ATE475653T1 - Verfahren zur herstellung von valsartan - Google Patents
Verfahren zur herstellung von valsartanInfo
- Publication number
- ATE475653T1 ATE475653T1 AT05815283T AT05815283T ATE475653T1 AT E475653 T1 ATE475653 T1 AT E475653T1 AT 05815283 T AT05815283 T AT 05815283T AT 05815283 T AT05815283 T AT 05815283T AT E475653 T1 ATE475653 T1 AT E475653T1
- Authority
- AT
- Austria
- Prior art keywords
- formula
- compound
- valsartan
- salt
- pharmaceutically acceptable
- Prior art date
Links
- 239000004072 C09CA03 - Valsartan Substances 0.000 title abstract 3
- SJSNUMAYCRRIOM-QFIPXVFZSA-N valsartan Chemical compound C1=CC(CN(C(=O)CCCC)[C@@H](C(C)C)C(O)=O)=CC=C1C1=CC=CC=C1C1=NN=N[N]1 SJSNUMAYCRRIOM-QFIPXVFZSA-N 0.000 title abstract 3
- 229960004699 valsartan Drugs 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 abstract 4
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract 2
- VFWCMGCRMGJXDK-UHFFFAOYSA-N 1-chlorobutane Chemical compound CCCCCl VFWCMGCRMGJXDK-UHFFFAOYSA-N 0.000 abstract 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 abstract 1
- BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 abstract 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- JMMWKPVZQRWMSS-UHFFFAOYSA-N isopropanol acetate Natural products CC(C)OC(C)=O JMMWKPVZQRWMSS-UHFFFAOYSA-N 0.000 abstract 1
- 229940011051 isopropyl acetate Drugs 0.000 abstract 1
- GWYFCOCPABKNJV-UHFFFAOYSA-N isovaleric acid Chemical compound CC(C)CC(O)=O GWYFCOCPABKNJV-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 239000004474 valine Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04028356A EP1661891A1 (de) | 2004-11-30 | 2004-11-30 | Verfahren zur Herstellung von Valsartan |
| PCT/EP2005/012736 WO2006058701A1 (en) | 2004-11-30 | 2005-11-29 | A process for the synthesis of valsartan |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE475653T1 true ATE475653T1 (de) | 2010-08-15 |
Family
ID=34927585
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05815283T ATE475653T1 (de) | 2004-11-30 | 2005-11-29 | Verfahren zur herstellung von valsartan |
Country Status (5)
| Country | Link |
|---|---|
| EP (2) | EP1661891A1 (de) |
| AT (1) | ATE475653T1 (de) |
| DE (1) | DE602005022619D1 (de) |
| SI (1) | SI1831186T1 (de) |
| WO (1) | WO2006058701A1 (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008035364A2 (en) * | 2006-06-23 | 2008-03-27 | Usv Limited | Process for the preparation of micronized valsartan |
| EP2057132A2 (de) * | 2006-07-03 | 2009-05-13 | Aurobindo Pharma Limited | Verfahren zur herstellung des angiotensin-ii-antagonisten valsartan |
| WO2008007391A2 (en) * | 2006-07-10 | 2008-01-17 | Manne Satyanarayana Reddy | An improved process for the preparation of valsartan |
| CN100522953C (zh) * | 2007-04-03 | 2009-08-05 | 浙江天宇药业有限公司 | 一种缬沙坦的新合成方法 |
| JP2010526126A (ja) * | 2007-05-07 | 2010-07-29 | シプラ・リミテッド | バルサルタンの製造方法 |
