NO159166B - ANALOGY PROCEDURE FOR THE PREPARATION OF PHARMACOLOGICALLY ACTIVE BENZOAZEPINE DERIVATIVES. - Google Patents

ANALOGY PROCEDURE FOR THE PREPARATION OF PHARMACOLOGICALLY ACTIVE BENZOAZEPINE DERIVATIVES. Download PDF

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NO159166B
NO159166B NO821645A NO821645A NO159166B NO 159166 B NO159166 B NO 159166B NO 821645 A NO821645 A NO 821645A NO 821645 A NO821645 A NO 821645A NO 159166 B NO159166 B NO 159166B
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benzenesulfonyl
ethyl
melting point
carbonamido
urea
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Manfred Reiffen
Joachim Heider
Norbert Hauel
Volkhard Austel
Wolfgang Eberlein
Walter Kobinger
Helmut Pieper
Gerd Krueger
Johannes Keck
Christian Lillie
Klaus Noll
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Thomae Gmbh Dr K
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/02—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/04—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Description

Analogifremgangsmåte til fremstilling av terapeutisk aktive benzolsulfonylurinstoffer. Analogous process for the preparation of therapeutically active benzenesulfonylureas.

Oppfinnelsens gjenstand er en analogifremgangsmåte til fremstilling av benzolsulfonylurinstoffer med formel The object of the invention is an analogous method for the preparation of benzenesulfonylureas of formula

hvori Ri betyr in which Ri means

a) alkyl med 3 til 6 karbonatomer, a) alkyl with 3 to 6 carbon atoms,

b) lavere fenylalkyl, b) lower phenylalkyl,

c) lavere cykloheksylalkyl, c) lower cyclohexylalkyl,

d) endoalkylencykloheksyl, endoalkylencyklohekse-nyl, endoalkylencykloheksylmetyl, eller endoal-kylencykloheksenylmetyl med 1 til 2 endoalky-lenkarbonatomer, e) lavere alkyleykloheksyl, lavere alkoksyoklo-heksyl, d) endoalkylenecyclohexyl, endoalkylenecyclohexenyl, endoalkylenecyclohexylmethyl, or endoalkylenecyclohexenylmethyl with 1 to 2 endoalkylene carbon atoms, e) lower alkylenecyclohexyl, lower alkoxycyclohexyl,

f) cykloalkyl med 5 til 8 karbonatomer, f) cycloalkyl with 5 to 8 carbon atoms,

g) cykloheksenyl, cykloheksenylmetyl, g) cyclohexenyl, cyclohexenylmethyl,

X betyr X means

a) tiofenyl, som eventuelt kan ha 1 til 2 substituenter fra gruppen halogen, lavere alkyl, lavere alkoksy, lavere alkenyloksy, lavere alkok-sylakoksy eller fenyl-(laverealkoksy) ellerfenyl eller en ved begge ender med tiofenkjernen sammenknyttet tetrametylenkjede, b) furyl, som eventuelt kan ha en halogensubsti-tuent, a) thiophenyl, which may optionally have 1 to 2 substituents from the group of halogen, lower alkyl, lower alkoxy, lower alkenyloxy, lower alkoxy-syl oxy or phenyl-(lower alkyloxy) or phenyl or a tetramethylene chain linked at both ends to the thiophene nucleus, b) furyl, which may optionally have a halogen substituent,

og n er 2 eller 3, eller deres salter. and n is 2 or 3, or their salts.

I det ovenfor nevnte og i de følgende defini-sjoner betyr «lavere alkyl» alltid en slik med 1 til 4 karbonatomer i rettlinjet eller forgrenet kjede. «Lavere acyl» betyr en acylrest (organisk syrerest) med inntil 4 karbonatomer, fortrinnsvis en rettlinjet eller forgrenet alkanoylrest av tilsvarende kjedelengde. In the above-mentioned and in the following definitions, "lower alkyl" always means one with 1 to 4 carbon atoms in a straight or branched chain. "Lower acyl" means an acyl residue (organic acid residue) with up to 4 carbon atoms, preferably a straight or branched alkanoyl residue of corresponding chain length.

Ri kan eksempelvis bety propyl, isopropyl, butyl, isobutyl, sek. butyl, rettlinjet eller forgrenet amyl (pentyl), ■heksyl. Videre kan det som Ri anvendes benzyl, «-fenyletyl, /?-fenyletyl, a-, eller Ri can, for example, mean propyl, isopropyl, butyl, isobutyl, sec. butyl, straight or branched amyl (pentyl), ■hexyl. Furthermore, benzyl, ?-phenylethyl, ?-phenylethyl, α-, or

•y-fenylpropyl eller fenylbutyl. •y-phenylpropyl or phenylbutyl.

Spesielt foretrukket er innen oppfinnelsens ramme slike forbindelser som, som R<1>, inneholder cy-kloheksylmetyl, a- eller j8-cykloheksyletyl, cyklohek-sylpropyler, endometylen-cykloheksyl (2,2,1-tricy-kloheptyl), endoetylencykloheksyl (2,2,2-tricyklo-oktyl), endometylencykloheksenyl, endotylencyklo-heksenyl, endometylencykloheksylmetyl, endoetylen-cykloheksylmetyl, endometylencykloheksenylmetyl eller endoetylencykloheksenylmetyl. Particularly preferred within the scope of the invention are such compounds which, as R<1>, contain cyclohexylmethyl, a- or j8-cyclohexylethyl, cyclohexylpropyl, endomethylene-cyclohexyl (2,2,1-tricycloheptyl), endoethylenecyclohexyl (2 ,2,2-tricyclooctyl), endomethylenecyclohexenyl, endothylenecyclohexenyl, endomethylenecyclohexylmethyl, endoethylenecyclohexylmethyl, endomethylenecyclohexenylmethyl or endoethylenecyclohexenylmethyl.

De som ledd X i ovennevnte formel aktuelle heterocykliske ringsystemer er følgende: The heterocyclic ring systems relevant to term X in the above formula are the following:

Disse ringsystemer, som dessuten kan ha en, eller for tiofenyringenes vedkommende også to like eller to forskjellige av de i innledningen nevnte substituenter i vilkårlig stilling, er med de i formle-ne gjengitte frie valenser hver gang bundet direkte til en karbonylgruppe. These ring systems, which can also have one, or in the case of the thiopheny rings also two identical or two different, of the substituents mentioned in the introduction in any position, are each time bound directly to a carbonyl group with the free valences shown in the formulas.

Broleddet CnH2n kan være —CH2—, —CH2—, CH2—, —CH(CH3)—, —CH2—CH2—CH2—, —CH-(CH3) —CH2—, —CH2—CH(CHg)— eller —C (CH3)2—. The bridge link CnH2n can be —CH2—, —CH2—, CH2—, —CH(CH3)—, —CH2—CH2—CH2—, —CH-(CH3) —CH2—, —CH2—CH(CHg)— or — C(CH3)2—.

Analogifremgangsmåten ifølge oppfinnelsen er karakterisert ved at man enten , The analogy method according to the invention is characterized in that one either,

a) omsetter med gruppen a) transacts with the group

substituerte benzolsulfonylisocyanater, -karbaminsyreestere, -tiolkarbaminsyreestere, -karbaminsyrehalogenider eller -urinstoffer eller reaksjonsdyktige derivater derav, med Ri-substituerte aminer eller eventuelt deres salter, eller b) omsetter benzolsulfonamider med formel eller eventuelt deres salter, med R1-substituerte isocyanater, karbaminsyreestere, tiolkarbaminsyreestere, karbaminsyrehalogenider eller urinstoffer eller reaksjonsdyktige derivater derav, eller c) hydrolyserer tilsvarende substituerte benzolsul-fonylisourinstoffetere, -isotio-urinstoffetere eller -parabansyrer, eller d) i tilsvarende substituerte benzolsulfonyltiourin-stoffer utveksler svovelatomet på kjent måte substituted benzenesulfonyl isocyanates, -carbamic acid esters, -thiocarbamic acid esters, -carbamic acid halides or -ureas or reactive derivatives thereof, with Ri-substituted amines or optionally their salts, or b) reacts benzenesulfonamides of formula or optionally their salts, with R1-substituted isocyanates, carbamic acid esters, thiolcarbamic acid esters , carbamic acid halides or ureas or reactive derivatives thereof, or c) hydrolyze correspondingly substituted benzenesulfonylurea ethers, isothiourea ethers or parabanic acids, or d) in correspondingly substituted benzenesulfonylthioureas, exchange the sulfur atom in a known manner

med et oksygenatom , eller with an oxygen atom, or

e) oksyderer tilsvarende benzolsulfinyl- resp. ben-zolsulfenylurinstoffer, eller e) correspondingly oxidizes benzenesulfinyl- or benzenesulfenyl ureas, or

f) i benzolsulfonylurinstoffer med formel f) in benzenesulfonylureas of formula

ved acylering innfører resten X—CO—, eller g) omsetter tilsvarende substituerte benzolsulfo-nylhalogenider med Ri-substituerte urinstoffer, by acylation the residue introduces X—CO—, or g) reacts correspondingly substituted benzenesulfonyl halides with Ri-substituted ureas,

og eventuelt behandler reaksjonsproduktene med alkaliske midler for saltdannelse. and optionally treating the reaction products with alkaline agents for salt formation.

Alt etter naturen av leddet X vil i enkelte tilfelle den ene eller andre av de nevnte fremgangs- Depending on the nature of section X, in some cases one or the other of the aforementioned progress-

måter være uegnet for fremstilling av de under den generelle formel fallende individuelle forbindelser eller i det minste nødvendiggjøre forholdsregler til beskyttelse av aktive grupper. Slike forholdsvis sjel-dent opptredende tilfeller kan lett erkjennes av fag-folk, og det byr ikke på noen vanskeligheter i slike tilfeller med resultat å anvende en annen av de nevnte synteseveier. ways be unsuitable for the preparation of the individual compounds falling under the general formula or at least necessitate precautions for the protection of active groups. Such relatively rarely occurring cases can be easily recognized by those skilled in the art, and it does not present any difficulties in such cases with the result of using another of the aforementioned synthesis routes.

Istedenfor benzolsulfonyl-isocyanater kan man også anvende omsetningsprodukter av benzolsulfonyl-isocyanater med syreamider som kaprolaktam eller butyrolaktam, videre med svakt basiske aminer som karbazoler. Instead of benzenesulfonyl isocyanates, one can also use reaction products of benzenesulfonyl isocyanates with acid amides such as caprolactam or butyrolactam, further with weakly basic amines such as carbazoles.

De nevnte benzolsulfonyl-karbaminsyreestere resp. -tiolkarbaminsyreestere kan i alkoholkompo-nenten ha en lavmolekylær alkylrest eller en fenyl-rest. Det samme gjelder for de R<1->substituerte karbaminsyreestere resp. de tilsvarende monotiokarba-minsyreestere. Med en lavmolekylær resp. lavere alkylrest skal det innen oppfinnelsens ramme for-ståes i alle tilfelle en slik med ikke mer enn 4 karbonatomer. The mentioned benzenesulfonyl-carbamic acid esters resp. -thiocarbamic acid esters can have a low molecular weight alkyl residue or a phenyl residue in the alcohol component. The same applies to the R<1->substituted carbamic acid esters or the corresponding monothiocarbamic acid esters. With a low molecular resp. lower alkyl residue, within the scope of the invention, is to be understood in all cases as one with no more than 4 carbon atoms.

Som karbaminsyrehalogenider egner seg i før-ste rekke kloridene. The chlorides are primarily suitable as carbamic acid halides.

De som utgangsstoffer for fremgangsmåten anvendte benzolsulfonylurinstoffer kan ved den siden av urinstoffmolekylet som er vendt bort fra sulfo-nylgruppen, være usubstituert eller en eller to gan-ger substituert med fortrinnsvis lavere alkylrester eller arylrester. Istedenfor på slik måte substituerte benzolsulfonyl-urinstoff er kan det også anvendes tilsvarende N-benzolsulfonyl-N'-acyl-urinstoffer (aeyl = lavere alifatisk acyl som acetyl, propionyl eller butyryl, imidlertid også benzoyl) og også bis-(benzolsulfonyl-urinstoff er. Man kan eksempelvis be-handle slike bis-(benzolsylfonyl)-urinstoffer eller N-benzolsulfonyl-N'-acylurinstoffer med aminer R<i>NH2 og oppvarme de dannede salter til forhøyede temperaturer, spesielt slike over 100°C. The benzenesulfonylureas used as starting materials for the method can, on the side of the urea molecule facing away from the sulfonyl group, be unsubstituted or substituted once or twice with preferably lower alkyl residues or aryl residues. Instead of substituted benzenesulfonyl ureas in this way, corresponding N-benzenesulfonyl-N'-acyl ureas can also be used (aeyl = lower aliphatic acyl such as acetyl, propionyl or butyryl, however also benzoyl) and also bis-(benzenesulfonyl ureas) One can, for example, treat such bis-(benzenesulfonyl)-ureas or N-benzenesulfonyl-N'-acyl ureas with amines R<i>NH2 and heat the formed salts to elevated temperatures, especially those above 100°C.

