BG60412B2 - Нови бензазепинпроизводни,тяхното получаване и приложение като лекарствени средства - Google Patents

Нови бензазепинпроизводни,тяхното получаване и приложение като лекарствени средства Download PDF

Info

Publication number
BG60412B2
BG60412B2 BG98418A BG9841894A BG60412B2 BG 60412 B2 BG60412 B2 BG 60412B2 BG 98418 A BG98418 A BG 98418A BG 9841894 A BG9841894 A BG 9841894A BG 60412 B2 BG60412 B2 BG 60412B2
Authority
BG
Bulgaria
Prior art keywords
group
amino
carbon atoms
general formula
alkyl
Prior art date
Application number
BG98418A
Other languages
Bulgarian (bg)
English (en)
Inventor
Manfred Reiffen
Joachim Heider
Norbert Hauel
Volkhard Austel
Wolfgang Eberiein
Walter Kobinger
Christian Lillie
Klaus Noll
Helmut Pieper
Gerd Krueger
Johannes Keck
Original Assignee
Dr. Karl Thomae Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr. Karl Thomae Gmbh filed Critical Dr. Karl Thomae Gmbh
Publication of BG60412B2 publication Critical patent/BG60412B2/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/02—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/04—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
BG98418A 1981-05-19 1994-01-25 Нови бензазепинпроизводни,тяхното получаване и приложение като лекарствени средства BG60412B2 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19813119874 DE3119874A1 (de) 1981-05-19 1981-05-19 "benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel"

Publications (1)

Publication Number Publication Date
BG60412B2 true BG60412B2 (bg) 1995-02-28

Family

ID=6132690

Family Applications (1)

Application Number Title Priority Date Filing Date
BG98418A BG60412B2 (bg) 1981-05-19 1994-01-25 Нови бензазепинпроизводни,тяхното получаване и приложение като лекарствени средства

Country Status (29)

