MX355627B - Clorhidratos de metiltioninio (azul de metileno) cristalinos. - Google Patents
Clorhidratos de metiltioninio (azul de metileno) cristalinos.Info
- Publication number
- MX355627B MX355627B MX2015008552A MX2015008552A MX355627B MX 355627 B MX355627 B MX 355627B MX 2015008552 A MX2015008552 A MX 2015008552A MX 2015008552 A MX2015008552 A MX 2015008552A MX 355627 B MX355627 B MX 355627B
- Authority
- MX
- Mexico
- Prior art keywords
- hydrates
- methylene blue
- crystalline
- chloride
- methylthionium chloride
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/18—[b, e]-condensed with two six-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4515—Non condensed piperidines, e.g. piperocaine having a butyrophenone group in position 1, e.g. haloperidol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/18—[b, e]-condensed with two six-membered rings
- C07D279/22—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
La presente invención se refiere a tres formas B, C y D del dihidrato y a una forma E del monohidrato del cloruro de metiltioninio (azul de metileno). Las formas B, C, D y E pueden ser preparadas bajo temperatura y humedad controladas a partir del cloruro de metiltioninio con un contenido de agua más elevado o la conversión de un hidrato. Los hidratos pueden ser incorporados en las composiciones farmacéuticas.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24539109P | 2009-09-24 | 2009-09-24 | |
| PCT/IB2010/002526 WO2011036558A2 (en) | 2009-09-24 | 2010-09-23 | Crystalline methylthionium chloride (methylene blue) hydrates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX355627B true MX355627B (es) | 2018-04-25 |
Family
ID=43415329
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2012003083A MX2012003083A (es) | 2009-09-24 | 2010-09-23 | Clorhidratos de metiltioninio (azul de metileno) cristalinos. |
| MX2015008552A MX355627B (es) | 2009-09-24 | 2010-09-23 | Clorhidratos de metiltioninio (azul de metileno) cristalinos. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2012003083A MX2012003083A (es) | 2009-09-24 | 2010-09-23 | Clorhidratos de metiltioninio (azul de metileno) cristalinos. |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8765742B2 (es) |
| EP (4) | EP2963024B1 (es) |
| JP (1) | JP5806217B2 (es) |
| KR (3) | KR20120099409A (es) |
| CN (2) | CN102666511B (es) |
| AU (1) | AU2010299571B2 (es) |
| BR (4) | BR122019022631B8 (es) |
| CA (4) | CA3141737C (es) |
| DK (4) | DK3792254T3 (es) |
| ES (4) | ES2960761T3 (es) |
| FI (1) | FI3792254T3 (es) |
| HK (2) | HK1213897A1 (es) |
| HR (3) | HRP20181567T2 (es) |
| MX (2) | MX2012003083A (es) |
| MY (1) | MY159782A (es) |
| PL (4) | PL2480541T3 (es) |
| PT (4) | PT2963024T (es) |
| SG (1) | SG10201408584UA (es) |
| SI (4) | SI2963024T1 (es) |
| WO (1) | WO2011036558A2 (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9925282B2 (en) | 2009-01-29 | 2018-03-27 | The General Hospital Corporation | Cromolyn derivatives and related methods of imaging and treatment |
| JP5918136B2 (ja) * | 2009-09-24 | 2016-05-18 | ウィスタ ラボラトリーズ リミテッド | プロセス |
