZ250842A/en not_active IP Right Cessation
- 1992-02-17 NZ NZ241625A patent/NZ241625A/en not_active IP Right Cessation
- 1992-02-20 WO PCT/US1992/001339 patent/WO1992014743A2/en active IP Right Grant
- 1992-02-20 RO RO93-01137A patent/RO119365B1/ro unknown
- 1992-02-20 CZ CS1992497A patent/CZ295074B6/cs not_active IP Right Cessation
- 1992-02-20 JP JP4507549A patent/JP2901160B2/ja not_active Expired - Lifetime
- 1992-02-20 AT AT04076245T patent/ATE469147T1/de active
- 1992-02-20 CA CA2513440A patent/CA2513440C/en not_active Expired - Lifetime
- 1992-02-20 DE DE69233379T patent/DE69233379T2/de not_active Expired - Lifetime
- 1992-02-20 DK DK04076245.2T patent/DK1439177T3/da active
- 1992-02-20 DE DE69233786T patent/DE69233786D1/de not_active Expired - Lifetime
- 1992-02-20 KR KR1019930702516A patent/KR0172590B1/ko not_active IP Right Cessation
- 1992-02-20 CA CA002104399A patent/CA2104399C/en not_active Expired - Lifetime
- 1992-02-20 ES ES04076245T patent/ES2345102T3/es not_active Expired - Lifetime
- 1992-02-20 RO ROA200400584A patent/RO122814B1/ro unknown
- 1992-02-20 EP EP04076245A patent/EP1439177B1/en not_active Expired - Lifetime
- 1992-02-20 EP EP19920908027 patent/EP0575482A1/en not_active Ceased
- 1992-02-20 DK DK99203367T patent/DK0984013T3/da active
- 1992-02-20 ES ES99203367T patent/ES2224547T3/es not_active Expired - Lifetime
- 1992-02-20 HU HU9302377A patent/HU227823B1/hu active Protection Beyond IP Right Term
- 1992-02-20 BR BR9205661A patent/BR9205661A/pt not_active Application Discontinuation
- 1992-02-20 EP EP99203367A patent/EP0984013B1/en not_active Expired - Lifetime
- 1992-02-20 AT AT99203367T patent/ATE270291T1/de active
- 1992-02-21 IE IE054592A patent/IE920545A1/en not_active Application Discontinuation
- 1992-02-21 PT PT100151A patent/PT100151B/pt not_active IP Right Cessation
- 1992-02-21 MY MYPI92000287A patent/MY114350A/en unknown
- 1992-02-21 MX MX9200747A patent/MX9200747A/es active IP Right Grant
- 1992-02-22 CN CN92101981A patent/CN1037682C/zh not_active Expired - Lifetime
-
1993
- 1993-08-20 BG BG98062A patent/BG62053B1/bg unknown
- 1993-08-20 FI FI933684A patent/FI114915B/fi not_active IP Right Cessation
- 1993-08-20 NO NO19932980A patent/NO312399B1/no active IP Right Maintenance
-
1995
- 1995-06-28 HU HU95P/P00510P patent/HU211344A9/hu unknown
- 1995-08-18 CN CN95109814A patent/CN1109108C/zh not_active Expired - Lifetime
- 1995-11-20 AU AU37943/95A patent/AU679649B2/en not_active Withdrawn - After Issue
-
1997
- 1997-11-06 JP JP34046997A patent/JP3292830B2/ja not_active Expired - Lifetime
-
1998
- 1998-05-15 CN CN98108905A patent/CN1084745C/zh not_active Expired - Lifetime
- 1998-08-17 AU AU80773/98A patent/AU8077398A/en not_active Abandoned
- 1998-12-28 HK HK00105566A patent/HK1026419A1/xx not_active IP Right Cessation
-
2002
- 2002-09-30 CN CNB021440336A patent/CN100396785C/zh not_active Expired - Lifetime
-
2003
- 2003-06-24 FI FI20030932A patent/FI20030932A/fi unknown
-
2005
- 2005-07-01 NO NO2005015C patent/NO2005015I2/no not_active Application Discontinuation
-
2008
- 2008-06-13 NO NO2008010C patent/NO2008010I1/no unknown
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