PL2158315T3 - Sposoby modyfikowania przeciwciał i zmodyfikowane przeciwciała o ulepszonych właściwościach funkcjonalnych - Google Patents
Sposoby modyfikowania przeciwciał i zmodyfikowane przeciwciała o ulepszonych właściwościach funkcjonalnychInfo
- Publication number
- PL2158315T3 PL2158315T3 PL08757278.0T PL08757278T PL2158315T3 PL 2158315 T3 PL2158315 T3 PL 2158315T3 PL 08757278 T PL08757278 T PL 08757278T PL 2158315 T3 PL2158315 T3 PL 2158315T3
- Authority
- PL
- Poland
- Prior art keywords
- antibodies
- methods
- functional properties
- improved functional
- modifying
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93711207P | 2007-06-25 | 2007-06-25 | |
| US6905608P | 2008-03-12 | 2008-03-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2158315T3 true PL2158315T3 (pl) | 2016-10-31 |
Family
ID=39820887
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL08757278.0T PL2158315T3 (pl) | 2007-06-25 | 2008-06-25 | Sposoby modyfikowania przeciwciał i zmodyfikowane przeciwciała o ulepszonych właściwościach funkcjonalnych |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US20090074780A1 (pl) |
| EP (1) | EP2158315B1 (pl) |
| JP (5) | JP5611820B2 (pl) |
| KR (1) | KR101573086B1 (pl) |
| CN (6) | CN101849001B (pl) |
| AU (1) | AU2008267734B9 (pl) |
| BR (1) | BRPI0813645A2 (pl) |
| CA (1) | CA2689941C (pl) |
| DK (1) | DK2158315T3 (pl) |
| ES (1) | ES2566737T3 (pl) |
| HR (1) | HRP20160730T1 (pl) |
| HU (1) | HUE027507T2 (pl) |
| IL (1) | IL202360A (pl) |
| MX (1) | MX2009013328A (pl) |
| NZ (2) | NZ601946A (pl) |
| PL (1) | PL2158315T3 (pl) |
| RU (3) | RU2540150C2 (pl) |
| SI (1) | SI2158315T1 (pl) |
| WO (1) | WO2009000099A2 (pl) |
| ZA (1) | ZA200908384B (pl) |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN2014DN10515A (pl) | 2006-03-31 | 2015-08-21 | Chugai Pharmaceutical Co Ltd | |
| CN101222758B (zh) | 2007-01-08 | 2011-10-26 | 中兴通讯股份有限公司 | 一种在高速分组数据网传递1x寻呼被拒绝的方法 |
| JP5622397B2 (ja) | 2007-03-12 | 2014-11-12 | エスバテック− ア ノバルティス カンパニー エルエルシー | 一本鎖抗体の配列に基づく操作および最適化 |
| DK2158315T3 (en) * | 2007-06-25 | 2016-06-06 | Esbatech Alcon Biomed Res Unit | Methods of modifying antibodies and modified antibodies with improved functional properties |
| AU2008267733B2 (en) | 2007-06-25 | 2013-11-14 | Esbatech, An Alcon Biomedical Research Unit Llc | Sequence based engineering and optimization of single chain antibodies |
| MX336725B (es) | 2007-09-26 | 2016-01-28 | Chugai Pharmaceutical Co Ltd | Metodo de modificacion del punto isoelectrico de anticuerpos medinate la sustitucion de aminoacidos en region de determinacion de complementariedad (cdr). |
| TWI700293B (zh) | 2008-04-11 | 2020-08-01 | 日商中外製藥股份有限公司 | 重複結合複數個抗原的抗體 |
| US9556265B2 (en) | 2008-06-25 | 2017-01-31 | Esbatech, An Alcon Biomedical Research Unit Llc | Solubility optimization of immunobinders |
| CN104004094B (zh) | 2008-06-25 | 2017-09-22 | 艾斯巴技术-诺华有限责任公司 | 使用通用抗体构架进行的兔抗体的人源化 |
