CN102838673A - 修饰抗体的方法和具有改善的功能性质的修饰抗体 - Google Patents
修饰抗体的方法和具有改善的功能性质的修饰抗体 Download PDFInfo
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- CN102838673A CN102838673A CN201210317160XA CN201210317160A CN102838673A CN 102838673 A CN102838673 A CN 102838673A CN 201210317160X A CN201210317160X A CN 201210317160XA CN 201210317160 A CN201210317160 A CN 201210317160A CN 102838673 A CN102838673 A CN 102838673A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- Biochemistry (AREA)
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- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
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- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
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- Wood Science & Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
残基 | VH4 | VH 12 | VH 103 | VH 144 | VL 15 | VL 147 |
A | 0.23046215 | 0 | 0 | 0 | 3.8647343 | 0.176821923 |
C | 0 | 0 | 0 | 0 | 0 | 0 |
D | 0 | 0 | 0 | 0 | 0 | 0 |
E | 0 | 0 | 0 | 0 | 0 | 0 |
F | 0.483091787 | 0 | 0.483091787 | 0 | 0 | 0 |
G | 0 | 0 | 0 | 0 | 0 | 0 |
H | 0 | 0 | 0 | 0 | 0 | 0 |
I | 0 | 2.415458937 | 9.661835749 | 0 | 5.314009662 | 70.38834951 |
K | 0 | 0 | 0 | 0 | 0 | 0 |
L | 96.61835749 | 89.85507246 | 7.246376812 | 27.0531401 | 45.89371981 | 15.53398058 |
M | 0 | 0 | 10.62801932 | 1.93236715 | 0 | 0.970873786 |
N | 0 | 0 | 0 | 0 | 0 | 0 |
P | 0.966183575 | 0 | 0 | 0.966183575 | 21.73913043 | 0.485436893 |
Q | 0 | 0 | 0 | 0.483091787 | 0 | 0 |
R | 0 | 0 | 7.246376812 | 0 | 0 | 0 |
S | 0 | 0.966183575 | 0 | 18.84057971 | 0 | 0 |
T | 0 | 0 | 15.4589372 | 50.72463768 | 0.966183575 | 0 |
V | 1.93236715 | 6.763285024 | 49.27536232 | 0 | 22.22222222 | 12.62135922 |
W | 0 | 0 | 0 | 0 | 0 | 0 |
Y | 0 | 0 | 0 | 0 | 0 | 0 |
蛋白质 | 蛋白质丧失(不溶性聚集物) |
ESBA105 | 1.14% |
ESBA105 Opt 1_0 | 8.17% |
ESBA105 Opt 0_2 | 4.45% |
ESBA105 Opt 1_2 | 46.60% |
ESBA105 VH V103T | -1.95% |
Claims (51)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US93711207P | 2007-06-25 | 2007-06-25 | |
US60/937,112 | 2007-06-25 | ||
US6905608P | 2008-03-12 | 2008-03-12 | |
US61/069,056 | 2008-03-12 | ||
CN200880021889.4A CN101849001B (zh) | 2007-06-25 | 2008-06-25 | 修饰抗体的方法和具有改善的功能性质的修饰抗体 |
Related Parent Applications (1)
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CN200880021889.4A Division CN101849001B (zh) | 2007-06-25 | 2008-06-25 | 修饰抗体的方法和具有改善的功能性质的修饰抗体 |
Publications (2)
Publication Number | Publication Date |
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CN102838673A true CN102838673A (zh) | 2012-12-26 |
CN102838673B CN102838673B (zh) | 2016-05-11 |
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Application Number | Title | Priority Date | Filing Date |
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CN201310383003.3A Active CN103435696B (zh) | 2007-06-25 | 2008-06-25 | 修饰抗体的方法和具有改善的功能性质的修饰抗体 |
CN201210317160.XA Active CN102838673B (zh) | 2007-06-25 | 2008-06-25 | 修饰抗体的方法和具有改善的功能性质的修饰抗体 |
CN201510357753.2A Pending CN105017427A (zh) | 2007-06-25 | 2008-06-25 | 修饰抗体的方法和具有改善的功能性质的修饰抗体 |
