HU201577B - Process for producing cyclosporin antibiotics - Google Patents

Process for producing cyclosporin antibiotics

Info

Publication number
HU201577B
HU201577B HU886497A HU649788A HU201577B HU 201577 B HU201577 B HU 201577B HU 886497 A HU886497 A HU 886497A HU 649788 A HU649788 A HU 649788A HU 201577 B HU201577 B HU 201577B
Authority
HU
Hungary
Prior art keywords
antibiotics
producing cyclosporin
cyclosporin
producing
cyclosporin antibiotics
Prior art date
Application number
HU886497A
Other languages
English (en)
Other versions
HUT52164A (en
Inventor
Antalne Dr Jekkel
Gabor Ambrus
Sarudy Eva Toth
Istvan Mihaly Szabo
Dobos Agota Huelberne
Attila Andor
Karoly Albrecht
Kalman Koenczoel
Valeria Szell
Laszlone Tomori
Imre Moravcsik
Kalman Polya
Janos Erdei
Lajos Kiss
Bela Makadi
Karoly Nagy
Bela Palotas
Jozsefne Deli
Karoly Buzasi
Dr Antal Aniko Molnarne
Gyoergy Sandtha
Vilma Szaszhegyesi
Original Assignee
Gyogyszerkutato Intezet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gyogyszerkutato Intezet filed Critical Gyogyszerkutato Intezet
Priority to HU886497A priority Critical patent/HU201577B/hu
Priority to DK198906409A priority patent/DK174719B1/da
Priority to SU4742791A priority patent/RU1836425C/ru
Priority to UA4742791A priority patent/UA13320A/uk
Priority to SE8904262A priority patent/SE505442C2/sv
Priority to FR898916878A priority patent/FR2640641B1/fr
Priority to NO895160A priority patent/NO175873C/no
Priority to GB8928715A priority patent/GB2227489B/en
Priority to DD89335977A priority patent/DD290356A5/de
Priority to SK7225-89A priority patent/SK279768B6/sk
Priority to FI896157A priority patent/FI92603C/fi
Priority to IT22765A priority patent/IT1237799B/it
Priority to US07/454,005 priority patent/US5156960A/en
Priority to CS897225A priority patent/CZ283557B6/cs
Priority to CA002006144A priority patent/CA2006144C/en
Priority to SI8912415A priority patent/SI8912415B/sl
Priority to BG90701A priority patent/BG60274B2/xx
Priority to EP89123535A priority patent/EP0379708B1/de
Priority to YU241589A priority patent/YU47100B/sh
Priority to DE58908740T priority patent/DE58908740D1/de
Priority to AT2891/89A priority patent/AT393135B/de
Priority to PL28287689A priority patent/PL162959B1/pl
Priority to JP1328529A priority patent/JPH0763356B2/ja
Publication of HUT52164A publication Critical patent/HUT52164A/hu
Publication of HU201577B publication Critical patent/HU201577B/hu
Priority to LVP-92-10A priority patent/LV10102B/en
Priority to HRP-2415/89A priority patent/HRP930570B1/xx
Priority to LVP-93-708A priority patent/LV10500B/lv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Botany (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Transplantation (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
HU886497A 1988-12-20 1988-12-20 Process for producing cyclosporin antibiotics HU201577B (en)

Priority Applications (26)