| RU2653753C1 (ru) | 2008-06-25 | 2018-05-14 | ИЭсБиЭйТЕК, ЭН АЛЬКОН БАЙОМЕДИКАЛ РИСЕРЧ ЮНИТ ЭлЭлСи | СТАБИЛЬНЫЕ И РАСТВОРИМЫЕ АНТИТЕЛА, ИНГИБИРУЮЩИЕ TNFα |
| HUE032894T2 (hu) | 2008-06-25 | 2017-11-28 | Esbatech Alcon Biomed Res Unit | VEGF-gátló, stabilis és oldható antitestek |
| MX344076B (es) * | 2008-06-30 | 2016-12-05 | Esbatech Alcon Biomed Res Unit | Polipeptidos funcionalizados. |
| WO2010108154A2 (en) | 2009-03-20 | 2010-09-23 | Amgen Inc. | Selective and potent peptide inhibitors of kv1.3 |
| US8399624B1 (en) | 2009-06-25 | 2013-03-19 | Esbatech, An Alcon Biomedical Research Unit Llc | Acceptor framework for CDR grafting |
| US20120231006A1 (en) | 2009-11-20 | 2012-09-13 | Amgen Inc. | Anti-orai1 antigen binding proteins and uses thereof |
| CN103339145A (zh) | 2010-09-22 | 2013-10-02 | 安姆根有限公司 | 运载体免疫球蛋白及其用途 |
| US8962804B2 (en) | 2010-10-08 | 2015-02-24 | City Of Hope | Meditopes and meditope-binding antibodies and uses thereof |
| KR102344129B1 (ko) | 2010-10-08 | 2021-12-30 | 시티 오브 호프 | 메디토프를 위한 단일클론 항체 프레임워크 결합 계면, 메디토프 전달 시스템 및 이의 사용 방법 |
| AR083495A1 (es) * | 2010-10-22 | 2013-02-27 | Esbatech Alcon Biomed Res Unit | Anticuerpos estables y solubles |
| AU2016277637B2 (en) * | 2010-10-22 | 2018-11-08 | Novartis Ag | Stable and soluble antibodies |
| AU2013203189B2 (en) * | 2010-10-22 | 2014-12-11 | Novartis Ag | Stable and soluble antibodies |
| KR102568454B1 (ko) | 2010-11-30 | 2023-08-18 | 추가이 세이야쿠 가부시키가이샤 | 복수 분자의 항원에 반복해서 결합하는 항원 결합 분자 |
| CN104039809A (zh) * | 2011-10-10 | 2014-09-10 | 希望之城公司 | 中间位和中间位结合抗体及其用途 |
| CN109608543A (zh) * | 2011-10-20 | 2019-04-12 | 艾斯巴技术-诺华有限责任公司 | 稳定的多抗原结合抗体 |
| US9428553B2 (en) | 2012-02-10 | 2016-08-30 | City Of Hope | Meditopes and meditope-binding antibodies and uses thereof |
| CA2872908C (en) | 2012-05-10 | 2023-11-14 | Gerhard Frey | Multi-specific monoclonal antibodies |
| EP3597747B1 (en) | 2012-08-24 | 2023-03-15 | Chugai Seiyaku Kabushiki Kaisha | Mouse fcgammarii-specific fc antibody |
| TWI855488B (zh) | 2012-08-24 | 2024-09-11 | 日商中外製藥股份有限公司 | FcγRIIb特異性Fc區域變異體 |
| AU2014250434B2 (en) | 2013-04-02 | 2019-08-08 | Chugai Seiyaku Kabushiki Kaisha | Fc region variant |
| IL243311B (en) | 2013-06-26 | 2022-07-01 | Numab Therapeutics AG | New frameworks for antibodies |
| CN104341501B (zh) * | 2013-07-29 | 2019-08-30 | 上海睿智化学研究有限公司 | 抗IL-1β人源化单克隆抗体及其制备方法和应用 |
| KR20250099289A (ko) | 2014-05-16 | 2025-07-01 | 아블린쓰 엔.브이. | 개선된 면역글로불린 가변 도메인 |
| HUE050007T2 (hu) | 2014-05-16 | 2020-11-30 | Ablynx Nv | Immunglobulin variábilis domének |
| CA2960756C (en) | 2014-09-15 | 2023-08-01 | Amgen Inc. | Bi-specific anti-cgrp receptor/pac1 receptor antigen binding proteins and uses thereof |
| TWI656133B (zh) | 2014-12-19 | 2019-04-11 | 日商中外製藥股份有限公司 | 抗肌抑素之抗體、含變異Ｆｃ區域之多胜肽及使用方法 |
| WO2016125495A1 (en) | 2015-02-05 | 2016-08-11 | Chugai Seiyaku Kabushiki Kaisha | Antibodies comprising an ion concentration dependent antigen-binding domain, fc region variants, il-8-binding antibodies, and uses therof |
