DK1614687T3 - Fremgangsmåde til fremstilling af 1,3,4,5-tetrahydro-2H-3-benzazepin-2-onderivater og deres anvendelse ved syntese af ivabradin og farmaceutisk acceptable salte deraf - Google Patents
Fremgangsmåde til fremstilling af 1,3,4,5-tetrahydro-2H-3-benzazepin-2-onderivater og deres anvendelse ved syntese af ivabradin og farmaceutisk acceptable salte derafInfo
- Publication number
- DK1614687T3 DK1614687T3 DK05290383.8T DK05290383T DK1614687T3 DK 1614687 T3 DK1614687 T3 DK 1614687T3 DK 05290383 T DK05290383 T DK 05290383T DK 1614687 T3 DK1614687 T3 DK 1614687T3
- Authority
- DK
- Denmark
- Prior art keywords
- ivabradine
- benzazepine
- tetrahydro
- synthesis
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0403828A FR2868775B1 (fr) | 2004-04-13 | 2004-04-13 | Nouveau procede de synthese de derives de la 1,3,4,5- tetrahydro-2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1614687T3 true DK1614687T3 (da) | 2010-03-29 |
Family
ID=34941961
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK05290383.8T DK1614687T3 (da) | 2004-04-13 | 2005-02-21 | Fremgangsmåde til fremstilling af 1,3,4,5-tetrahydro-2H-3-benzazepin-2-onderivater og deres anvendelse ved syntese af ivabradin og farmaceutisk acceptable salte deraf |
Country Status (33)
| Country | Link |
|---|---|
| US (1) | US7064200B2 (da) |
| EP (1) | EP1614687B1 (da) |
| JP (2) | JP4515933B2 (da) |
| KR (1) | KR100636499B1 (da) |
| CN (1) | CN100348585C (da) |
| AR (1) | AR047707A1 (da) |
| AT (1) | ATE448221T1 (da) |
| AU (1) | AU2005200884B2 (da) |
| BR (1) | BRPI0500590B8 (da) |
| CA (1) | CA2496712C (da) |
| CY (1) | CY1109740T1 (da) |
| DE (1) | DE602005017541D1 (da) |
| DK (1) | DK1614687T3 (da) |
| EA (1) | EA007743B1 (da) |
| EG (1) | EG25619A (da) |
| ES (1) | ES2336461T3 (da) |
| FR (1) | FR2868775B1 (da) |
| GE (1) | GEP20074136B (da) |
| HK (1) | HK1079777A1 (da) |
| HR (1) | HRP20100024T1 (da) |
| MA (1) | MA27598A1 (da) |
| MX (1) | MXPA05003696A (da) |
| MY (1) | MY140904A (da) |
| NO (1) | NO329861B1 (da) |
| NZ (1) | NZ538328A (da) |
| PL (1) | PL1614687T3 (da) |
| PT (1) | PT1614687E (da) |
| RS (1) | RS51232B (da) |
| SG (1) | SG116574A1 (da) |
| SI (1) | SI1614687T1 (da) |
| UA (1) | UA81773C2 (da) |
| WO (1) | WO2005111027A1 (da) |
| ZA (1) | ZA200501468B (da) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2868775B1 (fr) * | 2004-04-13 | 2008-04-11 | Servier Lab | Nouveau procede de synthese de derives de la 1,3,4,5- tetrahydro-2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
| FR2868777B1 (fr) * | 2004-04-13 | 2006-05-26 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
| GT200500185A (es) * | 2004-08-09 | 2006-04-10 | Moduladores del receptor de progesterona que comprenden derivados de pirrol-oxindol y sus usos | |
| RU2473544C2 (ru) | 2007-05-30 | 2013-01-27 | Инд-Свифт Лабораториз Лимитед | Способ получения ивабрадина гидрохлорида и его полиморфных модификаций |
| WO2010072409A1 (en) | 2008-12-22 | 2010-07-01 | Krka, D. D., Novo Mesto | Process for preparation of ivabradine |
| FR2940287B1 (fr) * | 2008-12-24 | 2010-12-24 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable. |
| PL2902384T3 (pl) | 2010-02-12 | 2018-04-30 | Krka, D.D., Novo Mesto | Postać chlorowodorku iwabradyny |
| FR2956401B1 (fr) * | 2010-02-17 | 2012-02-03 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
| FR2971507B1 (fr) * | 2011-02-14 | 2013-01-18 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
| FR2984320B1 (fr) * | 2011-12-20 | 2013-11-29 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