Application Number Priority Date Filing Date Title
HU886497A HU201577B (en) 1988-12-20 1988-12-20 Process for producing cyclosporin antibiotics
DK198906409A DK174719B1 (da) 1988-12-20 1989-12-18 Mikrobiel fremgangsmåde til fremstilling af immunundertrykkende antibiotika omfattende dyrkning af en ny Tolypocladium svamp og svampestammen Tolypocladium varium sp. nov. CY/93
SU4742791A RU1836425C (ru) 1988-12-20 1989-12-19 Способ получени комплексного антибиотика циклоспорина и/или его компонентов и штамм грибка ТоLYросLаDIUм VаRIUм
UA4742791A UA13320A (uk) 1988-12-20 1989-12-19 Спосіб одержаhhя комплексhого аhтибіотика циклоспоріhу та/або його компоhеhтів та штам грибка tolypocladium varium
SE8904262A SE505442C2 (sv) 1988-12-20 1989-12-19 Mikrobiell process för framställning av immunosuppressiva antibiotika innefattande odling av en ny Tolypocladium svamp
CS897225A CZ283557B6 (cs) 1988-12-20 1989-12-20 Plísňový kmen Tylypocladium varium a způsob mikrobiální přípravy cyklosporinového komplexu za použití tohoto kmene
BG90701A BG60274B2 (en) 1988-12-20 1989-12-20 Microbial process for the production of immunosuppressive antibiotics
GB8928715A GB2227489B (en) 1988-12-20 1989-12-20 Cyclosporins obtained from tolypocladium nova species
DD89335977A DD290356A5 (de) 1988-12-20 1989-12-20 Verfahren zur herstellung eines antibiotikums
SK7225-89A SK279768B6 (sk) 1988-12-20 1989-12-20 Plesňový kmeň tolypocladium varium a spôsob mikrob
FI896157A FI92603C (fi) 1988-12-20 1989-12-20 Mikrobinen menetelmä syklosporiinien valmistamiseksi
IT22765A IT1237799B (it) 1988-12-20 1989-12-20 Processo microbico per la produzione di antibiotici immunosoppressivi
US07/454,005 US5156960A (en) 1988-12-20 1989-12-20 Microbial process for the production of immunosuppressive antibiotics
FR898916878A FR2640641B1 (fr) 1988-12-20 1989-12-20 Procede microbien pour la production du complexe antibiotique de cyclosporines
CA002006144A CA2006144C (en) 1988-12-20 1989-12-20 Microbial process for the production of immunosuppressive antibiotics
SI8912415A SI8912415B (sl) 1988-12-20 1989-12-20 Mikrobni postopek za proizvodnjo imunosupresivnih antibiotikov
NO895160A NO175873C (no) 1988-12-20 1989-12-20 Mikrobiell fremgangsmåte for fremstilling av immunhemmende antibiotika
EP89123535A EP0379708B1 (de) 1988-12-20 1989-12-20 Pilzart Tolypocladium varium und Verfahren zur Herstellung des Antibioticumkomplexes Cyclosporin und/oder seiner Bestandteile
YU241589A YU47100B (sh) 1988-12-20 1989-12-20 Mikrobiološki postupak za proizvodnju ciklosporinskog kompleksa ili njegovih komponenti
DE58908740T DE58908740D1 (de) 1988-12-20 1989-12-20 Pilzart Tolypocladium varium und Verfahren zur Herstellung des Antibioticumkomplexes Cyclosporin und/oder seiner Bestandteile.
AT2891/89A AT393135B (de) 1988-12-20 1989-12-20 Verfahren zur herstellung eines antibiotikums
PL28287689A PL162959B1 (en) 1988-12-20 1989-12-20 Method for manufacturing a complex of cyclosporine antibiotics
JP1328529A JPH0763356B2 (ja) 1988-12-20 1989-12-20 新種トリポクラディウム・バリウム、及びそれを利用するサイクロスポリン系抗生物質の生産方法
LVP-92-10A LV10102B (en) 1988-12-20 1992-05-04 New non-hygroscopic mono-ammonium salts
HRP-2415/89A HRP930570B1 (en) 1988-12-20 1993-03-26 Microbial process for the production of immunosuppressive antibiotics
LVP-93-708A LV10500B (en) 1988-12-20 1993-06-28 Method for producing of complex antibiotic- cyclosporin and/or it's components and method for producing of tolypocladium varium culture

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU886497A HU201577B (en) 1988-12-20 1988-12-20 Process for producing cyclosporin antibiotics

Publications (2)

Publication Number Publication Date
HUT52164A HUT52164A (en) 1990-06-28
HU201577B true HU201577B (en) 1990-11-28

