CS410291A3 - Novel benzazepine derivatives, process of their preparation andpharmaceuticals comprising them - Google Patents

Novel benzazepine derivatives, process of their preparation andpharmaceuticals comprising them

Info

Publication number
CS410291A3
CS410291A3 CS914102A CS410291A CS410291A3 CS 410291 A3 CS410291 A3 CS 410291A3 CS 914102 A CS914102 A CS 914102A CS 410291 A CS410291 A CS 410291A CS 410291 A3 CS410291 A3 CS 410291A3
Authority
CS
Czechoslovakia
Prior art keywords
andpharmaceuticals
preparation
benzazepine derivatives
novel benzazepine
novel
Prior art date
Application number
CS914102A
Other languages
Czech (cs)
Inventor
Manfred Dr Dipl Ing Reiffen
Joachim Dr Dipl Ing Heider
Norbert Dr Dipl Chem Hauel
Volkhard Dr Dipl Chem Austel
Wolfgang Dr Dipl Chem Eberlein
Walter Prof Dr Kobinger
Christien Dr Lillie
Klaus Dr Dipl Chem Noll
Helmut Dr Dipl Chem Pieper
Gerd Dr Dipl Chem Kruger
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of CS410291A3 publication Critical patent/CS410291A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/02—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/04—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
CS914102A 1981-05-19 1991-12-27 Novel benzazepine derivatives, process of their preparation andpharmaceuticals comprising them CS410291A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19813119874 DE3119874A1 (en) 1981-05-19 1981-05-19 "BENZAZEPINE DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS"

Publications (1)

Publication Number Publication Date
CS410291A3 true CS410291A3 (en) 1992-08-12

Family

ID=6132690

Family Applications (2)

Application Number Title Priority Date Filing Date
CS823456A CS251760B2 (en) 1981-05-19 1982-05-12 Method of benzazepines and benzodiazepines production
CS914102A CS410291A3 (en) 1981-05-19 1991-12-27 Novel benzazepine derivatives, process of their preparation andpharmaceuticals comprising them

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CS823456A CS251760B2 (en) 1981-05-19 1982-05-12 Method of benzazepines and benzodiazepines production

Country Status (29)

Country Link
EP (1) EP0065229B1 (en)
JP (1) JPS57193462A (en)
KR (3) KR890001545B1 (en)
AR (1) AR231130A1 (en)
AT (1) ATE14725T1 (en)
AU (1) AU551509B2 (en)
BG (1) BG60412B2 (en)
CA (1) CA1185239A (en)
CS (2) CS251760B2 (en)
DD (1) DD202872A5 (en)
DE (2) DE3119874A1 (en)
DK (1) DK156720C (en)
ES (5) ES8306726A1 (en)
FI (1) FI77856C (en)
GB (1) GB2099425B (en)
GR (1) GR76458B (en)
HK (1) HK43388A (en)
HU (1) HU186584B (en)
IE (1) IE53016B1 (en)
IL (1) IL65814A (en)
MX (1) MX9202743A (en)
NO (1) NO159166C (en)
NZ (1) NZ200659A (en)
PL (1) PL136914B1 (en)
PT (1) PT74919B (en)
SU (1) SU1160935A3 (en)
UA (1) UA8038A1 (en)
YU (1) YU44674B (en)
ZA (1) ZA823413B (en)

