FR2868775B1 - Nouveau procede de synthese de derives de la 1,3,4,5- tetrahydro-2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable - Google Patents
Nouveau procede de synthese de derives de la 1,3,4,5- tetrahydro-2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptableInfo
- Publication number
- FR2868775B1 FR2868775B1 FR0403828A FR0403828A FR2868775B1 FR 2868775 B1 FR2868775 B1 FR 2868775B1 FR 0403828 A FR0403828 A FR 0403828A FR 0403828 A FR0403828 A FR 0403828A FR 2868775 B1 FR2868775 B1 FR 2868775B1
- Authority
- FR
- France
- Prior art keywords
- synthesis
- ivabradine
- benzazepin
- tetrahydro
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Priority Applications (34)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0403828A FR2868775B1 (fr) | 2004-04-13 | 2004-04-13 | Nouveau procede de synthese de derives de la 1,3,4,5- tetrahydro-2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
CA2496712A CA2496712C (fr) | 2004-04-13 | 2005-02-07 | Nouveau procede de synthese de derives de la 1,3,4,5-tetrahydro-2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
SG200500770A SG116574A1 (en) | 2004-04-13 | 2005-02-15 | New process for the synthesis of 1,3,4,5-tetrahydro-2H-3-benzazepin-2-one compounds, and applicationin the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid. |
US11/060,043 US7064200B2 (en) | 2004-04-13 | 2005-02-17 | Process for the synthesis of 1,3,4,5-tetrahydro-2H-3-benzazepin-2-one compounds, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid |
NZ538328A NZ538328A (en) | 2004-04-13 | 2005-02-18 | New process for the synthesis of 1,3,4,5-tetrahydro-2H-3-benzazepin-2-one compounds, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid |
GEAP8647A GEP20074136B (en) | 2004-04-13 | 2005-02-18 | New process for the synthesis of 1,3,4,5-tetrahydro-2h-3-benzazepin-2-one compounds, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid |
JP2005041810A JP4515933B2 (ja) | 2004-04-13 | 2005-02-18 | 1,3,4,5−テトラヒドロ−2h−3−ベンゾアゼピン−2−オン化合物の新規な合成方法、並びにイバブラジン及び薬学的に許容され得る酸とのその付加塩の合成への適用 |
CNB2005100542167A CN100348585C (zh) | 2004-04-13 | 2005-02-18 | 1,3,4,5-四氢-2h-3-苯并氮杂䓬-2-酮化合物的合成方法及其应用 |
ZA2005/01468A ZA200501468B (en) | 2004-04-13 | 2005-02-18 | Process for the synthesis of 1,3,4,5-tetrahydro-3-benzazepin-2-one compounds, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid |
MYPI20050621A MY140904A (en) | 2004-04-13 | 2005-02-18 | Process for the synthesis of 1,3,4,5-tetrahydro-2h-3-benzazepin-2-one compounds, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid |
NO20050888A NO329861B1 (no) | 2004-04-13 | 2005-02-18 | Ny fremgangsmate for syntesen av 1,3,4,5-tetrahydro-2H-3-benzazepin-2-onforbindelser, og anvendelse i syntesen av ivabradin og addisjonssalter derav med en farmasoytisk akseptabel syre |
AU2005200884A AU2005200884B2 (en) | 2004-04-13 | 2005-02-18 | New process for the synthesis of 1,3,4,5-tetrahydro-2H-3-benzazepin-2-one compounds, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid |
BRPI0500590A BRPI0500590B8 (pt) | 2004-04-13 | 2005-02-18 | processo para a síntese de compostos de 1,3,4,5-tetraidro-2h-3-benzazepin-2-ona, e aplicação na síntese de ivabradina e sais de adição desta com um ácido farmaceuticamente aceitável |
UAA200501524A UA81773C2 (uk) | 2004-04-13 | 2005-02-18 | Спосіб синтезу сполук 1,3,4,5-тетрагідро-2н-3-бензазепін-2-ону і застосування їх у синтезі івабрадину і його адитивних солей з фармацевтично прийнятною кислотою |
