AU656832B2 - Anti-rheumatic naphthyridine derivatives - Google Patents

Anti-rheumatic naphthyridine derivatives Download PDF

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Publication number
AU656832B2
AU656832B2 AU31587/93A AU3158793A AU656832B2 AU 656832 B2 AU656832 B2 AU 656832B2 AU 31587/93 A AU31587/93 A AU 31587/93A AU 3158793 A AU3158793 A AU 3158793A AU 656832 B2 AU656832 B2 AU 656832B2
Authority
AU
Australia
Prior art keywords
group
formula
represents hydrogen
alkyl group
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU31587/93A
Other languages
English (en)
Other versions
AU3158793A (en
Inventor
Bernard John Armitage
John Gareth Bowen
Malcolm John Crossley
Ian Michael Hunneyball
Bruce William Leslie
Thomas Kerr Miller
Michael Spowage
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boots Co PLC
Original Assignee
Boots Co PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boots Co PLC filed Critical Boots Co PLC
Publication of AU3158793A publication Critical patent/AU3158793A/en
Application granted granted Critical
Publication of AU656832B2 publication Critical patent/AU656832B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU31587/93A 1991-12-23 1992-12-12 Anti-rheumatic naphthyridine derivatives Ceased AU656832B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB919127252A GB9127252D0 (en) 1991-12-23 1991-12-23 Therapeutic agents
GB9127252 1991-12-23
PCT/EP1992/002901 WO1993013097A1 (en) 1991-12-23 1992-12-12 Anti-rheumatic naphthyridine derivatives
CN93109454A CN1096784A (zh) 1991-12-23 1993-06-22 含取代4(5)-氨基-1,8-二氨杂萘的治疗剂

Publications (2)

Publication Number Publication Date
AU3158793A AU3158793A (en) 1993-07-28
AU656832B2 true AU656832B2 (en) 1995-02-16

Family

ID=36822317

Family Applications (1)

Application Number Title Priority Date Filing Date
AU31587/93A Ceased AU656832B2 (en) 1991-12-23 1992-12-12 Anti-rheumatic naphthyridine derivatives

Country Status (22)

Country Link
US (1) US5464781A (OSRAM)
EP (1) EP0618916B1 (OSRAM)
JP (1) JP2527917B2 (OSRAM)
CN (1) CN1096784A (OSRAM)
AT (1) ATE171452T1 (OSRAM)
AU (1) AU656832B2 (OSRAM)
BG (1) BG98813A (OSRAM)
CA (1) CA2125858A1 (OSRAM)
CZ (1) CZ153594A3 (OSRAM)
DE (1) DE69227125T2 (OSRAM)
FI (1) FI943019A7 (OSRAM)
GB (1) GB9127252D0 (OSRAM)
HR (1) HRP921455A2 (OSRAM)
HU (1) HUT66971A (OSRAM)
IL (1) IL104169A0 (OSRAM)
IN (1) IN174405B (OSRAM)
MX (1) MX9207494A (OSRAM)
NO (1) NO942376L (OSRAM)
NZ (1) NZ246156A (OSRAM)
SI (1) SI9200408A (OSRAM)
SK (1) SK75094A3 (OSRAM)
WO (1) WO1993013097A1 (OSRAM)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9312891D0 (en) * 1993-06-22 1993-08-04 Boots Co Plc Therapeutic agents
GB9318931D0 (en) * 1993-09-14 1993-10-27 Boots Co Plc Therapeutic agents
GB9420168D0 (en) * 1994-10-06 1994-11-23 Boots Co Plc Therapeutic agents
AR004010A1 (es) 1995-10-11 1998-09-30 Glaxo Group Ltd Compuestos heterociclicos
CA2263479A1 (en) 1996-09-25 1998-04-02 Zeneca Limited Quinoline derivatives inhibiting the effect of growth factors such as vegf
RS49779B (sr) 1998-01-12 2008-06-05 Glaxo Group Limited, Biciklična heteroaromatična jedinjenja kao inhibitori protein tirozin kinaze
US6166069A (en) * 1998-05-12 2000-12-26 American Home Products Corporation Phenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
US6933299B1 (en) 1999-07-09 2005-08-23 Smithkline Beecham Corporation Anilinoquinazolines as protein tyrosine kinase inhibitors
DE60037020T2 (de) 1999-07-09 2008-08-21 Glaxo Group Ltd., Greenford Anilinochinazoline als protein-tyrosin-kinasehemmer
CN1240688C (zh) 2000-04-07 2006-02-08 阿斯特拉曾尼卡有限公司 喹唑啉化合物
US6534656B2 (en) * 2001-05-31 2003-03-18 North Carolina State University Short synthesis of pyridine-based pharmaceutical intermediates
JP2003329989A (ja) * 2002-03-06 2003-11-19 Nippon Telegr & Teleph Corp <Ntt> 光送信装置
GB0230018D0 (en) 2002-12-23 2003-01-29 Syngenta Ltd Fungicides
US8309562B2 (en) * 2003-07-03 2012-11-13 Myrexis, Inc. Compounds and therapeutical use thereof
US7618975B2 (en) 2003-07-03 2009-11-17 Myriad Pharmaceuticals, Inc. 4-arylamino-quinazolines and analogs as activators of caspases and inducers of apoptosis and the use thereof
WO2005063739A1 (en) 2003-12-23 2005-07-14 Pfizer Inc. Novel quinoline derivatives
US8258145B2 (en) * 2005-01-03 2012-09-04 Myrexis, Inc. Method of treating brain cancer
CA2592900A1 (en) 2005-01-03 2006-07-13 Myriad Genetics Inc. Nitrogen containing bicyclic compounds and therapeutical use thereof
EP1971611B1 (en) * 2005-12-21 2012-10-10 Abbott Laboratories Anti-viral compounds
CA2633760A1 (en) * 2005-12-21 2007-07-05 Abbott Laboratories Anti-viral compounds
NZ569817A (en) * 2005-12-21 2011-10-28 Abbott Lab Anti-viral compounds
TW200738707A (en) * 2005-12-21 2007-10-16 Abbott Lab Anti-viral compounds
EP2345652A1 (en) 2005-12-21 2011-07-20 Abbott Laboratories Antiviral compounds
US8236950B2 (en) 2006-12-20 2012-08-07 Abbott Laboratories Anti-viral compounds
BRPI0914936A2 (pt) * 2008-07-03 2015-10-20 Merck Patent Gmbh naftiridininonas como inibidores de aurora quinase
ES2432070T3 (es) 2009-02-24 2013-11-29 Respiratorius Ab Diazaheteroarilos broncodilatadores novedosos
WO2011063398A1 (en) * 2009-11-23 2011-05-26 Cylene Pharamaceuticals, Inc. Polymorphs and salts of a kinase inhibitor
RU2605549C2 (ru) 2010-04-02 2016-12-20 Синомикс, Инк. Производные 3-карбокси-4-аминохинолина, полезные как модификаторы сладкого вкуса