Videre er det mulig å gå ut fra urinstoffer med formel Ri-NH-CO-NHZ, hvori Z betyr hydrogen eller en, fortrinnsvis lav-molekylær, alifatisk eller aromatisk syrerest eller en nitrogruppe, resp. fra fenyl-urinstoffer med formel Ri-NH-CO-NH-C6H5 eller fra difenylurinstoffer med formel Ri-NH-CO-N Furthermore, it is possible to proceed from ureas with the formula Ri-NH-CO-NHZ, in which Z means hydrogen or a, preferably low-molecular, aliphatic or aromatic acid residue or a nitro group, resp. from phenylureas with the formula Ri-NH-CO-NH-C6H5 or from diphenylureas with the formula Ri-NH-CO-N

(C6H5)2 idet fenylrestene kan være såvel direkte (C6H5)2 in that the phenyl residues can be either direct

forbundet eller også forbundet med hverandre over et broledd som -CH2-, -NH-, -O- eller -S-, eller fra N,N'-disubstituerte urinstoffer med formel Ri-NH-CO-NH-Ri og omsette disse med X-CONHCnH2n-substituerte benzolsulfonamider. connected or also connected to each other via a bridge link such as -CH2-, -NH-, -O- or -S-, or from N,N'-disubstituted ureas of the formula Ri-NH-CO-NH-Ri and reacting these with X-CONHCnH2n-substituted benzenesulfonamides.

Svovelatomets erstatning med et oksygenatom i de tilsvarende substituerte benzolsylfonyl-tiourin-stoffer kan eksempelvis utføres ved hjelp av oksyder eller salter av tungmetaller eller også ved anvendelse av oksydasjonsmidler som hydrogenperoksyd, na-triumperoksyd eller salpetersyrling. The replacement of the sulfur atom with an oxygen atom in the correspondingly substituted benzenesulfonyl-thiourine substances can be carried out, for example, by means of oxides or salts of heavy metals or also by using oxidizing agents such as hydrogen peroxide, sodium peroxide or nitric acid.

Tiourinstoffene kan også avsvovles ved behandling med fosgen eller fosforpentaklorid. Som mel-lomtrinn dannede klormaursyreamider resp. — kar-bodiimider kan ved egnede forholdsregler som for-såpning eller tilleiring av vann overføres i bensol-sulfonylurinstoffene. The thioureas can also be desulphurised by treatment with phosgene or phosphorus pentachloride. As intermediate steps formed chloroformic acid amides resp. - carbodiimides can be transferred into the benzol-sulfonylureas by suitable precautions such as saponification or addition of water.

Utf ørelsesf ormen av fremgangsmåten ifølge oppfinnelsen kan generelt varieres sterkt med hensyn til reaksjonsbetingelser og tilpasses de eventuelle forhold. The embodiment of the method according to the invention can generally be varied greatly with regard to reaction conditions and adapted to any conditions.

Eksempelvis kan omsetningen gjennomføres under anvendelse av oppløsningsmidler ved værelsestemperatur eller ved forhøyet temperatur. For example, the reaction can be carried out using solvents at room temperature or at an elevated temperature.

Som utgangsstoffer anvender man på den ene side slike forbindelser som inneholder en med grup- As starting materials, on the one hand, such compounds are used which contain a with group

pen X-CONHCnH2n^substituert benzolrest. Som eksempel på bestanddelen X-CO- i denne formel skal neat X-CONHCnH2n^substituted benzene residue. As an example of the component X-CO- in this formula shall

det.nevnes følgende, uten dermed krav på fullsten-dighet : the following is mentioned, with no claim to completeness:

De omtalte benzolsulfonylurinstoff-derivaters blodsukkersenkende virkning kunne fastslåes ved at man foret dem i doser på 10 mg/kg til kaniner og bestemte blodsukkerverdien etter den kjente metode av Hagedorn-Jensen eller med autoanalysør over et lengre tidsrom. The blood sugar-lowering effect of the mentioned benzenesulfonylurea derivatives could be determined by feeding them in doses of 10 mg/kg to rabbits and determining the blood sugar value according to the known method of Hagedorn-Jensen or with an autoanalyzer over a longer period of time.

Således ble det eksempelvis- fastslått at 10 mg/kg N-[-(/Murfuroylaminoetyl)-benzolsulfonyl]-N'-(4-metylcykloheksyl)-urinstoff eller N-[4-(/3-fur-f uroylaminoetyl) ^benzolsulf onyl] -N'-cykloheksyl-urinstoff etter 3 timer bevirker en blodsukkersenkning på 30 % og 10 mg/kg N- [4- (/?-furfuroylamino-etyl) -benzolsulf onyl] -N'- (4-etylcykloheksyl) -urinstoff sogar bevirker en blodsukkersenkning på 37 %. i Samtidig ble det fastslått at 10 mg/kg N-[4-(j8-tiofen^karbonamido-etyl) -benzolsulfonyl] -N'-cykloheksyl-urinstoff etter 3 timer bevirker en blodsukkersenkning på 45 %, mens det kjente N-(4-metyl-benzosulfonyl)-N'-butylurinstoff ved en dosering på mindre enn 25 mg/kg på kaniner ikke mere frembringer noen senkning av blodsukkerspeilet. Thus, for example, it was established that 10 mg/kg N-[-(/Murfuroylaminoethyl)-benzenesulfonyl]-N'-(4-methylcyclohexyl)-urea or N-[4-(/3-fur-furoylaminoethyl) ^benzenesulph onyl] -N'-cyclohexyl-urea after 3 hours causes a blood glucose lowering of 30% and 10 mg/kg N- [4-(/?-furfuroylamino-ethyl)-benzenesulfonyl]-N'-(4-ethylcyclohexyl)- urea even causes a 37% drop in blood sugar. i At the same time, it was determined that 10 mg/kg of N-[4-(j8-thiophene^carbonamido-ethyl)-benzenesulfonyl]-N'-cyclohexyl-urea after 3 hours causes a blood sugar lowering of 45%, while the known N-( 4-methyl-benzosulfonyl)-N'-butylurea at a dosage of less than 25 mg/kg in rabbits no longer produces any lowering of the blood sugar level.

De beskrevne benzolsulfonyl-urinstoffers sterke virkning blir spesielt tydelig når man ytterligere nedsetter dosen. Administrerer man N-[4-(/?-fur-f uroylaminoetyl) -benzolsulfonyl] -N'- (4-etylcykloheksyl )-urinstoff i en dosering på 0,2 mg/kg eller N- [4- (/3-tiof en-2-karbonamidoetyl) -benzolsulfonyl] - i N'-cykloheksyl-urinstoff i en dosering på 1 mg/kg i eller N-[4-(JS-3-metoksy-tiofen-2-karbonamidoetyl)-benzolsulfonyl]-N'-cykloheksyl-urinstoff i en dosering på 0,2 mg/kg eller N-[4-(/3-3-benzyloksy-tiofen- ] 2-karbonamido-etyl) -benzolsulfonyl] -N'- (-metyl-cykloheksyl)-urinstoff i en dosering på 0,2 mg/kg i på kaniner, så kan det stadig fastslåes en tydelig blodsukkersenkning. The strong effect of the described benzenesulfonylureas becomes particularly evident when the dose is further reduced. Administering N-[4-(/?-fur-furoylaminoethyl)-benzenesulfonyl]-N'-(4-ethylcyclohexyl)-urea in a dosage of 0.2 mg/kg or N- [4- (/3- thiophene-2-carbonamidoethyl)-benzenesulfonyl] - in N'-cyclohexyl-urea in a dosage of 1 mg/kg in or N-[4-(JS-3-methoxythiophene-2-carbonamidoethyl)-benzenesulfonyl]- N'-cyclohexyl-urea in a dosage of 0.2 mg/kg or N-[4-(/3-3-benzyloxy-thiophene-] 2-carbonamido-ethyl)-benzenesulfonyl]-N'-(-methyl- cyclohexyl)-urea in a dosage of 0.2 mg/kg in rabbits, a clear lowering of blood sugar can still be determined.

De omtalte benzolsulfonylurinstoffer skal for- ; trinnsvis tjene til fremstilling av oralt administrer- : bare preparater med blodsukkersenkende virkning for behandling av diabetes mellitus, og kan appli-seres som sådanne eller i form av deres salter resp. ] i nærvær av stoffer som fører til en saltdannelse. 1 Til saltdannelse kan det eksempelvis anvendes: Alkaliske midler som alkali- eller jordalkali-hydroksy-der, -karbonater eller -bikarbonater. The mentioned benzenesulfonylureas must for- ; gradually serve for the production of orally administrable preparations with a blood sugar-lowering effect for the treatment of diabetes mellitus, and can be applied as such or in the form of their salts or ] in the presence of substances that lead to salt formation. 1 For salt formation, for example, the following can be used: Alkaline agents such as alkali or alkaline earth hydroxides, carbonates or bicarbonates.

Som medisinske preparater kommer det fortrinnsvis i betraktning tabletter som ved siden av fremgangsmåteproduktene inneholder de vanlige hjelpe- og bærestoffer, som talkum, stivelse, melke-sukker, tragant eller magnesiumstearat. As medicinal preparations, tablets are preferably taken into consideration which, in addition to the process products, contain the usual auxiliary and carrier substances, such as talc, starch, milk sugar, tragacanth or magnesium stearate.

Et preparat som inneholder de beskrevne benzolsulfonylurinstoffer som virksomt stoff, f.eks. en A preparation containing the described benzenesulfonylureas as active substance, e.g. one

tablett eller et pulver med eller uten de nevnte til-setninger er hensiktsmessig bragt i en egnet dose-form. Som dose velges da en slik som er tilpasset det anvendte benzol-l-sulfonylurinstoffs virkning og den ønskede effekt. Hensiktsmessig utgjør doserin-gen per enhet ca. 0,5 til 100 mg, fortrinnsvis 2 til 10 mg, imidlertid kan det også anvendes betraktelig høyere eller lavere liggende doseringsenheter som eventuelt før applikasjonen må deles resp. mang-foldiggjøres. tablet or a powder with or without the aforementioned additives is suitably brought into a suitable dosage form. The dose is then chosen which is adapted to the effect of the benzol-l-sulfonylurea used and the desired effect. Appropriately, the dosage per unit amounts to approx. 0.5 to 100 mg. many-multiplied.

Eksempel 1: N- [4- (/?-tiofen-2-karbonamido-etyl) -benzolsulfonyl] Example 1: N-[4-(/?-thiophene-2-carbonamido-ethyl)-benzenesulfonyl]

-N'-cykloheksyl-urinstoff. -N'-cyclohexyl urea.

15,5 g 4-(j8-tiofen-2-karbonamido-etyl)-benzolsulf onamid (smeltepunkt 238 °C, fremstilt av 4-(/}-aminoetyl-benzolsulfonamid og tiofen-2-karbonsyre-klorid) bringes i oppløsning i 200 ml aceton ved tilsetning av 2 g NaOH og vann. Hertil drypper man under omrøring ved værelsestemperatur 6,5 g cykloheksylisocyanat, etteromrører i 2 timer, filtrerer fra en lett uklarhet og surgjør filtratet med saltsyre. Det utfelte reaksjonsprodukt gjenutfelles fra 1 %-ig ammoniakk og omkrystalliseres fra eta-tiol/vann. N- [4-/3-tiof en-2-karbonamido-etyl) -ben-2olsulfonyl]-N'-cykloheksyl-urinstoff smelter ved 194—196° C. 15.5 g of 4-(18-thiophene-2-carbonamido-ethyl)-benzenesulfonamide (melting point 238 °C, prepared from 4-(/}-aminoethyl-benzenesulfonamide and thiophene-2-carbonic acid chloride) are dissolved in 200 ml of acetone by adding 2 g of NaOH and water. 6.5 g of cyclohexyl isocyanate is added dropwise while stirring at room temperature, stirring for 2 hours, filtering from a slight haze and acidifying the filtrate with hydrochloric acid. The precipitated reaction product is reprecipitated from 1% ammonia and recrystallized from ethyl thiol/water.N-[4-(3-thiophene-2-carbonamido-ethyl)-ben-2olsulfonyl]-N'-cyclohexylurea melts at 194-196°C.

