SI3792254T1 - Kristalinični hidrati metiltioninijevega klorida - Google Patents
Kristalinični hidrati metiltioninijevega kloridaInfo
- Publication number
- SI3792254T1 SI3792254T1 SI201032134T SI201032134T SI3792254T1 SI 3792254 T1 SI3792254 T1 SI 3792254T1 SI 201032134 T SI201032134 T SI 201032134T SI 201032134 T SI201032134 T SI 201032134T SI 3792254 T1 SI3792254 T1 SI 3792254T1
- Authority
- SI
- Slovenia
- Prior art keywords
- methylthioninium chloride
- chloride hydrates
- crystalline methylthioninium
- crystalline
- hydrates
- Prior art date
Links
- LXQCLHQAJVBFGN-UHFFFAOYSA-N 2-methylthionin-1-ium;chloride;hydrate Chemical class O.[Cl-].CC1=CC=CC=CC=C[SH+]1 LXQCLHQAJVBFGN-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/18—[b, e]-condensed with two six-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4515—Non condensed piperidines, e.g. piperocaine having a butyrophenone group in position 1, e.g. haloperidol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/18—[b, e]-condensed with two six-membered rings
- C07D279/22—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Dermatology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24539109P | 2009-09-24 | 2009-09-24 | |
| EP20203173.8A EP3792254B1 (en) | 2009-09-24 | 2010-09-23 | Crystalline methylthioninium chloride hydrates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI3792254T1 true SI3792254T1 (sl) | 2023-11-30 |
Family
ID=43415329
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201032051T SI3378856T1 (sl) | 2009-09-24 | 2010-09-23 | Kristalinični metiltioninijevi klorid hidrati |
| SI201031765T SI2963024T1 (sl) | 2009-09-24 | 2010-09-23 | Kristalinični hidrati metiltioninijevega klorida-del 2 |
| SI201031101T SI2480541T1 (sl) | 2009-09-24 | 2010-09-23 | Kristalinični hidrati metiltioninijevega klorida (metilen modrega) |
| SI201032134T SI3792254T1 (sl) | 2009-09-24 | 2010-09-23 | Kristalinični hidrati metiltioninijevega klorida |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201032051T SI3378856T1 (sl) | 2009-09-24 | 2010-09-23 | Kristalinični metiltioninijevi klorid hidrati |
| SI201031765T SI2963024T1 (sl) | 2009-09-24 | 2010-09-23 | Kristalinični hidrati metiltioninijevega klorida-del 2 |
| SI201031101T SI2480541T1 (sl) | 2009-09-24 | 2010-09-23 | Kristalinični hidrati metiltioninijevega klorida (metilen modrega) |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8765742B2 (sl) |
| EP (4) | EP2480541B1 (sl) |
| JP (1) | JP5806217B2 (sl) |
| KR (3) | KR20180094126A (sl) |
| CN (2) | CN102666511B (sl) |
| AU (1) | AU2010299571B2 (sl) |
| BR (4) | BR122019022612B8 (sl) |
| CA (4) | CA3077911C (sl) |
| DK (4) | DK2480541T3 (sl) |
| ES (4) | ES2689029T3 (sl) |
| FI (1) | FI3792254T3 (sl) |
| HK (2) | HK1213897A1 (sl) |
| HR (3) | HRP20181567T2 (sl) |
| MX (2) | MX355627B (sl) |
| MY (1) | MY159782A (sl) |
| PL (4) | PL3792254T3 (sl) |
| PT (4) | PT2963024T (sl) |
| SG (1) | SG10201408584UA (sl) |
| SI (4) | SI3378856T1 (sl) |
| WO (1) | WO2011036558A2 (sl) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9925282B2 (en) | 2009-01-29 | 2018-03-27 | The General Hospital Corporation | Cromolyn derivatives and related methods of imaging and treatment |
