FI942422A - Menetelmä fysostigmiinin valmistuksessa käytettyjen välituotteiden enantioselektiivistä synteesiä varten - Google Patents
Menetelmä fysostigmiinin valmistuksessa käytettyjen välituotteiden enantioselektiivistä synteesiä varten Download PDFInfo
- Publication number
- FI942422A FI942422A FI942422A FI942422A FI942422A FI 942422 A FI942422 A FI 942422A FI 942422 A FI942422 A FI 942422A FI 942422 A FI942422 A FI 942422A FI 942422 A FI942422 A FI 942422A
- Authority
- FI
- Finland
- Prior art keywords
- physostigmine
- preparation
- intermediates used
- enantioselective synthesis
- enantioselective
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/067,892 US5521320A (en) | 1990-01-22 | 1993-05-27 | Process for the enantioselective synthesis of intermediates used in the preparation of physostigmine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FI942422A0 FI942422A0 (fi) | 1994-05-25 |
| FI942422A true FI942422A (fi) | 1994-11-28 |
Family
ID=22079102
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI942422A FI942422A (fi) | 1993-05-27 | 1994-05-25 | Menetelmä fysostigmiinin valmistuksessa käytettyjen välituotteiden enantioselektiivistä synteesiä varten |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5521320A (fi) |
| EP (1) | EP0700381A4 (fi) |
| JP (1) | JP2843759B2 (fi) |
| KR (1) | KR100220766B1 (fi) |
| CN (1) | CN1047167C (fi) |
| AU (1) | AU683052B2 (fi) |
| CA (1) | CA2124430A1 (fi) |
| CZ (1) | CZ127894A3 (fi) |
| FI (1) | FI942422A (fi) |
| HU (1) | HUT72886A (fi) |
| IL (1) | IL109796A (fi) |
| NO (1) | NO941967L (fi) |
| NZ (1) | NZ260587A (fi) |
| RU (1) | RU2109013C1 (fi) |
| SG (1) | SG55156A1 (fi) |
| WO (1) | WO1994027963A1 (fi) |
| ZA (1) | ZA943684B (fi) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5840915A (en) * | 1990-01-22 | 1998-11-24 | Hoechst Marion Roussel, Inc. | Process for the enatioselective synthesis of intermediates used |
| US6596870B2 (en) | 2000-07-13 | 2003-07-22 | Brandeis University | Asymmetric synthetic methods based on phase transfer catalysis |
| WO2002070478A1 (en) * | 2001-03-06 | 2002-09-12 | Astrazeneca Ab | Indolone derivatives having vascular-damaging activity |
| US8399546B2 (en) * | 2004-08-05 | 2013-03-19 | Sabic Innovative Plastics Ip B.V. | Flame retardant thermoplastic compositions having EMI shielding |
| CN101121717B (zh) * | 2007-05-17 | 2010-07-28 | 四川大学 | 抗老年痴呆疾病的天然药物毒扁豆碱及其衍生物苯胺基甲酸酯毒扁豆酚碱的合成 |
| JP6075563B2 (ja) * | 2011-11-08 | 2017-02-08 | 日産化学工業株式会社 | 光学活性イソキサゾリン化合物の触媒的不斉合成方法及び光学活性イソキサゾリン化合物 |
| WO2017181012A1 (en) * | 2016-04-15 | 2017-10-19 | Brandeis University | Cinchonium betaine catalysts and methods of using same |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US404472A (en) * | 1889-06-04 | Steering appaeattts | ||
| US4072698A (en) * | 1976-12-02 | 1978-02-07 | The Upjohn Company | Resolution of aminonitriles |
| US4578509A (en) * | 1983-04-01 | 1986-03-25 | Merck & Co., Inc. | Process for preparing a manipulated enantiomer mixture by asymmetric chiral phase transfer catalysis |
