IL109796A - Method for the stereoselective synthesis of an alkylated oxindole and for separating an optically pure enantiomer thereof - Google Patents
Method for the stereoselective synthesis of an alkylated oxindole and for separating an optically pure enantiomer thereofInfo
- Publication number
- IL109796A IL109796A IL10979694A IL10979694A IL109796A IL 109796 A IL109796 A IL 109796A IL 10979694 A IL10979694 A IL 10979694A IL 10979694 A IL10979694 A IL 10979694A IL 109796 A IL109796 A IL 109796A
- Authority
- IL
- Israel
- Prior art keywords
- separating
- optically pure
- pure enantiomer
- stereoselective synthesis
- alkylated oxindole
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/067,892 US5521320A (en) | 1990-01-22 | 1993-05-27 | Process for the enantioselective synthesis of intermediates used in the preparation of physostigmine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL109796A0 IL109796A0 (en) | 1994-08-26 |
| IL109796A true IL109796A (en) | 1999-08-17 |
Family
ID=22079102
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL10979694A IL109796A (en) | 1993-05-27 | 1994-05-26 | Method for the stereoselective synthesis of an alkylated oxindole and for separating an optically pure enantiomer thereof |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5521320A (fi) |
| EP (1) | EP0700381A4 (fi) |
| JP (1) | JP2843759B2 (fi) |
| KR (1) | KR100220766B1 (fi) |
| CN (1) | CN1047167C (fi) |
| AU (1) | AU683052B2 (fi) |
| CA (1) | CA2124430A1 (fi) |
| CZ (1) | CZ127894A3 (fi) |
| FI (1) | FI942422A (fi) |
| HU (1) | HUT72886A (fi) |
| IL (1) | IL109796A (fi) |
| NO (1) | NO941967L (fi) |
| NZ (1) | NZ260587A (fi) |
| RU (1) | RU2109013C1 (fi) |
| SG (1) | SG55156A1 (fi) |
| WO (1) | WO1994027963A1 (fi) |
| ZA (1) | ZA943684B (fi) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5840915A (en) * | 1990-01-22 | 1998-11-24 | Hoechst Marion Roussel, Inc. | Process for the enatioselective synthesis of intermediates used |
| US6596870B2 (en) | 2000-07-13 | 2003-07-22 | Brandeis University | Asymmetric synthetic methods based on phase transfer catalysis |
| JP2004529110A (ja) * | 2001-03-06 | 2004-09-24 | アストラゼネカ アクチボラグ | 脈管損傷活性を有するインドール誘導体 |
| US8399546B2 (en) * | 2004-08-05 | 2013-03-19 | Sabic Innovative Plastics Ip B.V. | Flame retardant thermoplastic compositions having EMI shielding |
| CN101121717B (zh) * | 2007-05-17 | 2010-07-28 | 四川大学 | 抗老年痴呆疾病的天然药物毒扁豆碱及其衍生物苯胺基甲酸酯毒扁豆酚碱的合成 |
| WO2013069731A1 (ja) * | 2011-11-08 | 2013-05-16 | 日産化学工業株式会社 | 光学活性イソキサゾリン化合物の触媒的不斉合成方法及び光学活性イソキサゾリン化合物 |
| WO2017181012A1 (en) * | 2016-04-15 | 2017-10-19 | Brandeis University | Cinchonium betaine catalysts and methods of using same |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US404472A (en) * | 1889-06-04 | Steering appaeattts | ||
| US4072698A (en) * | 1976-12-02 | 1978-02-07 | The Upjohn Company | Resolution of aminonitriles |
| US4578509A (en) * | 1983-04-01 | 1986-03-25 | Merck & Co., Inc. | Process for preparing a manipulated enantiomer mixture by asymmetric chiral phase transfer catalysis |