På analog måte får man: Analogously, you get:

M- [4- (/3-tiof en-2-karbonamidoetyl) -benzolsulfonyl] - M'-butylurinstoff, smeltepunkt 213—215 °C, M-[4-(/3-thiophene-2-carbonamidoethyl)-benzenesulfonyl]-M'-butylurea, melting point 213-215 °C,

N- [4- (/Miofen-2-karbonamidoetyl) -benzolsulf onyl] - N'-(4-etyl-cykloheksyl)-urinstoff med smeltepunkt 192—194°C, N- [ 4- (/3-tiofen-2-karbonamidoetyl) -benzolsulfonyl ] - N'-(4-metyl-cykloheksyl)-urinstoff med smeltepunkt 181—183° C. N-[4-(/Miophene-2-carbonamidoethyl)-benzenesulfonyl]-N'-(4-ethyl-cyclohexyl)-urea with melting point 192—194°C, N-[ 4-(/3-thiophene-2 -carbonamidoethyl)-benzenesulfonyl]-N'-(4-methyl-cyclohexyl)-urea with melting point 181-183°C.

På analog måte vil man av 4- (tiofen-2-karbona-midometyl-benzolsulfonamid (smeltepunkt 219— 221°C) få: N- [4- (y8-tiof en-2-karbonamidoetyl) -benzolsulfonyl] - N'-butyl-urinstoff med smeltepunkt 155—157 °C, N- [4- (^-tiofen-2-karbonamidoetyl) -benzolsulfonyl] - N'-cykloheksyl-urinstoff med smeltepunkt 187— 188° C, In an analogous way, from 4-(thiophene-2-carbonamidomethyl-benzenesulfonamide (melting point 219-221°C) you get: N- [4-(y8-thiophene-2-carbonamidoethyl)-benzenesulfonyl] - N'- butyl urea with a melting point of 155—157 °C, N-[4-(^-thiophene-2-carbonamidoethyl)-benzenesulfonyl]-N'-cyclohexyl urea with a melting point of 187—188° C,

N- [4- (/3-tiofen-2-karbonamidoetyl) -benzolsulfonyl] - N'-(4-etyl-cykloheksyl)-urinstoff med smeltepunkt 196—198° C. N-[4-(/3-thiophene-2-carbonamidoethyl)-benzenesulfonyl]-N'-(4-ethyl-cyclohexyl)-urea with a melting point of 196-198°C.

Eksempel 2: Example 2:

N- [4- (^-5-klor-tiof en-2-karbonamidoetyl) -benzolsulfonyl] -N'-cykloheksyl-urinstoff. N-[4-(^-5-chloro-thiophene-2-carbonamidoethyl)-benzenesulfonyl]-N'-cyclohexylurea.

17,2 g 4- (J8-klor-tiofen-2-karbonamidoetyl) -benzolsulf onamid (smeltepunkt 280 °C, fremstilt fra 4- (/?-aminoetyl) -benzolsulfonamid og 5-klor-tiofen-2-karbonsyreklorid) suspenderes i 200 ml aceton og bringes i oppløsning ved tilsetning av 2 g natrium-hydroksyd og vann. Hertil drypper man 6,5 g cykloheksylisocyanat og etteromrører i 2 timer. En liten uklarhet suges fra, filtratet blandes med vann og saltsyre og det utfelte produkt omkrystalliseres fra etanol-vann. Det dannede N-[4-(/?-5-klor-tiofen-2-karbonamidoetyl) -benzolsulfonyl] -N'-cykloheksyl-urinstoff smelter ved 189—191° C. 17.2 g of 4-(J8-chloro-thiophene-2-carbonamidoethyl)-benzenesulfonamide (melting point 280 °C, prepared from 4-(/?-aminoethyl)-benzenesulfonamide and 5-chloro-thiophene-2-carbonic acid chloride) are suspended in 200 ml of acetone and dissolved by adding 2 g of sodium hydroxide and water. To this, 6.5 g of cyclohexyl isocyanate are added and stirred for 2 hours. A slight turbidity is sucked off, the filtrate is mixed with water and hydrochloric acid and the precipitated product is recrystallized from ethanol-water. The formed N-[4-(/?-5-chloro-thiophene-2-carbonamidoethyl)-benzenesulfonyl]-N'-cyclohexyl urea melts at 189-191°C.

På analog måte får man. N-[4-(/?-5-klor-tiofen-2-karbonamidoetyl)-benzolsulfonyl]-N'-butyl-urinstof f med smeltepunkt 188— 190 °C, Analogously, you get N-[4-(/?-5-chloro-thiophene-2-carbonamidoethyl)-benzenesulfonyl]-N'-butyl-urea f with melting point 188-190 °C,

N- [4- (j8-5-klor-tiof en-2-karbonamidoetyl) -benzolsulf onyl] -N'- (4-metyl-cykloheksyl) -urinstoff med smeltepunkt 190—192° C, N-[4-(j8-5-chloro-thiophene-2-carbonamidoethyl)-benzenesulfonyl]-N'-(4-methyl-cyclohexyl)-urea with melting point 190-192° C,

N- [4- (yS-5-klor-tiof en-2-karbonamidoetyl) -benzolsulfonyl] -N'- (4-etyl-cykloheksyl) -urinstoff med smeltepunkt 191—193° C. N-[4-(γS-5-chloro-thiophene-2-carbonamidoethyl)-benzenesulfonyl]-N'-(4-ethyl-cyclohexyl)-urea with melting point 191-193°C.

På analog måte vil man av In an analogous way, one wants off

4- (/?- f 3-metoksytiof en-2-karbonamido,) -etyl) -benzolsulf onamid (smeltepunkt 201—203°C) få: 4-(/?-f 3-methoxythiophene-2-carbonamido,)-ethyl)-benzenesulfonamide (melting point 201-203°C) get:

N- [4- (/?- f3-metoksytiof en-2-karbonamido) -etyl) - benzolsulfonyl] -N'- (cykloheksenf3,)yl-metyl) -urinstoff med smeltepunkt 164—165°C (fra metanol) og N- [4- ( fi- f3-metoksytiof en-2-karbonamido,) -etyl) - benzolsulfonyl] -N'- (2,5-endometylen-cykloheksyl) - urinstoff med smeltepunkt 190—191 °C (fra metanol) ; av 4- (/?- f3,5-dimetyltiof en-2-karbonamido,l -etyl) - benzolsulfonamid (smeltepunkt 176—177°C) få: N- [4- (j8- ("3,5-dimetyltiof en-2-karbonamido,) -etyl) - benzolsulf onyl ]-N'-(2,5-endometylen-cykloheksyl)-urinstoff med smeltepunkt 188—189°C (fra metanol) ; av 4- (j8- ^3-metoksymetoksytiof en-2-karbonamidoJ - etyl)-benzolsulfonamid (smeltepunkt 160—162° C) få: N- [4- (/?- ('3-metoksymetoksy tiof en-2-karbonamido) - etyl)-benzolsulfonyl]-N'-(4-etylcykloheksyl)-urinstoff (trans) med smeltepunkt 160—161° C (fra metanol). N-[4-(/?-f3-methoxythiophene-2-carbonamido)-ethyl)-benzenesulfonyl]-N'-(cyclohexenphenyl)yl-methyl)-urea with a melting point of 164-165°C (from methanol) and N-[4- (fi-f3-methoxythiophene-2-carbonamido,)-ethyl)-benzenesulfonyl]-N'-(2,5-endomethylene-cyclohexyl)-urea with melting point 190-191 °C (from methanol) ; of 4-(/?-f3,5-dimethylthiophene-2-carbonamido,1-ethyl)-benzenesulfonamide (melting point 176-177°C) obtain: N-[4-(j8- ("3,5-dimethylthiophene -2-carbonamido,)-ethyl)-benzenesulfonyl]-N'-(2,5-endomethylene-cyclohexyl)-urea with melting point 188-189°C (from methanol); of 4-(j8-^3-methoxymethoxythioph en-2-carbonamidoJ - ethyl)-benzenesulfonamide (melting point 160—162° C) get: N- [4- (/?- ('3-methoxymethoxythiophene-2-carbonamido)-ethyl)-benzenesulfonyl]-N' -(4-ethylcyclohexyl)-urea (trans) with melting point 160-161° C (from methanol).

Eksempel 3: Example 3:

N- [4- (jS-3-metoksytiof en-2-karbonamido-etyl) -benzolsulfonyl]-N'-cykloheksyl-urinstoff. 10 g 4-(y8-3-metoksytiofen-2-karbonamido-etyl)-benzolsulfonamid (smeltepunkt 201—203 °C, fra dimetylformamid/vann) oppløses i 15 ml 2n natronlut og 30 ml aceton og blandes ved 0—5°C dråpevis med 3,9 g cykloheksylisocyanat. Man etteromrører reaksjonsblandingen 3 timer, fortynner med vann, filtrerer og surgjør filtratet med fortynnet saltsyre. Det i krystallinsk form dannede N-[-4-(/?-3-metoksytiof en-2-karbonamido-etyl) Jbenzolsulf on<y>l] --N'-cykloheksyl-urinstoff omkrystalliseres fra dimetylformamid/vann og smelter ved 193—194°C. N-[4-(jS-3-Methoxythiophene-2-carbonamido-ethyl)-benzenesulfonyl]-N'-cyclohexylurea. 10 g of 4-(γ8-3-methoxythiophene-2-carbonamido-ethyl)-benzenesulfonamide (melting point 201-203 °C, from dimethylformamide/water) are dissolved in 15 ml of 2N caustic soda and 30 ml of acetone and mixed at 0-5°C dropwise with 3.9 g of cyclohexyl isocyanate. The reaction mixture is stirred for 3 hours, diluted with water, filtered and the filtrate acidified with dilute hydrochloric acid. The N-[-4-(/?-3-methoxythiophene-2-carbonamido-ethyl) Jbenzolsulfon<y>l] --N'-cyclohexylurea formed in crystalline form is recrystallized from dimethylformamide/water and melts at 193 -194°C.

På analog måte får man: Analogously, you get:

N- [4- (/?-3-metoksytiof en-2-karbonamido-etyl) -benzolsulf onyl]-N'-butyl-urinstoff med smeltepunkt 173 N-[4-(/?-3-Methoxythiophene-2-carbonamido-ethyl)-benzenesulfonyl]-N'-butylurea with melting point 173

—175°C (fra metanol) og N- [4- (/3-3-metoksytiof en-2-karbonamido-etyl) -benzolsulf onyl] -N'- (4-metylcykloheksyl) -urinstoff med —175°C (from methanol) and N-[4-([3-3-methoxythiophene-2-carbonamido-ethyl)-benzenesulfonyl]-N'-(4-methylcyclohexyl)-urea with

smeltepunkt 190—192 °C (fra dimetylformamid/ vann). melting point 190-192 °C (from dimethylformamide/water).

På analog måte vil man fra 4-(/?-3-etoksytiofen-2-karbonamido-etyl)-benzolsulfonamid (smeltepunkt 177°C) få: N- [4- (/3-3-etoksytiof en-2-karbonamido-etyl) -benzolsulfonyl]-N'-cyklooktyl-urinstoff med smeltepunkt 158—160°C (fra dimetylformamid/metanol), In an analogous way, from 4-(/?-3-ethoxythiophene-2-carbonamido-ethyl)-benzenesulfonamide (melting point 177°C) you get: N- [4-(/3-3-ethoxythiophene-2-carbonamido- ethyl)-benzenesulfonyl]-N'-cyclooctyl-urea with melting point 158-160°C (from dimethylformamide/methanol),

N- [4- (/3-3-etoksytiof en-2-karbonamido-etyl) -benzolsulfonyl] -N'-cykloheksyl-urinstoff med smeltepunkt 174—175°C (fra metanol/dimetylformaimid), N-[4-(/3-3-ethoxythiophene-2-carbonamido-ethyl)-benzenesulfonyl]-N'-cyclohexylurea with melting point 174-175°C (from methanol/dimethylformamide),

N- [4- (jS-3-etoksytiof en-2-karbonamido-etyl) -benzolsulfonyl] -N'-butyl-urinstoff med smeltepunkt 146— 147°C (fra dimetylformamid/vann) og N- [4- (/3-3-etoksytiof en-2-karbonamido-etyl) -benzolsulfonyl] -N'-(4-metylcykloheksyl) -urinstoff med smeltepunkt 174—176°C (fra dimetylformamid/ vann). N-[4-(jS-3-ethoxythiophene-2-carbonamido-ethyl)-benzenesulfonyl]-N'-butyl-urea with melting point 146—147°C (from dimethylformamide/water) and N-[4-(/ 3-3-ethoxythiophene-2-carbonamido-ethyl)-benzenesulfonyl]-N'-(4-methylcyclohexyl)-urea with melting point 174-176°C (from dimethylformamide/water).