| AU2016323440B2 (en) | 2015-09-15 | 2023-07-13 | Amgen Inc. | Tetravalent bispecific and tetraspecific antigen binding proteins and uses thereof |
| EP3390447A1 (en) | 2015-12-15 | 2018-10-24 | Amgen Inc. | Pacap antibodies and uses thereof |
| WO2017110981A1 (en) | 2015-12-25 | 2017-06-29 | Chugai Seiyaku Kabushiki Kaisha | Anti-myostatin antibodies and methods of use |
| KR20180111870A (ko) | 2016-02-25 | 2018-10-11 | 셀 메디카 스위처란트 아게 | Pd-l1에 대한 결합 성분 |
| CN109689099B (zh) | 2016-08-05 | 2023-02-28 | 中外制药株式会社 | 用于预防或治疗il-8相关疾病的组合物 |
| SG10201607778XA (en) | 2016-09-16 | 2018-04-27 | Chugai Pharmaceutical Co Ltd | Anti-Dengue Virus Antibodies, Polypeptides Containing Variant Fc Regions, And Methods Of Use |
| MX2019005552A (es) | 2016-11-14 | 2019-08-12 | Amgen Inc | Proteinas de union a antigenos biespecificas o biparatopicas y usos de las mismas. |
| AU2018237046B2 (en) * | 2017-03-20 | 2024-11-14 | Cancer Therapeutics Laboratories, Inc. | Humanized anti-nuclear antibodies for targeting necrosis in cancer therapy |
| JOP20190248A1 (ar) | 2017-04-21 | 2019-10-20 | Amgen Inc | بروتينات ربط مولد ضد trem2 واستخداماته |
| US10738110B2 (en) | 2018-01-12 | 2020-08-11 | Amgen Inc. | PAC1 antibodies and uses thereof |
| IL277375B2 (en) | 2018-03-15 | 2025-08-01 | Chugai Pharmaceutical Co Ltd | Anti-dengue virus antibodies having cross-reactivity to zika virus and methods of use |
| KR20210009421A (ko) | 2018-06-14 | 2021-01-26 | 바이오아트라, 엘엘씨 | 다중 특이적 항체 구조체 |
| AU2020204904A1 (en) * | 2019-01-03 | 2021-07-22 | Amgen Inc. | Engineering monoclonal antibodies to improve stability and production titer |
| WO2020243477A2 (en) | 2019-05-30 | 2020-12-03 | Amgen Inc. | Engineering the hinge region to drive antibody dimerization |
| JP7756001B2 (ja) | 2019-06-28 | 2025-10-17 | アムジエン・インコーポレーテツド | 抗ｃｇｒｐ受容体／抗ｐａｃ１受容体二重特異性抗原結合タンパク質 |
| EP3767628B1 (de) * | 2019-07-18 | 2024-03-27 | Bayer Aktiengesellschaft | Selektion von antikörpern / antikörperfragmenten |
| CA3160482A1 (en) | 2019-11-08 | 2021-05-14 | Amgen Inc. | Engineering charge pair mutations for pairing of hetero-igg molecules |
| MX2022005965A (es) | 2019-11-19 | 2022-08-08 | Amgen Inc | Formato de anticuerpos multiespecíficos novedosos. |
| AU2020405230A1 (en) | 2019-12-20 | 2022-06-23 | Amgen Inc. | Mesothelin-targeted CD40 agonistic multispecific antibody constructs for the treatment of solid tumors |
| AU2021329374A1 (en) | 2020-08-20 | 2023-03-09 | Amgen Inc. | Antigen binding proteins with non-canonical disulfide in FAB region |
| US20230374162A1 (en) | 2020-10-07 | 2023-11-23 | Amgen Inc. | Rational selection of building blocks for the assembly of multispecific antibodies |
| JP2023548595A (ja) | 2020-11-10 | 2023-11-17 | アムジエン・インコーポレーテツド | 多重特異性抗原結合ドメインの新規のリンカー |
| TW202246319A (zh) | 2021-02-12 | 2022-12-01 | 德商百靈佳殷格翰國際股份有限公司 | 補體c3抗原結合蛋白 |
