BG103735A - Метод за получаване на заместени тиазолидиндиони - Google Patents

Метод за получаване на заместени тиазолидиндиони

Info

Publication number
BG103735A
BG103735A BG103735A BG10373599A BG103735A BG 103735 A BG103735 A BG 103735A BG 103735 A BG103735 A BG 103735A BG 10373599 A BG10373599 A BG 10373599A BG 103735 A BG103735 A BG 103735A
Authority
BG
Bulgaria
Prior art keywords
formula
preparation
substituted
compound
thiazolidindions
Prior art date
Application number
BG103735A
Other languages
English (en)
Other versions
BG64311B1 (bg
Inventor
Robert Giles
Norman Lewis
Stephen Moore
Colin POOL
John Quick
Michael Urquhart
Original Assignee
Smithkline Beecham P.L.C.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27268725&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BG103735(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9703310.4A external-priority patent/GB9703310D0/en
Priority claimed from GBGB9703338.5A external-priority patent/GB9703338D0/en
Priority claimed from GBGB9703334.4A external-priority patent/GB9703334D0/en
Application filed by Smithkline Beecham P.L.C. filed Critical Smithkline Beecham P.L.C.
Publication of BG103735A publication Critical patent/BG103735A/bg
Publication of BG64311B1 publication Critical patent/BG64311B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Изобретението се отнася до метод за получаване назаместени тиазолидиндиони с формулите@@по-специално до метод за получаване на съединение с формула І или до тавтомерната му форма, или фармацевтично приемливите му соли и солвати, в които J означава О или S; T означава заместена или незаместена арилова група и Т1 означава О или S. Методът включва редуциране на съединение с формула ІІ или на тавтомерната му форма, или на неговите сол и солват, като Т и Т1 имат значенията, посочени за формула І, скомплексен хидриден редуциращ агент или с източник на комплексен редуциращ хидриден агент. Получават се фармацевтично приемливи соли или солвати на съединението с формула І или на тавтомерната му форма.
BG103735A 1997-02-18 1999-09-15 Метод за получаване на заместени тиазолидиндиони BG64311B1 (bg)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9703310.4A GB9703310D0 (en) 1997-02-18 1997-02-18 Novel process
GBGB9703338.5A GB9703338D0 (en) 1997-02-18 1997-02-18 Novel process
GBGB9703334.4A GB9703334D0 (en) 1997-02-18 1997-02-18 Novel compounds
PCT/EP1998/000818 WO1998037073A1 (en) 1997-02-18 1998-02-13 Process for the preparation of substituted thiazolidinedione

Publications (2)

Publication Number Publication Date
BG103735A true BG103735A (bg) 2000-06-30
BG64311B1 BG64311B1 (bg) 2004-09-30

Family

ID=27268725

Family Applications (1)

Application Number Title Priority Date Filing Date
BG103735A BG64311B1 (bg) 1997-02-18 1999-09-15 Метод за получаване на заместени тиазолидиндиони

Country Status (29)

Country Link
EP (2) EP0970063A1 (bg)
JP (2) JP2001514619A (bg)
KR (1) KR20000071138A (bg)
CN (1) CN1252065A (bg)
AP (1) AP1359A (bg)
AR (1) AR011447A1 (bg)
AU (1) AU6622398A (bg)
BG (1) BG64311B1 (bg)
BR (1) BR9807395A (bg)
CA (1) CA2281695C (bg)
CZ (1) CZ296272B6 (bg)
DZ (1) DZ2430A1 (bg)
EA (1) EA199900754A1 (bg)
HU (1) HUP0001459A3 (bg)
ID (1) ID22222A (bg)
IL (1) IL131392A (bg)
IN (1) IN188379B (bg)
MA (1) MA24475A1 (bg)
MY (1) MY129475A (bg)
NO (2) NO313290B1 (bg)
NZ (1) NZ337179A (bg)
OA (1) OA11148A (bg)
PE (1) PE71899A1 (bg)
PL (1) PL195482B1 (bg)
SK (2) SK285979B6 (bg)
TR (1) TR199902019T2 (bg)
TW (1) TWI222446B (bg)
UY (1) UY24886A1 (bg)
WO (1) WO1998037073A1 (bg)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7091359B2 (en) 1997-11-04 2006-08-15 Smithkline Beecham Plc Process for the preparation of thiazolidinedione derivatives
GB9723295D0 (en) 1997-11-04 1998-01-07 Smithkline Beecham Plc Novel process
ES2203453T3 (es) * 1999-04-23 2004-04-16 Smithkline Beecham Plc Polimorfo de sal del acido maleico de 5-(4-(2-(n-metil-n-(2-piridil)amino)etoxi)bentil)tiazolidina-2,4-diona.
FR2820741A1 (fr) * 2001-02-14 2002-08-16 Ppg Sipsy Procede de preparation de composes derives de thiazolidinedione, d'oxazolidinedione ou d'hydantoine
FR2820742B1 (fr) * 2001-02-14 2005-03-11 Ppg Sipsy Procede de preparation de composes derives de thiazolidinedione, d'oxazolidinedione ou d'hydantoine
OA12963A (en) 2002-11-22 2006-10-13 Smithkline Beecham Corp Novel chemical compounds.
AR047541A1 (es) * 2004-02-13 2006-01-25 Sandoz Ag Fosfato de 5-[[4-[2-metil-2-piridinil-amino-etoxi]fenil]metil]-2,4 tiazolidinadiona (rosiglitazona) y sus formas polimorficas
CA2566352A1 (en) * 2004-05-12 2005-11-17 Medichem S.A. Process for the preparation of rosiglitazone
CZ297266B6 (cs) * 2004-09-10 2006-10-11 Zentiva, A. S. Zpusob prípravy rosiglitazonu
CZ297347B6 (cs) * 2004-09-21 2006-11-15 Zentiva, A. S. Zpusob prípravy rosiglitazonu
CZ298424B6 (cs) * 2005-05-24 2007-09-26 Zentiva, A. S. Zpusob krystalizace rosiglitazonu a jeho derivátuze smesných rozpouštedel

