BE1004486A3 - Formulations a liberation prolongee de peptides solubles dans l'eau. - Google Patents

Formulations a liberation prolongee de peptides solubles dans l'eau. Download PDF

Info

Publication number
BE1004486A3
BE1004486A3 BE9000693A BE9000693A BE1004486A3 BE 1004486 A3 BE1004486 A3 BE 1004486A3 BE 9000693 A BE9000693 A BE 9000693A BE 9000693 A BE9000693 A BE 9000693A BE 1004486 A3 BE1004486 A3 BE 1004486A3
Authority
BE
Belgium
Prior art keywords
microparticles
water
days
polymer
emulsion
Prior art date
Application number
BE9000693A
Other languages
English (en)
French (fr)
Original Assignee
Sandoz Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Sa filed Critical Sandoz Sa
Application granted granted Critical
Publication of BE1004486A3 publication Critical patent/BE1004486A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/095—Oxytocins; Vasopressins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/23—Calcitonins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/31—Somatostatins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
BE9000693A 1989-07-07 1990-07-05 Formulations a liberation prolongee de peptides solubles dans l'eau. BE1004486A3 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37702389A 1989-07-07 1989-07-07
US41134789A 1989-09-22 1989-09-22

Publications (1)

Publication Number Publication Date
BE1004486A3 true BE1004486A3 (fr) 1992-12-01

Family

ID=27007654

Family Applications (1)

Application Number Title Priority Date Filing Date
BE9000693A BE1004486A3 (fr) 1989-07-07 1990-07-05 Formulations a liberation prolongee de peptides solubles dans l'eau.

Country Status (27)

