ES2105939B1 - Nuevos pirazoles con actividad antagonista de la angiotensina ii. - Google Patents

Nuevos pirazoles con actividad antagonista de la angiotensina ii.

Info

Publication number
ES2105939B1
ES2105939B1 ES09401711A ES9401711A ES2105939B1 ES 2105939 B1 ES2105939 B1 ES 2105939B1 ES 09401711 A ES09401711 A ES 09401711A ES 9401711 A ES9401711 A ES 9401711A ES 2105939 B1 ES2105939 B1 ES 2105939B1
Authority
ES
Spain
Prior art keywords
alkyl
angiotensin
aryl
pirazoles
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES09401711A
Other languages
English (en)
Other versions
ES2105939A1 (es
Inventor
Carmen Almansa
Concepcion Gonzalez
M Carmen Torres
Elena Carceller
Javier Bartroli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Noucor Health SA
Original Assignee
J Uriach y Cia SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ES09401711A priority Critical patent/ES2105939B1/es
Application filed by J Uriach y Cia SA filed Critical J Uriach y Cia SA
Priority to EP95929067A priority patent/EP0721454A1/en
Priority to PCT/EP1995/003086 priority patent/WO1996004273A1/en
Priority to CA002173258A priority patent/CA2173258A1/en
Priority to JP8506213A priority patent/JPH09504804A/ja
Priority to AU32563/95A priority patent/AU3256395A/en
Priority to US08/624,459 priority patent/US5827863A/en
Priority to NO961333A priority patent/NO961333D0/no
Publication of ES2105939A1 publication Critical patent/ES2105939A1/es
Application granted granted Critical
Publication of ES2105939B1 publication Critical patent/ES2105939B1/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Chemical Or Physical Treatment Of Fibers (AREA)

Abstract

COMPUESTOS DE FORMULA I Y SUS SALES Y SOLVATOS, EN DONDE R1 SIGNIFICA HIDROGENO, C1-6 ALQUILO, C1-6 HALOALQUILO, ARILO, -(CH2)MR5, O -(CH2)MCOR6; R2 REPRESENTA C1-6 HIDROXIALQUILO, C3-7 CICLOALQUILO, C3-7 CICLOALQUIL, C1-4 ALQUILO O ARILO; R3 REPRESENTA -(CH2)NR7 O -(CH2)NCOR7_; R4 REPRESENTA ENTRE OTROS -CO2H O -TETRAZOL-5-IL; R5 REPRESENTA HIDROXI, C1-6 ALQUILO, C1-6 ALCOXI, ARILO, ARILOXI O UN GRUPO NR10R11; R7 REPRESENTA HIDROGENO, HIDROXI, C1-6 ALCOXI, ARILOXI O ARILC1-4 ALCOXI; R10 Y R11 REPRESENTAN INDEPENDIENTEMENTE HIDROGENO O C1-6 ALQUILO; M REPRESENTA 1, 2, 3, O 4; N REPRESENTA 1, 2 O 3; Y P REPRESENTA 0, 1 O 2. DICHOS COMPUESTOS SON UTILES COMO ANTAGONISTAS DE LA ANGIOTENSINA II. LA PRESENTE INVENCION DESCRIBE TAMBIEN PROCEDIMIENTOS PARA SU OBTENCION Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN.
ES09401711A 1994-08-02 1994-08-02 Nuevos pirazoles con actividad antagonista de la angiotensina ii. Expired - Lifetime ES2105939B1 (es)

Priority Applications (8)

Application Number Priority Date Filing Date Title
ES09401711A ES2105939B1 (es) 1994-08-02 1994-08-02 Nuevos pirazoles con actividad antagonista de la angiotensina ii.
PCT/EP1995/003086 WO1996004273A1 (en) 1994-08-02 1995-08-02 New pyrazole derivatives as angiotensin ii antagonist
CA002173258A CA2173258A1 (en) 1994-08-02 1995-08-02 New pyrazole derivatives as angiotensin ii antagonist
JP8506213A JPH09504804A (ja) 1994-08-02 1995-08-02 アンジオテンシンｉｉ拮抗薬としての新規なピラゾール誘導体
EP95929067A EP0721454A1 (en) 1994-08-02 1995-08-02 New pyrazole derivatives as angiotensin ii antagonist
AU32563/95A AU3256395A (en) 1994-08-02 1995-08-02 New pyrazole derivatives as angiotensin ii antagonist
US08/624,459 US5827863A (en) 1994-08-02 1995-08-02 Pyrazole derivatives as angiotensin II antagonists
NO961333A NO961333D0 (no) 1994-08-02 1996-04-01 Nye pyrazolderivater som angiotensin-II-antagonister

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09401711A ES2105939B1 (es) 1994-08-02 1994-08-02 Nuevos pirazoles con actividad antagonista de la angiotensina ii.