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4466965A (en) * 1982-07-26 1984-08-21 American Hospital Supply Corporation Phthalazine compounds, compositions and use
NO174506B (no) * 1984-10-30 1994-02-07 Usv Pharma Corp Analogifremgangsmaate ved fremstilling av terapeutisk aktive forbindelser
EP0222839A4 (en) * 1985-05-17 1988-11-09 Univ Australian ANTI-MALARIA COMPOUNDS.
JPS6368568A (ja) * 1986-09-10 1988-03-28 Otsuka Pharmaceut Factory Inc ｐ−アミノフエノ−ル誘導体
DE3644825A1 (de) * 1986-12-31 1988-07-14 Basf Ag Substituierte 1,8-naphthyridin-derivate und diese enthaltende fungizide
JPH07116187B2 (ja) * 1987-07-22 1995-12-13 シェリング・コーポレーション 二環式化合物、それらを薬剤として使用すること、それらの製法、およびそれらの製造に有用な中間体
GB8804443D0 (en) * 1988-02-25 1988-03-23 Smithkline Beckman Intercredit Compounds
US4978661A (en) * 1988-09-29 1990-12-18 Innocenzo Caruso Use of 6-halo-4-quinolone compounds and pharmaceutical compositions thereof for the preparation of a medicament for the therapeutical application in rheumatoid arthritis
GR900100380A (el) * 1989-05-20 1991-10-10 Fisons Plc Μέ?οδος παρασκευής αντι-φλεγμονωδών παραγώγων αμινοφενόλης.
AU634561B2 (en) * 1989-07-27 1993-02-25 Eli Lilly And Company Naphthyridine derivatives
JP2988739B2 (ja) * 1990-04-16 1999-12-13 協和醗酵工業株式会社 １，８−ナフチリジン−２−オン誘導体
JP3157077B2 (ja) * 1994-02-16 2001-04-16 内山工業株式会社 ベアリングシール

Also Published As

Publication number Publication date
JPH07502280A (ja) 1995-03-09
NO942376D0 (OSRAM) 1994-06-22
AU3158793A (en) 1993-07-28
NO942376L (no) 1994-06-22
US5464781A (en) 1995-11-07
JP2527917B2 (ja) 1996-08-28
CZ153594A3 (en) 1995-02-15
SK75094A3 (en) 1995-04-12
BG98813A (bg) 1995-05-31
DE69227125T2 (de) 1999-02-18
EP0618916B1 (en) 1998-09-23
HUT66971A (en) 1995-01-30
CA2125858A1 (en) 1993-07-08
HRP921455A2 (en) 1994-12-31
NZ246156A (en) 1996-01-26
MX9207494A (es) 1993-07-01
ATE171452T1 (de) 1998-10-15
DE69227125D1 (de) 1998-10-29
IL104169A0 (en) 1993-05-13
EP0618916A1 (en) 1994-10-12
FI943019A0 (fi) 1994-06-22
IN174405B (OSRAM) 1994-11-26
GB9127252D0 (en) 1992-02-19
WO1993013097A1 (en) 1993-07-08
HU9401877D0 (en) 1994-09-28
SI9200408A (en) 1993-09-30
FI943019A7 (fi) 1994-06-22
CN1096784A (zh) 1994-12-28

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