EA199900281A1 - Стереоспецифический синтез хиральных 1-арил- и 1-гетероарил-2-замещенных этил-2-аминов - Google Patents

Стереоспецифический синтез хиральных 1-арил- и 1-гетероарил-2-замещенных этил-2-аминов

Info

Publication number
EA199900281A1
EA199900281A1 EA199900281A EA199900281A EA199900281A1 EA 199900281 A1 EA199900281 A1 EA 199900281A1 EA 199900281 A EA199900281 A EA 199900281A EA 199900281 A EA199900281 A EA 199900281A EA 199900281 A1 EA199900281 A1 EA 199900281A1
Authority
EA
Eurasian Patent Office
Prior art keywords
heteroaryl
aryl
substituted ethyl
charal
amins
Prior art date
Application number
EA199900281A
Other languages
English (en)
Other versions
EA001364B1 (ru
Inventor
Люк Грондард
Жан-Поль Казимир
Патрик Леон
Майкл К. О'Брайен
Мэттью Р. Пауэрс
Даниэль Робин
Original Assignee
Рон-Пуленк, Рорер Фармасьютикалз Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Рон-Пуленк, Рорер Фармасьютикалз Инк. filed Critical Рон-Пуленк, Рорер Фармасьютикалз Инк.
Publication of EA199900281A1 publication Critical patent/EA199900281A1/ru
Publication of EA001364B1 publication Critical patent/EA001364B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C07C303/38—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reaction of ammonia or amines with sulfonic acids, or with esters, anhydrides, or halides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/28—Halogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C07C303/40—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D203/22—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • C07D203/24—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Настоящее изобретение относится к способу стереоселективного синтеза [(1-необязательно замещенный арил)- или (1-необязательно замещенный гетероарил)]-2-замещенных этил-2-аминов, имеющих хиральный атом (центр) в положении 2, и к промежуточным продуктам (полупродуктам) для синтеза замещенных этил-2-аминов.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199900281A 1996-09-12 1997-09-10 Стереоспецифический синтез хиральных 1-арил- и 1-гетероарил-2-замещенных этил-2-аминов EA001364B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2600596P 1996-09-12 1996-09-12
PCT/US1997/015729 WO1998011064A1 (en) 1996-09-12 1997-09-10 Stereospecific preparation of chiral 1-aryl- and 1-heteroaryl-2-substituted ethyl-2-amines

Publications (2)

Publication Number Publication Date
EA199900281A1 true EA199900281A1 (ru) 1999-08-26
EA001364B1 EA001364B1 (ru) 2001-02-26

Family

ID=21829300

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199900281A EA001364B1 (ru) 1996-09-12 1997-09-10 Стереоспецифический синтез хиральных 1-арил- и 1-гетероарил-2-замещенных этил-2-аминов

Country Status (20)

Country Link
US (2) US6127550A (ru)
EP (1) EP0942900A4 (ru)
JP (1) JP2001501922A (ru)
KR (1) KR100317871B1 (ru)
CN (2) CN1112354C (ru)
AP (1) AP937A (ru)
AU (1) AU732332B2 (ru)
BG (1) BG103259A (ru)
BR (1) BR9711466A (ru)
CA (1) CA2265886A1 (ru)
EA (1) EA001364B1 (ru)
HK (1) HK1022296A1 (ru)
HU (1) HUP0000219A3 (ru)
IL (1) IL128813A0 (ru)
NO (1) NO991023L (ru)
OA (1) OA10991A (ru)
PL (1) PL331933A1 (ru)
SK (1) SK26999A3 (ru)
UA (1) UA54451C2 (ru)
WO (1) WO1998011064A1 (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU225504B1 (en) * 1997-05-13 2007-01-29 Sanofi Aventis Novel halophenyl-(2-(2-thienyl)-ethylamino)-acetonitriles and process for producing them
CN1383427A (zh) 1998-12-31 2002-12-04 阿温蒂斯药物公司 制备n6－取代的脱氮杂一腺苷衍生物的方法
KR100426030B1 (ko) * 2000-07-22 2004-04-03 (주) 한켐 락톤계 당화합물에서의 키랄성 전환방법
KR100440461B1 (ko) * 2000-08-19 2004-07-15 (주) 한켐 1,4-락톤을 이용한 ｌ-리보오스의 제조 방법
KR100433179B1 (ko) * 2001-11-10 2004-05-27 주식회사 삼천리제약 2-데옥시-ｌ-리보오스의 제조방법
CN100506919C (zh) * 2006-02-23 2009-07-01 中国科学院化学研究所 使用人血清蛋白对非手性菁染料聚集体进行手性诱导的方法
JP7229158B2 (ja) 2017-06-09 2023-02-27 中外製薬株式会社 Ｎ－置換アミノ酸を含むペプチドの合成方法
WO2020111238A1 (ja) * 2018-11-30 2020-06-04 中外製薬株式会社 ペプチド化合物、またはアミド化合物の脱保護法および固相反応における脱樹脂方法、並びにペプチド化合物の製造方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3431152A (en) * 1967-03-23 1969-03-04 American Cyanamid Co Compositions containing aromatic sulfonyl aziridine as curing agents
US4933470A (en) * 1987-10-05 1990-06-12 Neorx Corporation Method of synthesis of vicinal diamines
CA2092305C (en) * 1990-09-25 2003-02-11 Alfred P. Spada Compounds having antihypertensive and anti-ischemic properties

Also Published As

Publication number Publication date
CN1388119A (zh) 2003-01-01
CN1112354C (zh) 2003-06-25
EA001364B1 (ru) 2001-02-26
BR9711466A (pt) 1999-08-24
PL331933A1 (en) 1999-08-16
NO991023D0 (no) 1999-03-02
US6127550A (en) 2000-10-03
AP9901476A0 (en) 1999-03-31
EP0942900A1 (en) 1999-09-22
US6433172B1 (en) 2002-08-13
CN1230176A (zh) 1999-09-29
BG103259A (bg) 2000-02-29
OA10991A (en) 2001-11-07
WO1998011064A1 (en) 1998-03-19
EP0942900A4 (en) 2004-08-04
AU732332B2 (en) 2001-04-12
IL128813A0 (en) 2000-01-31
JP2001501922A (ja) 2001-02-13
NO991023L (no) 1999-03-02
SK26999A3 (en) 1999-10-08
AP937A (en) 2001-02-07
HUP0000219A2 (hu) 2000-12-28
AU4256297A (en) 1998-04-02
KR20000036007A (ko) 2000-06-26
CA2265886A1 (en) 1998-03-19
HK1022296A1 (en) 2000-08-04
HUP0000219A3 (en) 2001-04-28
UA54451C2 (ru) 2003-03-17
KR100317871B1 (ko) 2002-01-18

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Legal Events

Date Code Title Description
TC4A Change in name of a patent proprietor in a eurasian patent

Designated state(s): AM AZ BY KZ KG MD TJ TM RU

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU