BG60274B2 - Microbial process for the production of immunosuppressive antibiotics - Google Patents

Microbial process for the production of immunosuppressive antibiotics

Info

Publication number
BG60274B2
BG60274B2 BG90701A BG9070189A BG60274B2 BG 60274 B2 BG60274 B2 BG 60274B2 BG 90701 A BG90701 A BG 90701A BG 9070189 A BG9070189 A BG 9070189A BG 60274 B2 BG60274 B2 BG 60274B2
Authority
BG
Bulgaria
Prior art keywords
cyclosporine
production
medium containing
components
nutrient medium
Prior art date
Application number
BG90701A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG60274B1 (bg
Inventor
Antonia Jekkel
Gabor Ambrus
Eva Sarudy
Istvan Szabo
Agota Huelber
Attila Andor
Karoly Albrecht
Kalman Koenczoel
Valeria Szell
Eva Tomori
Imre Moravcsik
Kalman Polya
Janos Erdei
Lajos Kiss
Karoly Nagy
Bela Palotas
Etelka Deli
Karoly Buzasi
Aniko Molnar
Gyoergy Santha
Vilma Szaszhegyesi
Original Assignee
Biogal Gyogyszergyar Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogal Gyogyszergyar Rt. filed Critical Biogal Gyogyszergyar Rt.
Publication of BG60274B2 publication Critical patent/BG60274B2/xx
Publication of BG60274B1 publication Critical patent/BG60274B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
BG090701A 1988-12-20 1989-12-20 Микробиален метод за получаване на имуноподтискащи антибиотици BG60274B1 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU886497A HU201577B (en) 1988-12-20 1988-12-20 Process for producing cyclosporin antibiotics

Publications (2)

Publication Number Publication Date
BG60274B2 true BG60274B2 (en) 1994-03-31
BG60274B1 BG60274B1 (bg) 1994-03-31

Family

ID=10971727

Family Applications (1)

Application Number Title Priority Date Filing Date
BG090701A BG60274B1 (bg) 1988-12-20 1989-12-20 Микробиален метод за получаване на имуноподтискащи антибиотици

Country Status (23)

Country Link
US (1) US5156960A (sk)
EP (1) EP0379708B1 (sk)
JP (1) JPH0763356B2 (sk)
AT (1) AT393135B (sk)
BG (1) BG60274B1 (sk)
CA (1) CA2006144C (sk)
CZ (1) CZ283557B6 (sk)
DD (1) DD290356A5 (sk)
DE (1) DE58908740D1 (sk)
DK (1) DK174719B1 (sk)
FI (1) FI92603C (sk)
FR (1) FR2640641B1 (sk)
GB (1) GB2227489B (sk)
HU (1) HU201577B (sk)
IT (1) IT1237799B (sk)
LV (2) LV10102B (sk)
NO (1) NO175873C (sk)
PL (1) PL162959B1 (sk)
RU (1) RU1836425C (sk)
SE (1) SE505442C2 (sk)
SK (1) SK279768B6 (sk)
UA (1) UA13320A (sk)
YU (1) YU47100B (sk)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2101777A1 (en) * 1991-01-25 1992-07-26 Toshio Goto Process for producing cyclosporin a and/or c
ATE127528T1 (de) * 1991-04-06 1995-09-15 Dresden Arzneimittel Verfahren zur fermentativen herstellung und isolierung von cyclosporin a sowie neue cyclosporin- bildende stämme.
FI92334C (fi) * 1992-12-30 1994-10-25 Leiras Oy Menetelmä syklosporiinien tuottamiseksi ja menetelmässä käytettävä uusi Tolypocladium-kanta
SI9300303A (en) * 1993-06-08 1994-12-31 Krka Tovarna Zdravil Process for isolation of hypolipemic effective substance
KR100304324B1 (ko) * 1994-10-13 2001-11-22 김용규 사이클로스포린a의제조방법
KR100341355B1 (ko) * 1994-10-14 2002-10-25 주식회사종근당 사이클로스포린a의제조방법
KR0126610B1 (ko) * 1994-10-18 1997-12-29 김충환 고생산 세포융합변이균주에 의한 사이클로스포린 a의 제조방법
EP0725076B1 (en) * 1995-02-01 2001-06-06 National Research Development Corporation of India A process for the preparation of cyclosporin A from tolypocladium species
WO1997001575A1 (fr) * 1995-06-29 1997-01-16 Fujisawa Pharmaceutical Co., Ltd. Substance wf16616, procede de production et utilisation
DE19611094C2 (de) 1996-03-21 1999-06-17 Dresden Arzneimittel Verfahren zur Reinigung von Cyclosporin A und/oder verwandten Cyclosporinen aus einem Cyclosporin-haltigen Rohextrakt unter Anwendung chromatographischer Verfahren mit Kieselgel als Adsorbens
US5747330A (en) * 1996-06-05 1998-05-05 Poli Industria Chimica Antibiotic producing microbe
US5709797A (en) * 1996-06-05 1998-01-20 Poli Industria Chimica S.P.A. Method of isolating cyclosporins
IL143604A0 (en) 1998-12-30 2002-04-21 Dexcel Ltd Dispersable concentrate for the delivery of cyclosporin
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
US7176001B1 (en) 2000-02-29 2007-02-13 Biocon Limited Manufacture and purification of cyclosporin A
US7696166B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
US7696165B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
EP2151450A1 (de) * 2008-07-29 2010-02-10 Sandoz AG Verfahren zur Aufarbeitung von mikrobiologisch hergestellten zyklischen Oligopeptiden
JP6022548B2 (ja) * 2011-04-28 2016-11-09 セルジーン コーポレイション Ｐｄｅ４阻害剤を自己免疫疾患及び炎症性疾患の治療及び管理に使用する方法及び組成物
GB201319791D0 (en) * 2013-11-08 2013-12-25 Sigmoid Pharma Ltd Formulations

