AU2015330731B2 - Treatment of cancer using TLR9 agonist with checkpoint inhibitors - Google Patents

Treatment of cancer using TLR9 agonist with checkpoint inhibitors Download PDF

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Publication number
AU2015330731B2
AU2015330731B2 AU2015330731A AU2015330731A AU2015330731B2 AU 2015330731 B2 AU2015330731 B2 AU 2015330731B2 AU 2015330731 A AU2015330731 A AU 2015330731A AU 2015330731 A AU2015330731 A AU 2015330731A AU 2015330731 B2 AU2015330731 B2 AU 2015330731B2
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AU
Australia
Prior art keywords
cancer
inhibitor
tumor
immune checkpoint
cell
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Ceased
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AU2015330731A
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AU2015330731A1 (en
Inventor
Sudhir Agrawal
Wayne JIANG
Daqing Wang
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Aceragen Inc
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Idera Pharmaceuticals Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
AU2015330731A 2014-10-10 2015-10-09 Treatment of cancer using TLR9 agonist with checkpoint inhibitors Ceased AU2015330731B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2020250293A AU2020250293A1 (en) 2014-10-10 2020-10-09 Treatment of cancer using TLR9 agonist with checkpoint inhibitors

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462062274P 2014-10-10 2014-10-10
US62/062,274 2014-10-10
US201562218934P 2015-09-15 2015-09-15
US62/218,934 2015-09-15
PCT/US2015/054899 WO2016057898A1 (en) 2014-10-10 2015-10-09 Treatment of cancer using tlr9 agonist with checkpoint inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2020250293A Division AU2020250293A1 (en) 2014-10-10 2020-10-09 Treatment of cancer using TLR9 agonist with checkpoint inhibitors

Publications (2)

Publication Number Publication Date
AU2015330731A1 AU2015330731A1 (en) 2017-05-04
AU2015330731B2 true AU2015330731B2 (en) 2020-07-09

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AU2015330731A Ceased AU2015330731B2 (en) 2014-10-10 2015-10-09 Treatment of cancer using TLR9 agonist with checkpoint inhibitors
AU2020250293A Abandoned AU2020250293A1 (en) 2014-10-10 2020-10-09 Treatment of cancer using TLR9 agonist with checkpoint inhibitors

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Country Status (11)

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US (3) US20160101128A1 (enExample)
EP (2) EP4029508A1 (enExample)
JP (2) JP6991857B2 (enExample)
KR (1) KR20170072244A (enExample)
CN (2) CN106999574B (enExample)
AU (2) AU2015330731B2 (enExample)
CA (1) CA2964155A1 (enExample)
ES (1) ES2908056T3 (enExample)
IL (1) IL251669B2 (enExample)
MX (2) MX391478B (enExample)
WO (1) WO2016057898A1 (enExample)

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