HUP0001618A2 - Eljárás egy ismert tetrazolszármazék előállítására - Google Patents

Eljárás egy ismert tetrazolszármazék előállítására

Info

Publication number
HUP0001618A2
HUP0001618A2 HU0001618A HUP0001618A HUP0001618A2 HU P0001618 A2 HUP0001618 A2 HU P0001618A2 HU 0001618 A HU0001618 A HU 0001618A HU P0001618 A HUP0001618 A HU P0001618A HU P0001618 A2 HUP0001618 A2 HU P0001618A2
Authority
HU
Hungary
Prior art keywords
formula
potassium
tetrazol
biphenyl
producing
Prior art date
Application number
HU0001618A
Other languages
English (en)
Inventor
János Fischer
Ildikó Balló
Endréné Petényi
János Kreidl
László Czibula
Juhász Ida Deutschné
András Nemes
István Hegedűs
Jenőné Farkas
Bagdy Judit Nagyné
Papp Éva Werkné
Original Assignee
Richter Gedeon Vegyészeti Gyár Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyészeti Gyár Rt. filed Critical Richter Gedeon Vegyészeti Gyár Rt.
Priority to HU0001618A priority Critical patent/HU222773B1/hu
Publication of HU0001618D0 publication Critical patent/HU0001618D0/hu
Priority to UA2002119212A priority patent/UA72803C2/uk
Priority to PL356929A priority patent/PL198664B1/pl
Priority to TR2004/01058T priority patent/TR200401058T4/xx
Priority to AT01928134T priority patent/ATE259366T1/de
Priority to AU2001254998A priority patent/AU2001254998A1/en
Priority to EP01928134A priority patent/EP1274702B1/en
Priority to JP2001578426A priority patent/JP2003531203A/ja
Priority to EEP200200460A priority patent/EE05064B1/xx
Priority to ES01928134T priority patent/ES2215130T3/es
Priority to DE60102008T priority patent/DE60102008T2/de
Priority to EA200201122A priority patent/EA004633B1/ru
Priority to PCT/HU2001/000047 priority patent/WO2001081336A1/en
Priority to US10/182,109 priority patent/US6710183B2/en
Priority to CZ20023000A priority patent/CZ301029B6/cs
Priority to SK1289-2002A priority patent/SK286740B6/sk
Priority to BG107031A priority patent/BG65699B1/bg
Publication of HUP0001618A2 publication Critical patent/HUP0001618A2/hu
Publication of HU222773B1 publication Critical patent/HU222773B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

A találmány tárgya eljárás az (I) képletű losartan-kálium, kémiainevén: 2-n-butil-4-klór-1[(2'-(tetrazol-5-il)-1,1'-bifenil-4-il)-metil] -imidazol-5-metanol-kálium előállítására a (III) képletű 2-n-butil-4-klór-1[(2'-(2-trifenilmetil-2H-tetrazol-5-il)-1,1'-bifenil-4-il)metil]1H imidazol-4-metanolból kiindulva. Az eljárás szerint a(III) képletű vegyületet (VI) általános képletű alkoholban, - ahol Rjelentése 1-4 szénatom számú, egyenes láncú alkilcsoport - 0,1-1ekvivalens kálium-hidroxid jelenlétében, reagáltatják és az (I)végterméket aprotikus vagy gyengén protikus oldószercserévelkikristályosítják, majd izolálják. Ó
HU0001618A 2000-04-21 2000-04-21 Eljárás egy ismert tetrazolszármazék előállítására HU222773B1 (hu)

Priority Applications (17)