ARP050100586A AR047707A1 (es) | 2004-04-13 | 2005-02-18 | Un procedimiento de sintesis de compuestos de la 1,3,4,5-tetrahidro-2h-3-benzazepin-2-ona, y su aplicacion a la sintesis de la ivabradina y sus sales de adicion con un acido farmaceuticamente aceptable |
MA28112A MA27598A1 (fr) | 2004-04-13 | 2005-02-18 | Nouveau procede de synthese de derives de la 1,3,4,5-tetrahydro-2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
EG2005020086A EG25619A (en) | 2004-04-13 | 2005-02-19 | New process for the synthesis of 1,3,4,5-tetrahydro-2H-3-benzazepin-2-one compounds and application in the synthesis of iv abradine and addition saltsthereof wwith a pharmaceutically acceptable acid |
KR1020050013860A KR100636499B1 (ko) | 2004-04-13 | 2005-02-19 | 1,3,4,5-테트라히드로-2h-3-벤즈아제핀-2-온 화합물의 합성 방법, 및 이바브라딘 및 이의 약제학적으로 허용되는 산과의 부가염의 합성에서의 용도 |
DK05290383.8T DK1614687T3 (da) | 2004-04-13 | 2005-02-21 | Fremgangsmåde til fremstilling af 1,3,4,5-tetrahydro-2H-3-benzazepin-2-onderivater og deres anvendelse ved syntese af ivabradin og farmaceutisk acceptable salte deraf |
DE602005017541T DE602005017541D1 (de) | 2004-04-13 | 2005-02-21 | Verfahren zur Herstellung von 1,3,4,5-tetrahydro-2H-3-Benzazepin-2-on-Derivaten und dessen Anwendung in der Herstellung von Ivabradin sowie dessen pharmazeutisch verträglichen Salze |
PL05290383T PL1614687T3 (pl) | 2004-04-13 | 2005-02-21 | Sposób syntezy pochodnych 1,3,4,5-tetrahydro-2H-3-benzazepin-2-onu i ich zastosowania do syntezy iwabradyny oraz jej soli addycyjnych z dopuszczalnym farmaceutycznie kwasem |
SI200530864T SI1614687T1 (sl) | 2004-04-13 | 2005-02-21 | Nov postopek za sintezo derivatov 1,3,4,5-tetrahidro-2h-3-benzazepin-2-ona in njihova uporaba za sintezo ivabradina kot tudi njegovih adicijskih soli s farmacevtsko sprejemljivo kislino |
PT05290383T PT1614687E (pt) | 2004-04-13 | 2005-02-21 | Novo processo de síntese de derivados da 1,3,4,5- tetrahidro-2h-benzazepin-2-ona, e aplicação à síntese da ivabradina e dos seus sais de adição a um ácido aceitáveis do ponto de vista farmacêutico |
AT05290383T ATE448221T1 (de) | 2004-04-13 | 2005-02-21 | Verfahren zur herstellung von 1,3,4,5-tetrahydro- 2h-3-benzazepin-2-on-derivaten und dessen anwendung in der herstellung von ivabradin sowie dessen pharmazeutisch verträglichen salze |
PCT/FR2005/000396 WO2005111027A1 (fr) | 2004-04-13 | 2005-02-21 | Nouveau procede de synthese de derives de la 1,3,4,5 tetrahydro-2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
RSP-2010/0006A RS51232B (sr) | 2004-04-13 | 2005-02-21 | Novi postupak sinteze derivata 1,3,4,5-tetrahidro-2h-3benzazepin-2-on-a i primena u sintezi ivabradina i njegovih adicionih soli sa farmaceutski prihvatljivom kiselinom |
EP05290383A EP1614687B1 (fr) | 2004-04-13 | 2005-02-21 | Nouveau procédé de synthèse de dérivés de la 1,3,4,5-tétrahydro-2H-3-benzazépin-2-one, et application à la synthèse de l'ivabradine et de ses sels d'addition à un acide pharmaceutiquement acceptable |
EA200500240A EA007743B1 (ru) | 2004-04-13 | 2005-02-21 | Способ получения производных 1,3,4,5-тетрагидро-2н-3-бензазепин-2-она |
ES05290383T ES2336461T3 (es) | 2004-04-13 | 2005-02-21 | Nuevo procedimiento para la sintesis de derivados de 1,3,4,5-tetrahidro-2h-benzacepi-2-ona y su aplicacion a la sintesis de ivabradina y de sus sales de adicion de acido. |
