BG108038A - Nicotinamide biaryl derivatives useful as inhibitors of pde4 isozymes - Google Patents
Nicotinamide biaryl derivatives useful as inhibitors of pde4 isozymesInfo
- Publication number
- BG108038A BG108038A BG108038A BG10803803A BG108038A BG 108038 A BG108038 A BG 108038A BG 108038 A BG108038 A BG 108038A BG 10803803 A BG10803803 A BG 10803803A BG 108038 A BG108038 A BG 108038A
- Authority
- BG
- Bulgaria
- Prior art keywords
- alkyl
- inhibitors
- nicotinamide
- derivatives useful
- biaryl derivatives
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Communicable Diseases (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Psychiatry (AREA)
- Dermatology (AREA)
- Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biotechnology (AREA)
- Emergency Medicine (AREA)
- AIDS & HIV (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26549201P | 2001-01-31 | 2001-01-31 | |
PCT/IB2001/002341 WO2002060875A1 (en) | 2001-01-31 | 2001-12-06 | Nicotinamide biaryl derivatives useful as inhibitors of pde4 isozymes |
Publications (1)
Publication Number | Publication Date |
---|---|
BG108038A true BG108038A (en) | 2004-07-30 |
Family
ID=23010671
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BG108038A BG108038A (en) | 2001-01-31 | 2003-07-28 | Nicotinamide biaryl derivatives useful as inhibitors of pde4 isozymes |
Country Status (25)
Country | Link |
---|---|
US (2) | US6649633B2 (es) |
EP (1) | EP1355884A1 (es) |
JP (1) | JP2004520386A (es) |
KR (1) | KR20030074761A (es) |
CN (1) | CN1518542A (es) |
BG (1) | BG108038A (es) |
BR (1) | BR0116852A (es) |
CA (1) | CA2436535A1 (es) |
CR (1) | CR7025A (es) |
CZ (1) | CZ20031895A3 (es) |
EA (1) | EA200300621A1 (es) |
EC (2) | ECSP034709A (es) |
EE (1) | EE200300360A (es) |
HU (1) | HUP0400637A2 (es) |
IL (1) | IL156413A0 (es) |
IS (1) | IS6846A (es) |
MA (1) | MA26983A1 (es) |
MX (1) | MXPA03006887A (es) |
NO (1) | NO20033397L (es) |
NZ (1) | NZ526453A (es) |
OA (1) | OA12540A (es) |
PL (1) | PL364135A1 (es) |
SK (1) | SK8792003A3 (es) |
WO (1) | WO2002060875A1 (es) |
ZA (1) | ZA200304894B (es) |
Families Citing this family (62)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030055026A1 (en) | 2001-04-17 | 2003-03-20 | Dey L.P. | Formoterol/steroid bronchodilating compositions and methods of use thereof |
MXPA03010679A (es) * | 2001-05-23 | 2004-03-02 | Tanabe Seiyaku Co | Una composicion para acelerar la cicatrizacion de fractura osea. |
US20040180900A1 (en) * | 2001-05-23 | 2004-09-16 | Masaharu Takigawa | Therapeutic composition for repairing chondropathy |
AU2002367730A1 (en) * | 2002-02-26 | 2003-09-09 | Stephen L. Schlesinger | Use of leukotriene receptor antagonist for treatment of scarring |
EP1424101A3 (en) * | 2002-11-29 | 2004-08-18 | NOZAKI, Masako | Use of a leukotriene C4 and D4 receptor antagonist for the preparation of a medicament for treating or preventing brain inflammation and sepsis |
AU2003300076C1 (en) | 2002-12-30 | 2010-03-04 | Angiotech International Ag | Drug delivery from rapid gelling polymer composition |
AU2004226353A1 (en) * | 2003-04-01 | 2004-10-14 | Laboratoires Serono Sa | Inhibitors of phosphodiesterases in infertility |
GB0309781D0 (en) * | 2003-04-29 | 2003-06-04 | Glaxo Group Ltd | Compounds |
GB0317516D0 (en) * | 2003-07-25 | 2003-08-27 | Pfizer Ltd | Nicotinamide derivatives useful as PDE4 inhibitors |
US7153870B2 (en) | 2003-07-25 | 2006-12-26 | Pfizer Inc. | Nicotinamide derivatives useful as PDE4 inhibitors |
GB0317498D0 (en) * | 2003-07-25 | 2003-08-27 | Pfizer Ltd | Compounds |
US20050020587A1 (en) * | 2003-07-25 | 2005-01-27 | Pfizer Inc | Nicotinamide derivatives useful as PDE4 inhibitors |