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DE3242599A1 (en) * 1982-11-18 1984-05-24 Dr. Karl Thomae Gmbh, 7950 Biberach NEW BENZAZEPINE DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS
DE3343801A1 (en) * 1983-12-03 1985-06-13 Dr. Karl Thomae Gmbh, 7950 Biberach NEW INDOLDER DERIVATIVES, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF
DE3418270A1 (en) * 1984-05-17 1985-11-21 Dr. Karl Thomae Gmbh, 7950 Biberach NEW AMINOTETRAL DERIVATIVES, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF
DE3418271A1 (en) * 1984-05-17 1985-11-21 Dr. Karl Thomae Gmbh, 7950 Biberach NEW BENZAZEPINE DERIVATIVES, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF
EP0204349A3 (en) * 1985-06-01 1990-01-03 Dr. Karl Thomae GmbH Heteroaromatic amine derivatives, medicaments containing them and process for their preparation
DE3541811A1 (en) * 1985-11-27 1987-06-04 Thomae Gmbh Dr K NEW CYCLIC AMINE DERIVATIVES, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF
DE3717561A1 (en) * 1987-05-25 1988-12-08 Thomae Gmbh Dr K INDOL, ISOCHINOLINE AND BENZAZEPINE DERIVATIVES, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF
DE3736866A1 (en) * 1987-10-30 1989-05-11 Thomae Gmbh Dr K MEANS FOR THE TREATMENT OF HYPERTENSION AND HEART FAILURE
FR2624117B1 (en) * 1987-12-08 1991-02-22 Synthelabo HYDROXY-3 (METHOXY-4 PHENYL) -2 (METHYLAMINO-2 ETHYL) -5 DIHYDRO-2,3 5H-BENZOTHIAZEPINE-1,5 ONE-4 DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
JP2699511B2 (en) * 1988-01-29 1998-01-19 武田薬品工業株式会社 Substituted amines
JP2807577B2 (en) * 1990-06-15 1998-10-08 エーザイ株式会社 Cyclic amide derivative
FR2681862B1 (en) * 1991-09-27 1993-11-12 Adir Cie NOVELS (BENZOCYCLOALKYL) ALKYLAMINES, THEIR PREPARATION PROCESS, AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
EP0700389A1 (en) * 1993-05-27 1996-03-13 Smithkline Beecham Laboratoires Pharmaceutiques Anti-arrhythmic n-substituted 3-benzazepines or isoquinolines
FR2705675B1 (en) * 1993-05-27 1996-05-03 Smithkline Beecham Labo Pharma New compounds, their preparation process and their use as medicaments.
SE9303274D0 (en) * 1993-10-07 1993-10-07 Astra Ab Novel phenylethyl and phenylproplamines
DE10018401A1 (en) 2000-04-13 2001-10-25 Boehringer Ingelheim Pharma Medicament for treating hypertrophy-related myocardial disease, containing bradycardic agent, preferably cilobradine, and optionally another cardiac drug
AU2002317910B2 (en) 2001-06-07 2008-06-19 Via Pharmaceuticals, Inc. Cyclic nucleotide phosphodiesterase inhibitors, preparation and uses thereof
CA2904555C (en) * 2003-08-29 2017-03-07 Mitsui Chemicals, Inc. Agricultural/horticultural insecticide and method for using the same
FR2868777B1 (en) 2004-04-13 2006-05-26 Servier Lab NOVEL PROCESS FOR THE SYNTHESIS OF IVABRADINE AND ITS SALTS OF ADDITION TO A PHARMACEUTICALLY ACCEPTABLE ACID
FR2868775B1 (en) * 2004-04-13 2008-04-11 Servier Lab NOVEL PROCESS FOR THE SYNTHESIS OF 1,3,4,5-TETRAHYDRO-2H-3-BENZAZEPIN-2-ONE DERIVATIVES AND THE APPLICATION TO THE SYNTHESIS OF IVABRADINE AND ITS SALTS OF ADDITION TO A PHARMACEUTICALLY ACCEPTABLE ACID
FR2868776B1 (en) * 2004-04-13 2008-04-18 Servier Lab NOVEL PROCESS FOR THE SYNTHESIS OF 1,3-DIHYDRO-2H-3-BENZAZEPIN-2-ONE DERIVATIVES AND THE APPLICATION TO THE SYNTHESIS OF IVABRADINE AND ITS SALTS OF ADDITION TO A PHARMACEUTICALLY ACCEPTABLE ACID
FR2870537A1 (en) * 2004-05-19 2005-11-25 Servier Lab NOVEL PROCESS FOR SYNTHESIZING (1S) -4,5-DIMETHOXY-1- (METHYL AMINOMETHYL) BENZOCYCLOBUTANE AND ITS ADDITION SALTS AND APPLICATION TO THE SYNTHESIS OF IVABRADINE AND ITS ADDITION SALTS PHARMACEUTICALLY ACCEPTABLE ACID
FR2882553B1 (en) * 2005-02-28 2007-05-04 Servier Lab CRYSTALLINE BETA FORM OF IVABRADINE HYDROCHLORIDE, PROCESS FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
FR2882556B1 (en) * 2005-02-28 2007-05-04 Servier Lab CRYSTALLINE GAMMA D FORM OF IVABRADINE HYDROCHLORIDE, PROCESS FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
FR2882554B1 (en) * 2005-02-28 2007-05-04 Servier Lab IVABRADINE HYDROCHLORIDE BETA D-CRYSTALLINE FORM, PROCESS FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
FR2882555B1 (en) * 2005-02-28 2007-05-04 Servier Lab CRYSTALLINE GAMMA FORM OF IVABRADINE HYDROCHLORIDE, PROCESS FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
EP1762179A1 (en) 2005-09-07 2007-03-14 Boehringer Ingelheim Vetmedica Gmbh Method for improving diagnostic quality in echocardiography
FR2891826B1 (en) * 2005-10-11 2007-12-28 Servier Lab CRYSTALLINE FORM 6 OF IVABRADINE HYDROCHLORIDE, PROCESS FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
FR2891827B1 (en) * 2005-10-11 2007-12-28 Servier Lab CRYSTALLINE DELTAD FORM OF IVABRADINE HYDROCHLORIDE, PROCESS FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
FR2920773B1 (en) * 2007-09-11 2009-10-23 Servier Lab 1,2,4,5-TETRAHYDRO-3H-BENZAZEPINES DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FR2935381B1 (en) * 2008-08-29 2010-12-17 Servier Lab NOVEL METHOD FOR THE RESOLUTION OF ENANTIOMERES OF (3,4-DIMETHOXY-BICYCLOO-4.2.0-OCTA-1,3,5-TRIEN-7-YL) NITRILE AND APPLICATION TO THE SYNTHESIS OF IVABRADINE
FR2941695B1 (en) * 2009-02-04 2011-02-18 Servier Lab NOVEL PROCESS FOR THE SYNTHESIS OF IVABRADINE AND ITS SALTS OF ADDITION TO A PHARMACEUTICALLY ACCEPTABLE ACID
FR2943667B1 (en) * 2009-03-31 2011-05-06 Servier Lab NEW PROCESS FOR THE SYNTHESIS OF IVABRADINE AND ITS SALTS OF ADDITION TO A PHARMACEUTICALLY ACCEPTABLE ACID
ME00986B (en) * 2009-03-31 2012-06-20 Servier Lab New process for synthesiis of ivabradine and addition salts thereof with a pharmaceutically accept able acid
FR2956401B1 (en) * 2010-02-17 2012-02-03 Servier Lab NOVEL PROCESS FOR THE SYNTHESIS OF IVABRADINE AND ITS SALTS OF ADDITION TO A PHARMACEUTICALLY ACCEPTABLE ACID
EP2741736B1 (en) 2011-08-12 2017-11-22 Boehringer Ingelheim Vetmedica GmbH Taste masked pharmaceutical composition
EP2953612A1 (en) 2013-02-11 2015-12-16 Boehringer Ingelheim Vetmedica GmbH Kit-of-parts
FR3003859B1 (en) * 2013-03-26 2015-03-13 Servier Lab "PROCESS FOR THE SYNTHESIS OF 7,8-DIMETHOXY-1,3-DIHYDRO-2H-3-BENZAZEPIN-2-ONE DERIVATIVES AND APPLICATION TO THE SYNTHESIS OF IVABRADINE"
HU230826B1 (en) * 2014-11-19 2018-07-30 Richter Gedeon Nyrt. Process for preparation of benzazepine derivatives