På analog måte vil man fra 4-(/?-3,5-dimetyltiof en-2-karbonamido-etyl)-benzolsulfonamid (smeltepunkt 176—177°C) få: N- [4- (/?-3,5-dimetyltiof en-2-karbonamido-etyl) -benzolsulf onyl] -N'-cykloheksyl-urinstoff med smeltepunkt 189—190 °C (fra dimetylformamid/vann) og N- [4- (/3-3,5-dimetyltiof en-2-karbonamido-etyl) -benzolsulfonyl] -N'- (4-metylcykloheksyl) -urinstoff med smeltepunkt 173—175° C (fra dimetylformamid/ vann). In an analogous way, from 4-(/?-3,5-dimethylthiophene-2-carbonamido-ethyl)-benzenesulfonamide (melting point 176-177°C) you get: N- [4- (/?-3,5- dimethylthiophene-2-carbonamido-ethyl)-benzenesulfonyl]-N'-cyclohexyl-urea with melting point 189-190 °C (from dimethylformamide/water) and N-[4-(/3-3,5-dimethylthiophene- 2-carbonamido-ethyl)-benzenesulfonyl]-N'-(4-methylcyclohexyl)-urea with melting point 173-175° C (from dimethylformamide/water).

På analog måte vil man fra 4-(/?-3-metyltiofen-2-karbonamido-etyl) -benzolsulfonamid (smeltepunkt 198—200°C) få: N- [4- (/?-3-metyltiofen-2-karbonamido-etyl) -benzolsulfonyl] -N'-cyklooktyl-urinstoff med smeltepunkt 203—205°C (fra dimetylformamid/vann), In an analogous way, from 4-(/?-3-methylthiophene-2-carbonamido-ethyl)-benzenesulfonamide (melting point 198-200°C) you get: N-[4-(/?-3-methylthiophene-2-carbonamido -ethyl)-benzenesulfonyl]-N'-cyclooctyl-urea with melting point 203-205°C (from dimethylformamide/water),

N- [4- (yS-3-metyltiof en-2-karbonamido-etyl) -benzolsulfonyl] -N'-cykloheksyl-urinstoff med smeltepunkt 183—184°C (fra dimetylformamid/vann), N-[4-(γS-3-methylthiophene-2-carbonamido-ethyl)-benzenesulfonyl]-N'-cyclohexylurea with melting point 183-184°C (from dimethylformamide/water),

N- [4- (/3-3-metyltiof en-2-karbonamido-etyl) -benzolsulfonyl] -N'-butyl-urinstoff med smeltepunkt 175— 177°C (fra dimetylformamid/vann) og trans-N- [4- (/?-3-metyltiof en-2-karbonamido-etyl) - benzolsulf onyl] -N'- (4-metylcykloheksyl) -urinstoff med smeltepunkt 201—203 °C (fra dimetylformamid/ vann). N-[4-(/3-3-methylthiophene-2-carbonamido-ethyl)-benzenesulfonyl]-N'-butyl-urea with melting point 175—177°C (from dimethylformamide/water) and trans-N-[4 - (/?-3-methylthiophene-2-carbonamido-ethyl)-benzenesulfonyl]-N'-(4-methylcyclohexyl)-urea with melting point 201-203 °C (from dimethylformamide/water).

På analog måte vil man fra 4-(/3-3-klortiofen-2-karbonamido-étyl)-benzolsulfonamid (smeltepunkt 211—213°C) få: N- [4- (/?-3-klortiofen-2-karbonamido-etyl) -benzolsulfonyl] -N'-cykloheksyl-urinstoff med smeltepunkt 183—184°C (fra dimetylformamid/vann). N-[4-(/?-3-klortiofen-2-karbonamido-etyl) -benzolsulfonyl] -N'-butyl-urinstoff med smeltepunkt 189— 190°C (fra metanol), In an analogous way, from 4-(/3-3-chlorothiophene-2-carbonamido-ethyl)-benzenesulfonamide (melting point 211-213°C) you get: N-[4-(/?-3-chlorothiophene-2-carbonamido -ethyl)-benzenesulfonyl]-N'-cyclohexylurea with melting point 183-184°C (from dimethylformamide/water). N-[4-(/?-3-chlorothiophene-2-carbonamido-ethyl)-benzenesulfonyl]-N'-butyl-urea with melting point 189—190°C (from methanol),

trans-N- [4- (/2-3-klortiof en-2-karbonamido-etyl) - benzolsulf onyl ]-N'-(me ty 1-cykloheksyl)-urinstoff med smeltepunkt 207—209°C (fra dimetylformamid/ vann) og trans-N-[4-(/2-3-chlorothiophene-2-carbonamido-ethyl)-benzenesulfonyl]-N'-(methyl 1-cyclohexyl)-urea with melting point 207-209°C (from dimethylformamide/ water and

trans-N-[4-(yS-3-klortiofen-2-karbonamido-etyl)-benzolsulfonyl] -N'-(4-etylcykloheksyl) -urinstoff med smeltepunkt 177—178°C (fra metanol). trans-N-[4-(γS-3-chlorothiophene-2-carbonamido-ethyl)-benzenesulfonyl]-N'-(4-ethylcyclohexyl)-urea with melting point 177-178°C (from methanol).

På analog måte vil man av 4-(/3-f4-metoksytio-fen-3jkarbonamido,J-etyl)-benzolsulfonamid (smeltepunkt 194—196°C) få: N- [4- (/?- f4-metoksytiofen-3-karbonamido,)-etyl) - benzolsulfonyl]-N'-cykloheksyl-urinstoff med smel-testoff 199—200°C (fra metanol/dimetylformamid) og In an analogous way, from 4-(/3-f4-methoxythio-phen-3jcarbonamido,1-ethyl)-benzenesulfonamide (melting point 194-196°C) you will get: N-[4- (/?-f4-methoxythiophene-3 -carbonamido,)-ethyl)-benzenesulfonyl]-N'-cyclohexyl-urea with melting point 199-200°C (from methanol/dimethylformamide) and

N- [4- (/?- (4-metoksy tiof en-3-karbonamido ) -etyl) - benzolsulfonyl] -N'- (4-metylcykloheksyl) -urinstoff (trans) med smeltepunkt 215—217°C (fra metanol/ dimetylformamid). N- [4- (/?- (4-methoxythiophene-3-carbonamido)-ethyl)-benzenesulfonyl]-N'-(4-methylcyclohexyl)-urea (trans) with melting point 215-217°C (from methanol / dimethylformamide).

Eksempel 1/ : Example 1/ :

N- [4- (/3-3-benzyloksy-tiof en-2-karbonamido-etyl) - benzolsulfonyl]-N'-cykloheksyl-urinstoff. N-[4-([3-3-benzyloxy-thiophene-2-carbonamido-ethyl)-benzenesulfonyl]-N'-cyclohexylurea.

En blanding av 11,5 g N-[4-(/3-3-benzyloksytio-fen-2-karbonamido-etyl)-benzolsulfonyl]-urinstoff (smeltepunkt 109—110° C, fra dimetylformamid/ vann), 300 ml toluol, 30 ml glykolmonometyleter, 1,65 g iseddik og 2,8 g cykloheksylamin oppvarmes i 5 timer under omrøring og tilbakeløp. Man inndamper blandingen i vakuum og utrører residuet med metanol. Det i krystallinsk form dannede N- [4- (/?-3-benzyloksy-tiofen-2-karbonamido-etyl)-benzolsulfonyl]-N'-cykloheksyl-urinstoff suges fra og omkrystalliseres fra metanol/dimetylformamid. Smeltepunkt 167—168° C. A mixture of 11.5 g of N-[4-(/3-3-benzyloxythio-phen-2-carbonamido-ethyl)-benzenesulfonyl]-urea (melting point 109-110° C, from dimethylformamide/water), 300 ml of toluene , 30 ml of glycol monomethyl ether, 1.65 g of glacial acetic acid and 2.8 g of cyclohexylamine are heated for 5 hours with stirring and reflux. The mixture is evaporated in vacuo and the residue is stirred with methanol. The N-[4-(/?-3-benzyloxy-thiophene-2-carbonamido-ethyl)-benzenesulfonyl]-N'-cyclohexylurea formed in crystalline form is sucked off and recrystallized from methanol/dimethylformamide. Melting point 167-168° C.

Eksempel 5: N-[4-(/3-3-benzyloksytiofen-2-karbonamido-etyl)-benzolsulfonyl]-N'-(4-metylcykloheksyl) -urinstoff. Example 5: N-[4-([3-3-benzyloxythiophene-2-carbonamido-ethyl)-benzenesulfonyl]-N'-(4-methylcyclohexyl)-urea.

23,8 g N-[4-(/?-3-benzyloksytiofen-2-karbonamido-etyl) -benzolsulfonyl] -metylmetan (smeltepunkt 163—164°C, fra alkohol) suspenderes i 50 ml xylol og blandes ved 70 °C under omrøring dråp evis med 5,8 g 4-metylcykloheksylamin. Man øker temperaturen til 120—130 °C idet reaksjonen starter under metanolutvikling. Man holder det i 30 minutter ved 130 °C, lar det avkjøle, og frasuger utfelt råprodukt og omkrystalliserer fra metanol. Smeltepunkt for N- [4- (/3-3-benzyloksytiof en-2-karbonamido-etyl) - 23.8 g of N-[4-(/?-3-benzyloxythiophene-2-carbonamido-ethyl)-benzenesulfonyl]-methylmethane (melting point 163-164°C, from alcohol) are suspended in 50 ml of xylol and mixed at 70°C while stirring dropwise with 5.8 g of 4-methylcyclohexylamine. The temperature is increased to 120-130 °C as the reaction starts during methanol evolution. It is held for 30 minutes at 130 °C, allowed to cool, and the precipitated crude product is filtered off with suction and recrystallized from methanol. Melting point of N-[4-(/3-3-benzyloxythiophene-2-carbonamido-ethyl)-

benzolsulf onyl] -N'- (4-metylcykloheksyl) -urinstoff er 153—155° C. benzolsulfonyl]-N'-(4-methylcyclohexyl)-urea is 153-155°C.

Eksempel 6: Example 6:

N- [4- (jS-tiofen-2-karbonamido-etyl) -benzolsulfonyl ] -N'-cykloheksyl-urinstof f. N-[4-(jS-thiophene-2-carbonamido-ethyl)-benzenesulfonyl]-N'-cyclohexyl-urea f.

1,35 g N-[4-(^-tiofen-2-karbonamido-etyl)-ben-zosulf onyl] -N'-cykloheksyl-tiourinstoff (smeltepunkt 181—183°C fremstilt av 4-(/?-tiofen-2-karbonamido-etyl)-benzolsulfonamid og cykloheksyl- 1.35 g of N-[4-(^-thiophene-2-carbonamido-ethyl)-benzosulfonyl]-N'-cyclohexyl-thiourea (melting point 181-183°C prepared from 4-(/?-thiophene- 2-carbonamido-ethyl)-benzenesulfonamide and cyclohexyl-

sennepolje) oppløses med 3 ml ln natronlut og 30 ml vann og settes i denne form til en suspensjon av kvikksølvoksyd som ble dannet ved oppløsning av 0,81 g kvikksølv-(2)-klorid i 15 ml vann og tilsetning av 3 ml 2n natronlut. Man oppvarmer til 40°C, omrører i 5 minutter ved denne temperatur, fra-fdltrerer utfelt kvikksølvsulfid, surgjør filtratet med fortynnet saltsyre og frasuger utskilt reaksjonsprodukt. Etter omkrystallisering fra metanol smelter N- [4- (j8-tiof en-2-karbonamido-etyl) -benzolsulfonyl]-N'-cykloheksyl-urinstoff ved 191—193°C. mustard oil) is dissolved with 3 ml ln caustic soda and 30 ml water and added in this form to a suspension of mercuric oxide which was formed by dissolving 0.81 g of mercury (2)-chloride in 15 ml water and adding 3 ml 2n caustic soda . It is heated to 40°C, stirred for 5 minutes at this temperature, precipitated mercuric sulphide is filtered off, the filtrate is acidified with dilute hydrochloric acid and the secreted reaction product is sucked off. After recrystallization from methanol, N-[4-(j8-thiophene-2-carbonamido-ethyl)-benzenesulfonyl]-N'-cyclohexylurea melts at 191-193°C.