| US10058530B2 (en) | 2012-10-25 | 2018-08-28 | The General Hospital Corporation | Combination therapies for the treatment of Alzheimer's disease and related disorders |
| JP6499077B2 (ja) | 2012-10-25 | 2019-04-10 | ザ ジェネラル ホスピタル コーポレイション | アルツハイマー病と関連疾患の治療のための併用療法 |
| US10525005B2 (en) | 2013-05-23 | 2020-01-07 | The General Hospital Corporation | Cromolyn compositions and methods thereof |
| JP2016534063A (ja) | 2013-10-22 | 2016-11-04 | ザ ジェネラル ホスピタル コーポレイション | クロモリン誘導体ならびに関連するイメージングおよび治療方法 |
| US10765755B1 (en) | 2013-11-20 | 2020-09-08 | University Of South Florida | Preparation and characterization of methylene blue nanoparticles for Alzheimer's disease and other tauopathies |
| KR20230058533A (ko) | 2016-07-25 | 2023-05-03 | 위스타 레보레이토리스 리미티드 | 디아미노페노티아진 (diaminophenothiazines)의 투여 및 투여량 (dosage) |
| CN109922800B (zh) | 2016-08-31 | 2023-06-13 | 通用医疗公司 | 与神经退行性疾病相关的神经炎症中的巨噬细胞/小胶质细胞 |
| GB201614834D0 (en) | 2016-09-01 | 2016-10-19 | Wista Lab Ltd | Treatment of dementia |
| AU2017423862A1 (en) | 2017-07-20 | 2020-02-06 | Aztherapies, Inc. | Powdered formulations of cromolyn sodium and ibuprofen |
| AU2019299347A1 (en) | 2018-07-02 | 2021-01-21 | Aztherapies, Inc. | Powdered formulations of cromolyn sodium and alpha-lactose |
| WO2023232764A1 (en) | 2022-05-31 | 2023-12-07 | Wista Laboratories Ltd. | Treatment of neurodegenerative disorders utilising methylthioninium (mt)-containing compounds |
| WO2024063700A1 (en) | 2022-09-21 | 2024-03-28 | Yin Sze Loh | Oral formulation of diaminophenothiazines and methods of making and using the same in the treatment and/or prevention of diseases |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9506197D0 (en) | 1995-03-27 | 1995-05-17 | Hoffmann La Roche | Inhibition of tau-tau association. |
| GB0101049D0 (en) | 2001-01-15 | 2001-02-28 | Univ Aberdeen | Materials and methods relating to protein aggregation in neurodegenerative disease |
| GB0322756D0 (en) | 2003-09-29 | 2003-10-29 | Univ Aberdeen | Methods of chemical synthesis |
| AU2005286235C1 (en) | 2004-09-23 | 2013-08-22 | Wista Laboratories Ltd. | Methods of chemical synthesis and purification of diaminophenothiazinium compounds including Methylthioninium Chloride (MTC) |
| JP5186212B2 (ja) * | 2004-09-23 | 2013-04-17 | ウィスタ ラボラトリーズ リミテッド | メチルチオニニウム塩化物（ｍｔｃ）などのジアミノフェノチアジニウム化合物を化学合成および精製する方法 |
| DK2004155T3 (en) * | 2006-03-29 | 2018-04-30 | Wista Lab Ltd | PROTEIN AGGREGATION INHIBITORS |
| ATE478058T3 (de) * | 2006-03-29 | 2010-09-15 | Wista Lab Ltd | 3,7-diamino-10h-phenothiazinsalze und ihre verwendung |
| CN101631780A (zh) * | 2007-04-03 | 2010-01-20 | 普罗瑟塔生物谐成公司 | 用于抗病毒治疗的吩噻嗪衍生物 |
| US7603854B2 (en) | 2007-04-10 | 2009-10-20 | Illinois Tool Works Inc. | Pneumatically self-regulating valve |
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2010
- 2010-09-23 EP EP15176967.6A patent/EP2963024B1/en active Active
- 2010-09-23 CA CA3141737A patent/CA3141737C/en active Active
- 2010-09-23 CN CN201080053178.2A patent/CN102666511B/zh active Active
- 2010-09-23 PT PT15176967T patent/PT2963024T/pt unknown
- 2010-09-23 DK DK20203173.8T patent/DK3792254T3/da active
- 2010-09-23 ES ES20203173T patent/ES2960761T3/es active Active