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US3780023A (en) * 1972-06-30 1973-12-18 J Suh 2-aralkylamino-4,5-dihydro-3h-1,3-benzodiazepines
US4210749A (en) * 1974-11-12 1980-07-01 Pennwalt Corporation Substituted 1,2,4,5-tetrahydro-3H,3 benzazepines
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ZA786230B (en) * 1977-12-21 1979-10-31 Smithkline Corp 8 and/or 9 substituted 2-benzazepine compounds
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ES484553A1 (en) * 1978-10-05 1980-05-16 Hoechst Ag 4-Phenyl-1,3-benzodiazepines, method for their preparation, pharmaceutical compositions containing them, and the compounds for use as medicaments.
DE2850078A1 (en) * 1978-11-18 1980-05-29 Basf Ag AMINOPROPANOL DERIVATIVES OF 6-HYDROXY-2,3,4,5-TETRAHYDRO-1H-1-BENZAZEPIN-2-ONS

Also Published As

Publication number Publication date
HK43388A (en) 1988-06-17
FI77856C (en) 1989-05-10
ES512285A0 (en) 1983-06-01
KR890001544B1 (en) 1989-05-08
AU8379482A (en) 1982-11-25
NZ200659A (en) 1985-05-31
IE53016B1 (en) 1988-05-11
DK222382A (en) 1982-11-20
ES517758A0 (en) 1983-08-16
SU1160935A3 (en) 1985-06-07
ZA823413B (en) 1984-01-25
GB2099425B (en) 1985-02-06
AU551509B2 (en) 1986-05-01
DE3265206D1 (en) 1985-09-12
HU186584B (en) 1985-08-28
DK156720C (en) 1990-02-19
CA1185239A (en) 1985-04-09
PT74919A (en) 1982-06-01
DE3119874A1 (en) 1982-12-09
NO159166B (en) 1988-08-29
ES8306726A1 (en) 1983-06-01
EP0065229A1 (en) 1982-11-24
IL65814A0 (en) 1982-08-31
ES517753A0 (en) 1983-08-16
ATE14725T1 (en) 1985-08-15
EP0065229B1 (en) 1985-08-07
NO159166C (en) 1988-12-07
ES8308311A1 (en) 1983-08-16
CS251760B2 (en) 1987-08-13
BG60412B2 (en) 1995-02-28
ES517757A0 (en) 1983-08-16
PL236474A1 (en) 1983-06-20
YU44674B (en) 1990-12-31
GR76458B (en) 1984-08-10
PL136914B1 (en) 1986-04-30
ES8308310A1 (en) 1983-08-16
YU105182A (en) 1986-12-31
AR231130A1 (en) 1984-09-28
KR830010077A (en) 1983-12-26
MX9202743A (en) 1992-06-30
JPS57193462A (en) 1982-11-27
ES8308312A1 (en) 1983-08-16
FI77856B (en) 1989-01-31
ES517756A0 (en) 1983-08-16
GB2099425A (en) 1982-12-08
ES8308309A1 (en) 1983-08-16
KR890001545B1 (en) 1989-05-08
KR890001550B1 (en) 1989-05-08
FI821724A0 (en) 1982-05-17
UA8038A1 (en) 1995-12-26
DD202872A5 (en) 1983-10-05
NO821645L (en) 1982-11-22
PT74919B (en) 1985-05-16
IE821194L (en) 1982-11-19
DK156720B (en) 1989-09-25
JPH0136829B2 (en) 1989-08-02
IL65814A (en) 1986-02-28

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