Eksempel 7: N-[4-(^S-tiofen-2-karbonamido-etyl)-benzolsulfonyl) Example 7: N-[4-(^S-thiophene-2-carbonamido-ethyl)-benzenesulfonyl)

-N'-cykloheksyl-urinstoff. -N'-cyclohexyl urea.

1,2 g N-[4-(/3-tiofen-2-karbonamido-etyl)-benzolsulfonyl]-N'-cykloheksyl-isourinstoffmetyleter (olje, som ble dannet ved behandling av N-[4-(/3-tiof en-2-karbonamido-etyl) -benzolsulfonyl] -N'-cykloheksyl-tiourinstoff med kvikksølvoksyd i metanol) oppvarmes med 15 ml konsentrert saltsyre om-trent i 10 minutter på dampbad. Man lar reaksjonsblandingen avkjøle, fortynner med vann og frasuger reaksjonsproduktet. N-[4-(j8-tiofen-2-karbonamido-etyl)-benzolsulfonyl] -N'-cykloheksyl-urinstoff omkrystalliseres fra metanol og smelter ved 191—193°C. 1.2 g of N-[4-(/3-thiophene-2-carbonamido-ethyl)-benzenesulfonyl]-N'-cyclohexyl-isourea methyl ether (oil, which was formed by treatment of N-[4-(/3-thiophene en-2-carbonamido-ethyl)-benzenesulfonyl]-N'-cyclohexyl-thiourea with mercuric oxide in methanol) is heated with 15 ml of concentrated hydrochloric acid for approximately 10 minutes on a steam bath. The reaction mixture is allowed to cool, diluted with water and the reaction product is sucked off. N-[4-(18-thiophene-2-carbonamido-ethyl)-benzenesulfonyl]-N'-cyclohexylurea is recrystallized from methanol and melts at 191-193°C.

Eksempel 8: Example 8:

N- [4- (/3-f urfuroylaminoetyl) -benzolsulfonyl] -N'-cykloheksyl-l-urinstoff. N-[4-(/3-furfuroylaminoethyl)-benzenesulfonyl]-N'-cyclohexyl-1-urea.

14,7 g 4-(j8-furfuroylaminoetyl)-benzolsulfonamid (smeltepunkt 228—230°C, fremstilt ved omsetning av 4-(j8-aminoetyl)-benzolsulfonamid med py-roslimsyreklorid) suspenderes i 200 ml aceton og bringes i oppløsning ved tilsetning av 2 g natrium-hydroksyd og vann. Hertil drypper man under om-røring ved værelsestemperatur 6,5 g cykloheksylisocyanat og etteromrører i 2 timer. En dannet fin utfelling suges fra og filtratet blandes med vann og saltsyre. Man frasuger og omkrystalliserer pro-duktet fra etanol-vann. N-[4-(/?-furfuroylamino-etyl)-benzolsulfonyl]-N'-cykloheksyl-urinstoff smelter ved 176—178° C. 14.7 g of 4-(β-furfuroylaminoethyl)-benzenesulfonamide (melting point 228-230°C, prepared by reaction of 4-(β-aminoethyl)-benzenesulfonamide with pyroslimic acid chloride) are suspended in 200 ml of acetone and brought into solution by addition of 2 g of sodium hydroxide and water. To this, 6.5 g of cyclohexyl isocyanate are added while stirring at room temperature and stirred for 2 hours. A fine precipitate formed is sucked off and the filtrate is mixed with water and hydrochloric acid. The product is suctioned off and recrystallized from ethanol-water. N-[4-(/?-furfuroylamino-ethyl)-benzenesulfonyl]-N'-cyclohexyl-urea melts at 176-178°C.

På analog måte får man: Analogously, you get:

N- [4- (/?-furf uroylaminoetyl) -benzolsulfonyl] -N'- (4-etylcykloheksyl)-urinstoff med smeltepunkt 196— 198°C, N- [4- (/3-furf uroylaminoetyl) -benzolsulf onyl] -N'-butyl-urinstoff med smeltepunkt 201—203 °C, N- [ 4- (/?-furf uroylaminoetyl) -benzolsulfonyl ] -N'- (4-metylcykloheksyl)-urinstoff med smeltepunkt 184— 186 °C, N- [4-(/?-furfuroylaminoethyl)-benzenesulfonyl]-N'-(4-ethylcyclohexyl)-urea with melting point 196— 198°C, N- [4-(/3-furfuroylaminoethyl)-benzenesulfonyl] -N'-butyl urea with a melting point of 201—203 °C, N- [ 4-(/?-furfuroylaminoethyl)-benzenesulfonyl] -N'-(4-methylcyclohexyl)-urea with a melting point of 184— 186 °C,

N- [4- (/3-f urf uroylaminoetyl) -benzolsulfonyl] -N'- (4-isopropyl-cykloheksyl)-urinstoff med smeltepunkt 209—211°C. N-[4-(/3-fururoylaminoethyl)-benzenesulfonyl]-N'-(4-isopropyl-cyclohexyl)-urea with melting point 209-211°C.

På analog måte vil man fra In an analogous way, one wants from

2- (/3-furfuroylaminopropyl)-'benzolsulfonamid (smeltepunkt 192—194°C) få: 2-(/3-Furfuroylaminopropyl)-benzenesulfonamide (melting point 192-194°C) get:

N- [4- (/3-f urf uroylaminoetyl) -benzolsulfonyl] -N'- (4-cykloheksyl-urinstoff med smeltepunkt 196—198°C, N- [4- (/3-furfuroylaminopropyl) -benzolsulf onyl]-N'-(4-etyl-cykloheksyl)-urinstoff med smeltepunkt 179 —181°C. N- [4-(/3-fururoylaminoethyl)-benzenesulfonyl]-N'- (4-cyclohexylurea with melting point 196—198°C, N- [4-(/3-furfuroylaminopropyl)-benzenesulfonyl]- N'-(4-ethyl-cyclohexyl)-urea with a melting point of 179-181°C.

Eksempel 9: Example 9:

N- [4- (/3-f urf uroylaminoetyl) -benzolsulfonyl] -N'-cykloheksyl-urinstoff. N-[4-(/3-fururoylaminoethyl)-benzenesulfonyl]-N'-cyclohexylurea.

17,8 g N-[4-(/3-f urf uroylaminoetyl)-benzolsulfonyl] -karbaminsyremetylester (smeltepunkt 182— 184°C, fremstilt fra 4-(/?-furfuroylaminoetyl)-benzolsulfonamid og klormaursyre-metylester i nærvær av kaliumkarbonat) suspenderes i 50 ml xylol og blandes under omrøring ved ca. 60—80 °C dråpevis med 5 g cykloheksylamin. Man øker temperaturen til 120—130 °C hvorved omsetningen begynner under metanol-utvikling og etteromrører i ca. 1 time ved denne temperatur. Etter avkjøling blir det utskilte reaksjonsprodukt suget fra og omkrystallisert fra etanol-vann. Det dannede N-[4- (/3-furfuroylamino-etyl) -benzolsulfonyl]-N'-cykloheksyl-urinstoff smelter ved 176—178° C. 17.8 g of N-[4-(/3-furfuroylaminoethyl)-benzenesulfonyl]-carbamic acid methyl ester (melting point 182-184°C, prepared from 4-(/?-furfuroylaminoethyl)-benzenesulfonamide and chloroformic acid methyl ester in the presence of potassium carbonate ) are suspended in 50 ml xylol and mixed while stirring at approx. 60-80 °C dropwise with 5 g of cyclohexylamine. The temperature is increased to 120-130 °C, whereupon the reaction begins during methanol evolution and stirring for approx. 1 hour at this temperature. After cooling, the secreted reaction product is sucked off and recrystallized from ethanol-water. The formed N-[4-(/3-furfuroylaminoethyl)-benzenesulfonyl]-N'-cyclohexylurea melts at 176-178°C.

Eksempel 10: N- [4- (/3-furf uroylaminoetyl) -benzolsulfonyl ] -N'-cykloheksyl-urinstoff. 8 g [4-(/3-furfuroylaminoetyl)-benzolsulfonyl]-urinstoff (smeltepunkt 185—187°C, fremstilt av 4-(/?-f urf uroylaminoetyl) -benzolsulfonamid og kaliumkarbonat) oppvarmes i 250 ml toluol med 1,65 g iseddik og 2,9 g cykloheksylamin under omrøring i 5 timer under tilbakeløpskjøling. Etter avkjøling inndamper man i vakuum, behandler residuet med litt alkohol og vann og frasuger reaksjonsproduktet. N- [4- (/?-f urf uroylaminoetyl) -benzolsulfonyl] -N'-cykloheksyl-urinstoff smelter etter omkrystallisering fra etanol-vann ved 176—178°C. Example 10: N-[4-([3-furfuroylaminoethyl)-benzenesulfonyl]-N'-cyclohexylurea. 8 g of [4-(/3-furfuroylaminoethyl)-benzenesulfonyl]urea (melting point 185-187°C, prepared from 4-(/?-fururoylaminoethyl)-benzenesulfonamide and potassium carbonate) are heated in 250 ml of toluene with 1.65 g of glacial acetic acid and 2.9 g of cyclohexylamine with stirring for 5 hours under reflux. After cooling, the mixture is evaporated in a vacuum, the residue is treated with a little alcohol and water and the reaction product is filtered off with suction. N-[4-(/?-fururoylaminoethyl)-benzenesulfonyl]-N'-cyclohexylurea melts after recrystallization from ethanol-water at 176-178°C.

Eksempel 11: Example 11:

N-[4- (/?-f urf uroylaminoetyl) -benzolsulfonyl] -N'-isobutyl-urinstoff. 13,6 g kvikksølvklorid oppløses i 120 ml vann og blandes dråpevis med 50 ml 2n natronlut. Hertil setter man 16,5 g N-[4-(/3-furfuroylaminoetyl)-benzolsulfonyl] -N'-isobutyl-tio-urinstof f (smeltepunkt 131—133°C, fremstillet av 4-(/?-f urf uroylaminoetyl) -benzolsulfonamid og isobutylsennepolje i nærvær av kaliumkarbonat) oppløst i 80 ml av en blanding av like deler 1 n natronlut og dimetylformamid ved ca. 40°C. Man etteromrører ennå iQ2% time ved 40—50 °C, frasuger det dannede kvikksølvsulfid, klargjør filtratet med kull og surgjør det med fortynnet saltsyre. N- [4- (/?-furf uroylaminoetyl) -benzolsulfonyl-N'-isobutyl-urinstoff suges fra og omkrystalliseres fra metanol. Smeltepunkt 192—194°C. N-[4-(/?-fururoylaminoethyl)-benzenesulfonyl]-N'-isobutylurea. Dissolve 13.6 g of mercuric chloride in 120 ml of water and mix drop by drop with 50 ml of 2N caustic soda. To this is added 16.5 g of N-[4-(/3-furfuroylaminoethyl)-benzenesulfonyl]-N'-isobutyl-thio-urea (melting point 131-133°C, prepared from 4-(/?-fururoylaminoethyl ) -benzenesulfonamide and isobutyl mustard oil in the presence of potassium carbonate) dissolved in 80 ml of a mixture of equal parts of 1 N caustic soda and dimethylformamide at approx. 40°C. Stirring is continued for another 2% hour at 40-50 °C, the mercury sulphide formed is sucked off, the filtrate is clarified with charcoal and acidified with dilute hydrochloric acid. N-[4-(/?-furfuroylaminoethyl)-benzenesulfonyl-N'-isobutylurea is suctioned off and recrystallized from methanol. Melting point 192-194°C.