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1003445B (zh) * 1984-10-03 1989-03-01 武田药品工业株式会社 噻唑烷二酮衍生物，其制备方法和用途
EP0842925A1 (en) * 1987-09-04 1998-05-20 Beecham Group Plc Substituted thiazolidinedione derivatives
JPH0377875A (ja) * 1989-08-18 1991-04-03 Kaken Pharmaceut Co Ltd チアゾリジン‐２，４‐ジオン誘導体およびその製造法
EP0454501B1 (en) * 1990-04-27 2001-09-05 Sankyo Company Limited Benzylidenethiazolidine derivatives, their preparation and their use for the inhibition of lipid peroxides
US5585495A (en) * 1991-12-20 1996-12-17 The Upjohn Company Reduction method for substituted 5-methylene-thiazolidinediones
JPH08157473A (ja) * 1994-10-06 1996-06-18 Nissan Chem Ind Ltd ピラゾール系チアゾリジン類
JPH08217717A (ja) * 1995-02-10 1996-08-27 Sumitomo Chem Co Ltd 環状ケトン系化合物、その製造法およびそれを有効成分とするゴキブリ誘引剤
NZ308228A (en) * 1995-05-31 1999-11-29 Sumitomo Pharma Substituted 1,8-naphthyridine derivatives

Also Published As

Publication number Publication date
ID22222A (id) 1999-09-16
JP2009149616A (ja) 2009-07-09
NO20023937D0 (no) 2002-08-19
IN188379B (bg) 2002-09-14
IL131392A (en) 2005-07-25
MA24475A1 (fr) 1998-10-01
JP2001514619A (ja) 2001-09-11
SK112099A3 (en) 2000-05-16
NO313290B1 (no) 2002-09-09
CZ292499A3 (cs) 2000-02-16
CA2281695A1 (en) 1998-08-27
PL335163A1 (en) 2000-04-10
UY24886A1 (es) 2001-08-27
OA11148A (en) 2003-04-16
AP1359A (en) 2004-12-02
NZ337179A (en) 2001-07-27
AP9901626A0 (en) 1999-09-30
BR9807395A (pt) 2000-03-14
CZ296272B6 (cs) 2006-02-15
NO993949D0 (no) 1999-08-17
SK287512B6 (sk) 2010-12-07
HUP0001459A3 (en) 2002-11-28
WO1998037073A1 (en) 1998-08-27
EP1770092A1 (en) 2007-04-04
AU6622398A (en) 1998-09-09
NO20023937L (no) 1999-09-07
EP0970063A1 (en) 2000-01-12
IL131392A0 (en) 2001-01-28
PE71899A1 (es) 1999-09-15
DZ2430A1 (fr) 2003-01-11
AR011447A1 (es) 2000-08-16
CN1252065A (zh) 2000-05-03
TWI222446B (en) 2004-10-21
KR20000071138A (ko) 2000-11-25
TR199902019T2 (xx) 1999-12-21
PL195482B1 (pl) 2007-09-28
NO993949L (no) 1999-09-07
BG64311B1 (bg) 2004-09-30
HUP0001459A2 (hu) 2000-10-28
SK285979B6 (sk) 2007-12-06
CA2281695C (en) 2006-12-12
MY129475A (en) 2007-04-30
EA199900754A1 (ru) 2000-04-24

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