BE2013C004I2 - Phosphonocephem derivatives, process for the preparation of the same, and use thereof - Google Patents
Phosphonocephem derivatives, process for the preparation of the same, and use thereofInfo
- Publication number
- BE2013C004I2 BE2013C004I2 BE2013C004C BE2013C004C BE2013C004I2 BE 2013C004 I2 BE2013C004 I2 BE 2013C004I2 BE 2013C004 C BE2013C004 C BE 2013C004C BE 2013C004 C BE2013C004 C BE 2013C004C BE 2013C004 I2 BE2013C004 I2 BE 2013C004I2
- Authority
- BE
- Belgium
- Prior art keywords
- group
- substituted
- preparation
- same
- hydrogen atom
- Prior art date
Links
- JKKCZQKHMGGMQT-LWOQYNTDSA-N P(=O)(O)(O)C1S[C@H]2N(C=C1)C(C2)=O Chemical class P(=O)(O)(O)C1S[C@H]2N(C=C1)C(C2)=O JKKCZQKHMGGMQT-LWOQYNTDSA-N 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000001476 phosphono group Chemical group [H]OP(*)(=O)O[H] 0.000 abstract 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- -1 cephem compound Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 150000002430 hydrocarbons Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65613—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system (X = CH2, O, S, NH) optionally with an additional double bond and/or substituents, e.g. cephalosporins and analogs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP35149997 | 1997-12-19 | ||
| PCT/JP1998/005709 WO1999032497A1 (fr) | 1997-12-19 | 1998-12-17 | Derives de phosphonocephem, leur procede de preparation et leur utilisation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE2013C004I2 true BE2013C004I2 (en) | 2018-01-29 |
Family
ID=18417716
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE2013C004C BE2013C004I2 (en) | 1997-12-19 | 2013-01-08 | Phosphonocephem derivatives, process for the preparation of the same, and use thereof |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US6417175B1 (hu) |
| EP (2) | EP1043327B1 (hu) |
| JP (3) | JP3467418B2 (hu) |
| KR (1) | KR100384047B1 (hu) |
| CN (2) | CN1679595B (hu) |
| AT (1) | ATE430155T1 (hu) |
| AU (1) | AU1683299A (hu) |
| BE (1) | BE2013C004I2 (hu) |
| CA (1) | CA2314564C (hu) |
| CY (2) | CY1109276T1 (hu) |
| DE (1) | DE69840796D1 (hu) |
| DK (1) | DK1043327T3 (hu) |
| ES (1) | ES2325139T3 (hu) |
| FR (1) | FR13C0008I2 (hu) |
| LU (1) | LU92134I2 (hu) |
| NL (1) | NL300568I2 (hu) |
| PT (1) | PT1043327E (hu) |
| TW (1) | TW473479B (hu) |
| WO (1) | WO1999032497A1 (hu) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1189471C (zh) | 2000-08-10 | 2005-02-16 | 武田药品工业株式会社 | 膦酰基头孢烯化合物 |
| US20070249577A1 (en) * | 2005-05-10 | 2007-10-25 | Hopkins Scott J | Method for reducing the risk of or preventing infection due to surgical or invasive medical procedures |
| US20070238719A1 (en) * | 2005-05-10 | 2007-10-11 | Hopkins Scott J | Method for reducing the risk of or preventing infection due to surgical or invasive medical procedures |
| US20070238720A1 (en) * | 2005-05-10 | 2007-10-11 | Hopkins Scott J | Method for reducing the risk of or preventing infection due to surgical or invasive medical procedures |
| CN101357929B (zh) * | 2007-06-22 | 2010-12-15 | 山东轩竹医药科技有限公司 | 含有巯基噻二唑的头孢菌素衍生物 |