CN200880021889.4A Active CN101849001B (zh) | 2007-06-25 | 2008-06-25 | 修饰抗体的方法和具有改善的功能性质的修饰抗体 |
CN202010126672.2A Pending CN111253484A (zh) | 2007-06-25 | 2008-06-25 | 修饰抗体的方法和具有改善的功能性质的修饰抗体 |
CN201610852278.0A Active CN106366192B (zh) | 2007-06-25 | 2008-06-25 | 修饰抗体的方法和具有改善的功能性质的修饰抗体 |
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CN201310383003.3A Active CN103435696B (zh) | 2007-06-25 | 2008-06-25 | 修饰抗体的方法和具有改善的功能性质的修饰抗体 |
Family Applications After (4)
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CN201510357753.2A Pending CN105017427A (zh) | 2007-06-25 | 2008-06-25 | 修饰抗体的方法和具有改善的功能性质的修饰抗体 |
CN200880021889.4A Active CN101849001B (zh) | 2007-06-25 | 2008-06-25 | 修饰抗体的方法和具有改善的功能性质的修饰抗体 |
CN202010126672.2A Pending CN111253484A (zh) | 2007-06-25 | 2008-06-25 | 修饰抗体的方法和具有改善的功能性质的修饰抗体 |
CN201610852278.0A Active CN106366192B (zh) | 2007-06-25 | 2008-06-25 | 修饰抗体的方法和具有改善的功能性质的修饰抗体 |
Country Status (21)
Country | Link |
---|---|
US (2) | US20090074780A1 (zh) |
EP (1) | EP2158315B1 (zh) |
JP (5) | JP5611820B2 (zh) |
KR (1) | KR101573086B1 (zh) |
CN (6) | CN103435696B (zh) |
AU (1) | AU2008267734B9 (zh) |
BR (1) | BRPI0813645A2 (zh) |
CA (1) | CA2689941C (zh) |
DK (1) | DK2158315T3 (zh) |
ES (1) | ES2566737T3 (zh) |
HK (1) | HK1137483A1 (zh) |
HR (1) | HRP20160730T1 (zh) |
HU (1) | HUE027507T2 (zh) |
IL (1) | IL202360A (zh) |
MX (1) | MX2009013328A (zh) |
NZ (2) | NZ581468A (zh) |
PL (1) | PL2158315T3 (zh) |
RU (3) | RU2540150C2 (zh) |
SI (1) | SI2158315T1 (zh) |
WO (1) | WO2009000099A2 (zh) |
ZA (1) | ZA200908384B (zh) |
Cited By (2)
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CN113260627A (zh) * | 2019-01-03 | 2021-08-13 | 美国安进公司 | 工程化单克隆抗体以改善稳定性和生产滴度 |
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US20120121591A1 (en) | 2009-03-20 | 2012-05-17 | Amgen Inc. | SELECTIVE AND POTENT PEPTIDE INHIBITORS OF Kv1.3 |
US8399625B1 (en) | 2009-06-25 | 2013-03-19 | ESBATech, an Alcon Biomedical Research Unit, LLC | Acceptor framework for CDR grafting |
CA2781532A1 (en) | 2009-11-20 | 2011-05-26 | Amgen Inc. | Anti-orai1 antigen binding protein that binds the second extracellular loop of orai1 |
US8993727B2 (en) | 2010-09-22 | 2015-03-31 | Amgen Inc. | Carrier immunoglobulins and uses thereof |
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US11236168B2 (en) | 2012-08-24 | 2022-02-01 | Chugai Seiyaku Kabushiki Kaisha | Mouse FcγammaRII-specific Fc antibody |
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EP4326761A1 (en) | 2021-04-20 | 2024-02-28 | Amgen Inc. | Balanced charge distribution in electrostatic steering of chain pairing in multi-specific and monovalent igg molecule assembly |
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WO2024038095A1 (en) | 2022-08-16 | 2024-02-22 | Iome Bio | NOVEL ANTI-RGMb ANTIBODIES |
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Family Cites Families (73)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1197800A (en) * | 1983-05-02 | 1985-12-10 | William O. Weigle | Immune modulator peptides |
