AU2018373154B2 - Reducing junction epitope presentation for neoantigens - Google Patents

Reducing junction epitope presentation for neoantigens

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Publication number
AU2018373154B2
AU2018373154B2 AU2018373154A AU2018373154A AU2018373154B2 AU 2018373154 B2 AU2018373154 B2 AU 2018373154B2 AU 2018373154 A AU2018373154 A AU 2018373154A AU 2018373154 A AU2018373154 A AU 2018373154A AU 2018373154 B2 AU2018373154 B2 AU 2018373154B2
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AU
Australia
Prior art keywords
sequence
epitopes
peptide
presentation
neoantigens
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AU2018373154A
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English (en)
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AU2018373154A1 (en
Inventor
Thomas Francis Boucher
Brendan BULIK-SULLIVAN
Jennifer BUSBY
Roman YELENSKY
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Seattle Project Corp
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Seattle Project Corp
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Publication of AU2018373154A1 publication Critical patent/AU2018373154A1/en
Assigned to GRITSTONE BIO, INC. reassignment GRITSTONE BIO, INC. Request for Assignment Assignors: GRITSTONE ONCOLOGY, INC.
Assigned to SEATTLE PROJECT CORP. reassignment SEATTLE PROJECT CORP. Request for Assignment Assignors: GRITSTONE BIO, INC.
Application granted granted Critical
Publication of AU2018373154B2 publication Critical patent/AU2018373154B2/en
Priority to AU2025259935A priority Critical patent/AU2025259935A1/en
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Anticipated expiration legal-status Critical

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    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6878—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids in epitope analysis
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/20—Supervised data analysis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Cell Biology (AREA)
  • Theoretical Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Evolutionary Biology (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Data Mining & Analysis (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Databases & Information Systems (AREA)
  • Oncology (AREA)
  • Artificial Intelligence (AREA)
  • Bioethics (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Evolutionary Computation (AREA)
AU2018373154A 2017-11-22 2018-11-21 Reducing junction epitope presentation for neoantigens Active AU2018373154B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2025259935A AU2025259935A1 (en) 2017-11-22 2025-10-30 Reducing junction epitope presentation for neoantigens

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762590045P 2017-11-22 2017-11-22
US62/590,045 2017-11-22
PCT/US2018/062294 WO2019104203A1 (en) 2017-11-22 2018-11-21 Reducing junction epitope presentation for neoantigens

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2025259935A Division AU2025259935A1 (en) 2017-11-22 2025-10-30 Reducing junction epitope presentation for neoantigens

Publications (2)

Publication Number Publication Date
AU2018373154A1 AU2018373154A1 (en) 2020-07-02
AU2018373154B2 true AU2018373154B2 (en) 2025-08-07

Family

ID=66631144

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2018373154A Active AU2018373154B2 (en) 2017-11-22 2018-11-21 Reducing junction epitope presentation for neoantigens
AU2025259935A Pending AU2025259935A1 (en) 2017-11-22 2025-10-30 Reducing junction epitope presentation for neoantigens

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2025259935A Pending AU2025259935A1 (en) 2017-11-22 2025-10-30 Reducing junction epitope presentation for neoantigens

Country Status (8)

Country Link
US (2) US11885815B2 (enExample)
EP (1) EP3714275A4 (enExample)
JP (3) JP2021503897A (enExample)
CN (1) CN111630602A (enExample)
AU (2) AU2018373154B2 (enExample)
CA (1) CA3083097A1 (enExample)
IL (1) IL274799B2 (enExample)
WO (1) WO2019104203A1 (enExample)

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WO2016128060A1 (en) 2015-02-12 2016-08-18 Biontech Ag Predicting t cell epitopes useful for vaccination
AU2016369519B2 (en) 2015-12-16 2023-04-20 Seattle Project Corp. Neoantigen identification, manufacture, and use
WO2017194170A1 (en) 2016-05-13 2017-11-16 Biontech Rna Pharmaceuticals Gmbh Methods for predicting the usefulness of proteins or protein fragments for immunotherapy
WO2018224166A1 (en) 2017-06-09 2018-12-13 Biontech Rna Pharmaceuticals Gmbh Methods for predicting the usefulness of disease specific amino acid modifications for immunotherapy
CA3078744A1 (en) 2017-10-10 2019-04-18 Gritstone Oncology, Inc. Neoantigen identification using hotspots
AU2018373154B2 (en) 2017-11-22 2025-08-07 Seattle Project Corp. Reducing junction epitope presentation for neoantigens
JP2022516639A (ja) 2019-01-03 2022-03-01 エヴァクシオン・バイオテック・アクティエセルスカブ ネオエピトープを標的とするワクチン
JP7665205B2 (ja) 2019-03-11 2025-04-21 エヴァクシオン・バイオテック・アクティエセルスカブ ネオエピトープをコードするコンストラクトを用いた核酸ワクチン接種
JP7454645B2 (ja) 2019-07-16 2024-03-22 ギリアード サイエンシーズ， インコーポレイテッド Ｈｉｖワクチン並びにその作製方法及び使用方法
US20220334129A1 (en) 2019-09-13 2022-10-20 Evaxion Biotech A/S Method for identifying T-cell epitopes
CA3161242A1 (en) 2019-12-18 2021-06-24 Birgitte Rono Nucleic acid vaccination using neo-epitope encoding constructs
CN114929899A (zh) * 2020-01-07 2022-08-19 韩国科学技术院 一种新抗原的筛选方法、系统及其用途
CA3174417A1 (en) 2020-04-07 2021-10-14 Birgitte Rono Neoepitope immunotherapy with apc targeting unit
AU2021307553A1 (en) 2020-07-14 2023-02-16 Evaxion Biotech A/S APC targeting units for immunotherapy
CA3202382A1 (en) * 2020-12-18 2022-06-23 Yeda Research And Development Co. Ltd. Compositions for use in the treatment of chd2 haploinsufficiency and methods of identifying same
JP7693813B2 (ja) 2021-01-14 2025-06-17 ギリアード サイエンシーズ， インコーポレイテッド Ｈｉｖワクチン及び使用方法
CA3216276A1 (en) 2021-04-29 2022-11-03 Yardena Samuels T cell receptors directed against ras-derived recurrent neoantigens and methods of identifying same
KR102475794B1 (ko) * 2022-08-23 2022-12-08 주식회사 테라젠바이오 합성 긴 펩타이드의 면역원성 예측 장치, 면역원성 예측 방법 및 컴퓨터 프로그램

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