AU730302B2 - Microparticulate form of a tetrahydropyridin derivative - Google Patents

Microparticulate form of a tetrahydropyridin derivative Download PDF

Info

Publication number
AU730302B2
AU730302B2 AU56685/98A AU5668598A AU730302B2 AU 730302 B2 AU730302 B2 AU 730302B2 AU 56685/98 A AU56685/98 A AU 56685/98A AU 5668598 A AU5668598 A AU 5668598A AU 730302 B2 AU730302 B2 AU 730302B2
Authority
AU
Australia
Prior art keywords
microparticulate form
micrometers
ethyl
naphthyl
trifluoromethylphenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU56685/98A
Other languages
English (en)
Other versions
AU5668598A (en
Inventor
Antoine Caron
Jean-Pierre Chambon
Olivier Monnier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo SA filed Critical Sanofi Synthelabo SA
Publication of AU5668598A publication Critical patent/AU5668598A/en
Assigned to SANOFI-SYNTHELABO reassignment SANOFI-SYNTHELABO Amend patent request/document other than specification (104) Assignors: SANOFI
Application granted granted Critical
Publication of AU730302B2 publication Critical patent/AU730302B2/en
Assigned to SANOFI-AVENTIS reassignment SANOFI-AVENTIS Request to Amend Deed and Register Assignors: SANOFI-SYNTHELABO
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU56685/98A 1996-12-23 1997-12-23 Microparticulate form of a tetrahydropyridin derivative Ceased AU730302B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR96/15905 1996-12-23
FR9615905A FR2757510B1 (fr) 1996-12-23 1996-12-23 Forme microparticulaire d'un derive de tetrahydropyridine
PCT/FR1997/002394 WO1998028272A1 (fr) 1996-12-23 1997-12-23 Forme microparticulaire d'un derive de tetrahydropyridine

Publications (2)

Publication Number Publication Date
AU5668598A AU5668598A (en) 1998-07-17
AU730302B2 true AU730302B2 (en) 2001-03-01

Family

ID=9499044

Family Applications (1)

Application Number Title Priority Date Filing Date
AU56685/98A Ceased AU730302B2 (en) 1996-12-23 1997-12-23 Microparticulate form of a tetrahydropyridin derivative

Country Status (37)

Country Link
US (4) US20020028247A1 (forum.php)
EP (1) EP0950051B1 (forum.php)
JP (2) JP4422214B2 (forum.php)
KR (1) KR100455797B1 (forum.php)
CN (1) CN1088698C (forum.php)
AR (1) AR009673A1 (forum.php)
AT (1) ATE250032T1 (forum.php)
AU (1) AU730302B2 (forum.php)
BR (1) BR9714177A (forum.php)
CA (1) CA2275593C (forum.php)
CO (1) CO4920213A1 (forum.php)
CZ (1) CZ294272B6 (forum.php)
DE (1) DE69724999T2 (forum.php)
DK (1) DK0950051T3 (forum.php)
DZ (1) DZ2386A1 (forum.php)
EE (1) EE04112B1 (forum.php)
EG (1) EG24749A (forum.php)
ES (1) ES2207758T3 (forum.php)
FR (1) FR2757510B1 (forum.php)
HU (1) HU224348B1 (forum.php)
IL (1) IL129937A (forum.php)
IN (1) IN186977B (forum.php)
IS (1) IS2064B (forum.php)
MY (1) MY126298A (forum.php)
NO (1) NO311569B1 (forum.php)
NZ (1) NZ336129A (forum.php)
PL (1) PL190098B1 (forum.php)
PT (1) PT950051E (forum.php)
RU (1) RU2193031C2 (forum.php)
SI (1) SI0950051T1 (forum.php)
SK (1) SK283917B6 (forum.php)
TR (1) TR199901362T2 (forum.php)
TW (1) TW534820B (forum.php)
UA (1) UA66776C2 (forum.php)
WO (1) WO1998028272A1 (forum.php)
YU (1) YU49427B (forum.php)
ZA (1) ZA9711579B (forum.php)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100579514C (zh) * 2001-07-06 2010-01-13 生命周期药物公司 通过受控制的凝聚而制备颗粒物的方法以及提高生物利用度的方法
BE1015641A4 (fr) * 2003-05-26 2005-07-05 Mariani Jean Paul Micronisation 70.
RU2472490C1 (ru) * 2011-08-05 2013-01-20 Открытое акционерное общество "Биосинтез" Средство для лечения кожных гнойных инфекций, составы и способы получения

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0101381A1 (fr) * 1982-08-16 1984-02-22 Sanofi S.A. Trifluorométhylphényltétrahydropyridines à activité anorexigène, un procédé de préparation et compositions pharmaceutiques