| US12435444B2 (en) | 2021-03-09 | 2025-10-07 | Cdr-Life Ag | Rabbit-derived antigen binding protein nucleic acid libraries and methods of making the same |
| EP4304726A1 (en) | 2021-03-09 | 2024-01-17 | CDR-Life AG | Mage-a4 peptide-mhc antigen binding proteins |
| US20240182600A1 (en) | 2021-04-20 | 2024-06-06 | Amgen Inc. | Balanced Charge Distribution in Electrostatic Steering of Chain Pairing in Multi-specific and Monovalent IgG Molecule Assembly |
| EP4183800A1 (en) | 2021-11-19 | 2023-05-24 | Medizinische Hochschule Hannover | Novel sars-cov-2 neutralizing antibodies |
| CA3240046A1 (en) | 2021-12-14 | 2023-06-22 | Cdr-Life Ag | Dual mhc-targeting t cell engager |
| AU2022420788A1 (en) | 2021-12-22 | 2024-05-16 | Boehringer Ingelheim International Gmbh | Anti-c3 antibodies and antigen-binding fragments thereof and their uses for treating eye or ocular diseases |
| WO2024038095A1 (en) | 2022-08-16 | 2024-02-22 | Iome Bio | NOVEL ANTI-RGMb ANTIBODIES |
| US12161673B2 (en) | 2022-09-14 | 2024-12-10 | Cdr-Life Ag | MAGE-A4 peptide dual T cell engagers |
| CN121241395A (zh) * | 2023-06-05 | 2025-12-30 | 赛诺菲 | 使用机器学习模型预测单可变结构域的特性 |
| WO2025210181A1 (en) | 2024-04-04 | 2025-10-09 | Cdr-Life Ag | Antigen binding proteins targeting an hla-restricted kk-lc-1 peptide |
| WO2025215160A1 (en) | 2024-04-11 | 2025-10-16 | Cdr-Life Ag | Antigen binding proteins targeting an hla-restricted prame peptide |
Family Cites Families (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1197800A (en) * | 1983-05-02 | 1985-12-10 | William O. Weigle | Immune modulator peptides |
| KR100240308B1 (ko) | 1991-03-06 | 2000-01-15 | 플레믹 크리스티안 | 인간화된단클론성항체및혼성단클론성항체 |
| DE69233482T2 (de) * | 1991-05-17 | 2006-01-12 | Merck & Co., Inc. | Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen |
| US5824307A (en) | 1991-12-23 | 1998-10-20 | Medimmune, Inc. | Human-murine chimeric antibodies against respiratory syncytial virus |
| US5714350A (en) * | 1992-03-09 | 1998-02-03 | Protein Design Labs, Inc. | Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region |
| US5736137A (en) | 1992-11-13 | 1998-04-07 | Idec Pharmaceuticals Corporation | Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma |
| EP1005870B1 (en) | 1992-11-13 | 2009-01-21 | Biogen Idec Inc. | Therapeutic application of chimeric antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma |
| DK0698097T3 (da) * | 1993-04-29 | 2001-10-08 | Unilever Nv | Produktion af antistoffer eller (funktionaliserede) fragmenter deraf afledt af Camelidae-immunoglobuliner med tung kæde |
| US6740734B1 (en) * | 1994-01-14 | 2004-05-25 | Biovitrum Ab | Bacterial receptor structures |
| US5731168A (en) * | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| WO1997008320A1 (en) | 1995-08-18 | 1997-03-06 | Morphosys Gesellschaft Für Proteinoptimierung Mbh | Protein/(poly)peptide libraries |
| DE122004000004I1 (de) | 1996-02-09 | 2004-08-12 | Abott Biotechnology Ltd | Humane Antikörper welche an Humanen TNFalpha binden. |