Application Number Priority Date Filing Date Title
HU0001618A HU222773B1 (hu) 2000-04-21 2000-04-21 Eljárás egy ismert tetrazolszármazék előállítására
SK1289-2002A SK286740B6 (sk) 2000-04-21 2001-04-20 Spôsob syntézy draselnej soli losartanu
EEP200200460A EE05064B1 (et) 2000-04-21 2001-04-20 Meetod tuntud tetrasooli derivaadi snteesiks
DE60102008T DE60102008T2 (de) 2000-04-21 2001-04-20 Herstellungsverfahren für ein bekanntes terazolderivat
TR2004/01058T TR200401058T4 (tr) 2000-04-21 2001-04-20 Bilinen bir tetrazol türevinin sentezi için proses
AT01928134T ATE259366T1 (de) 2000-04-21 2001-04-20 Herstellungsverfahren für ein bekanntes terazolderivat
AU2001254998A AU2001254998A1 (en) 2000-04-21 2001-04-20 Process for the synthesis of a known tetrazol derivative
EP01928134A EP1274702B1 (en) 2000-04-21 2001-04-20 Process for the synthesis of a known tetrazol derivative
JP2001578426A JP2003531203A (ja) 2000-04-21 2001-04-20 公知のテトラゾ−ル誘導体の合成方法
UA2002119212A UA72803C2 (en) 2000-04-21 2001-04-20 A method for the preparation of losartan potassium
ES01928134T ES2215130T3 (es) 2000-04-21 2001-04-20 Proceso para la sintesis de un derivado conocido de tetrazol.
PL356929A PL198664B1 (pl) 2000-04-21 2001-04-20 Sposób wytwarzania lozartanu potasu
EA200201122A EA004633B1 (ru) 2000-04-21 2001-04-20 Способ получения производного тетразола
PCT/HU2001/000047 WO2001081336A1 (en) 2000-04-21 2001-04-20 Process for the synthesis of a known tetrazol derivative
US10/182,109 US6710183B2 (en) 2000-04-21 2001-04-20 Process for the synthesis of a known tetrazol derivative
CZ20023000A CZ301029B6 (cs) 2000-04-21 2001-04-20 Zpusob syntézy známého derivátu tetrazolu
BG107031A BG65699B1 (bg) 2000-04-21 2002-08-23 Метод за синтез на познато тетразолово производно

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU0001618A HU222773B1 (hu) 2000-04-21 2000-04-21 Eljárás egy ismert tetrazolszármazék előállítására

Publications (3)

Publication Number Publication Date
HU0001618D0 HU0001618D0 (en) 2000-06-28
HUP0001618A2 true HUP0001618A2 (hu) 2002-11-28
HU222773B1 HU222773B1 (hu) 2003-10-28

Family

ID=89978280

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0001618A HU222773B1 (hu) 2000-04-21 2000-04-21 Eljárás egy ismert tetrazolszármazék előállítására

Country Status (17)