| FR2993561B1 (fr) * | 2012-07-17 | 2014-10-31 | Servier Lab | Procede de synthese enzymatique de la (7s)-1-(3,4-dimethoxy bicyclo[4.2.0]octa-1,3,5-triene 7-yl) n-methyl methanamine, et application a la synthese de l'ivabradine et de ses sels |
| FR3003859B1 (fr) * | 2013-03-26 | 2015-03-13 | Servier Lab | "procede de synthese de derives de la 7,8-dimethoxy-1,3-dihydro-2h-3-benzazepin-2-one et application a la synthese de l'ivabradine" |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3119874A1 (de) * | 1981-05-19 | 1982-12-09 | Dr. Karl Thomae Gmbh, 7950 Biberach | "benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel" |
| DE3418270A1 (de) * | 1984-05-17 | 1985-11-21 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue aminotetralinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| DE3519735A1 (de) * | 1985-06-01 | 1986-12-04 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue heteroaromatische aminderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| EP0204349A3 (de) * | 1985-06-01 | 1990-01-03 | Dr. Karl Thomae GmbH | Neue heteroaromatische Aminderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| FR2681862B1 (fr) * | 1991-09-27 | 1993-11-12 | Adir Cie | Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent. |
| FR2868775B1 (fr) * | 2004-04-13 | 2008-04-11 | Servier Lab | Nouveau procede de synthese de derives de la 1,3,4,5- tetrahydro-2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
| FR2868777B1 (fr) * | 2004-04-13 | 2006-05-26 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
-
2004
- 2004-04-13 FR FR0403828A patent/FR2868775B1/fr not_active Expired - Fee Related
-
2005
- 2005-02-07 CA CA2496712A patent/CA2496712C/fr active Active
- 2005-02-15 SG SG200500770A patent/SG116574A1/en unknown
- 2005-02-17 US US11/060,043 patent/US7064200B2/en active Active
- 2005-02-18 ZA ZA2005/01468A patent/ZA200501468B/en unknown
- 2005-02-18 NO NO20050888A patent/NO329861B1/no unknown
- 2005-02-18 AR ARP050100586A patent/AR047707A1/es active IP Right Grant
- 2005-02-18 NZ NZ538328A patent/NZ538328A/en unknown
- 2005-02-18 BR BRPI0500590A patent/BRPI0500590B8/pt active IP Right Grant
- 2005-02-18 JP JP2005041810A patent/JP4515933B2/ja active Active
- 2005-02-18 GE GEAP8647A patent/GEP20074136B/en unknown
- 2005-02-18 UA UAA200501524A patent/UA81773C2/uk unknown
- 2005-02-18 MY MYPI20050621A patent/MY140904A/en unknown
- 2005-02-18 MA MA28112A patent/MA27598A1/fr unknown
- 2005-02-18 AU AU2005200884A patent/AU2005200884B2/en active Active
- 2005-02-18 CN CNB2005100542167A patent/CN100348585C/zh active Active
- 2005-02-19 KR KR1020050013860A patent/KR100636499B1/ko active IP Right Grant
- 2005-02-19 EG EG2005020086A patent/EG25619A/xx active
- 2005-02-21 ES ES05290383T patent/ES2336461T3/es active Active
- 2005-02-21 SI SI200530864T patent/SI1614687T1/sl unknown
- 2005-02-21 DK DK05290383.8T patent/DK1614687T3/da active
- 2005-02-21 PT PT05290383T patent/PT1614687E/pt unknown
- 2005-02-21 EA EA200500240A patent/EA007743B1/ru unknown
- 2005-02-21 WO PCT/FR2005/000396 patent/WO2005111027A1/fr active Application Filing
- 2005-02-21 PL PL05290383T patent/PL1614687T3/pl unknown
- 2005-02-21 DE DE602005017541T patent/DE602005017541D1/de active Active
- 2005-02-21 AT AT05290383T patent/ATE448221T1/de active
- 2005-02-21 RS RSP-2010/0006A patent/RS51232B/sr unknown
- 2005-02-21 EP EP05290383A patent/EP1614687B1/fr active Active
- 2005-04-07 MX MXPA05003696A patent/MXPA05003696A/es active IP Right Grant
- 2005-12-22 HK HK05111843A patent/HK1079777A1/xx unknown
-
2009
- 2009-09-25 JP JP2009220529A patent/JP5277130B2/ja active Active
-
2010
- 2010-01-13 HR HR20100024T patent/HRP20100024T1/hr unknown
- 2010-01-19 CY CY20101100053T patent/CY1109740T1/el unknown
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