| MX2010003112A (es) * | 2007-09-21 | 2010-08-11 | Astrazeneca Ab | Formas de dosificacion solubles que contienen derivados de cephem adecuados para administracion parenteral. |
| BRPI0916885B8 (pt) * | 2008-08-28 | 2021-05-25 | Astrazeneca Ab | composição farmacêutica |
| CA2753387C (en) * | 2009-02-23 | 2017-01-24 | Forest Laboratories Holdings Limited | Novel cephem compounds useful for the treatment of bacterial infections |
| US20110071114A1 (en) | 2009-09-21 | 2011-03-24 | Forest Laboratories Holdings Ltd. | Compositions and methods for treating bacterial infections using ceftaroline |
| FR2951171A1 (fr) | 2009-10-09 | 2011-04-15 | Novexel | Nouveau sel de sodium d'un compose azabicyclique sous forme enantiomere cristallisee et nouvelles formes polymorphes et pseudopolymorphes ainsi que leur preparation |
| BR112013032415B1 (pt) | 2011-06-17 | 2021-07-27 | Pfizer Anti-Infectives Ab | Processos para preparar compostos e compostos |
| EP2788361A1 (en) | 2011-12-07 | 2014-10-15 | Ranbaxy Laboratories Limited | Process for preparing ceftaroline salts or hydrates thereof |
| JP6301346B2 (ja) * | 2012-10-19 | 2018-03-28 | サンド・アクチエンゲゼルシヤフト | セフタロリンフォサミルの新規製造方法 |
| CN102977124B (zh) * | 2012-12-13 | 2014-11-26 | 山东诚创医药技术开发有限公司 | 7β-[(苯乙酰)氨基]-3-[4-(1-甲基-4-吡啶鎓)-2-噻唑硫基]-3-头孢烯-4-羧酸二苯甲基酯的制备方法 |
| JP2016501903A (ja) * | 2012-12-20 | 2016-01-21 | サンド・アクチエンゲゼルシヤフト | 新規結晶形のセフタロリンフォサミル |
| WO2015127316A1 (en) | 2014-02-21 | 2015-08-27 | Micurx Pharmaceuticals, Inc. | Water-soluble o-carbonyl phosphoramidate prodrugs for therapeutic administration |
| CN106565784B (zh) * | 2016-10-31 | 2019-02-26 | 瑞阳制药有限公司 | 头孢洛林酯二钠盐的纯化方法 |
| CN110872322B (zh) * | 2018-08-29 | 2022-08-02 | 上海博志研新药物技术有限公司 | 乙酸头孢罗膦一水合物及其中间体的制备方法 |
| CN113072567B (zh) * | 2021-03-26 | 2022-10-14 | 海南海灵化学制药有限公司 | 一种拉氧头孢钠合成工艺 |
| CN113214323A (zh) * | 2021-04-30 | 2021-08-06 | 瑞阳制药股份有限公司 | 分段式头孢罗膦高效稳定析晶方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5941999B2 (ja) | 1975-07-24 | 1984-10-11 | 武田薬品工業株式会社 | セフエムまたはベナム化合物の製造法 |
| JPS5511600A (en) * | 1978-07-10 | 1980-01-26 | Fujisawa Pharmaceut Co Ltd | Cephem compound, its salt, their preparation and remedy and prophylactic for microbism containing mainly the same |
| US4268509A (en) * | 1978-07-10 | 1981-05-19 | Fujisawa Pharmaceutical Co., Ltd. | New cephem compounds and processes for preparation thereof |
| FR2511372A1 (fr) | 1981-08-17 | 1983-02-18 | Rhone Poulenc Sante | Nouveaux derives de la cephalosporine et leur preparation |
| JPS5931791A (ja) * | 1982-07-19 | 1984-02-20 | Fujisawa Pharmaceut Co Ltd | 新規セフエム化合物およびその製造法、並びに細菌感染症予防・治療剤 |
| US4563449A (en) * | 1982-07-19 | 1986-01-07 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compounds |
| JPS62238291A (ja) * | 1986-04-10 | 1987-10-19 | Fujisawa Pharmaceut Co Ltd | セフエム化合物および医薬として許容されるその塩 |
| US4978663A (en) * | 1989-08-16 | 1990-12-18 | Hoechst-Roussel Pharmaceuticals Inc. | 5-(1-aminocyclohexyl)-2(1H)-pyridinone compounds which have pharmaceutical utility |
| JP3514495B2 (ja) | 1992-10-02 | 2004-03-31 | エーザイ株式会社 | ハロゲン化アミノチアジアゾリル酢酸誘導体の製造法 |