| US7147851B1 (en) | 1996-08-15 | 2006-12-12 | Millennium Pharmaceuticals, Inc. | Humanized immunoglobulin reactive with α4β7 integrin |
| US5942602A (en) * | 1997-02-13 | 1999-08-24 | Schering Aktiengessellschaft | Growth factor receptor antibodies |
| US6884879B1 (en) * | 1997-04-07 | 2005-04-26 | Genentech, Inc. | Anti-VEGF antibodies |
| US20020032315A1 (en) | 1997-08-06 | 2002-03-14 | Manuel Baca | Anti-vegf antibodies |
| WO1998056915A2 (en) * | 1997-06-12 | 1998-12-17 | Research Corporation Technologies, Inc. | Artificial antibody polypeptides |
| DE19742706B4 (de) | 1997-09-26 | 2013-07-25 | Pieris Proteolab Ag | Lipocalinmuteine |
| KR101023367B1 (ko) | 1998-08-11 | 2011-03-18 | 바이오겐 아이덱 인크. | Ｂ-세포 림프종을 치료하기 위한 항-ｃｄ２０ 항체를 포함하는 약제 |
| CA2352572C (en) | 1998-12-01 | 2010-04-20 | Abbvie Biotherapeutics Inc. | Humanized antibodies to gamma-interferon |
| US6818418B1 (en) | 1998-12-10 | 2004-11-16 | Compound Therapeutics, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
| SE9901379D0 (sv) | 1999-04-19 | 1999-04-19 | Pharmacia & Upjohn Ab | Receptor structures |
| US6602977B1 (en) | 1999-04-19 | 2003-08-05 | Biovitrum Ab | Receptor structures |
| EP1242457B1 (en) * | 1999-12-28 | 2004-08-11 | Esbatech AG | Intrabodies with defined framework that is stable in a reducing environment and applications thereof |
| CA2409515C (en) * | 2000-05-10 | 2015-11-24 | Mayo Foundation For Medical Education & Research | Human igm antibodies with the capability of inducing remyelination, and diagnostic and therapeutic uses thereof particularly in the central nervous system |
| CA2421447C (en) | 2000-09-08 | 2012-05-08 | Universitat Zurich | Collections of repeat proteins comprising repeat modules |
| EE200300179A (et) | 2000-10-13 | 2003-08-15 | Biogen, Inc. | Humaniseeritud LT-ß-R-i vastased antikehad |
| GB0029360D0 (en) | 2000-12-01 | 2001-01-17 | Univ Nottingham | Humanised antibodies and uses thereof |
| US7396917B2 (en) * | 2000-12-05 | 2008-07-08 | Alexion Pharmaceuticals, Inc. | Rationally designed antibodies |
| US20030157561A1 (en) | 2001-11-19 | 2003-08-21 | Kolkman Joost A. | Combinatorial libraries of monomer domains |
| WO2002088171A2 (en) | 2001-04-26 | 2002-11-07 | Avidia Research Institute | Combinatorial libraries of monomer domains |
| JP2005506833A (ja) * | 2001-06-04 | 2005-03-10 | キュラジェン コーポレイション | 抗原性ポリペプチドに結合する新規抗体、抗原をコード化する核酸、および使用方法 |
| CA2453662A1 (en) * | 2001-07-19 | 2003-01-30 | Stefan Ewert | Modification of human variable domains |
| AR037756A1 (es) * | 2001-12-17 | 2004-12-01 | Bayer Corp | Anticuerpo que inhibe la actividad del factor de las celulas precursoras y su uso para el tratamiento del asma. |
| KR100942402B1 (ko) | 2001-12-28 | 2010-02-17 | 교와 핫꼬 기린 가부시키가이샤 | 관절염 치료약 |
| US6905608B2 (en) | 2002-01-22 | 2005-06-14 | Exergy Technologies Corporation | Advanced electrodeionization for fluid recycling |