Family

ID=10971727

Family Applications (1)

Application Number Title Priority Date Filing Date
HU886497A HU201577B (en) 1988-12-20 1988-12-20 Process for producing cyclosporin antibiotics

Country Status (23)

Country Link
US (1) US5156960A (hu)
EP (1) EP0379708B1 (hu)
JP (1) JPH0763356B2 (hu)
AT (1) AT393135B (hu)
BG (1) BG60274B2 (hu)
CA (1) CA2006144C (hu)
CZ (1) CZ283557B6 (hu)
DD (1) DD290356A5 (hu)
DE (1) DE58908740D1 (hu)
DK (1) DK174719B1 (hu)
FI (1) FI92603C (hu)
FR (1) FR2640641B1 (hu)
GB (1) GB2227489B (hu)
HU (1) HU201577B (hu)
IT (1) IT1237799B (hu)
LV (2) LV10102B (hu)
NO (1) NO175873C (hu)
PL (1) PL162959B1 (hu)
RU (1) RU1836425C (hu)
SE (1) SE505442C2 (hu)
SK (1) SK279768B6 (hu)
UA (1) UA13320A (hu)
YU (1) YU47100B (hu)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5447854A (en) * 1991-01-25 1995-09-05 Fujisawa Pharmaceutical Co., Ltd. Production of cyclosporin A and/or C with a strain of NECTRIA
DE59106428D1 (de) * 1991-04-06 1995-10-12 Dresden Arzneimittel Verfahren zur fermentativen Herstellung und Isolierung von Cyclosporin A sowie neue Cyclosporin- bildende Stämme.
FI92334C (fi) * 1992-12-30 1994-10-25 Leiras Oy Menetelmä syklosporiinien tuottamiseksi ja menetelmässä käytettävä uusi Tolypocladium-kanta
SI9300303A (en) * 1993-06-08 1994-12-31 Krka Tovarna Zdravil Process for isolation of hypolipemic effective substance
KR100304324B1 (ko) * 1994-10-13 2001-11-22 김용규 사이클로스포린a의제조방법
KR100341355B1 (ko) * 1994-10-14 2002-10-25 주식회사종근당 사이클로스포린a의제조방법
KR0126610B1 (ko) * 1994-10-18 1997-12-29 김충환 고생산 세포융합변이균주에 의한 사이클로스포린 a의 제조방법
EP0725076B1 (en) * 1995-02-01 2001-06-06 National Research Development Corporation of India A process for the preparation of cyclosporin A from tolypocladium species
EP0846699A1 (en) * 1995-06-29 1998-06-10 Fujisawa Pharmaceutical Co., Ltd. Substance wf16616, process for production thereof, and use thereof
DE19611094C2 (de) 1996-03-21 1999-06-17 Dresden Arzneimittel Verfahren zur Reinigung von Cyclosporin A und/oder verwandten Cyclosporinen aus einem Cyclosporin-haltigen Rohextrakt unter Anwendung chromatographischer Verfahren mit Kieselgel als Adsorbens
US5709797A (en) * 1996-06-05 1998-01-20 Poli Industria Chimica S.P.A. Method of isolating cyclosporins
US5747330A (en) * 1996-06-05 1998-05-05 Poli Industria Chimica Antibiotic producing microbe
WO2000040219A1 (en) 1998-12-30 2000-07-13 Dexcel Ltd. Dispersible concentrate for the delivery of cyclosporin
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
CA2401700A1 (en) 2000-02-29 2001-09-07 Biocon India Limited Manufacture and purification of cyclosporin a
US7696165B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
US7696166B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
EP2151450A1 (de) 2008-07-29 2010-02-10 Sandoz AG Verfahren zur Aufarbeitung von mikrobiologisch hergestellten zyklischen Oligopeptiden
ES2661583T3 (es) * 2011-04-28 2018-04-02 Celgene Corporation Métodos y composiciones usando inhibidores de PDE4 para el tratamiento y gestión de enfermedades autoinmunes e inflamatorias
GB201319791D0 (en) * 2013-11-08 2013-12-25 Sigmoid Pharma Ltd Formulations
CN117025407A (zh) * 2023-06-28 2023-11-10 中国人民解放军海军特色医学中心 一株弯颈霉属真菌及其在制备抗辐损伤药物中的应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4117118A (en) * 1976-04-09 1978-09-26 Sandoz Ltd. Organic compounds
DE2819094A1 (de) * 1977-05-10 1978-11-23 Sandoz Ag Cyclosporin-derivate, ihre verwendung und herstellung
US4215199A (en) * 1978-06-05 1980-07-29 Sandoz Ltd. Antibiotic production
SE448386B (sv) * 1978-10-18 1987-02-16 Sandoz Ag Nya cyklosporinderivat, forfarande for framstellning av dem samt farmaceutisk komposition innehallande dem
US4764503A (en) * 1986-11-19 1988-08-16 Sandoz Ltd. Novel cyclosporins

Also Published As

Publication number Publication date
IT8922765A0 (it) 1989-12-20
FI896157A0 (fi) 1989-12-20
SE8904262D0 (sv) 1989-12-19
SK279768B6 (sk) 1999-03-12
PL162959B1 (en) 1994-01-31
NO175873B (hu) 1994-09-12
DK640989D0 (da) 1989-12-18
FI92603B (fi) 1994-08-31
GB2227489B (en) 1992-09-16
GB8928715D0 (en) 1990-02-28
JPH02231071A (ja) 1990-09-13
DD290356A5 (de) 1991-05-29
EP0379708A1 (de) 1990-08-01
NO895160L (no) 1990-06-21
LV10500B (en) 1995-08-20
NO175873C (no) 1994-12-21
CZ722589A3 (cs) 1998-01-14
CA2006144A1 (en) 1990-06-20
FR2640641A1 (fr) 1990-06-22
FI92603C (fi) 1994-12-12
HUT52164A (en) 1990-06-28
BG60274B1 (bg) 1994-03-31
NO895160D0 (no) 1989-12-20
JPH0763356B2 (ja) 1995-07-12
IT1237799B (it) 1993-08-31
AT393135B (de) 1991-08-26
LV10102B (en) 1995-02-20
EP0379708B1 (de) 1994-12-07
FR2640641B1 (fr) 1991-05-10
US5156960A (en) 1992-10-20
RU1836425C (ru) 1993-08-23
DK174719B1 (da) 2003-10-06
YU47100B (sh) 1994-12-28
BG60274B2 (en) 1994-03-31
LV10102A (lv) 1994-05-10
SE8904262L (sv) 1990-06-21
CA2006144C (en) 1995-02-21
ATA289189A (de) 1991-01-15
GB2227489A (en) 1990-08-01
YU241589A (en) 1991-02-28
DE58908740D1 (de) 1995-01-19
DK640989A (da) 1990-06-21
LV10500A (lv) 1995-02-20
UA13320A (uk) 1997-02-28
SE505442C2 (sv) 1997-08-25
CZ283557B6 (cs) 1998-05-13
SK722589A3 (en) 1999-03-10

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Legal Events

Date Code Title Description
HPC4 Succession in title of patentee

Owner name: BIOGAL GYOGYSZERGYAR RT., HU

FH91 Appointment of a representative

Free format text: FORMER REPRESENTATIVE(S): DANUBIA SZABADALMI ES VEDJEGY IRODA KFT., HU

Representative=s name: EMRI-PATENT IPARJOGVEDELMI KFT., HU

FH92 Termination of representative

Representative=s name: DANUBIA SZABADALMI ES VEDJEGY IRODA KFT., HU

HC9A Change of name, address

Owner name: TEVA GYOGYSZERGYAR ZRT., HU

Free format text: FORMER OWNER(S): BIOGAL GYOGYSZERGYAR RT., HU