DE60202682D1 - Chinoline derivate und ihre anwendung als antitumor agentien - Google Patents

Chinoline derivate und ihre anwendung als antitumor agentien

Info

Publication number
DE60202682D1
DE60202682D1 DE60202682T DE60202682T DE60202682D1 DE 60202682 D1 DE60202682 D1 DE 60202682D1 DE 60202682 T DE60202682 T DE 60202682T DE 60202682 T DE60202682 T DE 60202682T DE 60202682 D1 DE60202682 D1 DE 60202682D1
Authority
DE
Germany
Prior art keywords
formula
application
antitumor agents
compound
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60202682T
Other languages
English (en)
Other versions
DE60202682T2 (de
Inventor
P Horwitz
T Hazeldine
H Corbett
Lisa Polin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wayne State University
Original Assignee
Wayne State University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wayne State University filed Critical Wayne State University
Publication of DE60202682D1 publication Critical patent/DE60202682D1/de
Application granted granted Critical
Publication of DE60202682T2 publication Critical patent/DE60202682T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
DE60202682T 2001-07-31 2002-07-31 Chinoline derivate und ihre anwendung als antitumor agentien Expired - Lifetime DE60202682T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30914401P 2001-07-31 2001-07-31
US309144P 2001-07-31
PCT/US2002/024442 WO2003011832A1 (en) 2001-07-31 2002-07-31 Quinoline derivatives and use thereof as antitumor agents

Publications (2)

Publication Number Publication Date
DE60202682D1 true DE60202682D1 (de) 2005-02-24
DE60202682T2 DE60202682T2 (de) 2005-12-29

Family

ID=23196886

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60202682T Expired - Lifetime DE60202682T2 (de) 2001-07-31 2002-07-31 Chinoline derivate und ihre anwendung als antitumor agentien

Country Status (22)

Country Link
US (3) US6867219B2 (de)
EP (1) EP1412332B1 (de)
JP (1) JP4310185B2 (de)
KR (1) KR20040055774A (de)
AT (1) ATE287397T1 (de)
AU (1) AU2002355747B2 (de)
CA (1) CA2456173A1 (de)
DE (1) DE60202682T2 (de)
DK (1) DK1412332T3 (de)
EA (1) EA007205B1 (de)
ES (1) ES2236548T3 (de)
GE (1) GEP20063754B (de)
HU (1) HUP0401562A2 (de)
IL (2) IL160082A0 (de)
MX (1) MXPA04000968A (de)
NO (1) NO326463B1 (de)
NZ (1) NZ530806A (de)
PL (1) PL367340A1 (de)
PT (1) PT1412332E (de)
UA (1) UA75691C2 (de)
WO (1) WO2003011832A1 (de)
ZA (1) ZA200401185B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001064642A2 (en) * 2000-02-29 2001-09-07 Cor Therapeutics, Inc. Benzamides and related inhibitors of factor xa
PT1412332E (pt) * 2001-07-31 2005-06-30 Jerome P Horwitz Derivados de quinolina e sua utilizacao como agentes antitumorais
UA79293C2 (en) * 2002-07-03 2007-06-11 Univ Wayne State 4-(7'-halo-2-quino (xa-) linyloxy)phenoxy propionic acid derivatives as antineoplastic agents
KR20050038632A (ko) * 2002-08-24 2005-04-27 젠타리스 게엠베하 양성 및 악성 종양 질환의 치료를 위한 디스오라졸 및 이의유도체를 함유하는 의약
US20070054938A1 (en) * 2005-09-07 2007-03-08 Horwitz Jerome P Antitumor agents
US7470788B2 (en) * 2005-09-07 2008-12-30 Wayne State University Antitumor agents
US8183379B2 (en) * 2005-09-07 2012-05-22 Wayne State University Antitumor agents
EP1897542A1 (de) * 2006-09-07 2008-03-12 Sanofi-Aventis Wässrige Formulierung enthaltend einen antitumoralen Wirkstoff
JO2685B1 (en) * 2006-12-06 2013-03-03 جانسين فارماسوتيكا ان في Quinoline antibacterial derivatives
WO2009002955A1 (en) * 2007-06-27 2008-12-31 Sanofi-Aventis U.S. Llc Process for the preparation of (2r)-2-[4-(7-bromo-2-quinolyloxy)phenoxy]propanoic acid
US8809562B2 (en) 2011-06-06 2014-08-19 Chevron Phillips Chemical Company Lp Use of metallocene compounds for cancer treatment

