BG61122B2 - Оптично активни производни на пиридонкарбоксилната киселина - Google Patents

Оптично активни производни на пиридонкарбоксилната киселина Download PDF

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Publication number
BG61122B2
BG61122B2 BG98620A BG9862094A BG61122B2 BG 61122 B2 BG61122 B2 BG 61122B2 BG 98620 A BG98620 A BG 98620A BG 9862094 A BG9862094 A BG 9862094A BG 61122 B2 BG61122 B2 BG 61122B2
Authority
BG
Bulgaria
Prior art keywords
group
amino
cis
compound
methylamino
Prior art date
Application number
BG98620A
Other languages
Bulgarian (bg)
English (en)
Inventor
Youichi Kimura
Isao Hayakawa
Original Assignee
Daiichi Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Pharmaceutical Co., Ltd. filed Critical Daiichi Pharmaceutical Co., Ltd.
Publication of BG61122B2 publication Critical patent/BG61122B2/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
BG98620A 1988-04-27 1994-02-28 Оптично активни производни на пиридонкарбоксилната киселина BG61122B2 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP10462588 1988-04-27
JP29698488 1988-11-24

Publications (1)

Publication Number Publication Date
BG61122B2 true BG61122B2 (bg) 1996-11-29

Family

ID=26445063

Family Applications (1)

Application Number Title Priority Date Filing Date
BG98620A BG61122B2 (bg) 1988-04-27 1994-02-28 Оптично активни производни на пиридонкарбоксилната киселина

Country Status (26)

