BE1001159A4 - Nouveaux derives d'ergolene, compositions pharmaceutiques les contenant et procede pour leur preparation. - Google Patents

Nouveaux derives d'ergolene, compositions pharmaceutiques les contenant et procede pour leur preparation. Download PDF

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Publication number
BE1001159A4
BE1001159A4 BE8700445A BE8700445A BE1001159A4 BE 1001159 A4 BE1001159 A4 BE 1001159A4 BE 8700445 A BE8700445 A BE 8700445A BE 8700445 A BE8700445 A BE 8700445A BE 1001159 A4 BE1001159 A4 BE 1001159A4
Authority
BE
Belgium
Prior art keywords
formula
derivative
group
halogen
acyl
Prior art date
Application number
BE8700445A
Other languages
English (en)
French (fr)
Inventor
Tibor Keve Dr
Gabor Megyeri Dr
Bela Stefko Dr
Kovacs Lajos Jr
Kassai Anna
Kiss Bela
Istvan Laszlovszky Dr
Erzsebet Lapis Dr
Eva Palosi Dr
Dora Groo Dr
Laszlo Szporny Dr
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Application granted granted Critical
Publication of BE1001159A4 publication Critical patent/BE1001159A4/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
BE8700445A 1986-04-25 1987-04-24 Nouveaux derives d'ergolene, compositions pharmaceutiques les contenant et procede pour leur preparation. BE1001159A4 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU861719A HU196598B (en) 1986-04-25 1986-04-25 Process for producing 1- and/or 8-substituted 2-halogenated ergoline derivatives and pharmaceutics comprising such compounds

Publications (1)

Publication Number Publication Date
BE1001159A4 true BE1001159A4 (fr) 1989-08-01

Family

ID=10955843

Family Applications (1)

Application Number Title Priority Date Filing Date
BE8700445A BE1001159A4 (fr) 1986-04-25 1987-04-24 Nouveaux derives d'ergolene, compositions pharmaceutiques les contenant et procede pour leur preparation.

Country Status (30)

Country Link
US (1) US4859682A (h)
JP (1) JPS62258379A (h)
KR (1) KR920008167B1 (h)
CN (1) CN87102944A (h)
AT (1) AT391472B (h)
AU (1) AU592637B2 (h)
BE (1) BE1001159A4 (h)
CH (1) CH669791A5 (h)
CS (1) CS268534B2 (h)
DD (1) DD256133A5 (h)
DE (1) DE3713768A1 (h)
DK (1) DK208887A (h)
EG (1) EG18272A (h)
ES (1) ES2007339A6 (h)
FI (1) FI871128A7 (h)
FR (1) FR2597869B1 (h)
GB (1) GB2189487B (h)
GR (1) GR870645B (h)
HU (1) HU196598B (h)
IL (1) IL82324A0 (h)
IN (1) IN165245B (h)
IT (1) IT1203976B (h)
LU (1) LU86853A1 (h)
NL (1) NL8700966A (h)
NO (1) NO165800C (h)
PL (1) PL152619B1 (h)
PT (1) PT84739B (h)
SE (1) SE466401B (h)
SU (1) SU1500161A3 (h)
ZA (1) ZA872931B (h)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU196394B (en) * 1986-06-27 1988-11-28 Richter Gedeon Vegyeszet Process for preparing 2-halogenated ergoline derivatives
EP1465887A1 (en) * 2002-04-30 2004-10-13 Teva Gyogyszergyar Reszvenytarsasag Novel crystal forms of ondansetron, processes for their preparation, pharmaceutical compositions containing the novel forms and methods for treating nausea using them
WO2023018480A1 (en) * 2021-08-09 2023-02-16 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Selective psychedelic compounds

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2740792A1 (de) * 1976-09-15 1978-03-16 Lilly Co Eli Verfahren zur herstellung von 2-chlorergolinderivaten
EP0251732A2 (en) * 1986-06-27 1988-01-07 Richter Gedeon Vegyeszeti Gyar R.T. Process for the preparation of 2-halogenated ergoline derivatives