HU219537B (hu) | 1991-03-06 | 2001-05-28 | Merck Patent Gmbh. | Humanizált és kiméra monoklonális antitestek, azokat tartalmazó gyógyászati készítmények, az antitesteket kódoló szekvenciát tartalmazó expressziós vektorok, valamint eljárás az antitestek előállítására |
DE69233482T2 (de) * | 1991-05-17 | 2006-01-12 | Merck & Co., Inc. | Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen |
US5824307A (en) | 1991-12-23 | 1998-10-20 | Medimmune, Inc. | Human-murine chimeric antibodies against respiratory syncytial virus |
US5714350A (en) | 1992-03-09 | 1998-02-03 | Protein Design Labs, Inc. | Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region |
US5736137A (en) | 1992-11-13 | 1998-04-07 | Idec Pharmaceuticals Corporation | Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma |
ATE196606T1 (de) * | 1992-11-13 | 2000-10-15 | Idec Pharma Corp | Therapeutische verwendung von chimerischen und markierten antikörpern, die gegen ein differenzierung-antigen gerichtet sind, dessen expression auf menschliche b lymphozyt beschränkt ist, für die behandlung von b-zell-lymphoma |
ES2162863T3 (es) * | 1993-04-29 | 2002-01-16 | Unilever Nv | Produccion de anticuerpos o fragmentos (funcionalizados) de los mismos derivados de inmunoglobulinas de cadena pesada de camelidae. |
US6740734B1 (en) * | 1994-01-14 | 2004-05-25 | Biovitrum Ab | Bacterial receptor structures |
US5731168A (en) * | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
AU725609C (en) | 1995-08-18 | 2002-01-03 | Morphosys Ag | Protein/(poly)peptide libraries |
BRPI9715219B8 (pt) * | 1996-02-09 | 2015-07-07 | Abbvie Biotechnology Ltd | Vetor recombinante de expressão, e célula hospedeira procariótica. |
US7147851B1 (en) | 1996-08-15 | 2006-12-12 | Millennium Pharmaceuticals, Inc. | Humanized immunoglobulin reactive with α4β7 integrin |
US5942602A (en) * | 1997-02-13 | 1999-08-24 | Schering Aktiengessellschaft | Growth factor receptor antibodies |
US20020032315A1 (en) | 1997-08-06 | 2002-03-14 | Manuel Baca | Anti-vegf antibodies |
US6884879B1 (en) | 1997-04-07 | 2005-04-26 | Genentech, Inc. | Anti-VEGF antibodies |
ES2301198T3 (es) | 1997-06-12 | 2008-06-16 | Novartis International Pharmaceutical Ltd. | Polipeptidos artificiales de anticuerpos. |
DE19742706B4 (de) | 1997-09-26 | 2013-07-25 | Pieris Proteolab Ag | Lipocalinmuteine |
HU228180B1 (hu) * | 1998-08-11 | 2013-01-28 | Biogen Idec Inc | Anti-CD20-ellenanyag alkalmazása B-sejtes limfómák kombinációs terápiájára |
JP2002531466A (ja) | 1998-12-01 | 2002-09-24 | プロテイン デザイン ラブス, インコーポレイテッド | γ−インターフェロンに対するヒト化抗体 |
US6818418B1 (en) | 1998-12-10 | 2004-11-16 | Compound Therapeutics, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
US6602977B1 (en) * | 1999-04-19 | 2003-08-05 | Biovitrum Ab | Receptor structures |
SE9901379D0 (sv) | 1999-04-19 | 1999-04-19 | Pharmacia & Upjohn Ab | Receptor structures |
CA2396534C (en) * | 1999-12-28 | 2012-10-02 | Esbatech Ag | Intrabodies with defined framework that is stable in a reducing environment and applications thereof |
JP5670608B2 (ja) * | 2000-05-10 | 2015-02-18 | メイヨ ファンデーション フォア メディカル エディケイション アンド リサーチ | 髄鞘再形成を誘導する能力を有するヒトIgM抗体、および、特に中枢神経系における、その診断使用及び治療使用 |
AU2002218166A1 (en) | 2000-09-08 | 2002-03-22 | Universitat Zurich | Collections of repeat proteins comprising repeat modules |
