EA200201122A1 - Способ получения производного тетразола - Google Patents
Способ получения производного тетразолаInfo
- Publication number
- EA200201122A1 EA200201122A1 EA200201122A EA200201122A EA200201122A1 EA 200201122 A1 EA200201122 A1 EA 200201122A1 EA 200201122 A EA200201122 A EA 200201122A EA 200201122 A EA200201122 A EA 200201122A EA 200201122 A1 EA200201122 A1 EA 200201122A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- formula
- tetrazol
- potassium
- imidazol
- biphenyl
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- CWRVKFFCRWGWCS-UHFFFAOYSA-N Pentrazole Chemical compound C1CCCCC2=NN=NN21 CWRVKFFCRWGWCS-UHFFFAOYSA-N 0.000 title 1
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 abstract 3
- FDKIDFYIEWFERB-UHFFFAOYSA-N [2-butyl-5-chloro-3-[[4-[2-(2h-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol;potassium Chemical compound [K].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C=2NN=NN=2)C=C1 FDKIDFYIEWFERB-UHFFFAOYSA-N 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- QQPGGBNMTNDKEY-UHFFFAOYSA-N [2-butyl-5-chloro-3-[[4-[2-(2-trityltetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=NN(N=N2)C(C=2C=CC=CC=2)(C=2C=CC=CC=2)C=2C=CC=CC=2)C=C1 QQPGGBNMTNDKEY-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- 239000012467 final product Substances 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Cephalosporin Compounds (AREA)
Abstract
Изобретение относится к способу синтеза лозартана калия формулы (I), имеющего химическое название 2-н-бутил-4-хлор-1-[(2'-(тетразол-5-ил)-1,1'-бифенил-4-ил)метил]имидазол-5-метанол калия, с использованием в качестве исходного соединения 2-н-бутил-4-хлор-1-[(2'-(2-трифенилметил-2Н-тетразол-5-ил)-1,1'-бифенил-4-ил)метил]-1Н-имидазол-5-метанол формулы (III). Согласно заявленному способу, соединение формулы (III) реагирует со спиртом формулы (VI), где R представляет собой C-Cлинейную алкильную группу, в присутствии 0,1-1 эквивалента гидроксида калия. Конечный продукт формулы (I) выделяют после кристаллизации при замене используемого растворителя на апротонный или слабопротонный растворитель.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU0001618A HU222773B1 (hu) | 2000-04-21 | 2000-04-21 | Eljárás egy ismert tetrazolszármazék előállítására |
PCT/HU2001/000047 WO2001081336A1 (en) | 2000-04-21 | 2001-04-20 | Process for the synthesis of a known tetrazol derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200201122A1 true EA200201122A1 (ru) | 2003-04-24 |
EA004633B1 EA004633B1 (ru) | 2004-06-24 |
Family
ID=89978280
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200201122A EA004633B1 (ru) | 2000-04-21 | 2001-04-20 | Способ получения производного тетразола |
Country Status (17)
Country | Link |
---|---|
US (1) | US6710183B2 (ru) |
EP (1) | EP1274702B1 (ru) |
JP (1) | JP2003531203A (ru) |
AT (1) | ATE259366T1 (ru) |
AU (1) | AU2001254998A1 (ru) |
BG (1) | BG65699B1 (ru) |
CZ (1) | CZ301029B6 (ru) |
DE (1) | DE60102008T2 (ru) |
EA (1) | EA004633B1 (ru) |
EE (1) | EE05064B1 (ru) |
ES (1) | ES2215130T3 (ru) |
HU (1) | HU222773B1 (ru) |
PL (1) | PL198664B1 (ru) |
SK (1) | SK286740B6 (ru) |
TR (1) | TR200401058T4 (ru) |
UA (1) | UA72803C2 (ru) |
WO (1) | WO2001081336A1 (ru) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2004520446A (ja) * | 2001-05-18 | 2004-07-08 | オーロビンド ファーマ リミテッド | ロサルタンカリウムの結晶化方法 |
CA2482857A1 (en) * | 2002-04-29 | 2003-11-13 | Teva Pharmaceutical Industries Ltd. | Processes for preparing losartan and losartan potassium |
WO2004039352A2 (en) * | 2002-10-31 | 2004-05-13 | Ranbaxy Laboratories Limited | Amorphous form of losartan potassium |
EP1608641A1 (en) * | 2003-04-03 | 2005-12-28 | IPCA Laboratories Limited | A process for the synthesis of losartan potassium |
US6916935B2 (en) * | 2003-05-06 | 2005-07-12 | Ipca Laboratories | Losartan potassium synthesis |
US7345071B2 (en) | 2003-05-07 | 2008-03-18 | Ipca Laboratories Limited | Process for the synthesis of Losartan potassium |
EP1709034A2 (en) * | 2004-01-06 | 2006-10-11 | IPCA Laboratories Limited | An improved process for the synthesis of losartan potassium |
