AU2013334874B2 - Combination therapies for the treatment of Alzheimer's disease and related disorders - Google Patents

Combination therapies for the treatment of Alzheimer's disease and related disorders Download PDF

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Publication number
AU2013334874B2
AU2013334874B2 AU2013334874A AU2013334874A AU2013334874B2 AU 2013334874 B2 AU2013334874 B2 AU 2013334874B2 AU 2013334874 A AU2013334874 A AU 2013334874A AU 2013334874 A AU2013334874 A AU 2013334874A AU 2013334874 B2 AU2013334874 B2 AU 2013334874B2
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Prior art keywords
cromolyn
ibuprofen
pct
disease
salt
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Ceased
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AU2013334874A
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AU2013334874A1 (en
Inventor
David R. Elmaleh
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General Hospital Corp
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General Hospital Corp
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Priority to AU2018204831A priority Critical patent/AU2018204831A1/en
Priority to AU2020203146A priority patent/AU2020203146A1/en
Ceased legal-status Critical Current
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/075—Ethers or acetals
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    • A61K31/13—Amines
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
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    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
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    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
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    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/0005—Vertebrate antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0453—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2013334874A 2012-10-25 2013-10-22 Combination therapies for the treatment of Alzheimer's disease and related disorders Ceased AU2013334874B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2018204831A AU2018204831A1 (en) 2012-10-25 2018-07-02 Combination therapies for the treatment of alzheimer's disease and related disorders
AU2020203146A AU2020203146A1 (en) 2012-10-25 2020-05-13 Combination therapies for the treatment of alzheimer's disease and related disorders

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261718303P 2012-10-25 2012-10-25
US61/718,303 2012-10-25
PCT/US2013/066069 WO2014066318A1 (en) 2012-10-25 2013-10-22 Combination therapies for the treatment of alzheimer's disease and related disorders

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2018204831A Division AU2018204831A1 (en) 2012-10-25 2018-07-02 Combination therapies for the treatment of alzheimer's disease and related disorders

Publications (2)

Publication Number Publication Date
AU2013334874A1 AU2013334874A1 (en) 2015-05-14
AU2013334874B2 true AU2013334874B2 (en) 2018-04-05

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AU2013334874A Ceased AU2013334874B2 (en) 2012-10-25 2013-10-22 Combination therapies for the treatment of Alzheimer's disease and related disorders
AU2018204831A Abandoned AU2018204831A1 (en) 2012-10-25 2018-07-02 Combination therapies for the treatment of alzheimer's disease and related disorders
AU2020203146A Abandoned AU2020203146A1 (en) 2012-10-25 2020-05-13 Combination therapies for the treatment of alzheimer's disease and related disorders

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AU2018204831A Abandoned AU2018204831A1 (en) 2012-10-25 2018-07-02 Combination therapies for the treatment of alzheimer's disease and related disorders
AU2020203146A Abandoned AU2020203146A1 (en) 2012-10-25 2020-05-13 Combination therapies for the treatment of alzheimer's disease and related disorders

Country Status (8)

Country Link
US (17) US9855276B2 (https=)
EP (2) EP3563849A3 (https=)
JP (3) JP6499077B2 (https=)
CN (2) CN104869993B (https=)
AU (3) AU2013334874B2 (https=)
CA (2) CA2889446C (https=)
ES (1) ES2749096T3 (https=)
WO (1) WO2014066318A1 (https=)

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