Eksempel 12: Example 12:

N- [4- (/?-f urf uroylaminoetyl) -benzolsulf onyl] -N'-isobutyl-urinstoff. 4 g N-[4-(/?-furfuroylaminoetyl)-benzolsulfonyl]-N'-isobutyl-isourinstoff-metyleter (olje, som ble dannet fra N-[4-(/J-f urf uroylaminoetyl)-benzolsulf onyl]-N'-isobutyl-tio-urinstof f ved omsetning med kvikksølvoksyd i metanol) oppvarmes med 30 ml konsentrert saltsyre på dampbad 'inntil gassut-viklingen er avsluttet (ca. 10 minutter). Man av-kjøler reaksjonsblandingen, fortynner den med vann og frasuger N-[4- (/?-furfuroylaminoetyl) -benzolsulfonyl] -N'-isobutyl-urinstoff som etter omkrystallisering fra metanol smelter ved 192—194°C. N-[4-(/?-fururoylaminoethyl)-benzenesulfonyl]-N'-isobutylurea. 4 g of N-[4-(/?-furfuroylaminoethyl)-benzenesulfonyl]-N'-isobutyl isourea methyl ether (oil, which was formed from N-[4-(/J-furfuroylaminoethyl)-benzenesulfonyl]-N' -isobutyl-thio-urea (by reaction with mercuric oxide in methanol) is heated with 30 ml of concentrated hydrochloric acid on a steam bath until the evolution of gas has ended (approx. 10 minutes). The reaction mixture is cooled, diluted with water and N-[4-(/?-furfuroylaminoethyl)-benzenesulfonyl]-N'-isobutylurea which, after recrystallization from methanol, melts at 192-194°C.

Eksempel 13: Example 13:

På analog måte som beskrevet i eksempel 1 får man: N- [4- (/?-f urf uroylaminoetyl) -benzolsulf onyl] -N'-(A3-cykloheksenyl) -urinstoff med smeltepunkt 166 —168°C og N- [4- (/?-tiofen-2-karbonamidoetyl) -benzolsulfonyl] - N'-(A3-cykloheksenyl)-urinstoff med smeltepunkt 181—183° C. In an analogous manner to that described in example 1, one obtains: N-[4-(/?-fururoylaminoethyl)-benzenesulfonyl]-N'-(A3-cyclohexenyl)-urea with melting point 166 -168°C and N- [ 4-(/?-thiophene-2-carbonamidoethyl)-benzenesulfonyl]-N'-(A3-cyclohexenyl)-urea with melting point 181-183° C.

Analogt eksempel 2 får man: Analogously to example 2, you get:

N- [4- (/?-5-klor-tiofen-2-karbonamidoetyl) -benzolsulf onyl]-N'-(å3.Cykloheksenyl)-urinstoff med smeltepunkt 186—188° C. N-[4-(/?-5-chloro-thiophene-2-carbonamidoethyl)-benzenesulfonyl]-N'-(α3.Cyclohexenyl)-urea with melting point 186-188° C.

Eksempel H: Example H:

Analogt eksempel 3 får man av 4-(/?-f'3-fenyl-4-metyltiof en-2-karbonamido i -etyl) -benzolsulfonamid (smeltepunkt 183—185°C): N-[4-(/?-f3-fenyl-4-metyltiofen-2-karbonamido,) -etyl)-benzolsulfonyl]-N'-cykloheksyl-urinstoff med smeltepunkt 150—152°C (fra metanol) og N- [4-(jS- f 3-f enyl-4-metyltiof en-2-karbonamido ) --etyl) -benzolsulf onyl] -N'- (4-metyl-cykloheksyl) - urinstoff (trans) med smeltepunkt 136—138°C (fra metanol); av (4- (3-metyltiof en-2-karbonamidometyl) -benzolsulfonamid (smeltepunkt 153°C): N- [4- (3-metyltiofen-2-karbonamidometyl) -benzolsulfonyl] -N'-cykloheksyl-urinstoff med smeltepunkt 163—165°C (fra metanol) og N- [4- (3-metyltiofen-2-karbonamidometyl) -benzolsulf onyl] -N'- (4-metylcykloheksyl) -urinstoff (trans) med smeltepunkt 190—191°C (fra metanol); av 4-(/?-f3,4-tetrametylentiofen-2-karbonamido,)-etyl)-benzolsulfonamid (smeltepunkt 173—174°C): N- [4- (/?- f 3,4-tetrametylentiof en-2-karbonamidoJ - etyl) -benzolsulf onyl] -N'-cykloheksyl-urinstoff med smeltepunkt 192—194 °C (fra dimetylformamid/ vann) og N- [4- (/?- f 3,4-tetrametylentiof en-2-karbonamido ) - etyl) -benzolsulfonyl] -N'- (4-metylcykloheksyl)-urinstoff (trans) med smeltepunkt 127—129°C (fra metanol) ; av 4- (/?- f3-metoksymetoksy-tiofen-2-karbonamido) - etyl)-benzolsulfonamid (smeltepunkt 160—162°C): N- [ 4- (/?- f3-metoksymetoksy-tiof en-2-karbonamido) -etyl) -benzolsulfonyl] -N'- (4-metylcykloheksyl) - urinstoff (trans) med smeltepunkt 163—165 °C (fra metanol); av 4- (/?- f 3-metoksyetoksy-tiof en-2-karbonamido) - etyl) -benzolsulfonamid (smeltepunkt 132—134° C): N- [4- (/?- f3-metoksyetoksy-tiof en-2-karbonamido) -etyl)-benzolsulfonyl] -N'-cykloheksyl-urinstoff med smeltepunkt 135—137°C (fra metanol) og N-[4-(/S-('3-J8-metoksyetoksy-tiofen-2-karbonamido/) -etyl) -benzolsulf onyl] -N'- (4-metylcykloheksyl) - urinstoff (trans) med smeltepunkt 103—105 °C (fra metanol); av 4- (/?- (-allyloksytiofen-2-karbonamido) -etyl) -benzolsulfonamid (smeltepunkt 145—147°C): N- [4- (/?- ^3-allyloksytiof en-2-karbonamido,) -etyl) - benzolsulfonyl] -N'- (4-metylcykloheksyl) -urinstoff (trans) med smeltepunkt 135—136°C (fra metanol). Analogously to example 3, one obtains from 4-(/?-f'3-phenyl-4-methylthiophene-2-carbonamido i -ethyl)-benzenesulfonamide (melting point 183-185°C): N-[4-(/?- f3-phenyl-4-methylthiophene-2-carbonamido,)-ethyl)-benzenesulfonyl]-N'-cyclohexyl-urea with melting point 150-152°C (from methanol) and N- [4-(jS- f 3-f enyl-4-methylthiophene-2-carbonamido)-ethyl)-benzenesulfonyl]-N'-(4-methyl-cyclohexyl)-urea (trans) with melting point 136-138°C (from methanol); of (4-(3-methylthiophene-2-carbonamidomethyl)-benzenesulfonamide (m.p. 153°C): N-[4-(3-methylthiophene-2-carbonamidomethyl)-benzenesulfonyl]-N'-cyclohexylurea with m.p. 163 —165°C (from methanol) and N-[4-(3-methylthiophene-2-carbonamidomethyl)-benzenesulfonyl]-N'-(4-methylcyclohexyl)-urea (trans) with melting point 190—191°C (from methanol); of 4-(/?-f3,4-tetramethylenethiophene-2-carbonamido,)-ethyl)-benzenesulfonamide (melting point 173-174°C): N- [4- (/?-f 3,4-tetramethylenethiophene en-2-carbonamidoJ - ethyl)-benzenesulfonyl]-N'-cyclohexyl-urea with melting point 192-194 °C (from dimethylformamide/water) and N- [4- (/?- f 3,4-tetramethylenethiophene- 2-carbonamido)-ethyl)-benzenesulfonyl]-N'-(4-methylcyclohexyl)-urea (trans) with melting point 127-129°C (from methanol); of 4-(/?-f3-methoxymethoxythiophene-2-carbonamido)-ethyl)-benzenesulfonamide (melting point 160—162°C): N-[ 4-(/?-f3-methoxymethoxythiophene-2-carbonamido )-ethyl)-benzenesulfonyl]-N'-(4-methylcyclohexyl)-urea (trans) with melting point 163-165 °C (from methanol); of 4-(/?-f 3-methoxyethoxythiophene-2-carbonamido)-ethyl)-benzenesulfonamide (melting point 132—134° C): N-[4-(/?-f3-methoxyethoxythiophene-2 -carbonamido)-ethyl)-benzenesulfonyl]-N'-cyclohexyl-urea with melting point 135-137°C (from methanol) and N-[4-(/S-('3-J8-methoxyethoxy-thiophene-2-carbonamido) /)-ethyl)-benzenesulfonyl]-N'-(4-methylcyclohexyl)-urea (trans) with melting point 103-105 °C (from methanol); of 4- (/?- (-allyloxythiophene-2-carbonamido) -ethyl) -benzenesulfonamide (melting point 145-147°C): N- [4- (/?- ^3-allyloxythiophene-2-carbonamido,) - ethyl) - benzenesulfonyl] -N'-(4-methylcyclohexyl) -urea (trans) with melting point 135-136°C (from methanol).

Eksempel 15: Example 15:

N- [4- (/?- ^3-metoksytiof en-2-karbonamido^ -etyl) - benzolsulfonyl] -N'-(/}-fenyletyl) -urinstoff. 10,08 g N-[4-(/3-('3-metoksytiofen-2-karbonami-doj-etyl) -benzolsulf onyl]-N'- (j8-fenyletyl)-tiourinstoff (fremstilt av 4-(/?-f3-metoksytiofen-2-karbon-amidoJ-etyl)-benzolsulfonamid og /?-fenyletylsen-nepolje ved koking i aceton/dioksan i nærvær av kaliumkarbonat (smeltepunkt 156—158 °C under •spaltning fra metanol) oppløses i 300 ml aceton og blandes med en oppløsning av 2,8 g natriumnitrit i 20 ml vann. Under omrøring tildryppes 30 ml 5 n eddiksyre ved +5°C og etteromrøres i 2% time ved værelsestemperatur. Man filtrerer, inndamper i vakuum, opptar residuet i fortynnet ammoniakk, klarer med kull og surgjør. Den dannede utfelling av N- [4- (/?- ^3^metoksytiofen-2-karbonamido> -etyl) - benzolsulfonyl]-N'-(/3-fenyletyl)-urinstoff suges fra, vaskes med vann og omkrystalliseres fra fortynnet metanol. Stoffet smelter ved 181—183° C. N-[4-(/?- ^3-methoxythiophene-2-carbonamido^-ethyl)-benzenesulfonyl]-N'-(/}-phenylethyl)-urea. 10.08 g of N-[4-(/3-('3-methoxythiophene-2-carbonamido-ethyl)-benzenesulfonyl]-N'-(j8-phenylethyl)-thiourea (prepared from 4-(/? -(3-methoxythiophene-2-carbon-amido-ethyl)-benzenesulfonamide and ?-phenylethyl senna oil by boiling in acetone/dioxane in the presence of potassium carbonate (melting point 156-158 °C during decomposition from methanol) are dissolved in 300 ml of acetone and mixed with a solution of 2.8 g of sodium nitrite in 20 ml of water. While stirring, 30 ml of 5 n acetic acid is added dropwise at +5°C and then stirred for 2% hour at room temperature. It is filtered, evaporated in vacuo, the residue taken up in dilute ammonia , clear with charcoal and acidify. The formed precipitate of N-[4- (/?- ^3^methoxythiophene-2-carbonamido>-ethyl)-benzolsulfonyl]-N'-(/3-phenylethyl)-urea is sucked off, washed with water and recrystallized from dilute methanol The substance melts at 181-183° C.

Eksempel 16: N- [4- (/3-tiof en-2-karbonamido-etyl) -benzolsulfonyl] Example 16: N-[4-([3-thiophene-2-carbonamido-ethyl)-benzenesulfonyl]

-N'-(A3-cykloheksenyl) -urinstoff. -N'-(A3-cyclohexenyl)-urea.

15,5 g 4-(jS-tiofen-2-karbonamido-etyl)-benzolsulfonamid (smeltepunkt 238°C; fremstilt av 4-(/3-amino-etyl-benzolsulfonamid og tiofen-2-karbonsyre-klorid) oppløses i 200 ml aceton ved tilsetning av 2 g NaOH og vann. 6,4 g A3-cykloheksenyl-isocyanat dryppes til oppløsningen under omrøring ved værelsestemperatur og omrøringen fortsettes i 2 timer og den svakt uklare oppløsning filtreres og filtratet surgjøres med saltsyre. Det utfelte reaksjonsprodukt gjenutfelles fra ammoniakk i 1 % og omkrystalliseres fra etanol/vann. N-[4-(/?-tiofen-2-karbonamido-etyl)-benzolsulfonyl]-N'-A3-cykl oheksenyl-urinstoff smelter ved 181—183 °C. 15.5 g of 4-(1S-thiophene-2-carbonamido-ethyl)-benzenesulfonamide (melting point 238°C; prepared from 4-(/3-amino-ethyl-benzenesulfonamide and thiophene-2-carbonic acid chloride) is dissolved in 200 ml of acetone by adding 2 g of NaOH and water. 6.4 g of A3-cyclohexenyl isocyanate is added dropwise to the solution with stirring at room temperature and stirring is continued for 2 hours and the slightly cloudy solution is filtered and the filtrate is acidified with hydrochloric acid. The precipitated reaction product is reprecipitated from ammonia in 1% and recrystallized from ethanol/water N-[4-(/?-thiophene-2-carbonamido-ethyl)-benzenesulfonyl]-N'-A3-cyclohexenyl-urea melts at 181-183 °C.