Country Link
US (4) US5587386A (fr)
EP (1) EP0341493B1 (fr)
JP (5) JP2714597B2 (fr)
KR (1) KR0184614B1 (fr)
CN (1) CN1033751C (fr)
AT (1) ATE182145T1 (fr)
AU (1) AU625414B2 (fr)
BG (1) BG61122B2 (fr)
CA (1) CA1340801C (fr)
DE (1) DE68929030T2 (fr)
DK (1) DK175467B1 (fr)
ES (1) ES2135372T3 (fr)
FI (1) FI96947C (fr)
GR (1) GR3031365T3 (fr)
HK (1) HK1002108A1 (fr)
HU (1) HU211136A9 (fr)
IL (1) IL90062A (fr)
LV (1) LV10092B (fr)
MY (1) MY105136A (fr)
NO (1) NO175939C (fr)
NZ (1) NZ228893A (fr)
PT (1) PT90377B (fr)
RU (1) RU2075475C1 (fr)
SG (1) SG48036A1 (fr)
UA (1) UA29378C2 (fr)
YU (1) YU48432B (fr)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY105136A (en) * 1988-04-27 1994-08-30 Daiichi Seiyaku Co Optically active pyridonecarboxylic acid derivatives.
JPH0674261B2 (ja) * 1988-06-21 1994-09-21 塩野義製薬株式会社 キノロンカルボン酸誘導体
CA1336090C (fr) * 1988-08-31 1995-06-27 Isao Hayakawa Amines cycliques a substituant spiro de derives de la quinolone
EP0443498A1 (fr) * 1990-02-19 1991-08-28 Kyorin Pharmaceutical Co., Ltd. Dérivés d'isoindoline
MY109714A (en) * 1990-10-18 1997-04-30 Daiichi Seiyaku Co Process for preparing 8-chloroquinolone derivatives
CA2110260C (fr) * 1991-05-28 2001-12-04 Isao Hayakawa Derives d'acide pyridonecarboxylique
ATE184603T1 (de) * 1991-06-19 1999-10-15 Pfizer Azaspirochinolone als antibakterielle wirkstoffe
KR960011370B1 (ko) * 1991-12-31 1996-08-22 재단법인 한국화학연구소 스피로알킬아민 유도체와 그의 제조방법
JP3268098B2 (ja) * 1992-12-25 2002-03-25 第一製薬株式会社 二環性環状アミン誘導体
ZA946853B (en) * 1993-09-10 1995-04-24 Daiichi Seiyaku Co Crystals of antimicrobial compound.
NZ287550A (en) * 1994-07-18 1998-01-26 Ube Industries 8-trifluoromethylquinolinecarboxylic acid derivatives; medicaments
WO1996023782A1 (fr) * 1995-02-02 1996-08-08 Daiichi Pharmaceutical Co., Ltd. Composes heterocycliques
CA2212163A1 (fr) * 1995-02-07 1996-08-15 Daiichi Pharmaceutical Co., Ltd. Derive spiro heterocyclique
JPH09124556A (ja) 1995-08-30 1997-05-13 Dai Ichi Seiyaku Co Ltd ハロゲン化シクロプロパン誘導体の製造方法
NZ322202A (en) * 1995-11-22 2000-05-26 Daiichi Pharmaceutical Company Aminocycloalkylpyrrolidine derivatives and salts thereof with antibacterial activity
US6121285A (en) 1995-11-22 2000-09-19 Daiichi Pharmaceutical Co., Ltd. Substituted aminocycloalkylpyrrolidine derivatives and cis-substituted aminocycloalkylpyrrolidine derivatives
CA2242242C (fr) * 1996-02-09 2001-08-07 Toyama Chemical Co., Ltd. Derives de l'acide quinolonecarboxylique et leurs sels
ID16655A (id) * 1996-04-24 1997-10-30 Daiichi Seiyaku Co Turunan-turunan sikloalkilaminometilpirolidina
AU1040597A (en) * 1996-12-04 1998-06-29 Daiichi Pharmaceutical Co., Ltd. Substituted aminomethylpyrrolidine derivatives
DE69925859T2 (de) 1998-11-24 2006-05-11 Daiichi Pharmaceutical Co., Ltd. Cycloalkylsubstituierte aminomethylpyrrolidin-derivate
CN1258531C (zh) 1999-03-10 2006-06-07 第一制药株式会社 芳香族取代基取代的氨基甲基吡咯烷衍生物
EP2275141A1 (fr) 1999-03-17 2011-01-19 Daiichi Pharmaceutical Co., Ltd. Compositions pharmaceutiques au gout camoufle
EP1262477B1 (fr) * 2000-02-09 2008-09-03 Daiichi Sankyo Company, Limited Agents antibacteriens acidoresistants renfermant des acides pyridonecarboxyliques comme principe actif
AR027761A1 (es) 2000-03-31 2003-04-09 Daiichi Seiyaku Co Un derivado del acido quinolonacarboxilico, las composiciones antibacterianas que lo contienen y el uso de dicho derivado para la elaboracion de drogaspara el tratamiento de enfermedades infecciosas
DK1277471T3 (da) 2000-04-24 2008-08-11 Daiichi Sankyo Co Ltd Stabilt væskepræparat omfattende sitafloxacin
US6861071B2 (en) * 2000-08-08 2005-03-01 Daiichi Pharmaceutical Co., Ltd. Highly absorptive solid preparation
WO2003097634A1 (fr) * 2002-05-17 2003-11-27 Daiichi Pharmaceutical Co., Ltd. Procede de production d'un derive d'acide carboxylique et quinoloneprocede de production d'un derive d'acide carboxylique et quinolone
ATE488489T1 (de) * 2003-01-07 2010-12-15 Daiichi Sankyo Co Ltd Verfahren zur reduktiven deshalogenierung
US7085154B2 (en) * 2003-06-03 2006-08-01 Samsung Electronics Co., Ltd. Device and method for pulse width control in a phase change memory device
JP4820290B2 (ja) 2004-05-13 2011-11-24 第一三共株式会社 置換ピロリジン誘導体
JP5063032B2 (ja) * 2005-05-19 2012-10-31 第一三共株式会社 トリ−、テトラ−置換−３−アミノピロリジン誘導体
US7563805B2 (en) 2005-05-19 2009-07-21 Daiichi Pharmaceutical Co., Ltd. Tri-, tetra-substituted-3-aminopyrrolidine derivative
US7928232B2 (en) * 2005-05-20 2011-04-19 Daiichi Sankyo Company, Limited Method for producing asymmetric tetrasubstituted carbon atom-containing compound
US7977346B2 (en) 2006-01-17 2011-07-12 Guoqing Paul Chen Spiro compounds and methods of use
TWI386401B (zh) * 2006-03-27 2013-02-21 Daiichi Seiyaku Co 醫藥用水合物
MY162052A (en) 2007-01-05 2017-05-31 Daiichi Sankyo Co Ltd Fused substitute aminopyrrolidine derivative
CN102089439B (zh) 2008-07-11 2013-11-13 住友化学株式会社 (1s，2r)-2-氯-2-氟环丙烷羧酸的制造方法
FR2961207B1 (fr) * 2010-06-09 2013-01-18 Oreal Utilisation d'un derive de 4- carboxy 2-pyrrolidinone comme solvant dans les compositions cosmetiques ; compositions cosmetiques les contenant ; nouveaux composes
CN103467448B (zh) * 2013-09-18 2015-04-15 浙江司太立制药股份有限公司 7-(3-氨基-4-烷氧亚胺基-1-哌啶基)-1-[(1r,2s)-2-氟环丙基]喹诺酮羧酸类化合物及其制备方法
EP2957561A1 (fr) * 2014-06-18 2015-12-23 Université Paris 6 Pierre et Marie Curie UPMC Nouveaux fluoroquinolones et leur utilisation pour traiter des infections bactériennes
CN105330590B (zh) * 2015-10-15 2018-09-25 广州市朗启医药科技有限责任公司 西他沙星五元环侧链中间体的制备方法
CN109912504B (zh) * 2019-04-04 2020-11-10 山东省联合农药工业有限公司 一种喹啉羧酸类化合物及其制备方法与用途

