AU2017232610B2 - Compounds and methods for kinase modulation and indications therefore - Google Patents

Compounds and methods for kinase modulation and indications therefore Download PDF

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Publication number
AU2017232610B2
AU2017232610B2 AU2017232610A AU2017232610A AU2017232610B2 AU 2017232610 B2 AU2017232610 B2 AU 2017232610B2 AU 2017232610 A AU2017232610 A AU 2017232610A AU 2017232610 A AU2017232610 A AU 2017232610A AU 2017232610 B2 AU2017232610 B2 AU 2017232610B2
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pyridyl
phenyl
acetamide
trifluoromethyl
amino
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AU2017232610A1 (en
Inventor
Aaron ALBERS
John BUELL
Zuojun GUO
Prabha N. Ibrahim
Jack Lin
Phuongly Pham
Hannah POWERS
Songyuan Shi
Wayne Spevak
Guoxian Wu
Jeffrey Wu
Jiazhong Zhang
Ying Zhang
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Plexxikon Inc
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Plexxikon Inc
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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  • Dermatology (AREA)
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  • Communicable Diseases (AREA)
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AU2017232610A 2016-03-16 2017-03-15 Compounds and methods for kinase modulation and indications therefore Active AU2017232610B2 (en)

Applications Claiming Priority (3)

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US201662309336P 2016-03-16 2016-03-16
US62/309,336 2016-03-16
PCT/US2017/022587 WO2017161045A1 (en) 2016-03-16 2017-03-15 Compounds and methods for kinase modulation and indications therefore

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AU2017232610B2 true AU2017232610B2 (en) 2021-07-22

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US (1) US10160747B2 (enExample)
EP (1) EP3430005B1 (enExample)
JP (1) JP6921846B6 (enExample)
AU (1) AU2017232610B2 (enExample)
CA (1) CA3017972C (enExample)
ES (1) ES2904615T3 (enExample)
WO (1) WO2017161045A1 (enExample)

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