Country Link
JP (5) JPH0832624B2 (cs)
KR (2) KR100303681B1 (cs)
AT (1) AT406225B (cs)
AU (2) AU641407B2 (cs)
BE (1) BE1004486A3 (cs)
CA (1) CA2020477C (cs)
CH (1) CH685230A5 (cs)
CY (1) CY1965A (cs)
DE (2) DE4021517B4 (cs)
DK (1) DK175849B1 (cs)
FI (3) FI108611B (cs)
FR (1) FR2649319A1 (cs)
GB (2) GB2234896B (cs)
GR (1) GR1001121B (cs)
HK (2) HK97695A (cs)
HU (2) HU221294B1 (cs)
IE (2) IE64216B1 (cs)
IL (3) IL131881A (cs)
IT (1) IT1241460B (cs)
LU (1) LU87764A1 (cs)
MY (1) MY106722A (cs)
NL (1) NL195027C (cs)
NO (2) NO302928B1 (cs)
NZ (1) NZ234384A (cs)
PT (1) PT94628B (cs)
SE (1) SE512992C2 (cs)
SG (1) SG26416G (cs)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4990336A (en) * 1989-02-08 1991-02-05 Biosearch, Inc. Sustained release dosage form
YU48420B (sh) * 1991-03-25 1998-07-10 Hoechst Aktiengesellschaft Postupak za dobijanje biološki razgradljivih mikročestica sa dugotrajnim delovanjem
CH683149A5 (fr) * 1991-07-22 1994-01-31 Debio Rech Pharma Sa Procédé pour la préparation de microsphères en matériau polymère biodégradable.
US6013853A (en) * 1992-02-14 2000-01-11 The University Of Texas System Continuous release polymeric implant carrier
US5876452A (en) * 1992-02-14 1999-03-02 Board Of Regents, University Of Texas System Biodegradable implant
DE4218510A1 (de) * 1992-06-02 1993-12-09 Pharmatech Gmbh Verfahren zur Herstellung biologisch abbaubarer Polyester
AU4198793A (en) † 1992-07-24 1994-01-27 Takeda Chemical Industries Ltd. Microparticle preparation and production thereof
EP0626170A3 (en) * 1993-05-10 1996-03-27 Sandoz Ltd Stabilization of pharmacologically active compounds in delayed release agents.
GB9310781D0 (en) * 1993-05-25 1993-07-14 Davis Stanley S Preparation of microparticles
US5603960A (en) * 1993-05-25 1997-02-18 O'hagan; Derek T. Preparation of microparticles and method of immunization
JP3645906B2 (ja) 1993-11-19 2005-05-11 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ マイクロカプセル封入された３−ピペリジニル−置換１，２−ベンズイソオキサゾール類及び１，２−ベンズイソチアゾール類
JP2000500744A (ja) 1995-11-09 2000-01-25 マイクロバイオロジカル リサーチ オーソリティー ワクチン接種および遺伝子治療のためのマイクロカプセル化ｄｎａ
US6270795B1 (en) 1995-11-09 2001-08-07 Microbiological Research Authority Method of making microencapsulated DNA for vaccination and gene therapy
DE19545257A1 (de) 1995-11-24 1997-06-19 Schering Ag Verfahren zur Herstellung von morphologisch einheitlichen Mikrokapseln sowie nach diesem Verfahren hergestellte Mikrokapseln
US5817343A (en) * 1996-05-14 1998-10-06 Alkermes, Inc. Method for fabricating polymer-based controlled-release devices
US5968895A (en) * 1996-12-11 1999-10-19 Praecis Pharmaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
US6126919A (en) 1997-02-07 2000-10-03 3M Innovative Properties Company Biocompatible compounds for pharmaceutical drug delivery systems
GB9810236D0 (en) * 1998-05-13 1998-07-08 Microbiological Res Authority Improvements relating to encapsulation of bioactive agents
US6632457B1 (en) * 1998-08-14 2003-10-14 Incept Llc Composite hydrogel drug delivery systems
US6226656B1 (en) 1998-11-12 2001-05-01 Sourcefinder, Inc. System and method for creating, generating and processing user-defined generic specs
