AU2014261329B2 - Fenfluramine for use in the treatment of dravet syndrome - Google Patents

Fenfluramine for use in the treatment of dravet syndrome Download PDF

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Publication number
AU2014261329B2
AU2014261329B2 AU2014261329A AU2014261329A AU2014261329B2 AU 2014261329 B2 AU2014261329 B2 AU 2014261329B2 AU 2014261329 A AU2014261329 A AU 2014261329A AU 2014261329 A AU2014261329 A AU 2014261329A AU 2014261329 B2 AU2014261329 B2 AU 2014261329B2
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AU
Australia
Prior art keywords
patient
fenfluramine
pharmaceutically acceptable
acceptable salt
seizures
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Active
Application number
AU2014261329A
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English (en)
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AU2014261329A1 (en
Inventor
Berten CEULEMANS
Lieven LAGAE
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UNIVERSITY HOSPITAL ANTWERP
Katholieke Universiteit Leuven
Original Assignee
HOSPITAL ANTWERP, University of
Katholieke Universiteit Leuven
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Application filed by HOSPITAL ANTWERP, University of, Katholieke Universiteit Leuven filed Critical HOSPITAL ANTWERP, University of
Publication of AU2014261329A1 publication Critical patent/AU2014261329A1/en
Application granted granted Critical
Publication of AU2014261329B2 publication Critical patent/AU2014261329B2/en
Priority to AU2019203448A priority Critical patent/AU2019203448B2/en
Priority to AU2019203832A priority patent/AU2019203832B2/en
Priority to AU2020267264A priority patent/AU2020267264A1/en
Active legal-status Critical Current
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pyridine Compounds (AREA)
AU2014261329A 2013-05-03 2014-05-01 Fenfluramine for use in the treatment of dravet syndrome Active AU2014261329B2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2019203448A AU2019203448B2 (en) 2013-05-03 2019-05-16 Fenfluramine for use in the treatment of dravet syndrome
AU2019203832A AU2019203832B2 (en) 2013-05-03 2019-05-31 Fenfluramine for use in the treatment of dravet syndrome
AU2020267264A AU2020267264A1 (en) 2013-05-03 2020-11-12 Fenfluramine for use in the treatment of dravet syndrome

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13/887,014 US9549909B2 (en) 2013-05-03 2013-05-03 Method for the treatment of dravet syndrome
US13/887,014 2013-05-03
PCT/EP2014/058954 WO2014177676A1 (en) 2013-05-03 2014-05-01 Fenfluramine for use in the treatment of dravet syndrome

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2019203448A Division AU2019203448B2 (en) 2013-05-03 2019-05-16 Fenfluramine for use in the treatment of dravet syndrome

Publications (2)

Publication Number Publication Date
AU2014261329A1 AU2014261329A1 (en) 2015-11-05
AU2014261329B2 true AU2014261329B2 (en) 2019-02-21

Family

ID=50729472

Family Applications (4)

Application Number Title Priority Date Filing Date
AU2014261329A Active AU2014261329B2 (en) 2013-05-03 2014-05-01 Fenfluramine for use in the treatment of dravet syndrome
AU2019203448A Active AU2019203448B2 (en) 2013-05-03 2019-05-16 Fenfluramine for use in the treatment of dravet syndrome
AU2019203832A Active AU2019203832B2 (en) 2013-05-03 2019-05-31 Fenfluramine for use in the treatment of dravet syndrome
AU2020267264A Abandoned AU2020267264A1 (en) 2013-05-03 2020-11-12 Fenfluramine for use in the treatment of dravet syndrome

Family Applications After (3)

Application Number Title Priority Date Filing Date
AU2019203448A Active AU2019203448B2 (en) 2013-05-03 2019-05-16 Fenfluramine for use in the treatment of dravet syndrome
AU2019203832A Active AU2019203832B2 (en) 2013-05-03 2019-05-31 Fenfluramine for use in the treatment of dravet syndrome
AU2020267264A Abandoned AU2020267264A1 (en) 2013-05-03 2020-11-12 Fenfluramine for use in the treatment of dravet syndrome

Country Status (17)

Country Link
US (13) US9549909B2 (https=)
EP (2) EP2991637B1 (https=)
JP (3) JP6441313B2 (https=)
AU (4) AU2014261329B2 (https=)
BR (1) BR112015027282A8 (https=)
CA (1) CA2909335C (https=)
CY (1) CY1124298T1 (https=)
DK (2) DK2991637T3 (https=)
ES (2) ES2666657T3 (https=)
HR (1) HRP20210819T1 (https=)
HU (1) HUE054577T2 (https=)
LT (1) LT3329909T (https=)
NO (1) NO3092234T3 (https=)
PL (2) PL3329909T3 (https=)
PT (2) PT3329909T (https=)
SI (1) SI3329909T1 (https=)
WO (1) WO2014177676A1 (https=)

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