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4117118A (en) * 1976-04-09 1978-09-26 Sandoz Ltd. Organic compounds
DE2819094A1 (de) * 1977-05-10 1978-11-23 Sandoz Ag Cyclosporin-derivate, ihre verwendung und herstellung
US4215199A (en) * 1978-06-05 1980-07-29 Sandoz Ltd. Antibiotic production
SE448386B (sv) * 1978-10-18 1987-02-16 Sandoz Ag Nya cyklosporinderivat, forfarande for framstellning av dem samt farmaceutisk komposition innehallande dem
US4764503A (en) * 1986-11-19 1988-08-16 Sandoz Ltd. Novel cyclosporins

Also Published As

Publication number Publication date
SK279768B6 (sk) 1999-03-12
LV10102A (lv) 1994-05-10
AT393135B (de) 1991-08-26
HU201577B (en) 1990-11-28
EP0379708A1 (de) 1990-08-01
NO175873C (no) 1994-12-21
DK640989A (da) 1990-06-21
EP0379708B1 (de) 1994-12-07
RU1836425C (ru) 1993-08-23
DK640989D0 (da) 1989-12-18
GB2227489A (en) 1990-08-01
PL162959B1 (en) 1994-01-31
DD290356A5 (de) 1991-05-29
SE8904262D0 (sv) 1989-12-19
GB8928715D0 (en) 1990-02-28
YU47100B (sh) 1994-12-28
GB2227489B (en) 1992-09-16
SK722589A3 (en) 1999-03-10
FR2640641A1 (fr) 1990-06-22
DE58908740D1 (de) 1995-01-19
NO895160D0 (no) 1989-12-20
NO175873B (sk) 1994-09-12
UA13320A (uk) 1997-02-28
FI92603C (fi) 1994-12-12
SE505442C2 (sv) 1997-08-25
CA2006144C (en) 1995-02-21
NO895160L (no) 1990-06-21
US5156960A (en) 1992-10-20
FR2640641B1 (fr) 1991-05-10
LV10500B (en) 1995-08-20
FI896157A0 (fi) 1989-12-20
CA2006144A1 (en) 1990-06-20
JPH02231071A (ja) 1990-09-13
YU241589A (en) 1991-02-28
IT8922765A0 (it) 1989-12-20
LV10102B (en) 1995-02-20
CZ722589A3 (cs) 1998-01-14
JPH0763356B2 (ja) 1995-07-12
FI92603B (fi) 1994-08-31
DK174719B1 (da) 2003-10-06
LV10500A (lv) 1995-02-20
ATA289189A (de) 1991-01-15
IT1237799B (it) 1993-08-31
BG60274B1 (bg) 1994-03-31
CZ283557B6 (cs) 1998-05-13
SE8904262L (sv) 1990-06-21
HUT52164A (en) 1990-06-28

Similar Documents

Publication Publication Date Title
BG60274B2 (en) Microbial process for the production of immunosuppressive antibiotics
KR960700346A (ko) 면역억제제의 제조방법 및 이에 사용되는 신규 미생물(a process for producing immunosuppressives and a novel microbial species to be employed therein)
EP0765938A3 (en) Fermentative production of vitamin B6
GB1474129A (en) Method for the production of d-ribose
EP0435551B1 (en) Process for preparation S-(+)-3 halogeno-1,2-propanediol by treatment with microorganism
EP0434393A2 (en) Process for preparation of R-(-)-3-halogeno-1,2-propanediol by treatment with microorganism
EP0799895B1 (en) Fermentative production of d-biotin
Karnetová et al. Production of phenazines by Streptomyces cinnamonensis
JPS55102393A (en) Enzymatic preparation of tyramine
US2798840A (en) Production of vitamin b12 by agrobacterium radiobacter
SI8912415B (sl) Mikrobni postopek za proizvodnjo imunosupresivnih antibiotikov
TH6008B (th) กรรมวิธีสำหรับการผลิตแอล-ไลซีนโดยการหมัก
Vraná et al. Production of ethanol by the yeast Candida utilis under autoanaerobic conditions
JPS6460393A (en) Production of l-threonine by fermentation
TH12886A (th) กรรมวิธีสำหรับการผลิตแอล-ไลซีนโดยการหมัก
TH2746B (th) การผลิตยาปฏิชีวนะKibdelosporangium aridum Shearer
TH12886EX (th) กรรมวิธีสำหรับการผลิตแอล-ไลซีนโดยการหมัก
JPS5794288A (en) Aristeromycin-producing bactria
JPS5618594A (en) Antibiotic, ab-111, and its preparation
JPS5618600A (en) Production of antibiotic, sf-2052
UA26314A (uk) Спосіб одержаhhя циклоспориhу а, штами гриба sesquicilliopsis rosariensis g.arnold-продуцеhти циклоспориhу а, штам гриба tolypocladium inflatum-продуцеhт циклоспориhу а
TH2142A (th) การผลิตยาปฏิชีวนะKibdelosporangium aridum Shearer
JPS6460394A (en) Production of l-threonine by fermentation
KR950018440A (ko) 엘(l)-세레노 메치오닌과 페닐 머큐릭 아세테이트에 내성을 갖는 세팔로스포리움속 미생물 및 이를 이용한 세팔로스포린 c의 제조방법
TH2142EX (th) การผลิตยาปฏิชีวนะKibdelosporangium aridum Shearer