AU758150B2 - Antimicrobial/endotoxin neutralizing polypeptide - Google Patents

Antimicrobial/endotoxin neutralizing polypeptide Download PDF

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Publication number
AU758150B2
AU758150B2 AU28226/00A AU2822600A AU758150B2 AU 758150 B2 AU758150 B2 AU 758150B2 AU 28226/00 A AU28226/00 A AU 28226/00A AU 2822600 A AU2822600 A AU 2822600A AU 758150 B2 AU758150 B2 AU 758150B2
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AU
Australia
Prior art keywords
polypeptide
cluster
amino acids
endotoxin
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU28226/00A
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English (en)
Other versions
AU2822600A (en
Inventor
David M. Mann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ENDOGEN RESEARCH PH AB
Original Assignee
ENDOGEN RES PH AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ENDOGEN RES PH AB filed Critical ENDOGEN RES PH AB
Publication of AU2822600A publication Critical patent/AU2822600A/en
Application granted granted Critical
Publication of AU758150B2 publication Critical patent/AU758150B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/08—Antibacterial agents for leprosy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU28226/00A 1999-02-05 2000-01-27 Antimicrobial/endotoxin neutralizing polypeptide Ceased AU758150B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/245527 1999-02-05
US09/245,527 US6399570B1 (en) 1999-02-05 1999-02-05 Antimicrobial/endotoxin neutralizing polypeptide
PCT/IB2000/000271 WO2000049040A2 (fr) 1999-02-05 2000-01-27 Polypeptide antimicrobien/neutralisant des endotoxines

Publications (2)

Publication Number Publication Date
AU2822600A AU2822600A (en) 2000-09-04
AU758150B2 true AU758150B2 (en) 2003-03-13

Family

ID=22927039

Family Applications (1)

Application Number Title Priority Date Filing Date
AU28226/00A Ceased AU758150B2 (en) 1999-02-05 2000-01-27 Antimicrobial/endotoxin neutralizing polypeptide

Country Status (12)

Country Link
US (2) US6399570B1 (fr)
EP (1) EP1151009B1 (fr)
JP (1) JP2002541066A (fr)
CN (1) CN1362969A (fr)
AT (1) ATE373679T1 (fr)
AU (1) AU758150B2 (fr)
CA (1) CA2362153C (fr)
DE (1) DE60036456T2 (fr)
DK (1) DK1151009T3 (fr)
ES (1) ES2293892T3 (fr)
MX (1) MXPA01007956A (fr)
WO (1) WO2000049040A2 (fr)