MXPA05003696A MXPA05003696A (es) | 2004-04-13 | 2005-04-07 | Nuevo proceso para la sintesis de compuestos de 1,3,4,5-tetrahidro-2h-3-benzazepin-2-ona, y aplicacion en la sintesis de ivabradina y sales de adicion de la misma con un acido farmaceuticamente aceptable. |
HK05111843A HK1079777A1 (en) | 2004-04-13 | 2005-12-22 | Process for the synthesis of 1,3,4,5-tetrahydro-2H-3-benzazepin-2-one compounds, and application thereof |
JP2009220529A JP5277130B2 (ja) | 2004-04-13 | 2009-09-25 | 1,3,4,5−テトラヒドロ−2h−3−ベンゾアゼピン−2−オン化合物の新規な合成方法、並びにイバブラジン及び薬学的に許容され得る酸とのその付加塩の合成への適用 |
HR20100024T HRP20100024T1 (hr) | 2004-04-13 | 2010-01-13 | Postupak priprave derivata 1,3,4,5-tetrahidro-2h-3-benzepin-2-ona, njihova primjena u sintezi ivabradina i njihove farmaceutski prihvatljive soli |
CY20101100053T CY1109740T1 (el) | 2004-04-13 | 2010-01-19 | Νεα μεθοδος συνθεσης παραγωγων της 1,3,4,5 -τετραϋδρο-2η- 3-βενζαζεπιν-2-ονης και εφαρμογη στη συνθεση της ιβαβραδινης και των αλατων προσθηκης της σε ενα φαρμακευτικως αποδεκτο οξυ |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0403828A FR2868775B1 (fr) | 2004-04-13 | 2004-04-13 | Nouveau procede de synthese de derives de la 1,3,4,5- tetrahydro-2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2868775A1 FR2868775A1 (fr) | 2005-10-14 |
FR2868775B1 true FR2868775B1 (fr) | 2008-04-11 |
Family
ID=34941961
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR0403828A Expired - Fee Related FR2868775B1 (fr) | 2004-04-13 | 2004-04-13 | Nouveau procede de synthese de derives de la 1,3,4,5- tetrahydro-2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
Country Status (33)
Country | Link |
---|---|
US (1) | US7064200B2 (fr) |
EP (1) | EP1614687B1 (fr) |
JP (2) | JP4515933B2 (fr) |
KR (1) | KR100636499B1 (fr) |
CN (1) | CN100348585C (fr) |
AR (1) | AR047707A1 (fr) |
AT (1) | ATE448221T1 (fr) |
AU (1) | AU2005200884B2 (fr) |
BR (1) | BRPI0500590B8 (fr) |
CA (1) | CA2496712C (fr) |
CY (1) | CY1109740T1 (fr) |
DE (1) | DE602005017541D1 (fr) |
DK (1) | DK1614687T3 (fr) |
EA (1) | EA007743B1 (fr) |
EG (1) | EG25619A (fr) |
ES (1) | ES2336461T3 (fr) |
FR (1) | FR2868775B1 (fr) |
GE (1) | GEP20074136B (fr) |
HK (1) | HK1079777A1 (fr) |
HR (1) | HRP20100024T1 (fr) |
MA (1) | MA27598A1 (fr) |
MX (1) | MXPA05003696A (fr) |
MY (1) | MY140904A (fr) |
NO (1) | NO329861B1 (fr) |
NZ (1) | NZ538328A (fr) |
PL (1) | PL1614687T3 (fr) |
PT (1) | PT1614687E (fr) |
RS (1) | RS51232B (fr) |
SG (1) | SG116574A1 (fr) |
SI (1) | SI1614687T1 (fr) |
UA (1) | UA81773C2 (fr) |
WO (1) | WO2005111027A1 (fr) |
ZA (1) | ZA200501468B (fr) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2868775B1 (fr) * | 2004-04-13 | 2008-04-11 | Servier Lab | Nouveau procede de synthese de derives de la 1,3,4,5- tetrahydro-2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
FR2868777B1 (fr) * | 2004-04-13 | 2006-05-26 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
GT200500185A (es) * | 2004-08-09 | 2006-04-10 | Moduladores del receptor de progesterona que comprenden derivados de pirrol-oxindol y sus usos | |
PT2471780E (pt) | 2007-05-30 | 2015-02-24 | Ind Swift Lab Ltd | Sais oxalato de ivabradina cristalinos e seus polimorfos |
ES2402765T3 (es) | 2008-12-22 | 2013-05-08 | Krka, D.D., Novo Mesto | Procedimiento de preparación de ivabradina |
FR2940287B1 (fr) * | 2008-12-24 | 2010-12-24 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable. |
EP2534135A2 (fr) | 2010-02-12 | 2012-12-19 | KRKA, D.D., Novo Mesto | Nouvelles formes de chlorhydrate d'ivabradine |