| JPS60169442A (ja) * | 1984-02-10 | 1985-09-02 | Mitsubishi Chem Ind Ltd | 桂皮酸エステル類の製造方法 |
| US4704472A (en) * | 1985-12-18 | 1987-11-03 | Merck & Co., Inc. | Preparation of an enantiomer of a substituted fluorenyloxyacetic acid |
| ATE125254T1 (de) * | 1989-09-19 | 1995-08-15 | Hoechst Roussel Pharma | Verfahren zur racematspaltung von 5-alkoxy- substituierten (+/-)-1,3- dimethyloxindolylethylaminen. |
| US5274117A (en) * | 1990-01-22 | 1993-12-28 | Hoechst-Roussel Pharmaceuticals, Inc. | Process for the enantioselective synthesis of intermediates used in the preparation of physostigmine |
| DE69032595T2 (de) * | 1990-01-22 | 1999-03-25 | Hoechst Marion Roussel, Inc., Kansas City, Mo. 64137 | Verfahren zur enantioselektiven Synthese alkylierter Oxindole zur Verwendung als Zwischenprodukte bei der Herstellung von Physostigminen |
-
1993
- 1993-05-27 US US08/067,892 patent/US5521320A/en not_active Expired - Fee Related
-
1994
- 1994-05-11 SG SG1996008293A patent/SG55156A1/en unknown
- 1994-05-11 WO PCT/US1994/005227 patent/WO1994027963A1/en not_active Application Discontinuation
- 1994-05-11 EP EP94917950A patent/EP0700381A4/en not_active Withdrawn
- 1994-05-24 NZ NZ260587A patent/NZ260587A/en unknown
- 1994-05-25 FI FI942422A patent/FI942422A/fi unknown
- 1994-05-25 AU AU63306/94A patent/AU683052B2/en not_active Ceased
- 1994-05-25 CZ CZ941278A patent/CZ127894A3/cs unknown
- 1994-05-26 RU RU94018531A patent/RU2109013C1/ru active
- 1994-05-26 CA CA002124430A patent/CA2124430A1/en not_active Abandoned
- 1994-05-26 IL IL10979694A patent/IL109796A/xx not_active IP Right Cessation
- 1994-05-26 JP JP6112654A patent/JP2843759B2/ja not_active Expired - Lifetime
- 1994-05-26 NO NO941967A patent/NO941967L/no unknown
- 1994-05-26 ZA ZA943684A patent/ZA943684B/xx unknown
- 1994-05-27 CN CN94105586A patent/CN1047167C/zh not_active Expired - Fee Related
- 1994-05-27 HU HU9401595A patent/HUT72886A/hu unknown
- 1994-05-27 KR KR1019940011636A patent/KR100220766B1/ko not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| SG55156A1 (en) | 1998-12-21 |
| FI942422A0 (fi) | 1994-05-25 |
| EP0700381A1 (en) | 1996-03-13 |
| IL109796A0 (en) | 1994-08-26 |
| FI942422A (fi) | 1994-11-28 |
| NZ260587A (en) | 1996-06-25 |
| NO941967D0 (no) | 1994-05-26 |
| EP0700381A4 (en) | 1996-05-22 |
| ZA943684B (en) | 1995-01-25 |
| HU9401595D0 (en) | 1994-08-29 |
| AU6330694A (en) | 1994-12-01 |
| CN1100094A (zh) | 1995-03-15 |
| US5521320A (en) | 1996-05-28 |
| AU683052B2 (en) | 1997-10-30 |
| JP2843759B2 (ja) | 1999-01-06 |
| HUT72886A (en) | 1996-06-28 |
| JPH06336476A (ja) | 1994-12-06 |
| NO941967L (no) | 1994-11-28 |
| KR100220766B1 (ko) | 1999-09-15 |
| WO1994027963A1 (en) | 1994-12-08 |
| CN1047167C (zh) | 1999-12-08 |
| CZ127894A3 (en) | 1994-12-15 |
| RU2109013C1 (ru) | 1998-04-20 |
| CA2124430A1 (en) | 1994-11-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| RH | Patent void |