US7107268B1 (en) 1998-11-12 2006-09-12 Printable Technologies, Inc. Centralized system and method for managing enterprise operations
US6204308B1 (en) 1999-03-01 2001-03-20 Novartis Ag Organic compounds
EP1044683A1 (en) * 1999-04-15 2000-10-18 Debio Recherche Pharmaceutique S.A. One-step dispersion method for the microencapsulation of water soluble substances
US6461631B1 (en) * 1999-11-16 2002-10-08 Atrix Laboratories, Inc. Biodegradable polymer composition
KR100392501B1 (ko) * 2000-06-28 2003-07-22 동국제약 주식회사 다중 에멀젼법에 의한 서방출성 미립구의 제조방법
US6824822B2 (en) * 2001-08-31 2004-11-30 Alkermes Controlled Therapeutics Inc. Ii Residual solvent extraction method and microparticles produced thereby
JP2004516262A (ja) 2000-12-21 2004-06-03 ネクター セラピューティクス 親水性活性剤を含有するマイクロ粒子の製造のための誘発相転移法
US20040097419A1 (en) * 2002-11-19 2004-05-20 Holger Petersen Organic compounds
AR044852A1 (es) * 2003-06-24 2005-10-05 Novartis Ag Una composicion farmaceutica para la administracion parenteral que comprende un analogo de somatostatina
US8343513B2 (en) * 2003-07-18 2013-01-01 Oakwood Laboratories, Llc Prevention of molecular weight reduction of the polymer, impurity formation and gelling in polymer compositions
MY158342A (en) 2003-11-14 2016-09-30 Novartis Ag Pharmaceutical composition
US20070259047A1 (en) * 2004-02-26 2007-11-08 Yasuaki Ogawa Protein Sustained-Release Microparticle Preparation for Injection and Process for Producing the Same
DE102004053373A1 (de) * 2004-11-02 2006-05-04 Justus-Liebig-Universität Giessen Erfindung betreffend anisometrische Partikel in Form von Nano-/Meso-Fasern -Röhren, -Kabeln -Bändern und deren gekrümmte oder verzweigte Abwandlungen
KR100741867B1 (ko) * 2005-07-05 2007-07-24 전북대학교산학협력단 수중유적 및 용매 증발법을 이용한 이중층 미립구의제조방법
PT2359809T (pt) * 2005-12-22 2019-11-04 Novartis Ag Formulação de libertação sustentada que compreende octreótido e dois ou mais polímeros poliláctido-co-glicólido
KR100816065B1 (ko) 2006-11-27 2008-03-24 동국제약 주식회사 초기 방출억제 특성이 우수한 서방출성 마이크로캡슐의제조방법 및 이에 의해 제조되는 마이크로캡슐
PT2247282E (pt) 2008-01-30 2014-11-11 Novartis Ag Formulação de libertação controlada compreendendo octreotido e três polímeros lineares de polilactido-coglicolido
USRE49251E1 (en) 2010-01-04 2022-10-18 Mapi Pharma Ltd. Depot systems comprising glatiramer or pharmacologically acceptable salt thereof
US20120083444A1 (en) * 2010-09-30 2012-04-05 Brenda Perkins Emulsion Method For Preparing Low Residual Solvent Microparticles
RU2013119811A (ru) * 2010-09-30 2014-11-10 Эвоник Корпорейшн Способ удаления остаточного органического растворителя из микрочастиц
TW201605488A (zh) 2013-10-15 2016-02-16 大塚製藥股份有限公司 用以預防及／或治療多囊腎病之藥物
KR102464650B1 (ko) 2016-05-03 2022-11-10 엘에스일렉트릭(주) 배선용 차단기의 한류장치
US12097292B2 (en) 2016-08-28 2024-09-24 Mapi Pharma Ltd. Process for preparing microparticles containing glatiramer acetate
HUE062393T2 (hu) 2016-08-31 2023-11-28 Mapi Pharma Ltd Glatiramer-acetátot tartalmazó depórendszerek
CA3050086A1 (en) 2017-03-26 2018-10-04 Mapi Pharma Ltd. Glatiramer depot systems for treating progressive forms of multiple sclerosis