FR2956401B1 (fr) * | 2010-02-17 | 2012-02-03 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
FR2971507B1 (fr) * | 2011-02-14 | 2013-01-18 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
FR2984320B1 (fr) * | 2011-12-20 | 2013-11-29 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
FR2993561B1 (fr) * | 2012-07-17 | 2014-10-31 | Servier Lab | Procede de synthese enzymatique de la (7s)-1-(3,4-dimethoxy bicyclo[4.2.0]octa-1,3,5-triene 7-yl) n-methyl methanamine, et application a la synthese de l'ivabradine et de ses sels |
FR3003859B1 (fr) * | 2013-03-26 | 2015-03-13 | Servier Lab | "procede de synthese de derives de la 7,8-dimethoxy-1,3-dihydro-2h-3-benzazepin-2-one et application a la synthese de l'ivabradine" |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3119874A1 (de) * | 1981-05-19 | 1982-12-09 | Dr. Karl Thomae Gmbh, 7950 Biberach | "benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel" |
DE3418270A1 (de) * | 1984-05-17 | 1985-11-21 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue aminotetralinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
DE3519735A1 (de) * | 1985-06-01 | 1986-12-04 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue heteroaromatische aminderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
EP0204349A3 (fr) | 1985-06-01 | 1990-01-03 | Dr. Karl Thomae GmbH | Dérivés d'amines hétéroaromatiques, médicaments les contenant et procédé pour leur préparation |
FR2681862B1 (fr) * | 1991-09-27 | 1993-11-12 | Adir Cie | Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent. |
FR2868775B1 (fr) * | 2004-04-13 | 2008-04-11 | Servier Lab | Nouveau procede de synthese de derives de la 1,3,4,5- tetrahydro-2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
FR2868777B1 (fr) * | 2004-04-13 | 2006-05-26 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
-
2004
- 2004-04-13 FR FR0403828A patent/FR2868775B1/fr not_active Expired - Fee Related
-
2005
- 2005-02-07 CA CA2496712A patent/CA2496712C/fr active Active
- 2005-02-15 SG SG200500770A patent/SG116574A1/en unknown
- 2005-02-17 US US11/060,043 patent/US7064200B2/en active Active
- 2005-02-18 JP JP2005041810A patent/JP4515933B2/ja active Active
- 2005-02-18 AU AU2005200884A patent/AU2005200884B2/en active Active
- 2005-02-18 CN CNB2005100542167A patent/CN100348585C/zh active Active
- 2005-02-18 MY MYPI20050621A patent/MY140904A/en unknown
- 2005-02-18 AR ARP050100586A patent/AR047707A1/es active IP Right Grant
- 2005-02-18 BR BRPI0500590A patent/BRPI0500590B8/pt active IP Right Grant
- 2005-02-18 MA MA28112A patent/MA27598A1/fr unknown
- 2005-02-18 NZ NZ538328A patent/NZ538328A/en unknown
- 2005-02-18 ZA ZA2005/01468A patent/ZA200501468B/en unknown
- 2005-02-18 NO NO20050888A patent/NO329861B1/no unknown
- 2005-02-18 GE GEAP8647A patent/GEP20074136B/en unknown
- 2005-02-18 UA UAA200501524A patent/UA81773C2/uk unknown
- 2005-02-19 EG EG2005020086A patent/EG25619A/xx active
- 2005-02-19 KR KR1020050013860A patent/KR100636499B1/ko active IP Right Grant
- 2005-02-21 EP EP05290383A patent/EP1614687B1/fr active Active
- 2005-02-21 WO PCT/FR2005/000396 patent/WO2005111027A1/fr active Application Filing
- 2005-02-21 DE DE602005017541T patent/DE602005017541D1/de active Active
- 2005-02-21 PT PT05290383T patent/PT1614687E/pt unknown
- 2005-02-21 EA EA200500240A patent/EA007743B1/ru unknown
- 2005-02-21 RS RSP-2010/0006A patent/RS51232B/sr unknown
- 2005-02-21 DK DK05290383.8T patent/DK1614687T3/da active