| CA2773306C (en) * | 2009-09-24 | 2018-04-24 | Wista Laboratories Ltd. | Process for the preparation of substantially pure methylthioninium chloride pentahydrate form a |
| CN104869993B (zh) | 2012-10-25 | 2019-01-15 | 通用医疗公司 | 治疗阿尔茨海默病及相关疾病的组合疗法 |
| US10058530B2 (en) | 2012-10-25 | 2018-08-28 | The General Hospital Corporation | Combination therapies for the treatment of Alzheimer's disease and related disorders |
| US10525005B2 (en) | 2013-05-23 | 2020-01-07 | The General Hospital Corporation | Cromolyn compositions and methods thereof |
| US10188757B2 (en) | 2013-10-22 | 2019-01-29 | The General Hospital Corporation | Cromolyn derivatives and related methods of imaging and treatment |
| US10765755B1 (en) | 2013-11-20 | 2020-09-08 | University Of South Florida | Preparation and characterization of methylene blue nanoparticles for Alzheimer's disease and other tauopathies |
| PT3487505T (pt) | 2016-07-25 | 2023-06-07 | Wista Lab Ltd | Administração e dosagem de diaminofenotiazinas |
| EP3506894B1 (en) | 2016-08-31 | 2023-08-23 | The General Hospital Corporation | Macrophages/microglia in neuro-inflammation associated with neurodegenerative diseases |
| GB201614834D0 (en) | 2016-09-01 | 2016-10-19 | Wista Lab Ltd | Treatment of dementia |
| WO2019017995A1 (en) | 2017-07-20 | 2019-01-24 | Aztherapies, Inc. | FORMULATIONS OF CROMOLYNE SODIUM POWDER AND IBUPROFEN |
| AU2019299347A1 (en) | 2018-07-02 | 2021-01-21 | Aztherapies, Inc. | Powdered formulations of cromolyn sodium and alpha-lactose |
| WO2023232764A1 (en) | 2022-05-31 | 2023-12-07 | Wista Laboratories Ltd. | Treatment of neurodegenerative disorders utilising methylthioninium (mt)-containing compounds |
| WO2024061971A1 (en) | 2022-09-21 | 2024-03-28 | Wista Laboratories Ltd. | Novel formulations and vehicles |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9506197D0 (en) | 1995-03-27 | 1995-05-17 | Hoffmann La Roche | Inhibition of tau-tau association. |
| GB0101049D0 (en) | 2001-01-15 | 2001-02-28 | Univ Aberdeen | Materials and methods relating to protein aggregation in neurodegenerative disease |
| GB0322756D0 (en) | 2003-09-29 | 2003-10-29 | Univ Aberdeen | Methods of chemical synthesis |
| JP5186212B2 (ja) * | 2004-09-23 | 2013-04-17 | ウィスタ ラボラトリーズ リミテッド | メチルチオニニウム塩化物（ｍｔｃ）などのジアミノフェノチアジニウム化合物を化学合成および精製する方法 |
| ES2736160T3 (es) | 2004-09-23 | 2019-12-26 | Wista Lab Ltd | Procedimientos de síntesis química y purificación de compuestos de diaminofenotiazinio que incluyen cloruro de metiltioninio (CMT) |
| WO2007110629A1 (en) | 2006-03-29 | 2007-10-04 | Wista Laboratories Ltd | Inhibitors of protein aggregation |
| CN104606199B (zh) * | 2006-03-29 | 2022-09-13 | 维斯塔实验室有限公司 | 3,7-二氨基-10h-吩噻嗪化合物盐及其用途 |
| US8227459B2 (en) * | 2007-04-03 | 2012-07-24 | Prosetta Antiviral Inc. | Diamino-phenothiazinyl derivatives as antiviral treatments |
| US7603854B2 (en) | 2007-04-10 | 2009-10-20 | Illinois Tool Works Inc. | Pneumatically self-regulating valve |
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2010
- 2010-09-23 AU AU2010299571A patent/AU2010299571B2/en active Active
- 2010-09-23 CN CN201080053178.2A patent/CN102666511B/zh active Active
- 2010-09-23 PT PT15176967T patent/PT2963024T/pt unknown
- 2010-09-23 SI SI201032051T patent/SI3378856T1/sl unknown