| EP2332989B1 (en) * | 2002-05-22 | 2015-04-01 | ESBATech, an Alcon Biomedical Research Unit LLC | Immunoglobulin frameworks which demonstrate enhanced stability in the intracellular environment and methods of identifying same |
| US7696320B2 (en) * | 2004-08-24 | 2010-04-13 | Domantis Limited | Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor |
| CA2491480A1 (en) | 2002-07-01 | 2004-01-08 | Biogen, Inc. | Humanized anti-lymphotoxin beta receptor antibodies |
| WO2004013180A2 (en) | 2002-08-01 | 2004-02-12 | Immunomedics, Inc. | Alpha-fetoprotein immu31 antibodies and fusion proteins and methods of use thereof |
| ES2347241T3 (es) * | 2002-12-16 | 2010-10-27 | Genentech, Inc. | Variantes de inmunoglobulina y sus utilizaciones. |
| US7575893B2 (en) * | 2003-01-23 | 2009-08-18 | Genentech, Inc. | Methods for producing humanized antibodies and improving yield of antibodies or antigen binding fragments in cell culture |
| JP4685764B2 (ja) * | 2003-04-10 | 2011-05-18 | アボット バイオセラピューティクス コーポレイション | 変異誘発による抗体のＦｃＲｎ結合親和力又は血清半減期の改変 |
| TWI306458B (en) | 2003-05-30 | 2009-02-21 | Elan Pharma Int Ltd | Humanized antibodies that recognize beta amyloid peptide |
| AU2004255553B2 (en) | 2003-06-19 | 2009-08-20 | Genentech, Inc. | Compositions and methods for treating coagulation related disorders |
| WO2005005604A2 (en) * | 2003-06-30 | 2005-01-20 | Centocor, Inc. | Engineered anti-target immunoglobulin derived proteins, compositions, methods and uses |
| AU2003264100A1 (en) | 2003-08-25 | 2005-03-10 | Pieris Proteolab Ag | Muteins of a bilin-binding protein with affinity for a given target |
| ES2672640T3 (es) | 2003-11-05 | 2018-06-15 | Roche Glycart Ag | Moléculas de unión a antígeno con afinidad de unión a receptores Fc y función efectora incrementadas |
| KR20060120161A (ko) * | 2003-11-28 | 2006-11-24 | 아스트라제네카 아베 | 항체 |
| US7276585B2 (en) | 2004-03-24 | 2007-10-02 | Xencor, Inc. | Immunoglobulin variants outside the Fc region |
| JP2008500064A (ja) | 2004-05-21 | 2008-01-10 | ザ ユーエービー リサーチ ファウンデーション | 可変性リンパ球受容体、その関連ポリペプチドおよび核酸、ならびにその使用 |
| NZ580607A (en) | 2004-05-27 | 2011-05-27 | Crucell Holland Bv | Binding molecules capable of neutralizing rabies virus and uses thereof |
| GB0416651D0 (en) * | 2004-07-26 | 2004-08-25 | Proteo Target Aps | Polypeptide |
| US7462697B2 (en) * | 2004-11-08 | 2008-12-09 | Epitomics, Inc. | Methods for antibody engineering |
| CA2599734C (en) | 2005-03-03 | 2014-01-28 | Immunomedics, Inc. | Humanized l243 antibodies |
| US8293233B2 (en) | 2005-03-25 | 2012-10-23 | National Research Council Of Canada | Method for isolation of soluble polypeptides |
| CN103665168A (zh) | 2005-06-03 | 2014-03-26 | 持田制药株式会社 | 抗cd14抗体融合蛋白质 |
| JP5089582B2 (ja) * | 2005-06-07 | 2012-12-05 | エスバテック、アン アルコン バイオメディカル リサーチ ユニット、エルエルシー | ＴＮＦαを阻害する安定な可溶性抗体 |
| WO2007003421A2 (en) | 2005-07-05 | 2007-01-11 | Glaxo Group Limited | Humanised antibodies specific for nogo-a and pharmaceutical uses thereof |
