BG107031A - Метод за синтез на тетразолово производно - Google Patents

Метод за синтез на тетразолово производно

Info

Publication number
BG107031A
BG107031A BG107031A BG10703102A BG107031A BG 107031 A BG107031 A BG 107031A BG 107031 A BG107031 A BG 107031A BG 10703102 A BG10703102 A BG 10703102A BG 107031 A BG107031 A BG 107031A
Authority
BG
Bulgaria
Prior art keywords
formula
tetrazol
synthesis
imidazol
biphenyl
Prior art date
Application number
BG107031A
Other languages
English (en)
Other versions
BG65699B1 (bg
Inventor
Janos Fischer
Ildiko Ballo
Endrene Patenyi
Janos Kreidl
Laszlo CZBULA
Andras Nemes
Juhasz Ida Deutschne
Papp Eva Werkne
Bagdy Judit Nagyne
Istvan Hegedus
Jenone Farkas
Original Assignee
Richter Gedeon Vegyeszeti Gyar Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar Rt. filed Critical Richter Gedeon Vegyeszeti Gyar Rt.
Publication of BG107031A publication Critical patent/BG107031A/bg
Publication of BG65699B1 publication Critical patent/BG65699B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

Изобретението се отнася до метод за синтез на калиева сол на лозартан с формула@@по-специално калиева сол на 2-n-бутил-4-хлоро-1[(2'- (тетразол-5-ил)- 1,1'-бифенил-4-ил)-метил] имидазол-5-метанол. Повишен е добивът на крайния продукт. По метода се работи с изходно съединение 2-n-бутил-4-хлоро- 1[(2'- (2-трифенилметил-2Н-тетразол-5-ил)- 1,1'-бифенил-4-ил)-метил] -1Н-имидазол-4-метанол с формула@@който реагира в алкохол с формула@@в която R означава С1-С4 алкилова група с права верига, с 0,1-1 еквивалент на калиев хидроксид. Крайният продукт с формула I се изолира след изкристализиране на разтвора, като разтворителят се сменя с апротонен или слабо протонен.
BG107031A 2000-04-21 2002-08-23 Метод за синтез на познато тетразолово производно BG65699B1 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU0001618A HU222773B1 (hu) 2000-04-21 2000-04-21 Eljárás egy ismert tetrazolszármazék előállítására

Publications (2)

Publication Number Publication Date
BG107031A true BG107031A (bg) 2003-08-29
BG65699B1 BG65699B1 (bg) 2009-07-31

Family

ID=89978280

Family Applications (1)

Application Number Title Priority Date Filing Date
BG107031A BG65699B1 (bg) 2000-04-21 2002-08-23 Метод за синтез на познато тетразолово производно

Country Status (17)

Country Link
US (1) US6710183B2 (bg)
EP (1) EP1274702B1 (bg)
JP (1) JP2003531203A (bg)
AT (1) ATE259366T1 (bg)
AU (1) AU2001254998A1 (bg)
BG (1) BG65699B1 (bg)
CZ (1) CZ301029B6 (bg)
DE (1) DE60102008T2 (bg)
EA (1) EA004633B1 (bg)
EE (1) EE05064B1 (bg)
ES (1) ES2215130T3 (bg)
HU (1) HU222773B1 (bg)
PL (1) PL198664B1 (bg)
SK (1) SK286740B6 (bg)
TR (1) TR200401058T4 (bg)
UA (1) UA72803C2 (bg)
WO (1) WO2001081336A1 (bg)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1294712A1 (en) * 2001-05-18 2003-03-26 Aurobindo Pharma Limited Process for the crystallization of losartan potassium
ES2259412T3 (es) * 2002-04-29 2006-10-01 Teva Pharmaceutical Industries Ltd. Procedimientos para la preparacion de losartan y losartan potasico.
AU2003278422A1 (en) * 2002-10-31 2004-05-25 Ranbaxy Laboratories Limited Amorphous form of losartan potassium
WO2004087691A1 (en) * 2003-04-03 2004-10-14 Ipca Laboratories Limited A process for the synthesis of losartan potassium
US6916935B2 (en) * 2003-05-06 2005-07-12 Ipca Laboratories Losartan potassium synthesis
US7345071B2 (en) 2003-05-07 2008-03-18 Ipca Laboratories Limited Process for the synthesis of Losartan potassium
EP1709034A2 (en) * 2004-01-06 2006-10-11 IPCA Laboratories Limited An improved process for the synthesis of losartan potassium
WO2006050922A1 (en) 2004-11-11 2006-05-18 Lek Pharmaceuticals D.D. Process for the synthesis of tetrazoles
ITTO20060560A1 (it) * 2006-07-27 2008-01-28 S I M S S R L Composti intermedi per la preparazione di antagonisti dell¿angiotensina ii
NZ574905A (en) * 2006-08-22 2011-12-22 Ranbaxy Lab Ltd Matrix metalloproteinase inhibitors
WO2018002673A1 (en) 2016-07-01 2018-01-04 N4 Pharma Uk Limited Novel formulations of angiotensin ii receptor antagonists
US11327065B1 (en) * 2021-08-27 2022-05-10 Jubilant Generics Limited Preparation of angiotensin receptor blockers or pharmaceutically acceptable salts thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1338238C (en) * 1988-01-07 1996-04-09 David John Carini Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids
DE4224133A1 (de) * 1992-07-22 1994-01-27 Thomae Gmbh Dr K Benzimidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DE4221583A1 (de) * 1991-11-12 1993-05-13 Bayer Ag Substituierte biphenylpyridone
DE69233734D1 (de) * 1991-11-18 2008-06-26 Du Pont 2-(2'-Triphenylmethyl-2'H-tetrazol-5'-yl)phenylborsäure als Zwischenprodukt zur Synthese von A II Receptorenantagonisten
US5206374A (en) * 1991-11-18 1993-04-27 E. I. Du Pont De Nemours And Company Process for preparing tetrazolylphenylboronic acid intermediates
EP0736021A4 (en) * 1993-12-23 1997-04-02 Merck & Co Inc LOSARTANE POLYMORPHS AND PROCESS FOR THE PREPARATION OF FORM II OF LOSARTANE
AU696868B2 (en) * 1994-03-29 1998-09-17 Merck & Co., Inc. Treatment of atherosclerosis with angiotensin II receptor blocking imidazoles
ES2105939B1 (es) * 1994-08-02 1998-07-01 Uriach & Cia Sa J Nuevos pirazoles con actividad antagonista de la angiotensina ii.