Country Link
US (1) US6710183B2 (hu)
EP (1) EP1274702B1 (hu)
JP (1) JP2003531203A (hu)
AT (1) ATE259366T1 (hu)
AU (1) AU2001254998A1 (hu)
BG (1) BG65699B1 (hu)
CZ (1) CZ301029B6 (hu)
DE (1) DE60102008T2 (hu)
EA (1) EA004633B1 (hu)
EE (1) EE05064B1 (hu)
ES (1) ES2215130T3 (hu)
HU (1) HU222773B1 (hu)
PL (1) PL198664B1 (hu)
SK (1) SK286740B6 (hu)
TR (1) TR200401058T4 (hu)
UA (1) UA72803C2 (hu)
WO (1) WO2001081336A1 (hu)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI21236A (sl) * 2001-05-18 2003-12-31 Aurobindo Pharma Limited Postopek kristalizacije losartan kalija
DE60304175T2 (de) * 2002-04-29 2007-03-15 Teva Pharmaceutical Industries Ltd. Verfahren zur herstellung von losartan und losartan-kaliumsalz
US20060241305A1 (en) * 2002-10-31 2006-10-26 Yatendra Kumar Amorphous form of losartan potassium
AU2003269470A1 (en) * 2003-04-03 2004-10-25 Ipca Laboratories Limited A process for the synthesis of losartan potassium
US6916935B2 (en) * 2003-05-06 2005-07-12 Ipca Laboratories Losartan potassium synthesis
US7345071B2 (en) 2003-05-07 2008-03-18 Ipca Laboratories Limited Process for the synthesis of Losartan potassium
WO2005066158A2 (en) * 2004-01-06 2005-07-21 Ipca Laboratories Limited An improved process for the synthesis of losartan potassium
EP1812423A1 (en) 2004-11-11 2007-08-01 LEK Pharmaceuticals D.D. Process for the synthesis of tetrazoles
ITTO20060560A1 (it) * 2006-07-27 2008-01-28 S I M S S R L Composti intermedi per la preparazione di antagonisti dell¿angiotensina ii
MY155277A (en) * 2006-08-22 2015-09-30 Ranbaxy Lab Ltd Matrix metalloproteinase inhibitors
WO2018002673A1 (en) 2016-07-01 2018-01-04 N4 Pharma Uk Limited Novel formulations of angiotensin ii receptor antagonists
US11327065B1 (en) * 2021-08-27 2022-05-10 Jubilant Generics Limited Preparation of angiotensin receptor blockers or pharmaceutically acceptable salts thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1338238C (en) * 1988-01-07 1996-04-09 David John Carini Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids
DE4224133A1 (de) * 1992-07-22 1994-01-27 Thomae Gmbh Dr K Benzimidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DE4221583A1 (de) * 1991-11-12 1993-05-13 Bayer Ag Substituierte biphenylpyridone
US5206374A (en) * 1991-11-18 1993-04-27 E. I. Du Pont De Nemours And Company Process for preparing tetrazolylphenylboronic acid intermediates
DE69233208T2 (de) 1991-11-18 2004-07-08 E.I. Du Pont De Nemours And Co., Wilmington Tetrazolylphenylborsäureintermediate zur synthese von aii rezeptor antagonisten
EP0736021A4 (en) * 1993-12-23 1997-04-02 Merck & Co Inc LOSARTANE POLYMORPHS AND PROCESS FOR THE PREPARATION OF FORM II OF LOSARTANE
JP3883205B2 (ja) * 1994-03-29 2007-02-21 メルク エンド カンパニー インコーポレーテッド アンギオテンシン▲ｉｉ▼レセプタ遮断イミダゾールによるアテローム性動脈硬化症の治療
ES2105939B1 (es) * 1994-08-02 1998-07-01 Uriach & Cia Sa J Nuevos pirazoles con actividad antagonista de la angiotensina ii.

Also Published As

Publication number Publication date
DE60102008T2 (de) 2004-12-09
BG65699B1 (bg) 2009-07-31
CZ301029B6 (cs) 2009-10-14
PL356929A1 (en) 2004-07-12
ES2215130T3 (es) 2004-10-01
UA72803C2 (en) 2005-04-15
WO2001081336A1 (en) 2001-11-01
SK286740B6 (sk) 2009-04-06
SK12892002A3 (sk) 2002-12-03
US20030078435A1 (en) 2003-04-24
EE05064B1 (et) 2008-08-15
WO2001081336A8 (en) 2002-08-29
DE60102008D1 (de) 2004-03-18
BG107031A (en) 2003-08-29
US6710183B2 (en) 2004-03-23
EA004633B1 (ru) 2004-06-24
EE200200460A (et) 2003-12-15
HU0001618D0 (en) 2000-06-28
AU2001254998A1 (en) 2001-11-07
ATE259366T1 (de) 2004-02-15
EP1274702A1 (en) 2003-01-15
PL198664B1 (pl) 2008-07-31
EP1274702B1 (en) 2004-02-11
TR200401058T4 (tr) 2004-06-21
HU222773B1 (hu) 2003-10-28
EA200201122A1 (ru) 2003-04-24
JP2003531203A (ja) 2003-10-21

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Legal Events

Date Code Title Description
HFG4 Patent granted, date of granting

Effective date: 20030902

HC9A Change of name, address

Owner name: RICHTER GEDEON NYRT., HU

Free format text: FORMER OWNER(S): RICHTER GEDEON VEGYESZETI GYAR RT., HU