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IL94183A (en) * 1989-05-05 2003-09-17 Baylor College Medicine cDNA SEQUENCE CODING FOR HUMAN LACTOFERRIN PROTEIN OR PORTION THEREOF AND LACTOFERRIN PROTEIN PRODUCED FROM SAID SEQUENCE
US6399570B1 (en) 1999-02-05 2002-06-04 Agennix, Inc. Antimicrobial/endotoxin neutralizing polypeptide
US7060677B1 (en) 1999-11-11 2006-06-13 Am-Pharma B.V. Antimicrobial activity of the first cationic cluster of human lactoferrin
EP1507554B1 (fr) * 2002-05-10 2011-08-10 Agennix Incorporated Lactoferrine dans le traitement de tumeurs malignes et autres maladies hyperproliferatives
WO2003099207A2 (fr) * 2002-05-24 2003-12-04 Agennix Incorporated Lactoferrine par voie orale dans le traitement des troubles respiratoires
EP2298338B1 (fr) 2002-09-16 2012-08-22 Agennix Incorporated Compositions à base de lactoferrine et méthodes de traitement des plaies cutanées.
CA2508912A1 (fr) * 2002-12-06 2004-06-24 Agennix Incorporated Lactoferrine orale pour le traitement des sepsies
US7592306B2 (en) * 2002-12-10 2009-09-22 Agennix, Inc. Lactoferrin as an agent in the prevention of organ transplant rejection and graft-versus-host-disease
US7034126B2 (en) 2003-05-14 2006-04-25 Agennix, Inc. Lactoferrin in the treatment of diabetes mellitus
WO2005046571A2 (fr) * 2003-06-06 2005-05-26 Agennix Incorporated Lactoferrine en tant qu'adjuvant de vaccins contre le cancer
WO2005018542A2 (fr) * 2003-07-10 2005-03-03 Agennix Incorporated Utilisation de lactoferrine dans une prophylaxie dirigee contre une infection et/ou contre une inflammation, chez des patients immunosupprimes
WO2005085287A1 (fr) * 2004-03-03 2005-09-15 En-N-Tech, Inc. Traitements pour la reduction de contaminants dans des preparations de lactoferrines et compositions contenant des lactoferrines
US7183381B2 (en) * 2004-10-26 2007-02-27 Agennix, Inc. Composition of lactoferrin related peptides and uses thereof
MX2008008548A (es) 2005-12-30 2008-09-10 Evonik Roehm Gmbh Peptidos utiles como petidos penetradores de celulas.
EP2050461A1 (fr) 2007-10-19 2009-04-22 PharmaSurgics in Sweden AB Peptides basées sur la séquence de lactoferrin humain et leur utilisation
EP2060586A1 (fr) * 2007-11-14 2009-05-20 PharmaSurgics in Sweden AB Nouveaux peptides synthétiques d'arginine substitué et leur utilisation
US20090209488A1 (en) * 2008-02-19 2009-08-20 Roger Wayne Brown Compositions for the treatment of exercise induced asthma
US20090208588A1 (en) * 2008-02-19 2009-08-20 Roger Wayne Brown GERD carbohydrate compositions
US20090209486A1 (en) * 2008-02-19 2009-08-20 Roger Wayne Brown Compositions of carbohydrates as dietary supplements
US20090209489A1 (en) * 2008-02-19 2009-08-20 Roger Wayne Brown Compositions for the treatment of diabetis, system PH disorders, high blood pressure, and a cancer marker system
US20090209487A1 (en) * 2008-02-19 2009-08-20 Roger Wayne Brown Compositions of carbohydrates as dietary supplements
CN101294188B (zh) * 2008-06-20 2011-06-15 江南大学 乳铁蛋白抗菌肽及其制备方法与它们的用途
JP5177901B2 (ja) * 2009-12-02 2013-04-10 株式会社明治 栄養組成物
CN101798337B (zh) * 2010-01-29 2013-04-24 中国人民解放军第三军医大学第一附属医院 内毒素中和肽突变体及其应用
EP2481751A1 (fr) * 2011-01-26 2012-08-01 PharmaSurgics in Sweden AB Homme peptides dérivés de lactoferrine
JP5763024B2 (ja) * 2012-09-07 2015-08-12 株式会社明治 栄養組成物
WO2014124047A1 (fr) 2013-02-06 2014-08-14 Academia Sinica Peptides antimicrobiens issus du domaine riche en arginine de la protéine cœur du virus de l'hépatite b
US20170296629A1 (en) * 2014-10-08 2017-10-19 Keio University Inhibitor of extracellular trap formation in leukocyte
KR101891455B1 (ko) 2014-11-03 2018-08-27 메르크 파텐트 게엠베하 생체분자를 정제하기 위한 가용성 인테인 융합 단백질 및 방법
AU2017270201A1 (en) * 2016-05-27 2018-11-29 Academia Sinica Modified antimicrobial peptide derived from an arginine-rich domain
CN105999236A (zh) * 2016-07-06 2016-10-12 方雅悯 一种治疗牛乳房炎的药剂及其应用

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US5571697A (en) 1989-05-05 1996-11-05 Baylor College Of Medicine Texas Medical Center Expression of processed recombinant lactoferrin and lactoferrin polypeptide fragments from a fusion product in Aspergillus
US6100054A (en) 1989-05-05 2000-08-08 Baylor College Of Medicine Production for recombinant lactoferrin and lactoferrin polypeptides using DNA sequences in various organisms
IL94183A (en) 1989-05-05 2003-09-17 Baylor College Medicine cDNA SEQUENCE CODING FOR HUMAN LACTOFERRIN PROTEIN OR PORTION THEREOF AND LACTOFERRIN PROTEIN PRODUCED FROM SAID SEQUENCE
US5571691A (en) * 1989-05-05 1996-11-05 Baylor College Of Medicine Production of recombinant lactoferrin and lactoferrin polypeptides using CDNA sequences in various organisms
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EP1507554B1 (fr) 2002-05-10 2011-08-10 Agennix Incorporated Lactoferrine dans le traitement de tumeurs malignes et autres maladies hyperproliferatives
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Also Published As

Publication number Publication date
WO2000049040A3 (fr) 2000-12-14
ES2293892T3 (es) 2008-04-01
DE60036456T2 (de) 2008-06-19
CN1362969A (zh) 2002-08-07
CA2362153A1 (fr) 2000-08-24
ATE373679T1 (de) 2007-10-15
WO2000049040A2 (fr) 2000-08-24
US6399570B1 (en) 2002-06-04
EP1151009B1 (fr) 2007-09-19
CA2362153C (fr) 2009-11-24
US7244706B2 (en) 2007-07-17
JP2002541066A (ja) 2002-12-03
DE60036456D1 (de) 2007-10-31
DK1151009T3 (da) 2008-01-28
MXPA01007956A (es) 2004-08-19
AU2822600A (en) 2000-09-04
US20030105006A1 (en) 2003-06-05
EP1151009A2 (fr) 2001-11-07

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FGA Letters patent sealed or granted (standard patent)
NB Applications allowed - extensions of time section 223(2)

Free format text: THE TIME IN WHICH TO PROVIDE SEARCH RESULTS UNDER S45(3) HAS BEEN EXTENDED TO 20040401