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6033389B2 (ja) * 1979-02-22 1985-08-02 日産化学工業株式会社 複素環エ−テル系フェノシキ脂肪酸誘導体、その製造法および該誘導体を含有する除草剤
US5364831A (en) 1980-08-06 1994-11-15 Nissan Chemical Industries Ltd. Quinoxaline derivatives and herbicidal composition
US6197728B1 (en) 1980-08-06 2001-03-06 Nissan Chemical Industries Ltd. Quinoxaline derivatives and herbicidal composition
US5250690A (en) * 1985-05-02 1993-10-05 Dowelanco Haloalkoxy anilide derivatives of 2-4(-heterocyclic oxyphenoxy)alkanoic or alkenoic acids and their use as herbicides
PT1412332E (pt) * 2001-07-31 2005-06-30 Jerome P Horwitz Derivados de quinolina e sua utilizacao como agentes antitumorais
UA79293C2 (en) * 2002-07-03 2007-06-11 Univ Wayne State 4-(7'-halo-2-quino (xa-) linyloxy)phenoxy propionic acid derivatives as antineoplastic agents
US7470788B2 (en) * 2005-09-07 2008-12-30 Wayne State University Antitumor agents

Also Published As

Publication number Publication date
AU2002355747B2 (en) 2007-12-20
KR20040055774A (ko) 2004-06-26
US7507749B2 (en) 2009-03-24
NZ530806A (en) 2006-05-26
UA75691C2 (en) 2006-05-15
MXPA04000968A (es) 2005-02-17
EA200400219A1 (ru) 2004-12-30
PL367340A1 (en) 2005-02-21
ES2236548T3 (es) 2005-07-16
US20050159447A1 (en) 2005-07-21
GEP20063754B (en) 2006-02-27
ZA200401185B (en) 2004-10-21
NO326463B1 (no) 2008-12-08
JP4310185B2 (ja) 2009-08-05
ATE287397T1 (de) 2005-02-15
US6867219B2 (en) 2005-03-15
US20030144321A1 (en) 2003-07-31
HUP0401562A2 (hu) 2004-12-28
PT1412332E (pt) 2005-06-30
EP1412332A1 (de) 2004-04-28
NO20040382L (no) 2004-03-26
US7241894B2 (en) 2007-07-10
JP2004538314A (ja) 2004-12-24
DK1412332T3 (da) 2005-05-30
IL160082A (en) 2009-06-15
EP1412332B1 (de) 2005-01-19
DE60202682T2 (de) 2005-12-29
US20070232643A1 (en) 2007-10-04
EA007205B1 (ru) 2006-08-25
WO2003011832A1 (en) 2003-02-13
IL160082A0 (en) 2004-06-20
CA2456173A1 (en) 2003-02-13

Similar Documents

Publication Publication Date Title
DE60206911D1 (de) Imidazol-2-carbonsäureamid derivate als raf-kinase-inhibitoren
DE60010076D1 (de) Chinolinderivate als antibakterielle mittel
DE60140814D1 (de) N-phenyl-2-pyrimidine-amine derivatives
EA200500814A1 (ru) Производные пирролопиримидина
DK2314582T3 (da) Heterocykliske forbindelser som antivirusmidler
EA200700099A1 (ru) Производные пиридина
DE60237145D1 (de) Chinazolinderivate
ATE517882T1 (de) Chinolinderivate
ATE297910T1 (de) Retinoid x rezeptormodulatoren
DK1487829T3 (da) Thiadizolylpiperazinderivater, der er nyttige til behandling eller forebyggelse af smerte
ATE537830T1 (de) Nicotinamid derivate und ihre verwendung als therapeutika
EA200701780A1 (ru) Противоопухолевое средство
BR0108816A (pt) Derivados de quinolina como antagonistas alfa-2
EA200501703A1 (ru) Применение производных азетидинкарбоксамида в терапии
DE60202682D1 (de) Chinoline derivate und ihre anwendung als antitumor agentien
EA200500095A1 (ru) Производные 4-(7-гало-2-хино(кса-)линилокси)феноксипропионовой кислоты в качестве противоопухолевых средств
ATE424200T1 (de) Solubilisierte topoisomerase-gift-mittel
EE05035B1 (et) 1-[fenüül-(8-kinolinüül)metüül]piperasiini derivaadid ning nende kasutamine meditsiinis
ITMI20042475A1 (it) Uso di derivati tiazolidinonici come agenti terapeutici
TNSN08093A1 (en) Quinoline derivatives and use as antitumor agents
EA200600022A1 (ru) Применение производных бицикло [2.2.1] гептана для приготовления нейропротекторных фармацевтических композиций
EE200200660A (et) Akrüloüüldistamütsiini derivaati sisaldav farmatseutiline kompositsioon, derivaadi kasutamine tuumorivastase ravimi valmistamiseks ning kombineeritudravimpreparaat
ATE476420T1 (de) Alkaloidverbindungen und ihre verwendung als antimalariamittel
ATE258934T1 (de) Azaindol derivate und ihre verwendung als antithrombotische wirkstoffe
TW200744596A (en) Antitumor agents

Legal Events

Date Code Title Description
8364 No opposition during term of opposition