Publications (2)

Publication Number Publication Date
ES2105939A1 ES2105939A1 (es) 1997-10-16
ES2105939B1 true ES2105939B1 (es) 1998-07-01

Family

ID=8287143

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09401711A Expired - Lifetime ES2105939B1 (es) 1994-08-02 1994-08-02 Nuevos pirazoles con actividad antagonista de la angiotensina ii.

Country Status (8)

Country Link
US (1) US5827863A (es)
EP (1) EP0721454A1 (es)
JP (1) JPH09504804A (es)
AU (1) AU3256395A (es)
CA (1) CA2173258A1 (es)
ES (1) ES2105939B1 (es)
NO (1) NO961333D0 (es)
WO (1) WO1996004273A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4432860A1 (de) * 1994-09-15 1996-03-21 Merck Patent Gmbh Imidazopyridine
DE19645313A1 (de) 1996-11-04 1998-05-07 Basf Ag Substituierte 3-Benzylpyrazole
SE9903028D0 (sv) * 1999-08-27 1999-08-27 Astra Ab New use
SK2692002A3 (en) * 1999-08-30 2002-07-02 Aventis Pharma Gmbh Use of inhibitors of the renin-angiotensin system in the prevention of cardiovascular events
HU222773B1 (hu) * 2000-04-21 2003-10-28 Richter Gedeon Vegyészeti Gyár Rt. Eljárás egy ismert tetrazolszármazék előállítására
DE10105916A1 (de) * 2001-02-09 2002-08-22 Siemens Ag Amorphe organische 1,3,2-Dioxaborinluminophore, Verfahren zu deren Herstellung und Verwendung davon
US7107198B2 (en) * 2001-11-02 2006-09-12 Sun Microsystems, Inc. Automatic generation of reduced-size circuit models including inductive interaction
EP2128138A1 (en) 2007-01-29 2009-12-02 Takeda Pharmaceutical Company Limited Pyrazole compound
WO2011005674A1 (en) * 2009-07-07 2011-01-13 Theravance, Inc. Dual-acting pyrazole antihypertensive agents
CN103772282B (zh) * 2014-02-26 2015-09-23 上海毕得医药科技有限公司 一种3-叔丁基-1h-吡唑-4-甲醛的制备方法
WO2016035328A1 (ja) 2014-09-01 2016-03-10 キヤノン株式会社 化合物、分散剤及びトナー
PY2485940A (es) * 2023-10-06 2025-10-30 Sumitomo Chemical Company Ltd Compuestos de biarilo y método para controlar enfermedades vegetales

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5189048A (en) * 1988-01-07 1993-02-23 E. I. Du Pont De Nemours And Company Substituted 1,2,3 triazole angiotensin II antagonists
GB9005354D0 (en) * 1990-03-09 1990-05-02 Glaxo Group Ltd Chemical compounds
WO1993005025A1 (en) * 1991-09-06 1993-03-18 Glaxo Group Limited C-linked pyrazole derivatives
AT398202B (de) * 1991-10-04 1994-10-25 Chem Pharm Forsch Gmbh Neue imidazolderivate, verfahren zu ihrer herstellung und ihre verwendung

Also Published As

Publication number Publication date
EP0721454A1 (en) 1996-07-17
NO961333L (no) 1996-04-01
ES2105939A1 (es) 1997-10-16
NO961333D0 (no) 1996-04-01
CA2173258A1 (en) 1996-02-15
JPH09504804A (ja) 1997-05-13
AU3256395A (en) 1996-03-04
WO1996004273A1 (en) 1996-02-15
US5827863A (en) 1998-10-27

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