AU634073B2 - A process for the preparation of an agent with the active substance flupirtine to combat muscular tension and the use of flupirtine for such purpose - Google Patents

A process for the preparation of an agent with the active substance flupirtine to combat muscular tension and the use of flupirtine for such purpose Download PDF

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Publication number
AU634073B2
AU634073B2 AU80403/91A AU8040391A AU634073B2 AU 634073 B2 AU634073 B2 AU 634073B2 AU 80403/91 A AU80403/91 A AU 80403/91A AU 8040391 A AU8040391 A AU 8040391A AU 634073 B2 AU634073 B2 AU 634073B2
Authority
AU
Australia
Prior art keywords
flupirtine
muscular tension
agent
disorders
consequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU80403/91A
Other languages
English (en)
Other versions
AU8040391A (en
Inventor
Peter Emig
Jurgen Engel
Michael Lobisch
Bernd Nickel
Istvan Szelenyi
Ralph Venhaus
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva GmbH
Original Assignee
Asta Medica GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asta Medica GmbH filed Critical Asta Medica GmbH
Publication of AU8040391A publication Critical patent/AU8040391A/en
Assigned to ASTA MEDICA AKTIENGESELLSCHAFT reassignment ASTA MEDICA AKTIENGESELLSCHAFT Amend patent request/document other than specification (104) Assignors: ASTA-PHARMA AKTIENGESELLSCHAFT
Application granted granted Critical
Publication of AU634073B2 publication Critical patent/AU634073B2/en
Assigned to AWD.PHARMA GMBH & CO. KG reassignment AWD.PHARMA GMBH & CO. KG Alteration of Name(s) in Register under S187 Assignors: ASTA MEDICA AKTIENGESELLSCHAFT
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02Muscle relaxants, e.g. for tetanus or cramps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Golf Clubs (AREA)
  • Details Of Television Scanning (AREA)
  • Paints Or Removers (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AU80403/91A 1990-07-14 1991-07-12 A process for the preparation of an agent with the active substance flupirtine to combat muscular tension and the use of flupirtine for such purpose Expired AU634073B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4022442 1990-07-14
DE4022442 1990-07-14
IN421CA1991 IN172468B (cs) 1990-07-14 1991-06-04

Publications (2)

Publication Number Publication Date
AU8040391A AU8040391A (en) 1992-01-16
AU634073B2 true AU634073B2 (en) 1993-02-11

Family

ID=25895002

Family Applications (1)

Application Number Title Priority Date Filing Date
AU80403/91A Expired AU634073B2 (en) 1990-07-14 1991-07-12 A process for the preparation of an agent with the active substance flupirtine to combat muscular tension and the use of flupirtine for such purpose

Country Status (30)