EP1326897A2 (en) | 2000-10-13 | 2003-07-16 | Biogen, Inc. | Humanized anti-lt-beta-r antibodies |
GB0029360D0 (en) | 2000-12-01 | 2001-01-17 | Univ Nottingham | Humanised antibodies and uses thereof |
US7396917B2 (en) * | 2000-12-05 | 2008-07-08 | Alexion Pharmaceuticals, Inc. | Rationally designed antibodies |
CA2444854A1 (en) | 2001-04-26 | 2002-11-07 | Avidia Research Institute | Combinatorial libraries of monomer domains |
US20030157561A1 (en) | 2001-11-19 | 2003-08-21 | Kolkman Joost A. | Combinatorial libraries of monomer domains |
CA2447935A1 (en) * | 2001-06-04 | 2002-12-12 | Curagen Corporation | Novel antibodies that bind to antigenic polypeptides, nucleic acids encoding the antigens, and methods of use |
CA2453662A1 (en) * | 2001-07-19 | 2003-01-30 | Stefan Ewert | Modification of human variable domains |
AR037756A1 (es) * | 2001-12-17 | 2004-12-01 | Bayer Corp | Anticuerpo que inhibe la actividad del factor de las celulas precursoras y su uso para el tratamiento del asma. |
JP4246069B2 (ja) | 2001-12-28 | 2009-04-02 | 協和発酵キリン株式会社 | 関節炎の治療薬 |
US6905608B2 (en) | 2002-01-22 | 2005-06-14 | Exergy Technologies Corporation | Advanced electrodeionization for fluid recycling |
NZ536412A (en) | 2002-05-22 | 2008-10-31 | Esbatech Ag | Immunoglobulin frameworks which demonstrate enhanced stability in the intracellular environment and methods of identifying same |
US7696320B2 (en) * | 2004-08-24 | 2010-04-13 | Domantis Limited | Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor |
AU2003248782A1 (en) | 2002-07-01 | 2004-01-19 | Biogen Idec Ma Inc. | Humanized anti-lymphotoxin beta receptor antibodies |
AU2003248982B2 (en) | 2002-08-01 | 2009-12-10 | Immunomedics, Inc. | Alpha-fetoprotein immu31 antibodies and fusion proteins and methods of use thereof |
SI1572744T1 (sl) * | 2002-12-16 | 2010-09-30 | Genentech Inc | Imunoglobulinske variante in njihove uporabe |
CA2513113A1 (en) | 2003-01-23 | 2004-08-05 | Genentech, Inc. | Methods for producing humanized antibodies and improving yield of antibodies or antigen binding fragments in cell culture |
CN1798767B (zh) * | 2003-04-10 | 2011-02-16 | 晶面生物技术公司 | 通过诱变来改变抗体对FcRn的结合亲和力或血清半衰期 |
PE20050627A1 (es) | 2003-05-30 | 2005-08-10 | Wyeth Corp | Anticuerpos humanizados que reconocen el peptido beta amiloideo |
KR100912381B1 (ko) | 2003-06-19 | 2009-08-19 | 타녹스 인코퍼레이티드 | 응고 관련 질병을 치료하기 위한 조성물 및 방법 |
US20050033029A1 (en) | 2003-06-30 | 2005-02-10 | Jin Lu | Engineered anti-target immunoglobulin derived proteins, compositions, methods and uses |
EP1658308A1 (en) | 2003-08-25 | 2006-05-24 | Pieris ProteoLab AG | Muteins of a bilin-binding protein with affinity for a given target |
TR201809892T4 (tr) | 2003-11-05 | 2018-07-23 | Roche Glycart Ag | Fc reseptörüne bağlanma afinitesi ve artırılmış efektör fonksiyonu bulunan antijen bağlayan moleküller. |
CN1890266B (zh) * | 2003-11-28 | 2012-10-03 | 阿斯特拉曾尼卡有限公司 | 抗体 |
WO2005092925A2 (en) | 2004-03-24 | 2005-10-06 | Xencor, Inc. | Immunoglobulin variants outside the fc region |