På analog måte fåes: In an analogous way, one obtains:

N- [4- (/?-5-klor-tiofen-3-karbonamid-etyl) -benzolsulfonyl] -N'-(A3-cykloheksenyl)-urinstoff (smeltepunkt 186—188° C). N-[4-(/?-5-chloro-thiophene-3-carbonamide-ethyl)-benzenesulfonyl]-N'-(A3-cyclohexenyl)-urea (melting point 186-188° C).

Eksempel 17: N- [ 4- (/?- f3-metoksymetoksy tiof en-2-karbonamid) - etyl) -benzolsulfonyl ] -N'-4-metyl-cykloheksy 1) -urinstoff (trans). 65 g [4-(/?-fmetoksymetoksytiofen-2-karbona-mid,)-etyl)-benzolsulfonamid (smeltepunkt 160— 162°C fra metanol) oppløses i 9 ml 2 n natrium-hydroksydoppløsning og 40 ml aceton og 2,6 g 4-metyl-cykloheksylisocyanat tilsettes dråpevis ved 0—5°C. Reaksjonsblandingen omrøres i 3 timer, for-tynnes med vann og filtreres og filtratet surgjøres ved hjelp av fortynnet eddiksyre.N- [4- (/?- ^3-metoksymetoksytiof en-karbonamido) -etyl) -benzolsulf o-nyl]-N'-(4-metylcykloheksyl) -urinstoff som utfelles i form av krystaller omkrystalliseres fra metanol og smelter ved 163—165°C. Example 17: N-[4-(/?-f3-Methoxymethoxythiophene-2-carbonamide)-ethyl)-benzenesulfonyl]-N'-4-methyl-cyclohexy1)-urea (trans). 65 g of [4-(?-fmethoxymethoxythiophene-2-carbonamide,)-ethyl)-benzenesulfonamide (melting point 160-162°C from methanol) are dissolved in 9 ml of 2 N sodium hydroxide solution and 40 ml of acetone and 2.6 g of 4-methyl-cyclohexyl isocyanate is added dropwise at 0-5°C. The reaction mixture is stirred for 3 hours, diluted with water and filtered and the filtrate is acidified using dilute acetic acid. '-(4-methylcyclohexyl)-urea which precipitates in the form of crystals is recrystallized from methanol and melts at 163-165°C.

På analog måte får man: Analogously, you get:

av 4-(yg-^3-metoksymetoksy-tiofen-2-karbonamido> etyl)-benzolsulfonamid (smeltepunkt 160—162°C): N- [4- (/3- (3-metoksymetoksy-tiof en-2-karbonamido) -etyl) -benzolsulf onyl] -N'-cykloheksyl-urinstoff (smeltepunkt 169—171°C) (fra metanol); av 4- (/?- f 3-metoksyetoksy-tiof en-2-karbonamido) - etyl)-benzolsulfonamid (smeltepunkt 132—134°C): N- [4- (/?- f3-/3-metoksyetoksy-tiof en-2-karbonamddo) -etyl) -benzolsulf onyl] -N'- (4-etylcykloheksyl) -urinstoff (trans) (smeltepunkt 132—133° C (fra metanol) ; av 4- (/?-ally loksy tiof en-2-karbonamidoetyl) -benzolsulfonamid (smeltepunkt 145—147°C): N- [4- (/?- f3-allyloksytiof en-2-karbonamido>-etyl) - benzolsulf onyl] -N'-cykloheksyl-urinstoff (smeltepunkt 132—134°C (fra metanol): av 4- (/3- f 3-etoksymetoksy-tiof en-2-karbonamido.> - etyl)-benzolsulfonamid (smeltepunkt 187—188°C): N-[4-(j3-('3-etoksymetoksy-tiofen-2-karbonamidoj-etyl) -benzolsulfonyl ] -N'-cykloheksyl-urinstof f (smeltepunkt 144—146°C) (fra metanol) og N- [4- (/?-f3-etoksymetoksy-tiofen-2-karbonamido,J-etyl) -benzolsulf onyl] -N'- (4-metylcykloheksyl) - urinstoff (trans) (smeltepunkt 145—146°C) (fra metanol). of 4-(γ-[3-methoxymethoxy-thiophene-2-carbonamido>ethyl)-benzenesulfonamide (melting point 160—162°C): N-[4-(/3-(3-methoxymethoxy-thiophene-2-carbonamido )-ethyl)-benzenesulfonyl]-N'-cyclohexylurea (m.p. 169-171°C) (from methanol); of 4-(/?- f 3-methoxyethoxythiophene-2-carbonamido) - ethyl)-benzenesulfonamide (melting point 132-134°C): N- [4- (/?- ethylcyclohexyl)-urea (trans) (melting point 132—133°C (from methanol) ; of 4-(/?-allyloxythiophene-2-carbonamidoethyl)-benzenesulfonamide (melting point 145—147°C): N- [4 - (/?- f3-allyloxythiophene-2-carbonamido>-ethyl)-benzenesulfonyl]-N'-cyclohexyl-urea (melting point 132-134°C (from methanol): of 4- (/3- f 3- ethoxymethoxy-thiophene-2-carbonamido.> - ethyl)-benzenesulfonamide (melting point 187-188°C): N-[4-(j3-('3-ethoxymethoxy-thiophene-2-carbonamido-ethyl)-benzenesulfonyl ] - N'-cyclohexyl-urea f (m.p. 144-146°C) (from methanol) and N-[4-(/?-f3-ethoxymethoxythiophene-2-carbonamido,J-ethyl)-benzenesulfonyl]-N' - (4-methylcyclohexyl) - urea (trans) (melting point 145-146°C) (from methanol).

Eksempel 18: Example 18:

4- [4- (/}- ^3,4-tetrametylentiofen-2-karbonamidy) - etyl) -benzolsulf onyl] -N'- (4-metylcykloheksyl) -urinstoff (trans). 21,2 g N-[4-(/^3,4-tetrametylentiofen-2-karbonamido^-etyl)-benzolsulfonyl]-metyluretan (smeltepunkt 194—196°C) (fra metanol) suspenderes i 50 ml xylol og 5,8 g 4-metylcykloheksylamin tildryppes ved 70 °C under omrøring. Temperaturen økes til 120—130 °C, mens reaksjonen starter under dannelse av metanol. Temperaturen opprettholdes ved 130 °C i 30 minutter, deretter avkjøles det hele, det utfelte råprodukt filtreres fra under sug og omkrystalliseres fra metanol. N-[4-(/?-f3,4-tetrametylentiof en-2-karbonamido) -etyl) -benzolsulfonyl] - N'-(4-metylcykloheksyl)-urinstoff smelter ved 127 —129°C. 4-[4-(/}-^3,4-tetramethylenethiophene-2-carbonamidy)-ethyl)-benzenesulfonyl]-N'-(4-methylcyclohexyl)-urea (trans). 21.2 g of N-[4-(/^3,4-tetramethylenethiophene-2-carbonamido^-ethyl)-benzenesulfonyl]-methylurethane (melting point 194-196°C) (from methanol) are suspended in 50 ml of xylene and 5, 8 g of 4-methylcyclohexylamine are added dropwise at 70 °C with stirring. The temperature is increased to 120-130 °C, while the reaction starts with the formation of methanol. The temperature is maintained at 130 °C for 30 minutes, then the whole is cooled, the precipitated crude product is filtered off under suction and recrystallized from methanol. N-[4-(/?-f3,4-tetramethylenethiophene-2-carbonamido)-ethyl)-benzenesulfonyl]-N'-(4-methylcyclohexyl)-urea melts at 127-129°C.

På analog måte vil man: Analogously, one would:

av N- [4- (/?-f3-etoksytdofenyl-2-karbonamido) -etyl) - benzolsulfonyl ] -karbaminsyremetylester (smeltepunkt 158°C) få: N- [4- (/?- (^3-etoksytiof enyl-2-karbonamido^ -etyl) - benzolsulfonyl]-N'-cykloheptylmetyl-urinstoff (smeltepunkt 158°C) (fra metalon/vann) og N- [4- (/?- f3-etoksy-tiof enyl-2-karbonamido) -etyl-benzolsulfonyl] -N'-cykloheptyletyl-urinstoff (smeltepunkt 151 °C) (fra metanol/vann). of N- [4- (/?-f3-ethoxytdophenyl-2-carbonamido)-ethyl)-benzolsulfonyl]-carbamic acid methyl ester (melting point 158°C) obtain: N- [4- (/?- (^3-ethoxythiophenyl- 2-carbonamido^ -ethyl)-benzolsulfonyl]-N'-cycloheptylmethyl-urea (melting point 158°C) (from metalon/water) and N- [4-(/?-f3-ethoxy-thiophenyl-2-carbonamido) -ethyl-benzenesulfonyl]-N'-cycloheptylethyl-urea (m.p. 151 °C) (from methanol/water).

Eksempel 19: Example 19:

N- [4- (/?- f3-etoksytiof en-2-karbonamido^ -etyl) -benzolsulfonyl] -N'- (2,5-endometylen-cykloheksyl-metyl) -urinstoff. la) 27,4 g 4-(/3-f'3-etoksytiofen-2-karbonamido; -etyl)-benzolsulfonamid oppløses i en blanding av 200 ml aceton og 100 ml dioksan. 22,1 g finpulveri-sert natriumkarbonat tilsettes og oppvarmes i 1% time under tilbakeløp under omrøring. Deretter tilsettes 13,4 g 2,5-endometylen-cykloheksyl-metyl-sennepolje og omrøringen fortsetter i 6 timer ved koketemperatur for aceton. Det hele helles i 2 liter vann og surgjøres med saltsyre. N-[4-(/?-f3-ethoxythiophene-2-carbonamido^-ethyl)-benzenesulfonyl]-N'-(2,5-endomethylene-cyclohexyl-methyl)-urea. 1a) 27.4 g of 4-([3-f'3-ethoxythiophene-2-carbonamido;-ethyl)-benzenesulfonamide are dissolved in a mixture of 200 ml of acetone and 100 ml of dioxane. 22.1 g of finely powdered sodium carbonate are added and heated for 1% hour under reflux with stirring. 13.4 g of 2,5-endomethylene-cyclohexyl-methyl-mustard oil are then added and stirring is continued for 6 hours at the boiling temperature of acetone. The whole thing is poured into 2 liters of water and acidified with hydrochloric acid.