| CN102875681A (zh) | 2005-07-08 | 2013-01-16 | 拜奥根Idec马萨诸塞公司 | 抗-αvβ6抗体及其用途 |
| TWI478940B (zh) | 2005-08-26 | 2015-04-01 | Roche Glycart Ag | 具有經改變細胞傳訊活性之改質抗原結合分子 |
| EP1957541A2 (en) * | 2005-11-21 | 2008-08-20 | Laboratoires Serono SA | Compositions and methods of producing hybrid antigen binding molecules and uses thereof |
| WO2007060411A1 (en) | 2005-11-24 | 2007-05-31 | Ucb Pharma S.A. | Anti-tnf alpha antibodies which selectively inhibit tnf alpha signalling through the p55r |
| LT2481753T (lt) * | 2005-12-13 | 2018-05-25 | Eli Lilly And Company | Anti-il-17 antikūnai |
| US20070218116A1 (en) * | 2006-03-14 | 2007-09-20 | Schwendener Reto A | Compositions and methods for the treatment of tumors and tumor metastases |
| WO2007114325A1 (ja) | 2006-03-31 | 2007-10-11 | Chugai Seiyaku Kabushiki Kaisha | 二重特異性抗体を精製するための抗体改変方法 |
| DK2046382T3 (en) * | 2006-07-10 | 2016-12-12 | Esbatech Alcon Biomed Res Unit | scFv Antibodies which passes through the epithelial and / or endothelial layer |
| AU2007285695B2 (en) | 2006-08-18 | 2012-05-24 | Ablynx N.V. | Amino acid sequences directed against IL-6R and polypeptides comprising the same for the treatment of diseases and disorders associated with IL-6-mediated signalling |
| CN101210241A (zh) * | 2006-12-27 | 2008-07-02 | 陕西超英生物科技有限公司 | 一种噬菌体基因工程抗体库基因组装的方法 |
| JP5622397B2 (ja) | 2007-03-12 | 2014-11-12 | エスバテック− ア ノバルティス カンパニー エルエルシー | 一本鎖抗体の配列に基づく操作および最適化 |
| DK2158315T3 (en) | 2007-06-25 | 2016-06-06 | Esbatech Alcon Biomed Res Unit | Methods of modifying antibodies and modified antibodies with improved functional properties |
| AU2008267733B2 (en) | 2007-06-25 | 2013-11-14 | Esbatech, An Alcon Biomedical Research Unit Llc | Sequence based engineering and optimization of single chain antibodies |
| MX336725B (es) | 2007-09-26 | 2016-01-28 | Chugai Pharmaceutical Co Ltd | Metodo de modificacion del punto isoelectrico de anticuerpos medinate la sustitucion de aminoacidos en region de determinacion de complementariedad (cdr). |
-
2008
- 2008-06-25 DK DK08757278.0T patent/DK2158315T3/en active
- 2008-06-25 HU HUE08757278A patent/HUE027507T2/en unknown
- 2008-06-25 WO PCT/CH2008/000285 patent/WO2009000099A2/en not_active Ceased
- 2008-06-25 EP EP08757278.0A patent/EP2158315B1/en not_active Revoked
- 2008-06-25 AU AU2008267734A patent/AU2008267734B9/en active Active
- 2008-06-25 PL PL08757278.0T patent/PL2158315T3/pl unknown
- 2008-06-25 NZ NZ601946A patent/NZ601946A/en not_active IP Right Cessation
- 2008-06-25 MX MX2009013328A patent/MX2009013328A/es active IP Right Grant
- 2008-06-25 CA CA2689941A patent/CA2689941C/en active Active
- 2008-06-25 CN CN200880021889.4A patent/CN101849001B/zh active Active
- 2008-06-25 SI SI200831598A patent/SI2158315T1/sl unknown
- 2008-06-25 KR KR1020097027049A patent/KR101573086B1/ko active Active