Country Link
EP (1) EP0065229B1 (ja)
JP (1) JPS57193462A (ja)
KR (3) KR890001545B1 (ja)
AR (1) AR231130A1 (ja)
AT (1) ATE14725T1 (ja)
AU (1) AU551509B2 (ja)
BG (1) BG60412B2 (ja)
CA (1) CA1185239A (ja)
CS (2) CS251760B2 (ja)
DD (1) DD202872A5 (ja)
DE (2) DE3119874A1 (ja)
DK (1) DK156720C (ja)
ES (5) ES8306726A1 (ja)
FI (1) FI77856C (ja)
GB (1) GB2099425B (ja)
GR (1) GR76458B (ja)
HK (1) HK43388A (ja)
HU (1) HU186584B (ja)
IE (1) IE53016B1 (ja)
IL (1) IL65814A (ja)
MX (1) MX9202743A (ja)
NO (1) NO159166C (ja)
NZ (1) NZ200659A (ja)
PL (1) PL136914B1 (ja)
PT (1) PT74919B (ja)
SU (1) SU1160935A3 (ja)
UA (1) UA8038A1 (ja)
YU (1) YU44674B (ja)
ZA (1) ZA823413B (ja)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3242599A1 (de) * 1982-11-18 1984-05-24 Dr. Karl Thomae Gmbh, 7950 Biberach Neue benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel
DE3343801A1 (de) * 1983-12-03 1985-06-13 Dr. Karl Thomae Gmbh, 7950 Biberach Neue indolderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3418270A1 (de) * 1984-05-17 1985-11-21 Dr. Karl Thomae Gmbh, 7950 Biberach Neue aminotetralinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3418271A1 (de) * 1984-05-17 1985-11-21 Dr. Karl Thomae Gmbh, 7950 Biberach Neue benzazepinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
EP0204349A3 (de) * 1985-06-01 1990-01-03 Dr. Karl Thomae GmbH Neue heteroaromatische Aminderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DE3541811A1 (de) * 1985-11-27 1987-06-04 Thomae Gmbh Dr K Neue cyclische aminderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3717561A1 (de) * 1987-05-25 1988-12-08 Thomae Gmbh Dr K Indol-, isochinolin- und benzazepinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3736866A1 (de) * 1987-10-30 1989-05-11 Thomae Gmbh Dr K Mittel zur behandlung des bluthochdrucks und der herzinsuffizienz
FR2624117B1 (fr) * 1987-12-08 1991-02-22 Synthelabo Derives de hydroxy-3 (methoxy-4 phenyl)-2 (methylamino-2 ethyl)-5 dihydro-2,3 5h-benzothiazepine-1,5 one-4, leur preparation et leur application en therapeutique
JP2699511B2 (ja) * 1988-01-29 1998-01-19 武田薬品工業株式会社 置換アミン類
JP2807577B2 (ja) * 1990-06-15 1998-10-08 エーザイ株式会社 環状アミド誘導体
FR2681862B1 (fr) * 1991-09-27 1993-11-12 Adir Cie Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent.
EP0700389A1 (en) * 1993-05-27 1996-03-13 Smithkline Beecham Laboratoires Pharmaceutiques Anti-arrhythmic n-substituted 3-benzazepines or isoquinolines
FR2705675B1 (fr) * 1993-05-27 1996-05-03 Smithkline Beecham Labo Pharma Nouveaux composés, leur procédé de préparation et leur utilisation en tant que médicaments.
SE9303274D0 (sv) * 1993-10-07 1993-10-07 Astra Ab Novel phenylethyl and phenylproplamines
DE10018401A1 (de) 2000-04-13 2001-10-25 Boehringer Ingelheim Pharma Verwendung von Bradycardica bei der Behandlung von mit Hypertrophie einhergehenden Myocarderkrankungen und neue Arzneimittelkombinationen
AU2002317910B2 (en) 2001-06-07 2008-06-19 Via Pharmaceuticals, Inc. Cyclic nucleotide phosphodiesterase inhibitors, preparation and uses thereof
CA2904555C (en) * 2003-08-29 2017-03-07 Mitsui Chemicals, Inc. Agricultural/horticultural insecticide and method for using the same
FR2868777B1 (fr) 2004-04-13 2006-05-26 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2868775B1 (fr) * 2004-04-13 2008-04-11 Servier Lab Nouveau procede de synthese de derives de la 1,3,4,5- tetrahydro-2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2868776B1 (fr) * 2004-04-13 2008-04-18 Servier Lab Nouveau procede de synthese de derives de la 1,3-dihydro- 2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2870537A1 (fr) * 2004-05-19 2005-11-25 Servier Lab Nouveau procede de synthese du (1s)-4,5-dimethoxy-1-(methyl aminomethyl-)-benzocyclobutane et de ses sels d'addition, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2882553B1 (fr) * 2005-02-28 2007-05-04 Servier Lab Forme cristalline beta du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2882556B1 (fr) * 2005-02-28 2007-05-04 Servier Lab Forme cristalline gamma d du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2882554B1 (fr) * 2005-02-28 2007-05-04 Servier Lab Forme critalline beta d du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2882555B1 (fr) * 2005-02-28 2007-05-04 Servier Lab Forme cristalline gamma du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
EP1762179A1 (en) 2005-09-07 2007-03-14 Boehringer Ingelheim Vetmedica Gmbh Method for improving diagnostic quality in echocardiography
FR2891826B1 (fr) * 2005-10-11 2007-12-28 Servier Lab Forme cristalline 6 du chlorhydrate de l'ivabradine, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2891827B1 (fr) * 2005-10-11 2007-12-28 Servier Lab Forme cristalline deltad du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2920773B1 (fr) * 2007-09-11 2009-10-23 Servier Lab Derives de 1,2,4,5-tetrahydro-3h-benzazepines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2935381B1 (fr) * 2008-08-29 2010-12-17 Servier Lab Nouveau procede de resolution des enantiomerees du (3,4-dimethoxy-bicyclo°4.2.0!octa-1,3,5-trien-7-yl)nitrile et application a la synthese de l'ivabradine
FR2941695B1 (fr) * 2009-02-04 2011-02-18 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2943667B1 (fr) * 2009-03-31 2011-05-06 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable.
ME00986B (me) * 2009-03-31 2012-06-20 Servier Lab Novi postupak sinteze ivabradina i njegovih adicionih soli sa farmaceutski prihvatljivom kiselinom
FR2956401B1 (fr) * 2010-02-17 2012-02-03 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
EP2741736B1 (en) 2011-08-12 2017-11-22 Boehringer Ingelheim Vetmedica GmbH Taste masked pharmaceutical composition
EP2953612A1 (en) 2013-02-11 2015-12-16 Boehringer Ingelheim Vetmedica GmbH Kit-of-parts
FR3003859B1 (fr) * 2013-03-26 2015-03-13 Servier Lab "procede de synthese de derives de la 7,8-dimethoxy-1,3-dihydro-2h-3-benzazepin-2-one et application a la synthese de l'ivabradine"
HU230826B1 (hu) * 2014-11-19 2018-07-30 Richter Gedeon Nyrt. Eljárás benzazepin származékok előállítására