- 2010-09-23 CA CA3077911A patent/CA3077911C/en active Active
- 2010-09-23 PL PL20203173.8T patent/PL3792254T3/pl unknown
- 2010-09-23 SI SI201031765T patent/SI2963024T1/sl unknown
- 2010-09-23 BR BR122019022612A patent/BR122019022612B8/pt active IP Right Grant
- 2010-09-23 SI SI201031101T patent/SI2480541T1/sl unknown
- 2010-09-23 CN CN201510501874.XA patent/CN105061358A/zh active Pending
- 2010-09-23 KR KR1020187022958A patent/KR20180094126A/ko not_active Application Discontinuation
- 2010-09-23 SG SG10201408584UA patent/SG10201408584UA/en unknown
- 2010-09-23 DK DK10771516.1T patent/DK2480541T3/en active
- 2010-09-23 MY MYPI2012001322A patent/MY159782A/en unknown
- 2010-09-23 MX MX2015008552A patent/MX355627B/es unknown
- 2010-09-23 CA CA3141737A patent/CA3141737C/en active Active
- 2010-09-23 PL PL15176967T patent/PL2963024T3/pl unknown
- 2010-09-23 ES ES15176967.6T patent/ES2689029T3/es active Active
- 2010-09-23 BR BR122019022628A patent/BR122019022628B8/pt active IP Right Grant
- 2010-09-23 ES ES20203173T patent/ES2960761T3/es active Active
- 2010-09-23 SI SI201032134T patent/SI3792254T1/sl unknown
- 2010-09-23 CA CA3004822A patent/CA3004822C/en active Active
- 2010-09-23 DK DK18170358.8T patent/DK3378856T3/da active
- 2010-09-23 EP EP10771516.1A patent/EP2480541B1/en active Active
- 2010-09-23 CA CA2773305A patent/CA2773305C/en active Active
- 2010-09-23 PT PT107715161T patent/PT2480541E/pt unknown
- 2010-09-23 EP EP18170358.8A patent/EP3378856B1/en active Active
- 2010-09-23 HR HRP20181567TT patent/HRP20181567T2/hr unknown
- 2010-09-23 BR BR122019022631A patent/BR122019022631B8/pt active IP Right Grant
- 2010-09-23 KR KR1020127009853A patent/KR20120099409A/ko active Application Filing
- 2010-09-23 WO PCT/IB2010/002526 patent/WO2011036558A2/en active Application Filing
- 2010-09-23 MX MX2012003083A patent/MX2012003083A/es active IP Right Grant
- 2010-09-23 BR BR112012006638-2A patent/BR112012006638B1/pt active IP Right Grant
- 2010-09-23 ES ES18170358T patent/ES2847003T3/es active Active
- 2010-09-23 PL PL10771516T patent/PL2480541T3/pl unknown
- 2010-09-23 PT PT202031738T patent/PT3792254T/pt unknown
- 2010-09-23 FI FIEP20203173.8T patent/FI3792254T3/fi active
- 2010-09-23 PL PL18170358T patent/PL3378856T3/pl unknown
- 2010-09-23 PT PT181703588T patent/PT3378856T/pt unknown
- 2010-09-23 EP EP20203173.8A patent/EP3792254B1/en active Active
- 2010-09-23 US US13/497,686 patent/US8765742B2/en active Active
- 2010-09-23 DK DK15176967.6T patent/DK2963024T3/en active
- 2010-09-23 DK DK20203173.8T patent/DK3792254T3/da active
- 2010-09-23 KR KR1020177013764A patent/KR20170061177A/ko active Search and Examination
- 2010-09-23 ES ES10771516.1T patent/ES2557318T3/es active Active
- 2010-09-23 HR HRP20231201TT patent/HRP20231201T1/hr unknown
- 2010-09-23 EP EP15176967.6A patent/EP2963024B1/en active Active
- 2010-09-23 JP JP2012530357A patent/JP5806217B2/ja active Active
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2012
- 2012-08-29 HK HK16101978.6A patent/HK1213897A1/zh unknown
- 2012-08-29 HK HK12108434.3A patent/HK1167653A1/xx unknown
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2021
- 2021-01-19 HR HRP20210086TT patent/HRP20210086T1/hr unknown
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