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2070153A1 (cs) * 1969-10-23 1971-09-10 Du Pont
FR2400950A1 (fr) * 1977-08-25 1979-03-23 Sandoz Sa Procede de preparation de microspheres comportant un noyau solide et une matiere polymere
EP0142272A1 (en) * 1983-10-11 1985-05-22 The Administrators Of The Tulane University Educational Fund Peptides and their use in therapy
EP0145240A2 (en) * 1983-11-04 1985-06-19 Takeda Chemical Industries, Ltd. Method for producing Microcapsule
EP0190833A2 (en) * 1985-02-07 1986-08-13 Takeda Chemical Industries, Ltd. Method for producing microcapsule

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4622244A (en) * 1979-09-04 1986-11-11 The Washington University Process for preparation of microcapsules
US4293539A (en) * 1979-09-12 1981-10-06 Eli Lilly And Company Controlled release formulations and method of treatment
ATE2512T1 (de) * 1979-11-27 1983-03-15 Sandoz Ag Polypeptide, verfahren zu ihrer herstellung, pharmazeutische zusammensetzungen, die diese polypeptide enthalten, und ihre verwendung.
US4389330A (en) * 1980-10-06 1983-06-21 Stolle Research And Development Corporation Microencapsulation process
US4675189A (en) * 1980-11-18 1987-06-23 Syntex (U.S.A.) Inc. Microencapsulation of water soluble active polypeptides
PH19942A (en) * 1980-11-18 1986-08-14 Sintex Inc Microencapsulation of water soluble polypeptides
IE52535B1 (en) * 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
EP0092918B1 (en) * 1982-04-22 1988-10-19 Imperial Chemical Industries Plc Continuous release formulations
CH656884A5 (de) * 1983-08-26 1986-07-31 Sandoz Ag Polyolester, deren herstellung und verwendung.
JPH0657658B2 (ja) * 1985-04-11 1994-08-03 住友製薬株式会社 徐放性製剤
GB8331158D0 (en) * 1983-11-22 1983-12-29 British Telecomm Metal/semiconductor deposition
JPS60181029A (ja) * 1984-02-29 1985-09-14 Toyo Jozo Co Ltd 徐放性製剤の製法
CH660302A5 (fr) * 1984-10-17 1987-04-15 Debiopharm Sa Procede de micro-encapsulation en phase heterogene de substances medicamenteuses hydrosolubles.
US4725577A (en) * 1985-04-25 1988-02-16 Administrators Of The Tulane Educational Fund Biologically active lysine containing octapeptides
CH665558A5 (en) * 1985-10-09 1988-05-31 Debiopharm Sa Phase sepn. prodn. of microcapsules for water soluble pharmaceuticals - using fluoro-substd. aliphatic hydrocarbon as non-solvent in the hardening stage
JP2539789B2 (ja) * 1986-03-06 1996-10-02 日本原子力研究所 ポリラクトンからなる徐放性薬物複合体の製造方法
GB2193891B (en) * 1986-08-18 1990-07-25 Sandoz Ltd Nasal pharmaceutical composition containing a somatostatin anologue.
JPH0725689B2 (ja) * 1986-10-07 1995-03-22 中外製薬株式会社 顆粒球コロニ−刺激因子を含有する徐放性製剤
GB2209937B (en) * 1987-09-21 1991-07-03 Depiopharm S A Water insoluble polypeptides
CH672887A5 (cs) * 1987-10-14 1990-01-15 Debiopharm Sa
DE3738228A1 (de) * 1987-11-11 1989-05-24 Hoechst Ag Verfahren zur herstellung von bioabbaubaren mikrokapseln wasserloeslicher peptide und proteine sowie nach diesem verfahren erhaltene mikrokapseln
JP2653255B2 (ja) * 1990-02-13 1997-09-17 武田薬品工業株式会社 長期徐放型マイクロカプセル

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2070153A1 (cs) * 1969-10-23 1971-09-10 Du Pont
FR2400950A1 (fr) * 1977-08-25 1979-03-23 Sandoz Sa Procede de preparation de microspheres comportant un noyau solide et une matiere polymere
EP0142272A1 (en) * 1983-10-11 1985-05-22 The Administrators Of The Tulane University Educational Fund Peptides and their use in therapy
EP0145240A2 (en) * 1983-11-04 1985-06-19 Takeda Chemical Industries, Ltd. Method for producing Microcapsule
EP0190833A2 (en) * 1985-02-07 1986-08-13 Takeda Chemical Industries, Ltd. Method for producing microcapsule

