NO941967L - Fremgangsmåte for enantioselektivsyntesen for mellomprodukter anvendt i fremstillingen av fysostigmin - Google Patents

Fremgangsmåte for enantioselektivsyntesen for mellomprodukter anvendt i fremstillingen av fysostigmin

Info

Publication number
NO941967L
NO941967L NO941967A NO941967A NO941967L NO 941967 L NO941967 L NO 941967L NO 941967 A NO941967 A NO 941967A NO 941967 A NO941967 A NO 941967A NO 941967 L NO941967 L NO 941967L
Authority
NO
Norway
Prior art keywords
enantlomer
physostigmine
preparation
mixture
intermediates used
Prior art date
Application number
NO941967A
Other languages
English (en)
Other versions
NO941967D0 (no
Inventor
Thomas Bing Kin Lee
Georg Seung-Kit Wong
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Publication of NO941967D0 publication Critical patent/NO941967D0/no
Publication of NO941967L publication Critical patent/NO941967L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Fremgangsmåte for fremstilling av en optisk ren enantlomer av en. alkylert oksindol valgt blant eller hvor R er valgt fra gruppen bestående av metyl, etyl og benzyl, fra en blanding omfattende en første og en andre enantlomer av nevnte oksindol, hvor den første enantlomeren er tilstede l en mengde som er større enn den andre enantlomeren, som omfatter: a) behandling av blandingen med et passende rekrystalliserings-oppløsningsmiddel for selektivt å skille en hovedmengde av nevnte enantlomer for å danne en oppløsning, og for å danne en utfelling av en blanding omfattende minst den andre enantiomeren; og b) skille nevnte oppløsning fra nevnte utfelling. De optisk rene alkylerte okslndolene er nyttige l fremstillingen av enantiomerer av fysostigmin og fysostlgminllgnende forbindelser med farmasøtyisk aktivitet.
NO941967A 1993-05-27 1994-05-26 Fremgangsmåte for enantioselektivsyntesen for mellomprodukter anvendt i fremstillingen av fysostigmin NO941967L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/067,892 US5521320A (en) 1990-01-22 1993-05-27 Process for the enantioselective synthesis of intermediates used in the preparation of physostigmine

Publications (2)

Publication Number Publication Date
NO941967D0 NO941967D0 (no) 1994-05-26
NO941967L true NO941967L (no) 1994-11-28

Family

ID=22079102

Family Applications (1)

Application Number Title Priority Date Filing Date
NO941967A NO941967L (no) 1993-05-27 1994-05-26 Fremgangsmåte for enantioselektivsyntesen for mellomprodukter anvendt i fremstillingen av fysostigmin

Country Status (17)

Country Link
US (1) US5521320A (no)
EP (1) EP0700381A4 (no)
JP (1) JP2843759B2 (no)
KR (1) KR100220766B1 (no)
CN (1) CN1047167C (no)
AU (1) AU683052B2 (no)
CA (1) CA2124430A1 (no)
CZ (1) CZ127894A3 (no)
FI (1) FI942422A (no)
HU (1) HUT72886A (no)
IL (1) IL109796A (no)
NO (1) NO941967L (no)
NZ (1) NZ260587A (no)
RU (1) RU2109013C1 (no)
SG (1) SG55156A1 (no)
WO (1) WO1994027963A1 (no)
ZA (1) ZA943684B (no)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5840915A (en) * 1990-01-22 1998-11-24 Hoechst Marion Roussel, Inc. Process for the enatioselective synthesis of intermediates used
US6596870B2 (en) 2000-07-13 2003-07-22 Brandeis University Asymmetric synthetic methods based on phase transfer catalysis
US7186745B2 (en) 2001-03-06 2007-03-06 Astrazeneca Ab Indolone derivatives having vascular damaging activity
US8399546B2 (en) * 2004-08-05 2013-03-19 Sabic Innovative Plastics Ip B.V. Flame retardant thermoplastic compositions having EMI shielding
CN101121717B (zh) * 2007-05-17 2010-07-28 四川大学 抗老年痴呆疾病的天然药物毒扁豆碱及其衍生物苯胺基甲酸酯毒扁豆酚碱的合成
JP6075563B2 (ja) * 2011-11-08 2017-02-08 日産化学工業株式会社 光学活性イソキサゾリン化合物の触媒的不斉合成方法及び光学活性イソキサゾリン化合物
US10610857B2 (en) 2016-04-15 2020-04-07 Brandeis University Cinchonium betaine catalysts and methods of using same

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US404472A (en) * 1889-06-04 Steering appaeattts
US4072698A (en) * 1976-12-02 1978-02-07 The Upjohn Company Resolution of aminonitriles
US4578509A (en) * 1983-04-01 1986-03-25 Merck & Co., Inc. Process for preparing a manipulated enantiomer mixture by asymmetric chiral phase transfer catalysis
JPS60169442A (ja) * 1984-02-10 1985-09-02 Mitsubishi Chem Ind Ltd 桂皮酸エステル類の製造方法
US4704472A (en) * 1985-12-18 1987-11-03 Merck & Co., Inc. Preparation of an enantiomer of a substituted fluorenyloxyacetic acid
ES2075102T3 (es) * 1989-09-19 1995-10-01 Hoechst Roussel Pharma Procedimiento para la resolucion quimica de (+/-)-1,3-dimetiloxiindoliletilaminas 5-alcoxi sustituidas.
US5274117A (en) * 1990-01-22 1993-12-28 Hoechst-Roussel Pharmaceuticals, Inc. Process for the enantioselective synthesis of intermediates used in the preparation of physostigmine
DK0438796T3 (da) * 1990-01-22 1999-05-25 Hoechst Marion Roussel Inc Fremgangsmåde til enantioselektiv syntese af alkylerede oxindoler, som anvendes som mellemprodukter ved fremstilling af phy

Also Published As

Publication number Publication date
AU6330694A (en) 1994-12-01
AU683052B2 (en) 1997-10-30
JPH06336476A (ja) 1994-12-06
NO941967D0 (no) 1994-05-26
RU2109013C1 (ru) 1998-04-20
JP2843759B2 (ja) 1999-01-06
HU9401595D0 (en) 1994-08-29
WO1994027963A1 (en) 1994-12-08
ZA943684B (en) 1995-01-25
EP0700381A4 (en) 1996-05-22
KR100220766B1 (ko) 1999-09-15
NZ260587A (en) 1996-06-25
FI942422A (fi) 1994-11-28
CZ127894A3 (en) 1994-12-15
FI942422A0 (fi) 1994-05-25
US5521320A (en) 1996-05-28
EP0700381A1 (en) 1996-03-13
IL109796A (en) 1999-08-17
CN1047167C (zh) 1999-12-08
SG55156A1 (en) 1998-12-21
CA2124430A1 (en) 1994-11-28
IL109796A0 (en) 1994-08-26
HUT72886A (en) 1996-06-28
CN1100094A (zh) 1995-03-15

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