US7132435B2 (en) * | 2003-07-25 | 2006-11-07 | Pfizer Inc. | Compounds |
GB0317482D0 (en) * | 2003-07-25 | 2003-08-27 | Pfizer Ltd | Nicotinamide derivatives useful as pde4 inhibitors |
GB0317484D0 (en) * | 2003-07-25 | 2003-08-27 | Pfizer Ltd | Nicotinamide derivatives useful as pde4 inhibitors |
US7534894B2 (en) * | 2003-09-25 | 2009-05-19 | Wyeth | Biphenyloxy-acids |
US20050154006A1 (en) * | 2004-01-09 | 2005-07-14 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions based on a scopineester and nicotinamide derivatives |
WO2006073413A1 (en) * | 2004-02-20 | 2006-07-13 | The Board Of Trustees Of The University Of Illinois | Blood pressure reduction in salt-sensitive |
EP1725236A4 (en) * | 2004-03-11 | 2009-05-13 | Glaxo Group Ltd | NEW M3 MUSCARIN ACETYLCHOLINE RECEPTOR ANTAGONISTS |
EP2172222A3 (en) * | 2004-04-26 | 2010-06-23 | Ono Pharmaceutical Co., Ltd. | Novel BLT2-mediated disease, BLT2-binding agent and compound |
US7704522B2 (en) | 2004-09-08 | 2010-04-27 | Clyde Morgan | Topical medicament |
EP1844136B1 (en) | 2004-12-29 | 2014-08-27 | Hadasit Medical Research Services And Development Ltd. | Stem cells culture systems |
US8597947B2 (en) | 2004-12-29 | 2013-12-03 | Hadasit Medical Research Services & Development Limited | Undifferentiated stem cell culture systems |
EP2258358A3 (en) | 2005-08-26 | 2011-09-07 | Braincells, Inc. | Neurogenesis with acetylcholinesterase inhibitor |
EP2275095A3 (en) | 2005-08-26 | 2011-08-17 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
JP2009512711A (ja) | 2005-10-21 | 2009-03-26 | ブレインセルス,インコーポレイティド | Pde阻害による神経新生の調節 |
CA2625210A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
TWI385169B (zh) | 2005-10-31 | 2013-02-11 | Eisai R&D Man Co Ltd | 經雜環取代之吡啶衍生物及含有彼之抗真菌劑 |
EP2218442A1 (en) | 2005-11-09 | 2010-08-18 | CombinatoRx, Inc. | Methods, compositions, and kits for the treatment of ophthalmic disorders |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
AU2007249435A1 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | 5 HT receptor mediated neurogenesis |
WO2007134136A2 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
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- 2001-12-06 JP JP2002561026A patent/JP2004520386A/ja active Pending
- 2001-12-06 OA OA1200300175A patent/OA12540A/en unknown
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- 2001-12-06 HU HU0400637A patent/HUP0400637A2/hu unknown
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- 2001-12-06 KR KR10-2003-7010074A patent/KR20030074761A/ko not_active Application Discontinuation
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ECSP034709A (es) | 2003-09-24 |
MA26983A1 (fr) | 2004-12-20 |
EA200300621A1 (ru) | 2003-12-25 |
EP1355884A1 (en) | 2003-10-29 |
CN1518542A (zh) | 2004-08-04 |
CZ20031895A3 (cs) | 2004-08-18 |
NZ526453A (en) | 2005-01-28 |
MXPA03006887A (es) | 2003-11-13 |
US6649633B2 (en) | 2003-11-18 |
NO20033397D0 (no) | 2003-07-30 |
US6953810B2 (en) | 2005-10-11 |
ECSP034710A (es) | 2003-09-24 |
NO20033397L (no) | 2003-09-19 |
IS6846A (is) | 2003-06-16 |
BR0116852A (pt) | 2004-02-25 |
CR7025A (es) | 2003-11-25 |
WO2002060875A1 (en) | 2002-08-08 |
KR20030074761A (ko) | 2003-09-19 |
OA12540A (en) | 2006-06-05 |
SK8792003A3 (en) | 2004-09-08 |
PL364135A1 (en) | 2004-12-13 |
ZA200304894B (en) | 2004-06-24 |
US20040048903A1 (en) | 2004-03-11 |
WO2002060875A8 (en) | 2003-07-31 |
CA2436535A1 (en) | 2002-08-08 |
HUP0400637A2 (hu) | 2004-06-28 |
US20020193612A1 (en) | 2002-12-19 |
EE200300360A (et) | 2003-12-15 |
JP2004520386A (ja) | 2004-07-08 |
IL156413A0 (en) | 2004-01-04 |
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