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE237837C (h) *
DE1936410A1 (de) * 1969-07-17 1971-02-11 Hoechst Ag O-Acyl-lysergole und Verfahren zu ihrer Herstellung
AR206772A1 (es) * 1972-07-21 1976-08-23 Lilly Co Eli Procedimiento para preparar una nueva d-2-halo-6-metil-8-ciano(carboxamido)metil ergolina
US3992385A (en) * 1975-01-20 1976-11-16 Eli Lilly And Company 2,3-Dihydroergolines
CH619709A5 (en) * 1975-03-14 1980-10-15 Siphar Sa Process for the preparation of carbamates of 2-halogenoergolines and 2-halogenoergolenes
DE2656344A1 (de) * 1975-12-23 1977-07-07 Sandoz Ag Ergolinderivate, ihre verwendung und herstellung
US4035094A (en) * 1976-03-11 1977-07-12 Trw Inc. Ball and socket joint
DK75177A (da) * 1976-04-27 1977-10-28 Sandoz Ag Fremgangsmade til fremstilling af prostaglandiner
DE3001752A1 (de) * 1980-01-16 1981-07-30 Schering Ag Berlin Und Bergkamen, 1000 Berlin Verfahren zur herstellung von 8(alpha)-substituierten 6-methylergolinen
DE3151912A1 (de) * 1981-12-23 1983-06-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue ergolin-aminoderivate, verfahren zu ihrer herstellung und deren verwendung als arzneimittel
DD237837A1 (de) * 1983-11-29 1986-07-30 1086 Berlin,Otto-Nuscke-Str. 2/23,Dd Verfahren zur herstellung von 2-bromergolinen
DE3403067A1 (de) * 1984-01-30 1985-08-14 Eckart Prof. Dr. 6500 Mainz Eich Ergolin-derivate, verfahren zu ihrer herstellung, sie enthaltende arzneimittel und deren verwendung
DE3413657A1 (de) * 1984-04-09 1985-10-17 Schering AG, 1000 Berlin und 4709 Bergkamen Neue ergoline
HU193781B (en) * 1985-06-21 1987-11-30 Richter Gedeon Vegyeszet Process for producing 10alpha-methoxy-6-methylergoline derivatives and acid additional salts thereof
US4782152A (en) * 1985-08-16 1988-11-01 Eli Lilly And Company Decyanation of pergolide intermediate

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2740792A1 (de) * 1976-09-15 1978-03-16 Lilly Co Eli Verfahren zur herstellung von 2-chlorergolinderivaten
EP0251732A2 (en) * 1986-06-27 1988-01-07 Richter Gedeon Vegyeszeti Gyar R.T. Process for the preparation of 2-halogenated ergoline derivatives

Also Published As

Publication number Publication date
AU7194587A (en) 1987-10-29
GB2189487B (en) 1990-05-23
FI871128A0 (fi) 1987-03-13
AU592637B2 (en) 1990-01-18
PT84739A (en) 1987-05-01
CS268534B2 (en) 1990-03-14
IN165245B (h) 1989-09-09
DK208887A (da) 1987-10-26
NO165800C (no) 1991-04-10
NL8700966A (nl) 1987-11-16
CS292087A2 (en) 1989-06-13
DE3713768A1 (de) 1987-10-29
IT8720271A0 (it) 1987-04-24
DK208887D0 (da) 1987-04-24
NO871721D0 (no) 1987-04-24
US4859682A (en) 1989-08-22
PT84739B (pt) 1989-12-29
SE466401B (sv) 1992-02-10
FR2597869A1 (fr) 1987-10-30
ES2007339A6 (es) 1989-06-16
EG18272A (en) 1993-04-30
FI871128A7 (fi) 1987-10-26
SU1500161A3 (ru) 1989-08-07
GB2189487A (en) 1987-10-28
SE8701700D0 (sv) 1987-04-24
CN87102944A (zh) 1987-11-25
ZA872931B (h) 1987-10-19
SE8701700L (sv) 1987-10-26
PL265357A1 (en) 1988-07-21
JPH0462316B2 (h) 1992-10-05
DD256133A5 (de) 1988-04-27
ATA102287A (de) 1990-04-15
NO165800B (no) 1991-01-02
IT1203976B (it) 1989-02-23
PL152619B1 (en) 1991-01-31
CH669791A5 (h) 1989-04-14
HU196598B (en) 1988-12-28
LU86853A1 (de) 1987-08-12
NO871721L (no) 1987-10-26
FR2597869B1 (fr) 1991-04-26
GR870645B (en) 1987-08-28
IL82324A0 (en) 1987-10-30
AT391472B (de) 1990-10-10
KR870010051A (ko) 1987-11-30
GB8709893D0 (en) 1987-06-03
JPS62258379A (ja) 1987-11-10
KR920008167B1 (ko) 1992-09-24

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: RICHTER GEDEON VEGYESZETI GYAR R.T.

Effective date: 19940430