DK1773872T3 (en) | 2004-05-21 | 2017-05-08 | Uab Res Found | VARIABLE Lymphocyte Receptors, Associated Polypeptides and Nucleic Acids, and Uses thereof |
ES2426725T3 (es) | 2004-05-27 | 2013-10-24 | Crucell Holland B.V. | Método para identificar moléculas de unión que pueden neutralizar el virus de la rabia |
GB0416651D0 (en) * | 2004-07-26 | 2004-08-25 | Proteo Target Aps | Polypeptide |
US7462697B2 (en) * | 2004-11-08 | 2008-12-09 | Epitomics, Inc. | Methods for antibody engineering |
US7612180B2 (en) | 2005-03-03 | 2009-11-03 | Immunomedics, Inc. | Humanized L243 antibodies |
EP2377936A3 (en) | 2005-03-25 | 2012-06-13 | National Research Council of Canada | Method for isolation of soluble polypeptides |
WO2006129849A1 (ja) | 2005-06-03 | 2006-12-07 | Mochida Pharmaceutical Co., Ltd. | 抗cd14抗体融合蛋白質 |
EP1891110A2 (en) * | 2005-06-07 | 2008-02-27 | Esbatech AG | STABLE AND SOLUBLE ANTIBODIES INHIBITING TNF-alpha |
AU2006265276B2 (en) | 2005-07-05 | 2011-10-13 | Glaxo Group Limited | Humanised antibodies specific for NOGO-A and pharmaceutical uses thereof |
CN102875681A (zh) | 2005-07-08 | 2013-01-16 | 拜奥根Idec马萨诸塞公司 | 抗-αvβ6抗体及其用途 |
KR101460932B1 (ko) | 2005-08-26 | 2014-11-12 | 로슈 글리카트 아게 | 변형된 세포 신호 활성을 가진 개질된 항원 결합 분자 |
CA2627446A1 (en) * | 2005-11-21 | 2007-05-31 | Laboratoires Serono S.A. | Compositions and methods of producing hybrid antigen binding molecules and uses thereof |
WO2007060411A1 (en) | 2005-11-24 | 2007-05-31 | Ucb Pharma S.A. | Anti-tnf alpha antibodies which selectively inhibit tnf alpha signalling through the p55r |
HUE039353T2 (hu) * | 2005-12-13 | 2018-12-28 | Lilly Co Eli | Anti-IL-17 ellenanyagok |
US20070218116A1 (en) * | 2006-03-14 | 2007-09-20 | Schwendener Reto A | Compositions and methods for the treatment of tumors and tumor metastases |
US9670269B2 (en) | 2006-03-31 | 2017-06-06 | Chugai Seiyaku Kabushiki Kaisha | Methods of modifying antibodies for purification of bispecific antibodies |
AU2007272224B2 (en) | 2006-07-10 | 2013-05-02 | Novartis Ag | scFv antibodies which pass epithelial and/or endothelial layers |
CA2666599A1 (en) | 2006-08-18 | 2008-02-21 | Ablynx N.V. | Amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of diseases and disorders associated with il-6-mediated signalling |
CN101210241A (zh) * | 2006-12-27 | 2008-07-02 | 陕西超英生物科技有限公司 | 一种噬菌体基因工程抗体库基因组装的方法 |
EP3202786A3 (en) | 2007-03-12 | 2017-10-11 | ESBATech, an Alcon Biomedical Research Unit LLC | Sequence based engineering and optimization of single chain antibodies |
CN101688200B (zh) | 2007-06-25 | 2012-08-08 | 艾斯巴技术,爱尔康生物医药研究装置有限责任公司 | 单链抗体的基于序列的改造和优化 |
CN103435696B (zh) * | 2007-06-25 | 2016-10-12 | 艾斯巴技术-诺华有限责任公司 | 修饰抗体的方法和具有改善的功能性质的修饰抗体 |
DK2202245T3 (en) | 2007-09-26 | 2016-11-21 | Chugai Pharmaceutical Co Ltd | A method of modifying an antibody isoelectric point VIA amino acid substitution in CDR |
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CN104341501B (zh) * | 2013-07-29 | 2019-08-30 | 上海睿智化学研究有限公司 | 抗IL-1β人源化单克隆抗体及其制备方法和应用 |
CN113260627A (zh) * | 2019-01-03 | 2021-08-13 | 美国安进公司 | 工程化单克隆抗体以改善稳定性和生产滴度 |
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