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3576335D1 (de) * 1984-12-14 1990-04-12 Daiichi Seiyaku Co Chinolincarbonsaeure-derivate.
HUT40639A (en) * 1985-03-08 1987-01-28 Kyorin Seiyaku Kk Process for producing quinolon-carboxylic acid derivative and pharmaceutical composition containing them
DE3509546A1 (de) * 1985-03-16 1986-09-25 Bayer Ag, 5090 Leverkusen 7-amino-1-(subst.cyclopropyl)-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
US4657913A (en) 1985-04-18 1987-04-14 Warner-Lambert Company Trifluoro- quinoline -3- carboxylic acids and their use as anti-bacterial agents
US4668680A (en) * 1985-12-12 1987-05-26 Warner-Lambert Company 5-amino-6,8-difluoroquinolones as antibacterial agents
US4735949A (en) 1986-02-18 1988-04-05 Warner-Lambert Company Disubstituted-7-pyrrolidinonaphthyridine antibacterial agents
DE3705621C2 (de) * 1986-02-25 1997-01-09 Otsuka Pharma Co Ltd Heterocyclisch substituierte Chinoloncarbonsäurederivate
DE3702393A1 (de) * 1987-01-28 1988-08-11 Bayer Ag 8-cyano-1-cyclopropyl-1,4-dihydro-4-oxo- 3-chinolincarbonsaeuren, verfahren zu ihrer herstellung und diese enthaltende antibakterielle mittel
US5290934A (en) * 1987-04-16 1994-03-01 Otsuka Pharmaceutical Company, Limited Benzoheterocyclic compounds
US4851418A (en) * 1987-08-21 1989-07-25 Warner-Lambert Company Naphthyridine antibacterial agents containing an α-amino acid in the side chain of the 7-substituent
MY105136A (en) * 1988-04-27 1994-08-30 Daiichi Seiyaku Co Optically active pyridonecarboxylic acid derivatives.
FI95130C (fi) * 1988-07-20 1995-12-27 Sankyo Co Menetelmä lääkeaineena käyttökelpoisten 4-oksokinoliini-3-karboksyylihapon johdannaisten valmistamiseksi
US5286723A (en) 1988-08-31 1994-02-15 Daiichi Seiyaku Co., Ltd. Spiro compound
FI901201A0 (fi) * 1989-03-13 1990-03-09 Bristol Myers Squibb Co Antibakteriella 5-substituerade 1,4-dihydro-4-oxonaftyridin-3-karboxylatderivat och deras framstaellning.
DE3910663A1 (de) * 1989-04-03 1990-10-04 Bayer Ag 5-alkylchinoloncarbonsaeuren
AR027761A1 (es) * 2000-03-31 2003-04-09 Daiichi Seiyaku Co Un derivado del acido quinolonacarboxilico, las composiciones antibacterianas que lo contienen y el uso de dicho derivado para la elaboracion de drogaspara el tratamiento de enfermedades infecciosas
JP4820290B2 (ja) * 2004-05-13 2011-11-24 第一三共株式会社 置換ピロリジン誘導体

Also Published As

Publication number Publication date
FI96947B (fi) 1996-06-14
ES2135372T3 (es) 1999-11-01
DE68929030D1 (de) 1999-08-19
IL90062A0 (en) 1989-12-15
IL90062A (en) 1994-10-07
RU2075475C1 (ru) 1997-03-20
GR3031365T3 (en) 2000-01-31
DK205789D0 (da) 1989-04-27
NO891698D0 (no) 1989-04-25
US5587386A (en) 1996-12-24
AU625414B2 (en) 1992-07-09
YU48432B (sh) 1998-07-10
JP2903292B2 (ja) 1999-06-07
SG48036A1 (en) 1998-04-17
JP2917010B2 (ja) 1999-07-12
CN1037507A (zh) 1989-11-29
JP2714597B2 (ja) 1998-02-16
PT90377B (pt) 1994-09-30
AU3370289A (en) 1989-11-02
FI96947C (fi) 1996-09-25
NO175939B (no) 1994-09-26
YU87589A (en) 1990-12-31
NO891698L (no) 1989-10-30
ATE182145T1 (de) 1999-07-15
KR900016205A (ko) 1990-11-12
LV10092B (en) 1995-02-20
PT90377A (pt) 1989-11-10
HK1002108A1 (en) 1998-07-31
FI891980A0 (fi) 1989-04-26
US6031102A (en) 2000-02-29
EP0341493B1 (fr) 1999-07-14
KR0184614B1 (ko) 1999-05-01
US5767127A (en) 1998-06-16
NO175939C (no) 1995-01-04
JPH11124380A (ja) 1999-05-11
JPH02231475A (ja) 1990-09-13
CN1033751C (zh) 1997-01-08
EP0341493A3 (fr) 1990-12-19
EP0341493A2 (fr) 1989-11-15
MY105136A (en) 1994-08-30
DK205789A (da) 1989-10-28
JPH11124367A (ja) 1999-05-11
CA1340801C (fr) 1999-10-26
FI891980A (fi) 1989-10-28
DE68929030T2 (de) 2000-03-23
JPH1067779A (ja) 1998-03-10
HU211136A9 (en) 1995-10-30
DK175467B1 (da) 2004-11-01
NZ228893A (en) 1990-06-26
UA29378C2 (uk) 2000-11-15
JPH07300416A (ja) 1995-11-14
USRE41149E1 (en) 2010-02-23

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