AU2017302668B9 - Combination therapies of chimeric antigen receptors and PD-1 inhibitors - Google Patents

Combination therapies of chimeric antigen receptors and PD-1 inhibitors Download PDF

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Publication number
AU2017302668B9
AU2017302668B9 AU2017302668A AU2017302668A AU2017302668B9 AU 2017302668 B9 AU2017302668 B9 AU 2017302668B9 AU 2017302668 A AU2017302668 A AU 2017302668A AU 2017302668 A AU2017302668 A AU 2017302668A AU 2017302668 B9 AU2017302668 B9 AU 2017302668B9
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seq
car
amino acid
acid sequence
cell
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AU2017302668A1 (en
AU2017302668B2 (en
Inventor
Oezlem ANAK
Sanela Bilic
Hans Bitter
Jennifer BROGDON
John Scott CAMERON
William Chou
Stephan GRUPP
Danny Roland Howard Jr.
Randi ISAACS
Carl H. June
Simon Lacey
Shannon MAUDE
Jan J. Melenhorst
Alfonso Quintas-Cardama
Stephen Schuster
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Novartis AG
University of Pennsylvania Penn
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Novartis AG
University of Pennsylvania Penn
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
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    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57426—Specifically defined cancers leukemia
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    • A61K2039/515—Animal cells
    • A61K2039/5156—Animal cells expressing foreign proteins
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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  • General Chemical & Material Sciences (AREA)
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AU2017302668A 2016-07-28 2017-07-28 Combination therapies of chimeric antigen receptors and PD-1 inhibitors Active AU2017302668B9 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2023284778A AU2023284778A1 (en) 2016-07-28 2023-12-18 Combination therapies of chimeric antigen receptors and PD-1 inhibitors

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201662368100P 2016-07-28 2016-07-28
US62/368,100 2016-07-28
US201762455547P 2017-02-06 2017-02-06
US62/455,547 2017-02-06
US201762482846P 2017-04-07 2017-04-07
US62/482,846 2017-04-07
US201762514542P 2017-06-02 2017-06-02
US62/514,542 2017-06-02
PCT/US2017/044425 WO2018023025A1 (en) 2016-07-28 2017-07-28 Combination therapies of chimeric antigen receptors adn pd-1 inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2023284778A Division AU2023284778A1 (en) 2016-07-28 2023-12-18 Combination therapies of chimeric antigen receptors and PD-1 inhibitors

Publications (3)

Publication Number Publication Date
AU2017302668A1 AU2017302668A1 (en) 2019-02-14
AU2017302668B2 AU2017302668B2 (en) 2023-06-08
AU2017302668B9 true AU2017302668B9 (en) 2023-06-22

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AU2017302668A Active AU2017302668B9 (en) 2016-07-28 2017-07-28 Combination therapies of chimeric antigen receptors and PD-1 inhibitors
AU2023284778A Withdrawn AU2023284778A1 (en) 2016-07-28 2023-12-18 Combination therapies of chimeric antigen receptors and PD-1 inhibitors

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AU2023284778A Withdrawn AU2023284778A1 (en) 2016-07-28 2023-12-18 Combination therapies of chimeric antigen receptors and PD-1 inhibitors

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US (1) US20190151365A1 (enExample)
EP (1) EP3491016A1 (enExample)
JP (3) JP2019523301A (enExample)
KR (3) KR20250061769A (enExample)
CN (3) CN117959417A (enExample)
AU (2) AU2017302668B9 (enExample)
BR (1) BR112019001570A2 (enExample)
CA (1) CA3032054A1 (enExample)
IL (2) IL264486B2 (enExample)
MY (1) MY205684A (enExample)
SG (1) SG11201900677SA (enExample)
TW (2) TW201806619A (enExample)
WO (1) WO2018023025A1 (enExample)

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