Also Published As

Publication number Publication date
ATA144090A (de) 1999-08-15
FR2649319B1 (cs) 1994-12-09
SG26416G (en) 1995-09-01
FI20000060L (fi) 2000-01-12
HU211602A9 (en) 1995-12-28
AU5874690A (en) 1991-01-10
CA2020477C (en) 2000-11-21
JP2931773B2 (ja) 1999-08-09
CY1965A (en) 1997-07-04
MY106722A (en) 1995-07-31
DE4021517B4 (de) 2009-04-09
GR1001121B (el) 1993-04-28
SE9002364D0 (sv) 1990-07-05
CH685230A5 (de) 1995-05-15
NO983923D0 (no) 1998-08-26
DE4042752B4 (de) 2009-05-07
NO903001L (no) 1991-01-08
DE4021517A1 (de) 1991-01-17
FI109543B (fi) 2002-08-30
IT9048113A0 (it) 1990-07-05
GB9014704D0 (en) 1990-08-22
IL94983A0 (en) 1991-06-10
IL131880A (en) 2001-12-23
IL94983A (en) 1999-08-17
JPH0832624B2 (ja) 1996-03-29
NL195027C (nl) 2003-12-02
FR2649319A1 (fr) 1991-01-11
SE512992C2 (sv) 2000-06-12
NL9001537A (nl) 1991-02-01
FI109334B (fi) 2002-07-15
AU687553B2 (en) 1998-02-26
NZ234384A (en) 1994-05-26
GB2265311A (en) 1993-09-29
NO903001D0 (no) 1990-07-05
KR100303681B1 (ko) 2002-05-16
DK162590A (da) 1991-01-08
PT94628A (pt) 1991-03-20
IL131881A (en) 2001-12-23
IT1241460B (it) 1994-01-17
IE64411B1 (en) 1995-08-09
KR910002430A (ko) 1991-02-25
CA2020477A1 (en) 1991-01-08
AU2332195A (en) 1995-09-07
GB2265311B (en) 1994-02-09
PT94628B (pt) 1997-06-30
JPH07285853A (ja) 1995-10-31
SE9002364L (sv) 1991-01-08
FI108611B (fi) 2002-02-28
LU87764A1 (fr) 1992-03-11
NL195027B (nl) 2003-08-01
AU641407B2 (en) 1993-09-23
JPH07309897A (ja) 1995-11-28
GR900100513A (en) 1991-12-10
FI903429A0 (fi) 1990-07-06
JPH0368511A (ja) 1991-03-25
AT406225B (de) 2000-03-27
DK175849B1 (da) 2005-03-29
IE902435A1 (en) 1991-02-13
HK97695A (en) 1995-06-23
DK162590D0 (da) 1990-07-05
HK197496A (en) 1996-11-08
NO320444B1 (no) 2005-12-05
FI20000059L (fi) 2000-01-12
GB9306204D0 (en) 1993-05-19
HUT54037A (en) 1991-01-28
JP2001233897A (ja) 2001-08-28
IE64216B1 (en) 1995-07-26
HU221294B1 (en) 2002-09-28
GB2234896B (en) 1994-01-19
GB2234896A (en) 1991-02-20
HU903974D0 (en) 1990-11-28
KR100442931B1 (ko) 2004-08-02
JPH08198771A (ja) 1996-08-06
NO302928B1 (no) 1998-05-11
NO983923L (no) 1991-01-08
IT9048113A1 (it) 1992-01-05

Similar Documents

Publication Publication Date Title
BE1004486A3 (fr) Formulations a liberation prolongee de peptides solubles dans l'eau.
US5876761A (en) Sustained release formulations of water soluble peptides
EP0585151B1 (fr) Procédé de préparation de microsphères pour la libération prolongée de l'hormone LHRH et ses analogues, microsphères et formulations obtenues
EP1450766B1 (fr) Microspheres biodegradables a liberation prolongee et leur procede de preparation
FR2811227A1 (fr) Vecteurs particulaires destines a ameliorer l'absorption orale de principes actifs
JPH04208217A (ja) 徐放性製剤およびその製造方法
FI106926B (fi) Menetelmä pitkäaikaisesti vapautuvan koostumuksen muodostamiseksi
NL195090C (nl) Preparaten van in water oplosbare peptiden met een langzame afgifte.
FR2762319A1 (fr) Microcapsules presentant une liberation prolongee et leur procede de preparation
FR2762318A1 (fr) Compositions presentant une liberation prolongee et leur procede de preparation
CA2535463A1 (en) Octreotide-pamoate and its use in sustained release formulations of water soluble peptides
WO2003043605A1 (fr) Procede de preparation de microparticules sans solvant toxique, microparticules obtenues selon ce procede, utilisations et compositions pharmaceutiques
FR2830448A1 (fr) Microspheres biodegradables a liberation prolongee et leur procede de preparation
CY1844A (en) Sustained release formulations of water soluble peptides
IL112286A (en) Process for the production of a microparticle and microparticle obtained thereby

Legal Events

Date Code Title Description
RE20 Patent expired

Owner name: *NOVARTIS A.G.

Effective date: 20100705