WO2006050922A1 (en) | 2004-11-11 | 2006-05-18 | Lek Pharmaceuticals D.D. | Process for the synthesis of tetrazoles |
ITTO20060560A1 (it) * | 2006-07-27 | 2008-01-28 | S I M S S R L | Composti intermedi per la preparazione di antagonisti dell¿angiotensina ii |
JP5399902B2 (ja) * | 2006-08-22 | 2014-01-29 | ランバクシー ラボラトリーズ リミテッド | マトリックスメタロプロテイナーゼ阻害剤 |
WO2018002673A1 (en) | 2016-07-01 | 2018-01-04 | N4 Pharma Uk Limited | Novel formulations of angiotensin ii receptor antagonists |
US11327065B1 (en) * | 2021-08-27 | 2022-05-10 | Jubilant Generics Limited | Preparation of angiotensin receptor blockers or pharmaceutically acceptable salts thereof |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1338238C (en) * | 1988-01-07 | 1996-04-09 | David John Carini | Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids |
DE4224133A1 (de) * | 1992-07-22 | 1994-01-27 | Thomae Gmbh Dr K | Benzimidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
DE4221583A1 (de) * | 1991-11-12 | 1993-05-13 | Bayer Ag | Substituierte biphenylpyridone |
KR100212257B1 (ko) | 1991-11-18 | 1999-08-02 | 미리암 디. 메코나헤이 | Aii 수용체 길항물질을 합성하기 위한 테트라졸릴페닐보론산 중간체의 제조 방법 |
US5206374A (en) * | 1991-11-18 | 1993-04-27 | E. I. Du Pont De Nemours And Company | Process for preparing tetrazolylphenylboronic acid intermediates |
EP0736021A4 (en) | 1993-12-23 | 1997-04-02 | Merck & Co Inc | LOSARTANE POLYMORPHS AND PROCESS FOR THE PREPARATION OF FORM II OF LOSARTANE |
JP3883205B2 (ja) * | 1994-03-29 | 2007-02-21 | メルク エンド カンパニー インコーポレーテッド | アンギオテンシン▲ii▼レセプタ遮断イミダゾールによるアテローム性動脈硬化症の治療 |
ES2105939B1 (es) * | 1994-08-02 | 1998-07-01 | Uriach & Cia Sa J | Nuevos pirazoles con actividad antagonista de la angiotensina ii. |
-
2000
- 2000-04-21 HU HU0001618A patent/HU222773B1/hu active IP Right Grant
-
2001
- 2001-04-20 TR TR2004/01058T patent/TR200401058T4/xx unknown
- 2001-04-20 CZ CZ20023000A patent/CZ301029B6/cs not_active IP Right Cessation
- 2001-04-20 AT AT01928134T patent/ATE259366T1/de not_active IP Right Cessation
- 2001-04-20 AU AU2001254998A patent/AU2001254998A1/en not_active Abandoned
- 2001-04-20 US US10/182,109 patent/US6710183B2/en not_active Expired - Fee Related
- 2001-04-20 UA UA2002119212A patent/UA72803C2/uk unknown
- 2001-04-20 SK SK1289-2002A patent/SK286740B6/sk not_active IP Right Cessation
- 2001-04-20 ES ES01928134T patent/ES2215130T3/es not_active Expired - Lifetime
- 2001-04-20 EP EP01928134A patent/EP1274702B1/en not_active Expired - Lifetime
- 2001-04-20 WO PCT/HU2001/000047 patent/WO2001081336A1/en active IP Right Grant
- 2001-04-20 JP JP2001578426A patent/JP2003531203A/ja active Pending
- 2001-04-20 DE DE60102008T patent/DE60102008T2/de not_active Expired - Fee Related
- 2001-04-20 PL PL356929A patent/PL198664B1/pl not_active IP Right Cessation
- 2001-04-20 EE EEP200200460A patent/EE05064B1/xx not_active IP Right Cessation
- 2001-04-20 EA EA200201122A patent/EA004633B1/ru not_active IP Right Cessation
-
2002
- 2002-08-23 BG BG107031A patent/BG65699B1/bg unknown
Also Published As
Publication number | Publication date |
---|---|
SK286740B6 (sk) | 2009-04-06 |
CZ301029B6 (cs) | 2009-10-14 |
HU222773B1 (hu) | 2003-10-28 |
TR200401058T4 (tr) | 2004-06-21 |
ATE259366T1 (de) | 2004-02-15 |
PL356929A1 (en) | 2004-07-12 |
AU2001254998A1 (en) | 2001-11-07 |
WO2001081336A8 (en) | 2002-08-29 |
EP1274702B1 (en) | 2004-02-11 |
BG107031A (en) | 2003-08-29 |
SK12892002A3 (sk) | 2002-12-03 |
ES2215130T3 (es) | 2004-10-01 |
DE60102008D1 (de) | 2004-03-18 |
US6710183B2 (en) | 2004-03-23 |
HU0001618D0 (en) | 2000-06-28 |
EP1274702A1 (en) | 2003-01-15 |
PL198664B1 (pl) | 2008-07-31 |
JP2003531203A (ja) | 2003-10-21 |
EA004633B1 (ru) | 2004-06-24 |
EE200200460A (et) | 2003-12-15 |
WO2001081336A1 (en) | 2001-11-01 |
EE05064B1 (et) | 2008-08-15 |
HUP0001618A2 (hu) | 2002-11-28 |
BG65699B1 (bg) | 2009-07-31 |
US20030078435A1 (en) | 2003-04-24 |
DE60102008T2 (de) | 2004-12-09 |
UA72803C2 (en) | 2005-04-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM |
|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): RU |