Country Link
US (2) US5162346A (cs)
EP (2) EP0467164B1 (cs)
KR (1) KR0182811B1 (cs)
CN (1) CN1070700C (cs)
AT (2) ATE206919T1 (cs)
AU (1) AU634073B2 (cs)
CA (1) CA2046943C (cs)
CZ (1) CZ280879B6 (cs)
DE (3) DE59107331D1 (cs)
DK (2) DK0467164T3 (cs)
EG (1) EG19814A (cs)
ES (2) ES2082887T3 (cs)
GR (1) GR3019179T3 (cs)
HR (1) HRP920667B1 (cs)
HU (1) HU206973B (cs)
IE (1) IE74688B1 (cs)
IL (1) IL98810A (cs)
IN (1) IN172468B (cs)
LT (1) LT3593B (cs)
LV (1) LV10048B (cs)
MC (1) MC2272A1 (cs)
MX (1) MX9100160A (cs)
NO (1) NO912758L (cs)
NZ (1) NZ238940A (cs)
PT (1) PT98291B (cs)
RO (1) RO108220B1 (cs)
RU (1) RU2070408C1 (cs)
SI (1) SI9111227B (cs)
SK (1) SK279567B6 (cs)
ZA (1) ZA915466B (cs)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0560092B1 (de) * 1992-03-11 1997-12-03 ASTA Medica Aktiengesellschaft Tabletten, Granulate und Pellets mit hohem Gehalt an Wirkstoffen für hochkonzentrierte, feste Darreichungsformen
DE4319649A1 (de) * 1993-03-18 1994-09-22 Asta Medica Ag Feste Flupirtin enthaltende orale Darreichungsformen mit kontrollierter Wirkstoffabgabe
DE4327516A1 (de) * 1993-08-17 1995-02-23 Asta Medica Ag Primäre und sekundäre neuroprotektive Wirkung bei neurodegenerativen Erkrankungen von Flupirtin
GB9426079D0 (en) * 1994-12-23 1995-02-22 Orion Yhtymae Oy A gelatine capsule
DE19541405A1 (de) * 1995-11-07 1997-05-15 Asta Medica Ag Verwendung von Flupirtin zur Prophylaxe und Therapie von Erkrankungen, die mit einer Beeinträchtigung des hämatopoetischen Zellsystems einhergehen
US6284794B1 (en) 1996-11-05 2001-09-04 Head Explorer Aps Method for treating tension-type headache with inhibitors of nitric oxide and nitric oxide synthase
US6610324B2 (en) * 1999-04-07 2003-08-26 The Mclean Hospital Corporation Flupirtine in the treatment of fibromyalgia and related conditions
MXPA02000997A (es) * 1999-08-03 2003-10-14 Awd Pharma Gmbh & Co Kg Uso de flupirtina para aliviar el dolor ocasionado por enfermedades degenerativas de las articulaciones en perros y gatos.
US6821995B1 (en) 1999-12-01 2004-11-23 Duke University Method of treating batten disease
US20040122090A1 (en) * 2001-12-07 2004-06-24 Lipton Stuart A. Methods for treating neuropsychiatric disorders with nmda receptor antagonists
RU2213565C1 (ru) * 2002-06-24 2003-10-10 Общество с ограниченной ответственностью "Паркинфарм" Способ лечебного воздействия на организм пациента при лечении болезни паркинсона
DE10255415A1 (de) * 2002-11-28 2004-06-09 Bayer Healthcare Ag Dermale Applikation von Flupirtin
DE10327674A1 (de) * 2003-06-20 2005-01-05 Awd.Pharma Gmbh & Co. Kg Injizierbare Darreichungsform von Flupirtin
US20050089559A1 (en) 2003-10-23 2005-04-28 Istvan Szelenyi Combinations of potassium channel openers and sodium channel inhibitors or sodium channel-influencing active compounds for treating pains
DE102004001558A1 (de) * 2004-01-10 2005-08-18 Bayer Healthcare Ag Arzneimittel zur topischen Applikation bei Tieren
US20050196461A1 (en) * 2004-01-14 2005-09-08 Udell Ronald G. Ceramide formulations suitable for oral administration
EP1715843A1 (en) * 2004-01-29 2006-11-02 Neuromolecular Inc. Combination of a nmda receptor antagonist and a mao-inhibitor or a gadph-inhibitor for the treatment of central nervous system-related conditions
US20050220862A1 (en) * 2004-03-31 2005-10-06 Bernstein Joel E Compositions with reduced hepatotoxicity
US7619007B2 (en) * 2004-11-23 2009-11-17 Adamas Pharmaceuticals, Inc. Method and composition for administering an NMDA receptor antagonist to a subject
EP1688141A1 (en) * 2005-01-31 2006-08-09 elbion AG The use of flupirtine for the treatment of overactive bladder and associated diseases, and for the treatment of irritable bowel syndrome
ATE481096T1 (de) 2005-04-06 2010-10-15 Adamas Pharmaceuticals Inc Verfahren und zusammensetzungen zur behandlung von zns-erkrankungen
JP2009535370A (ja) * 2006-05-02 2009-10-01 クリス ルントフェルト ジストニアおよびジストニア様症状の予防および治療におけるカリウムチャンネル活性剤
US7960436B2 (en) 2006-06-05 2011-06-14 Valeant Pharmaceuticals International Substituted arylamino-1,2,3,4-tetrahydro naphthalenes and-2,3-dihydro-1H-indenes as potassium channel modulators
WO2008024398A2 (en) * 2006-08-23 2008-02-28 Valeant Pharmaceuticals International Derivatives of 4-(n-azacycloalkyl) anilides as potassium channel modulators
US8993593B2 (en) * 2006-08-23 2015-03-31 Valeant Pharmaceuticals International N-(4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2,6-dimethylphenyl)-3,3-dimethylbutanamide as potassium channel modulators
US8722929B2 (en) * 2006-10-10 2014-05-13 Valeant Pharmaceuticals International N-[2-amino-4-(phenylmethoxy)phenyl] amides and related compounds as potassium channel modulators
KR20090083479A (ko) * 2006-11-28 2009-08-03 밸리언트 파마슈티컬즈 인터내셔널 칼륨 채널 조절제로서의 1,4 디아미노 이환 레티가빈 유사체
US20080279930A1 (en) * 2007-05-07 2008-11-13 Bernd Terhaag Controlled-Release Flupirtine Compositions, Compacts, Kits and Methods of Making and Use Thereof
US8367684B2 (en) * 2007-06-13 2013-02-05 Valeant Pharmaceuticals International Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators
MX2010001171A (es) * 2007-08-01 2010-03-01 Lundbeck & Co As H Uso de abridores de canales de potasio kcnq para reducir los sintomas o tratar desordenes o afecciones en las cuales se encuentra anulado el sistema dopaminergico.
US8563566B2 (en) * 2007-08-01 2013-10-22 Valeant Pharmaceuticals International Naphthyridine derivatives as potassium channel modulators
US7786146B2 (en) * 2007-08-13 2010-08-31 Valeant Pharmaceuticals International Derivatives of 5-amino-4,6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators
ES2347119B2 (es) * 2009-04-22 2011-04-28 Universidad De Santiago De Compostela Nanocapsulas de poliarginina.
DE102010030053A1 (de) 2010-06-14 2011-12-15 Awd.Pharma Gmbh & Co.Kg Injizierbare Darreichungsform von Flupirtin
JP6251667B2 (ja) * 2014-06-03 2017-12-20 アサヒカルピスウェルネス株式会社 錠剤型即放性製剤及びその製造方法
DE102017007385A1 (de) 2017-08-02 2019-02-07 Christoph Hoock Maleatfreie feste Arzneimittelformen
IL292005B2 (en) 2019-10-10 2025-05-01 Xenon Pharmaceuticals Inc Solid-state crystalline forms of N-[4-(6-fluoro-3,4-dihydro-H1-isoquinolin-2-yl)-2,6-dimethylphenyl]-3,3-dimethylbutanamide
JP2022553569A (ja) 2019-11-08 2022-12-23 ゼノン・ファーマシューティカルズ・インコーポレイテッド うつ病性障害の治療方法
CN116847843A (zh) 2021-02-09 2023-10-03 泽农医药公司 用于治疗快感缺乏的电压门控的钾通道开放剂