| JP3927262B2 (ja) * | 1995-07-19 | 2007-06-06 | 武田薬品工業株式会社 | セフェム化合物、その製造法および抗菌組成物 |
| JPH10265488A (ja) * | 1997-03-27 | 1998-10-06 | Takeda Chem Ind Ltd | ホスフォノセフェム誘導体 |
-
1998
- 1998-12-02 TW TW087119933A patent/TW473479B/zh not_active IP Right Cessation
- 1998-12-17 EP EP98961385A patent/EP1043327B1/en not_active Expired - Lifetime
- 1998-12-17 AT AT98961385T patent/ATE430155T1/de active
- 1998-12-17 DE DE69840796T patent/DE69840796D1/de not_active Expired - Lifetime
- 1998-12-17 KR KR10-2000-7006796A patent/KR100384047B1/ko not_active IP Right Cessation
- 1998-12-17 WO PCT/JP1998/005709 patent/WO1999032497A1/ja active IP Right Grant
- 1998-12-17 CA CA002314564A patent/CA2314564C/en not_active Expired - Lifetime
- 1998-12-17 AU AU16832/99A patent/AU1683299A/en not_active Abandoned
- 1998-12-17 US US09/555,949 patent/US6417175B1/en not_active Expired - Lifetime
- 1998-12-17 PT PT98961385T patent/PT1043327E/pt unknown
- 1998-12-17 DK DK98961385T patent/DK1043327T3/da active
- 1998-12-17 JP JP35888798A patent/JP3467418B2/ja not_active Expired - Lifetime
- 1998-12-17 CN CN2005100079635A patent/CN1679595B/zh not_active Expired - Lifetime
- 1998-12-17 EP EP09158866A patent/EP2080765A1/en not_active Withdrawn
- 1998-12-17 ES ES98961385T patent/ES2325139T3/es not_active Expired - Lifetime
- 1998-12-17 CN CNB988122944A patent/CN1194980C/zh not_active Expired - Lifetime
-
2000
- 2000-07-04 JP JP2000206824A patent/JP2001048893A/ja active Pending
-
2009
- 2009-01-16 JP JP2009007750A patent/JP2009114202A/ja not_active Abandoned
- 2009-07-29 CY CY20091100809T patent/CY1109276T1/el unknown
-
2013
- 2013-01-07 CY CY2013003C patent/CY2013003I2/el unknown
- 2013-01-08 BE BE2013C004C patent/BE2013C004I2/fr unknown
- 2013-01-11 NL NL300568C patent/NL300568I2/nl unknown
- 2013-01-16 LU LU92134C patent/LU92134I2/fr unknown
- 2013-02-06 FR FR13C0008C patent/FR13C0008I2/fr active Active
Also Published As
| Publication number | Publication date |
|---|---|
| KR20010015885A (ko) | 2001-02-26 |
| CN1679595B (zh) | 2010-05-12 |
| FR13C0008I1 (hu) | 2013-03-22 |
| CA2314564A1 (en) | 1999-07-01 |
| JP2001048893A (ja) | 2001-02-20 |
| PT1043327E (pt) | 2009-07-02 |
| CN1194980C (zh) | 2005-03-30 |
| CN1282335A (zh) | 2001-01-31 |
| NL300568I1 (hu) | 2016-01-18 |
| CN1679595A (zh) | 2005-10-12 |
| NL300568I2 (hu) | 2016-01-18 |
| JP3467418B2 (ja) | 2003-11-17 |
| AU1683299A (en) | 1999-07-12 |
| CY2013003I2 (el) | 2015-08-05 |
| EP1043327A4 (en) | 2001-12-12 |
| TW473479B (en) | 2002-01-21 |
| WO1999032497A1 (fr) | 1999-07-01 |
| LU92134I2 (fr) | 2013-03-18 |
| JP2009114202A (ja) | 2009-05-28 |
| FR13C0008I2 (fr) | 2013-08-16 |
| CA2314564C (en) | 2008-11-18 |
| ES2325139T3 (es) | 2009-08-26 |
| CY1109276T1 (el) | 2014-07-02 |
| DK1043327T3 (da) | 2009-08-17 |
| EP1043327B1 (en) | 2009-04-29 |
| DE69840796D1 (de) | 2009-06-10 |
| CY2013003I1 (el) | 2014-07-02 |
| ATE430155T1 (de) | 2009-05-15 |
| EP2080765A1 (en) | 2009-07-22 |
| US6417175B1 (en) | 2002-07-09 |
| JPH11255772A (ja) | 1999-09-21 |
| EP1043327A1 (en) | 2000-10-11 |
| KR100384047B1 (ko) | 2003-05-14 |
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