Also Published As

Publication number Publication date
EP1274702A1 (en) 2003-01-15
DE60102008D1 (de) 2004-03-18
SK286740B6 (sk) 2009-04-06
EP1274702B1 (en) 2004-02-11
PL356929A1 (en) 2004-07-12
PL198664B1 (pl) 2008-07-31
ES2215130T3 (es) 2004-10-01
US20030078435A1 (en) 2003-04-24
HU222773B1 (hu) 2003-10-28
WO2001081336A8 (en) 2002-08-29
UA72803C2 (en) 2005-04-15
CZ301029B6 (cs) 2009-10-14
HU0001618D0 (en) 2000-06-28
BG65699B1 (bg) 2009-07-31
US6710183B2 (en) 2004-03-23
WO2001081336A1 (en) 2001-11-01
SK12892002A3 (sk) 2002-12-03
TR200401058T4 (tr) 2004-06-21
ATE259366T1 (de) 2004-02-15
EA200201122A1 (ru) 2003-04-24
JP2003531203A (ja) 2003-10-21
EE05064B1 (et) 2008-08-15
DE60102008T2 (de) 2004-12-09
EA004633B1 (ru) 2004-06-24
EE200200460A (et) 2003-12-15
AU2001254998A1 (en) 2001-11-07
HUP0001618A2 (hu) 2002-11-28

Similar Documents

Publication Publication Date Title
BG107031A (bg) Метод за синтез на тетразолово производно
US9902751B2 (en) Process for the preparation of empagliflozin
WO2007032019A3 (en) Process for preparing valsartan
WO2007126812A3 (en) Process for preparation of hiv protease inhibitors
MA31080B1 (fr) Dérivés cyclisés en tant qu'inhibiteurs d'eg-5.
WO2009047313A3 (en) Method of producing 2' -deoxy-5-azacytidine (decitabine)
US5410043A (en) Process for the production of mono-N-substituted tetraaza macrocycles
JP5289331B2 (ja) ４−アミノ−ピリミジンの合成
NZ544004A (en) Novel method for the synthesis of perindopril and the pharmaceutically acceptable salts thereof
WO2008107799A3 (en) Improved process for preparing irbesartan
WO2007057919A3 (en) An improved process for preparation of (s)-n-(1-carboxy-2-methyl-prop-1-yl)-n-pentanoyl-n-[2'-(1h-tetrazol-5-yl)biphenyl-4-ylmethyl]-amine
EP3110791B1 (fr) Procede de preparation de derives d'acide 2,4-diamino-3-hydroxybutyrique
NO20053712L (no) Fremgangsmate for fremstilling av substituerte imidazolderivater og mellomprodukter anvendt i fremgangsmaten
US20100184991A1 (en) Preparation of terazole derivatives
KR20050006286A (ko) (Ｓ)-테트라하이드로-α-(1-메틸에틸)-2-옥소-1(2Ｈ)-피리미딘아세트산의 제조방법
KR101012135B1 (ko) 발사르탄 메틸 에스테르의 제조방법
AU712138B2 (en) Process for the preparation of 5-(alkoxymethyl)-2,3-pyridinedicarboximide compounds
EP1652833A4 (en) PROCESS FOR PRODUCING 4-HYDROXYDIPHENYL ETHER
CA2375625A1 (en) Process for production of substituted 1-(2-benzothiazolyl) alkylamine derivative
TW200503701A (en) Novel intermediate for the preparation of therapeutically active imidazopyridines
KR20070087764A (ko) 로사탄의 제조방법
JPH04273872A (ja) 新規ジケテンイミン誘導体およびその製造方法
WO2005046854A3 (en) A process for the preparation of diphenylmethylsulfinyl derivatives
SK54293A3 (en) Method of preparation of 1,2,2,6,6-pentamethyl-4-piperidinole
JO3022B1 (ar) طريقة لانتاج 2'-دياوكسي-5-ازاسيتيدين (ديسيتابين)