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US562883A (en) * 1896-06-30 Thill-coupling
US4826689A (en) * 1984-05-21 1989-05-02 University Of Rochester Method for making uniformly sized particles from water-insoluble organic compounds
FR2627696B1 (fr) * 1988-02-26 1991-09-13 Fournier Innovation Synergie Nouvelle forme galenique du fenofibrate
FR2639226B1 (fr) * 1988-11-18 1993-11-05 Sanofi Utilisation de trifluoromethylphenyltetrahydropyridines pour la preparation de medicaments destines a combattre les troubles anxio-depressifs
FR2662355B1 (fr) * 1990-05-22 1994-11-10 Sanofi Sa Utilisation de la 1-[2-(2-naphtyl)ethyl]-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine pour la preparation de medicaments destines au traitement de troubles cerebraux et neuronaux.
WO1994009898A1 (de) * 1992-10-26 1994-05-11 Schwarz Pharma Ag Verfahren zur herstellung von mikrokapseln
US5560932A (en) * 1995-01-10 1996-10-01 Nano Systems L.L.C. Microprecipitation of nanoparticulate pharmaceutical agents
US5662883A (en) * 1995-01-10 1997-09-02 Nanosystems L.L.C. Microprecipitation of micro-nanoparticulate pharmaceutical agents
US6489334B2 (en) * 1996-12-23 2002-12-03 Sanofi-Synthelabo Method for the crystallization of a tetrahydropyridin derivative and resulting crystalline forms
FR2763847B1 (fr) * 1997-05-28 2003-06-06 Sanofi Sa Utilisation de tetrahydropyridines 4-substituees pour fabriquer des medicaments agissant sur le tgf-beta-1
US20020147216A1 (en) * 2000-01-31 2002-10-10 Yuhong Zhou Mucin synthesis inhibitors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0101381A1 (fr) * 1982-08-16 1984-02-22 Sanofi S.A. Trifluorométhylphényltétrahydropyridines à activité anorexigène, un procédé de préparation et compositions pharmaceutiques

Also Published As

Publication number Publication date
US20080255365A1 (en) 2008-10-16
RU2193031C2 (ru) 2002-11-20
TW534820B (en) 2003-06-01
US20100021541A1 (en) 2010-01-28
EP0950051A1 (fr) 1999-10-20
ATE250032T1 (de) 2003-10-15
WO1998028272A1 (fr) 1998-07-02
CO4920213A1 (es) 2000-05-29
FR2757510A1 (fr) 1998-06-26
HUP0001181A3 (en) 2003-03-28
CN1088698C (zh) 2002-08-07
NO993077L (no) 1999-06-22
AR009673A1 (es) 2000-04-26
JP2009280581A (ja) 2009-12-03
TR199901362T2 (xx) 1999-09-21
DE69724999D1 (de) 2003-10-23
DE69724999T2 (de) 2004-07-22
UA66776C2 (uk) 2004-06-15
SK82999A3 (en) 1999-12-10
HU224348B1 (hu) 2005-08-29
EG24749A (en) 2010-07-20
CN1241179A (zh) 2000-01-12
YU28899A (sh) 2000-03-21
JP4422214B2 (ja) 2010-02-24
NO993077D0 (no) 1999-06-22
KR100455797B1 (ko) 2004-11-06
IS5077A (is) 1999-06-10
IL129937A (en) 2002-09-12
DZ2386A1 (fr) 2002-12-28
US20020028247A1 (en) 2002-03-07
ZA9711579B (en) 1998-06-25
IL129937A0 (en) 2000-02-29
YU49427B (sh) 2006-01-16
CZ229199A3 (cs) 1999-09-15
MY126298A (en) 2006-09-29
PL190098B1 (pl) 2005-10-31
SK283917B6 (sk) 2004-05-04
FR2757510B1 (fr) 2000-01-07
NZ336129A (en) 2000-11-24
HK1024000A1 (en) 2000-09-29
AU5668598A (en) 1998-07-17
EE04112B1 (et) 2003-08-15
KR20000069503A (ko) 2000-11-25
CA2275593C (en) 2005-12-20
JP2001507013A (ja) 2001-05-29
ES2207758T3 (es) 2004-06-01
SI0950051T1 (en) 2004-02-29
CA2275593A1 (en) 1998-07-02
PT950051E (pt) 2004-02-27
DK0950051T3 (da) 2004-01-26
CZ294272B6 (cs) 2004-11-10
BR9714177A (pt) 2000-02-29
IS2064B (is) 2005-11-15
US20020192292A1 (en) 2002-12-19
EP0950051B1 (fr) 2003-09-17
HUP0001181A2 (hu) 2000-11-28
IN186977B (forum.php) 2001-12-22
EE9900263A (et) 2000-02-15
PL334276A1 (en) 2000-02-14
NO311569B1 (no) 2001-12-10

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Legal Events

Date Code Title Description
TC Change of applicant's name (sec. 104)

Owner name: SANOFI-SYNTHELABO

Free format text: FORMER NAME: SANOFI

FGA Letters patent sealed or granted (standard patent)