| KR20100021433A (ko) * | 2007-05-07 | 2010-02-24 | 시플라 리미티드 | 발사르탄의 제조방법 |
| CN101481374B (zh) * | 2008-01-09 | 2013-01-09 | 浙江华海药业股份有限公司 | 1-三苯甲基-5-(1，1｀-联苯基-2基)-1h-四唑类化合物脱去三苯甲基的方法 |
| EP2260018A2 (de) | 2008-04-07 | 2010-12-15 | Hetero Research Foundation | Verfahren zur herstellung eines valsartan-zwischenprodukts |
| JP2010077077A (ja) * | 2008-09-26 | 2010-04-08 | Tokuyama Corp | Ｎ−ペンタノイル−ｎ−［２’−（１ｈ−テトラゾール−５−イル）ビフェニル−４−イルメチル］−ｌ−バリンの製造方法 |
| WO2012002189A1 (ja) * | 2010-06-30 | 2012-01-05 | 株式会社トクヤマ | バルサルタンの製造方法 |
| WO2013072924A1 (en) * | 2011-09-27 | 2013-05-23 | Alkem Laboratories Ltd. | An improved process for the preparation of angiotensin ii antagonists and intermediates thereof. |
| CN102617498B (zh) * | 2012-03-16 | 2013-06-12 | 张家港市华昌药业有限公司 | 一种缬沙坦的制备方法 |
| CN112603894A (zh) * | 2020-12-31 | 2021-04-06 | 浙江华海药业股份有限公司 | 一种缬沙坦颗粒的制备方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1600297A (en) * | 1996-02-15 | 1997-09-02 | Novartis Ag | Aryl derivatives |
| WO2003089417A1 (en) * | 2002-04-15 | 2003-10-30 | Dr. Reddy's Laboratories Limited | Novel crystalline forms of (s)-n-(1-carboxy-2-methyl-prop-1-yl) -n-pentanoyl-n- [2’-(1h-tetrazol-5-yl-)- biphenyl-4-yl methyl] amine (valsartan) |
| GB0222056D0 (en) * | 2002-09-23 | 2002-10-30 | Novartis Ag | Process for the manufacture of organic compounds |
| ATE393764T1 (de) * | 2003-03-17 | 2008-05-15 | Teva Pharma | Polymorphe formen von valsartan |
| TW200505879A (en) * | 2003-04-21 | 2005-02-16 | Teva Pharma | Process for the preparation of valsartan |
| WO2004094391A2 (en) * | 2003-04-21 | 2004-11-04 | Teva Pharmaceutical Industries Ltd. | Process for the preparation of valsartan and intermediates thereof |
| CZ298685B6 (cs) * | 2003-05-15 | 2007-12-19 | Zentiva, A.S. | Zpusob výroby N-(1-oxopentyl)-N-[[2´-(1H-tetrazol-5-yl)[1,1´-bifenyl]-4-yl]methyl]-L-valinu (valsartanu) |
| GB0316546D0 (en) * | 2003-07-15 | 2003-08-20 | Novartis Ag | Process for the manufacture of organic compounds |
| ES2348300T3 (es) * | 2003-08-27 | 2010-12-02 | Zentiva, K.S. | Procedimiento para eliminar el grupo protector trifenilmetano. |
-
2004
- 2004-11-30 EP EP04028356A patent/EP1661891A1/de not_active Withdrawn
-
2005
- 2005-11-29 DE DE602005022619T patent/DE602005022619D1/de not_active Expired - Lifetime
- 2005-11-29 AT AT05815283T patent/ATE475653T1/de not_active IP Right Cessation
- 2005-11-29 EP EP05815283A patent/EP1831186B1/de not_active Expired - Lifetime
- 2005-11-29 WO PCT/EP2005/012736 patent/WO2006058701A1/en not_active Ceased
- 2005-11-29 SI SI200531096T patent/SI1831186T1/sl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1831186A1 (de) | 2007-09-12 |
| WO2006058701A1 (en) | 2006-06-08 |
| EP1661891A1 (de) | 2006-05-31 |
| EP1831186B1 (de) | 2010-07-28 |
| SI1831186T1 (sl) | 2010-10-29 |
| DE602005022619D1 (de) | 2010-09-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |