BG103259A - Стереоспецифично получаване на хирални 1-арил- и 1- хетероарил-заместени етил-2-амини - Google Patents

Стереоспецифично получаване на хирални 1-арил- и 1- хетероарил-заместени етил-2-амини Download PDF

Info

Publication number
BG103259A
BG103259A BG103259A BG10325999A BG103259A BG 103259 A BG103259 A BG 103259A BG 103259 A BG103259 A BG 103259A BG 10325999 A BG10325999 A BG 10325999A BG 103259 A BG103259 A BG 103259A
Authority
BG
Bulgaria
Prior art keywords
optionally substituted
compound
formula
aryl
substituted aryl
Prior art date
Application number
BG103259A
Other languages
Bulgarian (bg)
English (en)
Inventor
Luc Grondard
Jean - Paul CASIMIR
Patrick Leon
Michael O'brien
Matthew Powers
Daniel Robin
Original Assignee
Aventis Pharmaceuticals Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharmaceuticals Inc. filed Critical Aventis Pharmaceuticals Inc.
Publication of BG103259A publication Critical patent/BG103259A/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C07C303/38—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reaction of ammonia or amines with sulfonic acids, or with esters, anhydrides, or halides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/28—Halogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C07C303/40—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D203/22—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • C07D203/24—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BG103259A 1996-09-12 1999-03-17 Стереоспецифично получаване на хирални 1-арил- и 1- хетероарил-заместени етил-2-амини BG103259A (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2600596P 1996-09-12 1996-09-12
PCT/US1997/015729 WO1998011064A1 (en) 1996-09-12 1997-09-10 Stereospecific preparation of chiral 1-aryl- and 1-heteroaryl-2-substituted ethyl-2-amines

Publications (1)

Publication Number Publication Date
BG103259A true BG103259A (bg) 2000-02-29

Family

ID=21829300

Family Applications (1)

Application Number Title Priority Date Filing Date
BG103259A BG103259A (bg) 1996-09-12 1999-03-17 Стереоспецифично получаване на хирални 1-арил- и 1- хетероарил-заместени етил-2-амини

Country Status (20)

Country Link
US (2) US6127550A (hu)
EP (1) EP0942900A4 (hu)
JP (1) JP2001501922A (hu)
KR (1) KR100317871B1 (hu)
CN (2) CN1112354C (hu)
AP (1) AP937A (hu)
AU (1) AU732332B2 (hu)
BG (1) BG103259A (hu)
BR (1) BR9711466A (hu)
CA (1) CA2265886A1 (hu)
EA (1) EA001364B1 (hu)
HK (1) HK1022296A1 (hu)
HU (1) HUP0000219A3 (hu)
IL (1) IL128813A0 (hu)
NO (1) NO991023L (hu)
OA (1) OA10991A (hu)
PL (1) PL331933A1 (hu)
SK (1) SK26999A3 (hu)
UA (1) UA54451C2 (hu)
WO (1) WO1998011064A1 (hu)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU225504B1 (en) * 1997-05-13 2007-01-29 Sanofi Aventis Novel halophenyl-(2-(2-thienyl)-ethylamino)-acetonitriles and process for producing them
AU2187100A (en) 1998-12-31 2000-07-24 Aventis Pharmaceuticals Products Inc. Process for preparing n6-substituted deaza-adenosine derivatives
KR100426030B1 (ko) * 2000-07-22 2004-04-03 (주) 한켐 락톤계 당화합물에서의 키랄성 전환방법
KR100440461B1 (ko) * 2000-08-19 2004-07-15 (주) 한켐 1,4-락톤을 이용한 ｌ-리보오스의 제조 방법
KR100433179B1 (ko) * 2001-11-10 2004-05-27 주식회사 삼천리제약 2-데옥시-ｌ-리보오스의 제조방법
CN100506919C (zh) * 2006-02-23 2009-07-01 中国科学院化学研究所 使用人血清蛋白对非手性菁染料聚集体进行手性诱导的方法
EP3636656A4 (en) 2017-06-09 2021-04-14 Chugai Seiyaku Kabushiki Kaisha PROCESS FOR SYNTHESIS OF A PEPTIDE CONTAINING AN N-SUBSTITUTED AMINO ACID
WO2020111238A1 (ja) * 2018-11-30 2020-06-04 中外製薬株式会社 ペプチド化合物、またはアミド化合物の脱保護法および固相反応における脱樹脂方法、並びにペプチド化合物の製造方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3431152A (en) * 1967-03-23 1969-03-04 American Cyanamid Co Compositions containing aromatic sulfonyl aziridine as curing agents
US4933470A (en) * 1987-10-05 1990-06-12 Neorx Corporation Method of synthesis of vicinal diamines
ATE147074T1 (de) * 1990-09-25 1997-01-15 Rhone Poulenc Rorer Int Verbindungen welche antihypertensive und antiischemische eigenschaften besitzen

Also Published As

Publication number Publication date
NO991023D0 (no) 1999-03-02
NO991023L (no) 1999-03-02
AU4256297A (en) 1998-04-02
US6433172B1 (en) 2002-08-13
KR20000036007A (ko) 2000-06-26
CN1112354C (zh) 2003-06-25
JP2001501922A (ja) 2001-02-13
BR9711466A (pt) 1999-08-24
HUP0000219A3 (en) 2001-04-28
EA001364B1 (ru) 2001-02-26
AP937A (en) 2001-02-07
AU732332B2 (en) 2001-04-12
US6127550A (en) 2000-10-03
AP9901476A0 (en) 1999-03-31
KR100317871B1 (ko) 2002-01-18
CA2265886A1 (en) 1998-03-19
CN1388119A (zh) 2003-01-01
PL331933A1 (en) 1999-08-16
CN1230176A (zh) 1999-09-29
EP0942900A1 (en) 1999-09-22
EA199900281A1 (ru) 1999-08-26
IL128813A0 (en) 2000-01-31
EP0942900A4 (en) 2004-08-04
HK1022296A1 (en) 2000-08-04
HUP0000219A2 (hu) 2000-12-28
UA54451C2 (uk) 2003-03-17
WO1998011064A1 (en) 1998-03-19
SK26999A3 (en) 1999-10-08
OA10991A (en) 2001-11-07

Similar Documents

Publication Publication Date Title
KR101379154B1 (ko) 카르보닐 비대칭 알킬화
RU2260589C2 (ru) Способ получения 3-алканоил- и 3-алкилиндолов
BG103259A (bg) Стереоспецифично получаване на хирални 1-арил- и 1- хетероарил-заместени етил-2-амини
JP4607877B2 (ja) Ｃｐｌａ２阻害剤の製法
JP2002534430A (ja) Ｎ６−置換デアザアデノシン誘導体類の製造法
KR20210014646A (ko) 키랄 2-[(헤테로)아릴알킬설파닐]피리미딘의 입체선택성 제조 공정 및 이로부터 얻을 수 있는 생성물
JP4150081B2 (ja) ２―イミダゾリン―５―オンの調製用中間体
US6271388B1 (en) Process for producing oxazolidin-2-one derivative
MXPA04008730A (es) Proceso para preparacion de piperazinas quirales 1,4-disustituidas.
JP2005501028A (ja) ベナゼプリル及びその類似体の生産に有用な中間体の速度論的分離
KR100365458B1 (ko) 아실화 방법
EP1182199B1 (en) Process for preparing amic acid esters
Ruano et al. Synthesis of enantiomerically pure acyclic α-sulfinyl ketimines
US6410750B1 (en) Processes and intermediates for preparing 3(S)-[(5-chloro-1H-indole-2-carbonyl)-amino]-2(R)-hydroxy-4-phenyl-butyric acid
JP2002536426A (ja) 対称及び非対称の炭酸エステルの製造方法
KR20020047255A (ko) 테트라하이드로푸란으로부터의 옥사졸린의 제조 방법
JP2002523394A (ja) スルホニルハロゲン化物の製造方法
CZ72199A3 (cs) Stereospecifická příprava chirálních 1-aryl- a 1- heteroaryl-2-substituovaných ethyl-2-aminů
US20020165269A1 (en) Process for preparing optically active dihydropyrones
US6891068B2 (en) Water as promoter in the nucleophilic substitution of chloride
JP3828197B2 (ja) 光学活性３−（ｐ−メトキシフェニル）グリシッド酸アルカリ金属塩の製造法
JP2002506430A (ja) キラルな３，４−デヒドロプロリンの製造法
JP2006169113A (ja) インドール類の合成方法および合成中間体
JP2006169114A (ja) ベンジル保護基等の水素添加反応による選択的脱保護
JP2006188505A (ja) インドール類の製造方法および製造中間体