- 2008-06-25 ES ES08757278.0T patent/ES2566737T3/es active Active
- 2008-06-25 CN CN201610852278.0A patent/CN106366192B/zh active Active
- 2008-06-25 CN CN201210317160.XA patent/CN102838673B/zh active Active
- 2008-06-25 JP JP2010513601A patent/JP5611820B2/ja active Active
- 2008-06-25 CN CN201310383003.3A patent/CN103435696B/zh active Active
- 2008-06-25 NZ NZ581468A patent/NZ581468A/xx not_active IP Right Cessation
- 2008-06-25 CN CN202010126672.2A patent/CN111253484A/zh active Pending
- 2008-06-25 RU RU2010102065/10A patent/RU2540150C2/ru active
- 2008-06-25 HR HRP20160730TT patent/HRP20160730T1/hr unknown
- 2008-06-25 CN CN201510357753.2A patent/CN105017427A/zh active Pending
- 2008-06-25 BR BRPI0813645-9A2A patent/BRPI0813645A2/pt not_active IP Right Cessation
- 2008-06-25 US US12/145,600 patent/US20090074780A1/en not_active Abandoned
-
2009
- 2009-11-26 ZA ZA2009/08384A patent/ZA200908384B/en unknown
- 2009-11-26 IL IL202360A patent/IL202360A/en active IP Right Grant
-
2014
- 2014-09-03 JP JP2014178667A patent/JP6129797B2/ja active Active
- 2014-10-22 RU RU2014142680A patent/RU2014142680A/ru not_active Application Discontinuation
-
2017
- 2017-04-12 JP JP2017079036A patent/JP2017186338A/ja active Pending
- 2017-09-12 US US15/701,923 patent/US20190002551A1/en not_active Abandoned
-
2019
- 2019-05-07 JP JP2019087504A patent/JP2019141091A/ja active Pending
- 2019-06-11 RU RU2019118109A patent/RU2019118109A/ru unknown
-
2021
- 2021-05-06 JP JP2021078725A patent/JP2021119782A/ja active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ZA200908384B (en) | Methods of modifying antibodies, and modified antibodies with improved functional properties | |
| IL248723A0 (en) | Specific antibodies against the bcr complex and methods of using them | |
| IL209309A0 (en) | Anti-fn14 antibodies and uses thereof | |
| EP2347038A4 (en) | METHOD FOR HUMANIZATION AND AFFINITY TREATMENT OF ANTIBODIES | |
| IL216731A (en) | And antibodies against p95 – her2 and their uses | |
| LT2373691T (lt) | Anti-fxi antikūnai ir jų panaudojimo būdai | |
| IL241091A0 (en) | Antibodies to fcrn and their use | |
| EP2334330A4 (en) | ANTI-CD147 ANTIBODIES, METHODS, AND USES | |
| ZA201100261B (en) | Anti-hepcidin-25 selective antibodies and uses thereof | |
| AP2929A (en) | Anti-TRKA antibodies and derivatives thereof | |
| IL211623A0 (en) | Anti-notch2 antibodies and methods of use | |
| IL205355A0 (en) | Anti- hepcidin antibodies and uses thereof | |
| PL2354161T3 (pl) | Przeciwciało anty -NR10 i jego zastosowanie | |
| ZA200900954B (en) | Ant-C5aR antibodies with improved properties | |
| PT2185719E (pt) | Anticorpos anti-rantes e processos para a sua utilização | |
| IL212040A0 (en) | Hepatitis c antibodies and uses thereof | |
| IL236237A (en) | Tmem154 antibodies and their segments and uses | |
| SI2354161T1 (sl) | Anti-NR10 protitelo in njegova uporaba | |
| EP2074258A4 (en) | FIBER PLATES, THEIR MANUFACTURE AND USE |