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5260486A (en) * 1985-01-23 1986-07-31 Degussa A.G. Synergistic flupirtine and non-steroidal antiinflammatories
AU5254886A (en) * 1985-06-28 1987-01-08 Degussa A.G. Pharmaceutical composition of flupirtine and 4-acetamidophenol

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1795858C2 (de) 1968-07-19 1979-01-11 Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler, 6000 Frankfurt Benzylaminopyridine
DE3133519A1 (de) 1980-09-13 1982-06-09 Degussa Ag, 6000 Frankfurt "2-amino-3-carbethoxyamino-6-(p-fluor-benzylamino)-pyridin-maleat"
EP0193056B1 (de) * 1985-02-23 1989-06-07 ASTA Pharma Aktiengesellschaft Kombination von Flupirtin und anticholinergisch wirkenden Spasmolytika
DE3604575A1 (de) * 1985-02-23 1986-08-28 Degussa Ag, 6000 Frankfurt Kombination von flupirtin und anticholinergisch wirkenden spasmolytika

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5260486A (en) * 1985-01-23 1986-07-31 Degussa A.G. Synergistic flupirtine and non-steroidal antiinflammatories
AU5254886A (en) * 1985-06-28 1987-01-08 Degussa A.G. Pharmaceutical composition of flupirtine and 4-acetamidophenol

Also Published As

Publication number Publication date
NO912758D0 (no) 1991-07-12
EP0659410A3 (de) 1995-10-25
NO912758L (no) 1992-01-15
CA2046943A1 (en) 1992-01-15
EP0467164B1 (de) 1996-01-31
HRP920667A2 (en) 1996-10-31
ATE206919T1 (de) 2001-11-15
DE59109222D1 (de) 2001-11-22
LTIP919A (en) 1995-03-27
SI9111227B (sl) 2000-12-31
IN172468B (cs) 1993-08-14
DK0467164T3 (da) 1996-03-04
MC2272A1 (fr) 1993-06-23
CS210191A3 (en) 1992-02-19
ES2164111T3 (es) 2002-02-16
AU8040391A (en) 1992-01-16
DE4122166A1 (de) 1992-01-16
EP0467164A3 (en) 1992-04-15
EP0659410A2 (de) 1995-06-28
EP0659410B1 (de) 2001-10-17
ATE133564T1 (de) 1996-02-15
KR920002147A (ko) 1992-02-28
US5284861A (en) 1994-02-08
RO108220B1 (ro) 1994-03-31
RU2070408C1 (ru) 1996-12-20
MX9100160A (es) 1992-02-28
PT98291A (pt) 1992-05-29
HRP920667B1 (en) 1998-06-30
HU912359D0 (en) 1991-12-30
SI9111227A (en) 1995-06-30
LV10048B (en) 1995-06-20
EP0467164A2 (de) 1992-01-22
ES2082887T3 (es) 1996-04-01
HUT59313A (en) 1992-05-28
IL98810A0 (en) 1992-07-15
IL98810A (en) 1996-01-19
LV10048A (lv) 1994-05-10
LT3593B (en) 1995-12-27
KR0182811B1 (ko) 1999-05-01
DE59107331D1 (de) 1996-03-14
IE912451A1 (en) 1992-01-15
CN1070700C (zh) 2001-09-12
GR3019179T3 (en) 1996-06-30
IE74688B1 (en) 1997-07-30
SK279567B6 (sk) 1999-01-11
DK0659410T3 (da) 2001-12-27
NZ238940A (en) 1997-05-26
CZ280879B6 (cs) 1996-04-17
CN1058716A (zh) 1992-02-19
US5162346A (en) 1992-11-10
EG19814A (en) 1996-02-29
CA2046943C (en) 1996-03-12
ZA915466B (en) 1992-04-29
HU206973B (en) 1993-03-01
PT98291B (pt) 1999-01-29

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PC Assignment registered

Owner name: AWD.PHARMA GMBH AND CO. KG

Free format text: FORMER OWNER WAS: ASTA MEDIICA AKTIENGESELLSCHAFT