- 2010-09-23 BR BR122019022631A patent/BR122019022631B8/pt active IP Right Grant
- 2010-09-23 JP JP2012530357A patent/JP5806217B2/ja active Active
- 2010-09-23 KR KR1020127009853A patent/KR20120099409A/ko active Application Filing
- 2010-09-23 PL PL10771516T patent/PL2480541T3/pl unknown
- 2010-09-23 PT PT181703588T patent/PT3378856T/pt unknown
- 2010-09-23 ES ES10771516.1T patent/ES2557318T3/es active Active
- 2010-09-23 MX MX2012003083A patent/MX2012003083A/es active IP Right Grant
- 2010-09-23 ES ES15176967.6T patent/ES2689029T3/es active Active
- 2010-09-23 EP EP18170358.8A patent/EP3378856B1/en active Active
- 2010-09-23 HR HRP20181567TT patent/HRP20181567T2/hr unknown
- 2010-09-23 BR BR112012006638-2A patent/BR112012006638B1/pt active IP Right Grant
- 2010-09-23 WO PCT/IB2010/002526 patent/WO2011036558A2/en active Application Filing
- 2010-09-23 CA CA2773305A patent/CA2773305C/en active Active
- 2010-09-23 KR KR1020177013764A patent/KR20170061177A/ko active Search and Examination
- 2010-09-23 DK DK18170358.8T patent/DK3378856T3/da active
- 2010-09-23 CA CA3004822A patent/CA3004822C/en active Active
- 2010-09-23 CN CN201510501874.XA patent/CN105061358A/zh active Pending
- 2010-09-23 KR KR1020187022958A patent/KR20180094126A/ko not_active Application Discontinuation
- 2010-09-23 PL PL15176967T patent/PL2963024T3/pl unknown
- 2010-09-23 MY MYPI2012001322A patent/MY159782A/en unknown
- 2010-09-23 HR HRP20231201TT patent/HRP20231201T1/hr unknown
- 2010-09-23 SI SI201031765T patent/SI2963024T1/sl unknown
- 2010-09-23 CA CA3077911A patent/CA3077911C/en active Active
- 2010-09-23 AU AU2010299571A patent/AU2010299571B2/en active Active
- 2010-09-23 EP EP10771516.1A patent/EP2480541B1/en active Active
- 2010-09-23 SG SG10201408584UA patent/SG10201408584UA/en unknown
- 2010-09-23 EP EP20203173.8A patent/EP3792254B1/en active Active
- 2010-09-23 PL PL20203173.8T patent/PL3792254T3/pl unknown
- 2010-09-23 PT PT107715161T patent/PT2480541E/pt unknown
- 2010-09-23 SI SI201032134T patent/SI3792254T1/sl unknown
- 2010-09-23 SI SI201032051T patent/SI3378856T1/sl unknown
- 2010-09-23 SI SI201031101T patent/SI2480541T1/sl unknown
- 2010-09-23 BR BR122019022612A patent/BR122019022612B8/pt active IP Right Grant
- 2010-09-23 PL PL18170358T patent/PL3378856T3/pl unknown
- 2010-09-23 FI FIEP20203173.8T patent/FI3792254T3/fi active
- 2010-09-23 DK DK10771516.1T patent/DK2480541T3/en active
- 2010-09-23 ES ES18170358T patent/ES2847003T3/es active Active
- 2010-09-23 BR BR122019022628A patent/BR122019022628B8/pt active IP Right Grant
- 2010-09-23 PT PT202031738T patent/PT3792254T/pt unknown
- 2010-09-23 DK DK15176967.6T patent/DK2963024T3/en active
- 2010-09-23 US US13/497,686 patent/US8765742B2/en active Active
- 2010-09-23 MX MX2015008552A patent/MX355627B/es unknown
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2012
- 2012-08-29 HK HK16101978.6A patent/HK1213897A1/zh unknown
- 2012-08-29 HK HK12108434.3A patent/HK1167653A1/xx unknown
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2021
- 2021-01-19 HR HRP20210086TT patent/HRP20210086T1/hr unknown
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