Den krystallinske utfelling N-[4-(/3-('3-etoksytiof en-2-karbonamid) -etyl) -benzolsulfonyl] -N'- (2,5-endometylen-cykloheksyl-metyl)-tiourinstoff smelter ved 184—186 °C etter omkrystallisering fra dioksan/ metanol under spaltning. The crystalline precipitate N-[4-(/3-('3-ethoxythiophene-2-carbonamide)-ethyl)-benzenesulfonyl]-N'-(2,5-endomethylene-cyclohexyl-methyl)-thiourea melts at 184— 186 °C after recrystallization from dioxane/methanol during cleavage.

b) 11,8 g av tiourinstoff fremstilt ifølge a) værelsestemperatur og heller deretter den samlede suspenderes i 100 ml 2N NaOH og 20 ml dioksan. blanding i en blanding av 120 ml vann, 120 ml is b) 11.8 g of thiourea prepared according to a) at room temperature and then the total is suspended in 100 ml of 2N NaOH and 20 ml of dioxane. mixture in a mixture of 120 ml water, 120 ml ice

30 ml hydrogenperoksyd 35 %-ig tilsettes og det og 50 ml 2n saltsyre. Man fraskiller det halvfaste oppvarmes i 10 minutter på dampbad. Etter av- reaksjonsprodukt og behandler det med 1 % am-kjøling surgjøres det ved tilsetning av saltsyre og moniakk. 2 g av det dannede N- [4- (/?- f5-klortiofen-den krystallinske utfelling av N-[4-(/?-f3-etoksytio- 2-karbonamidoJ-etyl)-benzolsulf inyl]-N'-cyklohek-fen-2-karbonamidOy)-etyl)-benzolsulfonyl]-N'-(2,5- syl-urinstoff oppløses i 25 ml dimetylformamid og endometylen-cykloheksyl-metyl)-urinstoff filtreres blandes under omrøring ved værelsestemperatur fra med sug og omkrystalliseres med fortynnet med en vandig kaliumpermanganatoppløsning inn-metanol. Stoffet smelter ved 164—165°C. til permanganatfarger bibeholdes. Man avfarger ved 30 ml of 35% hydrogen peroxide is added and that and 50 ml of 2N hydrochloric acid. The semi-solid is separated and heated for 10 minutes in a steam bath. After reaction product and treating it with 1% am cooling, it is acidified by adding hydrochloric acid and ammonia. 2 g of the formed N-[4-(/?-f5-chlorothiophene crystalline precipitate of N-[4-(/?-f3-ethoxythio-2-carbonamidoJ-ethyl)-benzenesulfinyl]-N'-cyclohex -phen-2-carbonamidoOy)-ethyl)-benzenesulfonyl]-N'-(2,5-syl-urea is dissolved in 25 ml of dimethylformamide and endomethylene-cyclohexyl-methyl)-urea is filtered, mixed while stirring at room temperature from with suction and recrystallized with diluted with an aqueous potassium permanganate solution in methanol. The substance melts at 164-165°C. until permanganate colors are retained. You decolorize wood

2a) 4,9 g av tiourinstoff dannet under la) opp- tilsetning av litt natriumbisulfitt, frasuger den dan-" løses i 250 ml metanol. 2,2 g kvikksølvoksyd tilset- nede brunsten og surgjør filtratet med fortynnet tes under omrøring og oppvarmes i 4 timer under saltsyre. Den utfelte utfelling suges fra, gjenutfel-koking og tilbakeløp. Etter filtrering av det dannede les fra 1 %-ig ammoniakk og omkrystalliseres fra kvikksølv konsentreres det hele. Det gjenværende vann/etanol. Det dannede N-[4-(/3-f'5-klortiofen-2-residuum av N-[4-(/?-f3-etoksytiofen-2-karbonami- karbonamido^-etyl)-benzolsulfonyl]-N'-cykloheksyl-do/)-etyl)-benzolsulfonyl]-N'-(2,5-endometylen-cy- urinstoff smelter ved 189—191°C. kloheksyl-metyl)-isourinstoff-metyleter smelter et- 2a) 4.9 g of thiourea formed during la) addition of a little sodium bisulphite, it is filtered off with suction then dissolved in 250 ml of methanol. 2.2 g of mercuric oxide is added to the slag and the filtrate is acidified with diluted tea while stirring and heated in 4 hours under hydrochloric acid. The precipitate that has formed is suctioned off, reprecipitation-boiling and refluxing. After filtering the formed read from 1% ammonia and recrystallizing from mercury, the whole is concentrated. The remaining water/ethanol. The formed N-[4- (/3-f'5-chlorothiophene-2-residue of N-[4-(/?-f3-ethoxythiophene-2-carbonamicarbonamido^-ethyl)-benzenesulfonyl]-N'-cyclohexyl-do/)-ethyl )-benzenesulfonyl]-N'-(2,5-endomethylene-cyurea melts at 189-191°C. chlorohexyl-methyl)-isourea-methyl ether melts et-

ter omkrystallisering fra fortynnet metanol ved 96 ter recrystallization from dilute methanol at 96

—98°C. Eksempel 21: -98°C. Example 21:

b) 1 g av isourinstof f eteren dannet under 2a) b) 1 g of the isourea ether formed under 2a)

oppløses i ca. 30 ml 2N NaOH og 20 ml dioksan. N-[4-(/3-^metoksytiofen-2-karbonamido/)-etyl)-ben-Omrøringen fortsettes i 4 timer under samtidig opp- zolsulfonyl]-N'-cykloheksyl-urinstoff. dissolves in approx. 30 ml 2N NaOH and 20 ml dioxane. N-[4-(/3-^Methoxythiophene-2-carbonamido/)-ethyl)-bene Stirring is continued for 4 hours under simultaneous stirring of zolsulfonyl]-N'-cyclohexylurea.

varming til 90°C. Ved surgjøring og fortynning med 8,2 g N- [4- (/?-aminoetyl) -benzolsulfonyl] -N'-vann fåes en krystallinsk masse av N-[4-(/?-fetok- cykloheksyl-urinstoff suspenderes i 70 ml kloroform. sytiofen-2-karbonamidoj-etyl)-benzolsulfonyl]-N'- Hertil setter man 4,5 g pyridin og 9,5 g 3-metoksy-(2,5-endometylen-cykloheksyl-metyl)-urinstoff. Et- tiofen-2-karbonsyreklorid og oppvarmer under om-ter omkrystallisering fra fortynnet metanol smelter r øring i 6 timer ved ca. 40 °C. Deretter inndampes stoffet ved 164—166°C. reaksjonsblandingen i vakuum og residuet behand-les med 1 %-ig ammoniakk under svak oppvarming. Eksempel 20: Man filtrerer, surgjør filtratet og omkrystalliserer heating to 90°C. By acidifying and diluting with 8.2 g of N-[4-(/?-aminoethyl)-benzenesulfonyl]-N'-water, a crystalline mass of N-[4-(/?-phetoc-cyclohexyl-urea is obtained, suspended in 70 ml of chloroform.cythiophene-2-carbonamido-ethyl)-benzenesulfonyl]-N'- 4.5 g of pyridine and 9.5 g of 3-methoxy-(2,5-endomethylene-cyclohexyl-methyl)-urea are added to this. Ethiophene-2-carbonic acid chloride and heating while re-recrystallization from dilute methanol melts stirring for 6 hours at approx. 40 °C. The substance is then evaporated at 164-166°C. the reaction mixture in vacuum and the residue is treated with 1% ammonia under gentle heating. Example 20: Filter, acidify the filtrate and recrystallize

N- [4- (/?-f3-metoksy tiof en-2-karbonamido,/-etyl) - N-[4-(/?-f3-methoxythiophene-2-carbonamido,/-ethyl)-

N- [4- (/?- f5-klor-tiofen-2-karbonamido) -etyl) -ben- benzolsulf onyl] -N'-cykloheksyl-urinstoff fra vann-zolsulfonyl]-N'-cykloheksyl-urinstoff. dimetylformamid. Smeltepunkt 193—194°C. N-[4-(/?-f5-Chloro-thiophene-2-carbonamido)-ethyl)-benz-benzenesulfonyl]-N'-cyclohexylurea from water-zolsulfonyl]-N'-cyclohexylurea. dimethylformamide. Melting point 193-194°C.

7,1 g cykloheksyl-urinstoff has i 75 ml pyridin I den følgende tabell er det angitt den blod-og blandes porsjonsvis med det av 15,7 g 4:-( ft-( 5- sukkersenkende virkning av enkelte forbindelser et-klortiofen-2-karbonamidoy-etyl)-benzolsulfinsyre og ter administrering av 10 mg/kg peroralt på kaniner tionylklorid ved værelsetemperatur dannede rå 4- etter 3 timer, samtidig som det for enkelte av for-f5-klortiofen-2-karbonamido^-etyl)-benzolsulfin- bindelsene er angitt grenseverdien av blodsukker-syreklorid. Man lar det henstå i noen timer ved senkningen på kaniner. 7.1 g of cyclohexyl urea is contained in 75 ml of pyridine. In the following table it is indicated the blood and is mixed in portions with that of 15.7 g of 4:-( ft-( 5- sugar-lowering effect of certain compounds et-chlorothiophene- 2-carbonamido-ethyl)-benzenesulfinic acid and ter administration of 10 mg/kg orally to rabbits thionyl chloride at room temperature formed raw 4- after 3 hours, while for some of for-f5-chlorothiophene-2-carbonamido^-ethyl)- the benzolsulfine bonds are indicated as the limit value of blood glucose-acid chloride. It is allowed to stand for a few hours when submerging rabbits.

Claims (1)

Analogifremgangsmåte til fremstilling av terapeutisk aktive benzolsulfonylurinstoffer med den generelle formelAnalogous process for the preparation of therapeutically active benzenesulfonylureas of the general formula hvori Ri betyr a) alkyl med 3 til 6 karbonatomer, b) lavere fenylalkyl, c) lavere cykloheksylalkyl, d) endoalkylencykloheksyl, endoalkylencyklohekse-nyl, endoalkylencykloheksylmetyl, eller endoal-kylencykloheksenylmetyl med 1 til 2 endoalkyl-enkarbonatomer, e) lavere alkylcykloheksyl, lavere alkoksycklohek-syl, f) cykloalkyl med 5 til 8 karbonatomer, g) cykloheksenyl, cykloheksenylmetyl,wherein Ri means a) alkyl of 3 to 6 carbon atoms, b) lower phenylalkyl, c) lower cyclohexylalkyl, d) endoalkylenecyclohexyl, endoalkylenecyclohexenyl, endoalkylenecyclohexylmethyl, or endoalkylenecyclohexenylmethyl of 1 to 2 endoalkylene carbon atoms, e) lower alkylcyclohexyl, lower alkoxycyclohexyl, f) cycloalkyl with 5 to 8 carbon atoms, g) cyclohexenyl, cyclohexenylmethyl, X betyr a) tiofenyl, som eventuelt kan ha 1 til 2 substituenter fra gruppen halogen, lavere alkyl, lavere alkoksy, lavere alkenyloksy, lavere alkok-syalkoksy eller fenyl (lavere^alkoksy) eller fenyl eller en ved begge ender med tiofenkjernen sammenknyttet tetrametylenkjede, b) furyl, som eventuelt kan ha en halogensubsti-X means a) thiophenyl, which may optionally have 1 to 2 substituents from the group halogen, lower alkyl, lower alkoxy, lower alkenyloxy, lower alkoxy-alkyloxy or phenyl (lower 4-alkyloxy) or phenyl or a tetramethylene chain linked at both ends to the thiophene nucleus, b) furyl, which may optionally have a halogen substituent tuent,tuent, og n er 2 eller 3, eller deres salter, karakterisert ved at man enten a) omsetter med gruppenand n is 2 or 3, or their salts, characterized by either a) reacting with the group stituerte benzolsulfonylisocyanater, karbaminsyreestere, -tiolkarbaminsyreestere, -karbaminsyrehalogenider eller -urinstoffer eller reaksjonsdyktige derivater derav, med Ri<->substituerte aminer eller eventuelt deres salter, eller b) omsetter benzolsulfonamider med formel eller eventuelt deres salter, med Ri-substituerte isocyanater, karbaminsyreestere, tiolkarbaminsyreestere, karbaminsyrehalogenider eller urinstoffer eller reaksjonsdyktige derivater derav, eller c) hydrolyserer tilsvarende substituerte benzolsul-fonylisourinstoffetere, -isotio-uiinstoffetere eller -parabansyrer, eller d) i tilsvarende substituerte benzolsulfonyl-tio-urinstoffer utveksler svovelatomet på kjent måte med et oksygenatom, eller e) oksyderer tilsvarende benzolsulfinyl- resp. benzolsulf enylurinstoffer, eller f) i benzolsulfonylurinstoffer med formelsubstituted benzenesulfonyl isocyanates, carbamic acid esters, -thiocarbamic acid esters, -carbamic acid halides or -ureas or reactive derivatives thereof, with Ri<-> substituted amines or optionally their salts, or b) reacts benzenesulfonamides of formula or optionally their salts, with Ri-substituted isocyanates, carbamic acid esters, thiolcarbamic acid esters, carbamic acid halides or ureas or reactive derivatives thereof, or c) hydrolyze correspondingly substituted benzenesulfonylurea ethers, isothiourea ethers or parabanic acids, or d) in correspondingly substituted benzenesulfonylthioureas, the sulfur atom is exchanged in a known manner with an oxygen atom, or e ) oxidizes the corresponding benzenesulfinyl- or benzenesulfonylureas, or f) in benzenesulfonylureas of formula ved acylering innfører resten X—CO—, eller g) omsetter tilsvarende substituerte benzolsulfo-in the case of acylation, the residue introduces X—CO—, or g) reacts correspondingly substituted benzenesulfo- nylhalogenider med Ri-substituerte urinstoffer, og eventuelt behandler reaksjonsprodukteme med alkaliske midler for saltdannelse.nyl halides with Ri-substituted ureas, and optionally treating the reaction products with alkaline agents for salt formation.
NO821645A 1981-05-19 1982-05-18 ANALOGY PROCEDURE FOR THE PREPARATION OF PHARMACOLOGICALLY ACTIVE BENZOAZEPINE DERIVATIVES. NO159166C (en)

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