- 2005-02-21 ES ES05290383T patent/ES2336461T3/es active Active
- 2005-02-21 SI SI200530864T patent/SI1614687T1/sl unknown
- 2005-02-21 AT AT05290383T patent/ATE448221T1/de active
- 2005-02-21 PL PL05290383T patent/PL1614687T3/pl unknown
- 2005-04-07 MX MXPA05003696A patent/MXPA05003696A/es active IP Right Grant
- 2005-12-22 HK HK05111843A patent/HK1079777A1/xx unknown
-
2009
- 2009-09-25 JP JP2009220529A patent/JP5277130B2/ja active Active
-
2010
- 2010-01-13 HR HR20100024T patent/HRP20100024T1/hr unknown
- 2010-01-19 CY CY20101100053T patent/CY1109740T1/el unknown
Also Published As
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FR2932800B1 (fr) | Nouveau procede de synthese de la 7,8-dimethoxy-1,3-dihydro- 2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable | |
FR2933975B1 (fr) | Nouveau procede de preparation de benzocyclobutenes fonctionnalises,et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable. | |
FR2941695B1 (fr) | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable | |
FR2866335B1 (fr) | Nouveau procede de synthese de l'agomelatine | |
FR2868775B1 (fr) | Nouveau procede de synthese de derives de la 1,3,4,5- tetrahydro-2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable | |
FR2943668B1 (fr) | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable. | |
FR2919606B1 (fr) | Nouveau procede de synthese du (7-methoxy-1-naphtyl) acetonitrile et application a la synthese de l'agomelatine. | |
FR2935381B1 (fr) | Nouveau procede de resolution des enantiomerees du (3,4-dimethoxy-bicyclo°4.2.0!octa-1,3,5-trien-7-yl)nitrile et application a la synthese de l'ivabradine | |
MA28144A1 (fr) | Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables | |
FR2950343B1 (fr) | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable | |
MA27633A1 (fr) | Nouveau procede de synthese de l'acide (2s)-indoline -2-carboxylique, et application a la synthese du perindopril. | |
FR2868776B1 (fr) | Nouveau procede de synthese de derives de la 1,3-dihydro- 2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable | |
FR2866334B1 (fr) | Nouveau procede de synthese du (7-methoxy-1-naphtyl) acetonitrile et application a la synthese de l'agomelatine | |
FR2943667B1 (fr) | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable. | |
FR2866336B1 (fr) | Nouveau procede de synthese du (7-methoxy-3,4-dihydro-1-naphtalenyl) acetonitrile et application a la synthese de l'agomelatine | |
MA27516A1 (fr) | Nouveau procede de synthese du (7-methoxy-1-naphtyl)acetonitrile et application a la synthese de l'agomelatine | |
MA26101A1 (fr) | Nouveau procede de synthese industriel du diester methylique de l'acide 5-amino-3-carboxymethy l-4-cyano-2-thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates. | |
MA32681B1 (fr) | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable | |
FR2907781B1 (fr) | Procede de synthese de diamines et/ou de triamines primaires de haute purete a partir d'acides dimeres ou trimeres | |
FR2997696B1 (fr) | Nouveau procede de synthese du (2e)-3-(3,4-dimethoxyphenyl)prop-2-enenitrile, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable | |
FR3005658B1 (fr) | "procede de synthese du 3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene-7-carbonitrile, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable" | |
MA27911A1 (fr) | Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables. |
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Effective date: 20111230 |