AU2018254600B2 - TREM2 antigen binding proteins and uses thereof - Google Patents

TREM2 antigen binding proteins and uses thereof Download PDF

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Publication number
AU2018254600B2
AU2018254600B2 AU2018254600A AU2018254600A AU2018254600B2 AU 2018254600 B2 AU2018254600 B2 AU 2018254600B2 AU 2018254600 A AU2018254600 A AU 2018254600A AU 2018254600 A AU2018254600 A AU 2018254600A AU 2018254600 B2 AU2018254600 B2 AU 2018254600B2
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Prior art keywords
seq
antibody
trem2
sequence
antigen binding
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AU2018254600A1 (en
Inventor
Irwin Chen
Ian DRIVER
Ian Foltz
Susie Miki Harris
Daniel Lu
Shilpa SAMBASHIVAN
Dora TOLEDO WARSHAVIAK
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Amgen Inc
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Amgen Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74—Inducing cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Psychiatry (AREA)
  • Biochemistry (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU2018254600A 2017-04-21 2018-04-20 TREM2 antigen binding proteins and uses thereof Active AU2018254600B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2022221560A AU2022221560B2 (en) 2017-04-21 2022-08-26 TREM2 antigen binding proteins and uses thereof

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201762488691P 2017-04-21 2017-04-21
US62/488,691 2017-04-21
US201762530753P 2017-07-10 2017-07-10
US62/530,753 2017-07-10
US201762580400P 2017-11-01 2017-11-01
US62/580,400 2017-11-01
PCT/US2018/028691 WO2018195506A1 (en) 2017-04-21 2018-04-20 Trem2 antigen binding proteins and uses thereof

Related Child Applications (1)

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AU2022221560A Division AU2022221560B2 (en) 2017-04-21 2022-08-26 TREM2 antigen binding proteins and uses thereof

Publications (2)

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AU2018254600A1 AU2018254600A1 (en) 2019-10-24
AU2018254600B2 true AU2018254600B2 (en) 2022-05-26

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AU2022221560A Active AU2022221560B2 (en) 2017-04-21 2022-08-26 TREM2 antigen binding proteins and uses thereof

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US (2) US11186636B2 (OSRAM)
EP (2) EP4617286A2 (OSRAM)
JP (2) JP7252134B2 (OSRAM)
KR (2) KR20250027855A (OSRAM)
CN (1) CN110709100A (OSRAM)
AU (2) AU2018254600B2 (OSRAM)
BR (1) BR112019021991A2 (OSRAM)
CA (1) CA3060409A1 (OSRAM)
CL (2) CL2019003000A1 (OSRAM)
CO (1) CO2019012998A2 (OSRAM)
CR (2) CR20190525A (OSRAM)
ES (1) ES3035028T3 (OSRAM)
JO (1) JOP20190248A1 (OSRAM)
MA (1) MA52273A (OSRAM)
MX (2) MX2019012364A (OSRAM)
PE (2) PE20200485A1 (OSRAM)
PH (1) PH12019502356A1 (OSRAM)
SG (1) SG11201909646TA (OSRAM)
TW (2) TWI812619B (OSRAM)
UY (1) UY37698A (OSRAM)
WO (1) WO2018195506A1 (OSRAM)

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KR20230130630A (ko) * 2020-12-04 2023-09-12 비질 뉴로사이언스 인코포레이티드 Trem2 작용제를 사용한 atp-결합 카세트 수송체 1 기능장애와 관련된 질환의 치료
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