DK1025083T3 - Fremgangsmåde til stereoselektiv syntese af prostacyclin-derivater - Google Patents
Fremgangsmåde til stereoselektiv syntese af prostacyclin-derivaterInfo
- Publication number
- DK1025083T3 DK1025083T3 DK98953972T DK98953972T DK1025083T3 DK 1025083 T3 DK1025083 T3 DK 1025083T3 DK 98953972 T DK98953972 T DK 98953972T DK 98953972 T DK98953972 T DK 98953972T DK 1025083 T3 DK1025083 T3 DK 1025083T3
- Authority
- DK
- Denmark
- Prior art keywords
- stereoselective synthesis
- prostacyclin derivatives
- making
- stereoselective
- prostacyclin
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 230000000707 stereoselective effect Effects 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- 150000003815 prostacyclins Chemical class 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Furan Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95773697A | 1997-10-24 | 1997-10-24 | |
| PCT/US1998/022585 WO1999021830A1 (en) | 1997-10-24 | 1998-10-26 | Process for stereoselective synthesis of prostacyclin derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1025083T3 true DK1025083T3 (da) | 2004-03-01 |
Family
ID=25500067
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98953972T DK1025083T3 (da) | 1997-10-24 | 1998-10-26 | Fremgangsmåde til stereoselektiv syntese af prostacyclin-derivater |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1025083B1 (da) |
| JP (1) | JP3717053B2 (da) |
| KR (1) | KR100447022B1 (da) |
| CN (1) | CN1264819C (da) |
| AT (1) | ATE245628T1 (da) |
| CA (2) | CA2307163C (da) |
| DE (1) | DE69816642T2 (da) |
| DK (1) | DK1025083T3 (da) |
| ES (1) | ES2198760T3 (da) |
| PT (1) | PT1025083E (da) |
| WO (1) | WO1999021830A1 (da) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6700025B2 (en) * | 2001-01-05 | 2004-03-02 | United Therapeutics Corporation | Process for stereoselective synthesis of prostacyclin derivatives |
| EP1628654B2 (en) | 2003-05-22 | 2019-12-04 | United Therapeutics Corporation | Compounds and methods for delivery of prostacyclin analogs |
| WO2009033039A2 (en) | 2007-09-07 | 2009-03-12 | United Therapeutics Corporation | Buffer solutions having selective bactericidal activity against gram negative bacteria and methods of using same |
| JP5851691B2 (ja) | 2007-12-17 | 2016-02-03 | ユナイテッド セラピューティクス コーポレーション | リモジュリンの活性成分であるトレプロスチニルを製造する改良方法 |
| CN101891596B (zh) * | 2009-05-22 | 2013-12-11 | 上海天伟生物制药有限公司 | 一种化合物及其制备方法和用途 |
| CA2777070C (en) * | 2010-06-03 | 2019-11-05 | United Therapeutics Corporation | Treprostinil production |
| CA2710725C (en) | 2010-07-22 | 2017-08-01 | Alphora Research Inc. | Protected aldehydes for use as intermediates in chemical syntheses, and processes for their preparation |
| CA2726599C (en) | 2010-12-30 | 2017-07-25 | Alphora Research Inc. | Process for treprostinil salt preparation |
| US8461393B2 (en) | 2011-03-02 | 2013-06-11 | United Therapeutics Corporation | Synthesis of intermediate for treprostinil production |
| US8524939B2 (en) * | 2011-08-24 | 2013-09-03 | Chirogate International Inc. | Intermediates for the synthesis of benzindene prostaglandins and preparations thereof |
| CN103193626B (zh) * | 2012-01-10 | 2016-05-11 | 上海天伟生物制药有限公司 | 一种前列腺素类似物的晶型及其制备方法和用途 |
| CN103193627B (zh) * | 2012-01-10 | 2016-04-20 | 上海天伟生物制药有限公司 | 一种前列腺素类似物的晶型及其制备方法和用途 |
| KR102347340B1 (ko) | 2013-03-14 | 2022-01-06 | 유나이티드 세러퓨틱스 코오포레이션 | 트레프로스티닐의 고체 형태 |
| HU231186B1 (hu) | 2014-10-08 | 2021-06-28 | CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. | Új eljárás treprostinil és sói előállítására |
| CN107108427A (zh) | 2014-10-20 | 2017-08-29 | 联合治疗学有限公司 | 用于制备前列环素衍生物的中间体的合成 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4306075A (en) * | 1980-03-28 | 1981-12-15 | The Upjohn Company | Composition and process |
| US4486598A (en) * | 1982-02-22 | 1984-12-04 | The Upjohn Company | Carbacyclin analogs |
| DE19708496A1 (de) * | 1997-03-03 | 1998-09-10 | Hoechst Ag | Verfahren zur enantionmerenreinen Anthracylin-Synthese |
-
1998
- 1998-10-26 DE DE69816642T patent/DE69816642T2/de not_active Expired - Lifetime
- 1998-10-26 ES ES98953972T patent/ES2198760T3/es not_active Expired - Lifetime
- 1998-10-26 EP EP98953972A patent/EP1025083B1/en not_active Expired - Lifetime
- 1998-10-26 CN CNB988126397A patent/CN1264819C/zh not_active Expired - Lifetime
- 1998-10-26 WO PCT/US1998/022585 patent/WO1999021830A1/en active IP Right Grant
- 1998-10-26 AT AT98953972T patent/ATE245628T1/de active
- 1998-10-26 PT PT98953972T patent/PT1025083E/pt unknown
- 1998-10-26 CA CA2307163A patent/CA2307163C/en not_active Expired - Lifetime
- 1998-10-26 CA CA2847985A patent/CA2847985C/en not_active Expired - Lifetime
- 1998-10-26 JP JP2000517942A patent/JP3717053B2/ja not_active Expired - Fee Related
- 1998-10-26 KR KR10-2000-7004300A patent/KR100447022B1/ko not_active IP Right Cessation
- 1998-10-26 DK DK98953972T patent/DK1025083T3/da active
Also Published As
| Publication number | Publication date |
|---|---|
| CA2307163A1 (en) | 1999-05-06 |
| CA2307163C (en) | 2014-05-06 |
| CN1264819C (zh) | 2006-07-19 |
| PT1025083E (pt) | 2003-10-31 |
| CA2847985C (en) | 2015-02-03 |
| EP1025083B1 (en) | 2003-07-23 |
| CN1283184A (zh) | 2001-02-07 |
| EP1025083A1 (en) | 2000-08-09 |
| JP3717053B2 (ja) | 2005-11-16 |
| DE69816642T2 (de) | 2004-06-09 |
| KR20010031309A (ko) | 2001-04-16 |
| CA2847985A1 (en) | 1999-05-06 |
| KR100447022B1 (ko) | 2004-09-07 |
| ATE245628T1 (de) | 2003-08-15 |
| JP2004500303A (ja) | 2004-01-08 |
| ES2198760T3 (es) | 2004-02-01 |
| WO1999021830A8 (en) | 1999-07-22 |
| WO1999021830A1 (en) | 1999-05-06 |
| DE69816642D1 (de) | 2003-08-28 |
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