| JPS60169442A (ja) * | 1984-02-10 | 1985-09-02 | Mitsubishi Chem Ind Ltd | 桂皮酸エステル類の製造方法 |
| US4704472A (en) * | 1985-12-18 | 1987-11-03 | Merck & Co., Inc. | Preparation of an enantiomer of a substituted fluorenyloxyacetic acid |
| DK0418770T3 (da) * | 1989-09-19 | 1995-10-30 | Hoechst Roussel Pharma | Fremgangsmåde til kemisk spaltning af 5-alkoxysubstituerede (+-)-1,3-dimethyloxindolylethylaminer |
| ES2120407T3 (es) * | 1990-01-22 | 1998-11-01 | Hoechst Marion Roussel Inc | Procedimiento para la sintesis enantioselectiva de oxindoles alquilados, utilizados como productos intermedios en la preparacion de fisostigmina. |
| US5274117A (en) * | 1990-01-22 | 1993-12-28 | Hoechst-Roussel Pharmaceuticals, Inc. | Process for the enantioselective synthesis of intermediates used in the preparation of physostigmine |
-
1993
- 1993-05-27 US US08/067,892 patent/US5521320A/en not_active Expired - Fee Related
-
1994
- 1994-05-11 EP EP94917950A patent/EP0700381A4/en not_active Withdrawn
- 1994-05-11 WO PCT/US1994/005227 patent/WO1994027963A1/en not_active Application Discontinuation
- 1994-05-11 SG SG1996008293A patent/SG55156A1/en unknown
- 1994-05-24 NZ NZ260587A patent/NZ260587A/en unknown
- 1994-05-25 AU AU63306/94A patent/AU683052B2/en not_active Ceased
- 1994-05-25 FI FI942422A patent/FI942422A/fi unknown
- 1994-05-25 CZ CZ941278A patent/CZ127894A3/cs unknown
- 1994-05-26 ZA ZA943684A patent/ZA943684B/xx unknown
- 1994-05-26 RU RU94018531A patent/RU2109013C1/ru active
- 1994-05-26 CA CA002124430A patent/CA2124430A1/en not_active Abandoned
- 1994-05-26 IL IL10979694A patent/IL109796A/xx not_active IP Right Cessation
- 1994-05-26 NO NO941967A patent/NO941967L/no unknown
- 1994-05-26 JP JP6112654A patent/JP2843759B2/ja not_active Expired - Lifetime
- 1994-05-27 CN CN94105586A patent/CN1047167C/zh not_active Expired - Fee Related
- 1994-05-27 HU HU9401595A patent/HUT72886A/hu unknown
- 1994-05-27 KR KR1019940011636A patent/KR100220766B1/ko not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CN1100094A (zh) | 1995-03-15 |
| AU683052B2 (en) | 1997-10-30 |
| KR100220766B1 (ko) | 1999-09-15 |
| IL109796A (en) | 1999-08-17 |
| JPH06336476A (ja) | 1994-12-06 |
| JP2843759B2 (ja) | 1999-01-06 |
| IL109796A0 (en) | 1994-08-26 |
| CZ127894A3 (en) | 1994-12-15 |
| CA2124430A1 (en) | 1994-11-28 |
| NO941967D0 (no) | 1994-05-26 |
| SG55156A1 (en) | 1998-12-21 |
| HU9401595D0 (en) | 1994-08-29 |
| RU2109013C1 (ru) | 1998-04-20 |
| ZA943684B (en) | 1995-01-25 |
| FI942422A0 (fi) | 1994-05-25 |
| NZ260587A (en) | 1996-06-25 |
| EP0700381A1 (en) | 1996-03-13 |
| AU6330694A (en) | 1994-12-01 |
| HUT72886A (en) | 1996-06-28 |
| WO1994027963A1 (en) | 1994-12-08 |
| NO941967L (no) | 1994-11-28 |
| EP0700381A4 (en) | 1996-05-22 |
| CN1047167C (zh) | 1999-12-08 |
| US5521320A (en) | 1996-05-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GB | Transfer or assigment of application |
Owner name: HOECHST MARION ROUSSEL, INC. |