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3474090A (en) * 1966-12-22 1969-10-21 American Cyanamid Co 3-aminoalkyl-1,3-benzodiazepin-2-ones
US3780023A (en) * 1972-06-30 1973-12-18 J Suh 2-aralkylamino-4,5-dihydro-3h-1,3-benzodiazepines
US4210749A (en) * 1974-11-12 1980-07-01 Pennwalt Corporation Substituted 1,2,4,5-tetrahydro-3H,3 benzazepines
DE2639718A1 (de) * 1976-09-03 1978-03-16 Thomae Gmbh Dr K Neue phenylaethylamine
ZA786230B (en) * 1977-12-21 1979-10-31 Smithkline Corp 8 and/or 9 substituted 2-benzazepine compounds
ZA792785B (en) 1978-07-07 1980-08-27 Smithkline Corp Mercapto substituted-2,3,4,5-tetrahydro-1h-3-benzazepines
ES484553A1 (es) * 1978-10-05 1980-05-16 Hoechst Ag Un metodo para preparar 4-fenil-1,3-benzodiazepinas
DE2850078A1 (de) * 1978-11-18 1980-05-29 Basf Ag Aminopropanolderivate des 6-hydroxy-2,3,4,5-tetrahydro-1h-1- benzazepin-2-ons

Also Published As

Publication number Publication date
HK43388A (en) 1988-06-17
FI77856C (fi) 1989-05-10
ES512285A0 (es) 1983-06-01
KR890001544B1 (ko) 1989-05-08
AU8379482A (en) 1982-11-25
NZ200659A (en) 1985-05-31
IE53016B1 (en) 1988-05-11
DK222382A (da) 1982-11-20
ES517758A0 (es) 1983-08-16
SU1160935A3 (ru) 1985-06-07
ZA823413B (en) 1984-01-25
GB2099425B (en) 1985-02-06
AU551509B2 (en) 1986-05-01
DE3265206D1 (en) 1985-09-12
HU186584B (en) 1985-08-28
DK156720C (da) 1990-02-19
CS410291A3 (en) 1992-08-12
CA1185239A (en) 1985-04-09
PT74919A (de) 1982-06-01
DE3119874A1 (de) 1982-12-09
NO159166B (no) 1988-08-29
ES8306726A1 (es) 1983-06-01
EP0065229A1 (de) 1982-11-24
IL65814A0 (en) 1982-08-31
ES517753A0 (es) 1983-08-16
ATE14725T1 (de) 1985-08-15
EP0065229B1 (de) 1985-08-07
NO159166C (no) 1988-12-07
ES8308311A1 (es) 1983-08-16
CS251760B2 (en) 1987-08-13
ES517757A0 (es) 1983-08-16
PL236474A1 (en) 1983-06-20
YU44674B (en) 1990-12-31
GR76458B (ja) 1984-08-10
PL136914B1 (en) 1986-04-30
ES8308310A1 (es) 1983-08-16
YU105182A (en) 1986-12-31
AR231130A1 (es) 1984-09-28
KR830010077A (ko) 1983-12-26
MX9202743A (es) 1992-06-30
JPS57193462A (en) 1982-11-27
ES8308312A1 (es) 1983-08-16
FI77856B (fi) 1989-01-31
ES517756A0 (es) 1983-08-16
GB2099425A (en) 1982-12-08
ES8308309A1 (es) 1983-08-16
KR890001545B1 (ko) 1989-05-08
KR890001550B1 (ko) 1989-05-08
FI821724A0 (fi) 1982-05-17
UA8038A1 (uk) 1995-12-26
DD202872A5 (de) 1983-10-05
NO821645L (no) 1982-11-22
PT74919B (de) 1985-05-16
IE821194L (en) 1982-11-19
DK156720B (da) 1989-09-25
JPH0136829B2 (ja) 1989-08-02
IL65814A (en) 1986-02-28

Similar Documents

Publication Publication Date Title
BG60412B2 (bg) Нови бензазепинпроизводни,тяхното получаване и приложение като лекарствени средства
US4490369A (en) Benzazepine derivatives, their pharmaceutical compositions and method of use
US4140789A (en) Etherified hydroxy-benzodiheterocyclic compounds
US4584293A (en) Aminotetralin derivatives
US5162318A (en) Benzimidazolinone derivatives
JPH0768190B2 (ja) 置換アミノアルキルビフエニル誘導体
EP0096838A1 (en) 1-Aryloxy-2,3,4,5-tetrahydro-3-benzazepines, a process for preparing the same and their use as medicaments
US4730042A (en) Compounds 1 or 3-hydroxy-4-benzyl-6-methyl-7-(4-isopropylamino-butoxy)-1,3-dihydro[3,4-C]pyridine and 2-methyl-3-(4-isopropyl-aminobutoxy)-4-(1'-morphilinomethyl)-5-hydroxymethyl-6-benzyl pyridine, useful for treating cardiac arrhythmias
FI62052B (fi) Foerfarande foer framstaellning av farmakologiskt vaerdefulla 4-aminofenyletanolaminer med saerskilt beta 2-mimetisk och/eller alfa 1-blockerande verkan
US4767769A (en) Antiulcer benzimidazole derivatives
US4363808A (en) N-(3-Phenoxy-2-hydroxypropyl)benzimidazole-1-alkanamines
PL179032B1 (pl) kwasu hydroksamowego oraz kompozycje farmaceutyczne zawierajace nowe pochodnekwasu hydroksamowego PL PL
US4086361A (en) Aminoethyl oximes having anti-depressive activity
DE3519735A1 (de) Neue heteroaromatische aminderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
US5932568A (en) 6-methoxy-1H-benzotriazole-5-carboxamide derivatives and pharmaceutical compositions containing them
Buzas et al. Synthesis and psychoanaleptic properties of new compounds structurally related to diphenhydramine
NO834222L (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive benzazepinderivater
NZ264883A (en) 5-phenylpyrazolyl-3-oxy derivatives and pharmaceutical compositions
Protiva et al. Potential noncataleptic neuroleptic agents; 2, 6-Dichloro-, 2, 7-dichloro-and 2, 8-dichloro-10-piperazino-10, 11-dihydrodibenzo [b, f] thiepins
JPH051040A (ja) 新規なベンズイミダゾリノン誘導体
SI8211051A8 (sl) Postopek za pripravo novih derivatov benzazepina
JPH0556345B2 (ja)
CS201042B2 (cs) Způsob výroby etherifikovaných hydroxybenzodiheterocyklických sloučenin