PT3792254T - Hidratos de cloreto de metiltionínio cristalino - Google Patents
Hidratos de cloreto de metiltionínio cristalinoInfo
- Publication number
- PT3792254T PT3792254T PT202031738T PT20203173T PT3792254T PT 3792254 T PT3792254 T PT 3792254T PT 202031738 T PT202031738 T PT 202031738T PT 20203173 T PT20203173 T PT 20203173T PT 3792254 T PT3792254 T PT 3792254T
- Authority
- PT
- Portugal
- Prior art keywords
- methylthioninium chloride
- chloride hydrates
- crystalline methylthioninium
- crystalline
- hydrates
- Prior art date
Links
- LXQCLHQAJVBFGN-UHFFFAOYSA-N 2-methylthionin-1-ium;chloride;hydrate Chemical class O.[Cl-].CC1=CC=CC=CC=C[SH+]1 LXQCLHQAJVBFGN-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/18—[b, e]-condensed with two six-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4515—Non condensed piperidines, e.g. piperocaine having a butyrophenone group in position 1, e.g. haloperidol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/18—[b, e]-condensed with two six-membered rings
- C07D279/22—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Psychiatry (AREA)
- Dermatology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24539109P | 2009-09-24 | 2009-09-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT3792254T true PT3792254T (pt) | 2023-10-19 |
Family
ID=43415329
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT202031738T PT3792254T (pt) | 2009-09-24 | 2010-09-23 | Hidratos de cloreto de metiltionínio cristalino |
| PT15176967T PT2963024T (pt) | 2009-09-24 | 2010-09-23 | Hidratos de cloreto de metiltionínio cristalino - parte 2 |
| PT107715161T PT2480541E (pt) | 2009-09-24 | 2010-09-23 | Hidratos de cloreto de metiltiónio cristalino (azul de metileno) |
| PT181703588T PT3378856T (pt) | 2009-09-24 | 2010-09-23 | Hidratos de cloreto de metiltionínio cristalino |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT15176967T PT2963024T (pt) | 2009-09-24 | 2010-09-23 | Hidratos de cloreto de metiltionínio cristalino - parte 2 |
| PT107715161T PT2480541E (pt) | 2009-09-24 | 2010-09-23 | Hidratos de cloreto de metiltiónio cristalino (azul de metileno) |
| PT181703588T PT3378856T (pt) | 2009-09-24 | 2010-09-23 | Hidratos de cloreto de metiltionínio cristalino |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8765742B2 (pt) |
| EP (4) | EP2963024B1 (pt) |
| JP (1) | JP5806217B2 (pt) |
| KR (3) | KR20120099409A (pt) |
| CN (2) | CN105061358A (pt) |
| AU (1) | AU2010299571B2 (pt) |
| BR (4) | BR122019022631B8 (pt) |
| CA (4) | CA3004822C (pt) |
| DK (4) | DK2480541T3 (pt) |
| ES (4) | ES2557318T3 (pt) |
| FI (1) | FI3792254T3 (pt) |
| HK (2) | HK1213897A1 (pt) |
| HR (3) | HRP20231201T1 (pt) |
| MX (2) | MX2012003083A (pt) |
| MY (1) | MY159782A (pt) |
| PL (4) | PL2963024T3 (pt) |
| PT (4) | PT3792254T (pt) |
| SG (1) | SG10201408584UA (pt) |
| SI (4) | SI3792254T1 (pt) |
| WO (1) | WO2011036558A2 (pt) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9925282B2 (en) | 2009-01-29 | 2018-03-27 | The General Hospital Corporation | Cromolyn derivatives and related methods of imaging and treatment |
| AU2010299574B2 (en) * | 2009-09-24 | 2013-09-26 | Wista Laboratories Ltd. | Process |
| CA3111941A1 (en) * | 2012-10-25 | 2014-05-01 | The General Hospital Corporation | Combination therapies for the treatment of alzheimer's disease and related disorders |
| US10058530B2 (en) | 2012-10-25 | 2018-08-28 | The General Hospital Corporation | Combination therapies for the treatment of Alzheimer's disease and related disorders |
| US10525005B2 (en) | 2013-05-23 | 2020-01-07 | The General Hospital Corporation | Cromolyn compositions and methods thereof |
| JP2016534063A (ja) | 2013-10-22 | 2016-11-04 | ザ ジェネラル ホスピタル コーポレイション | クロモリン誘導体ならびに関連するイメージングおよび治療方法 |
| US10765755B1 (en) | 2013-11-20 | 2020-09-08 | University Of South Florida | Preparation and characterization of methylene blue nanoparticles for Alzheimer's disease and other tauopathies |
| PT3487505T (pt) | 2016-07-25 | 2023-06-07 | Wista Lab Ltd | Administração e dosagem de diaminofenotiazinas |
| CN109922800B (zh) | 2016-08-31 | 2023-06-13 | 通用医疗公司 | 与神经退行性疾病相关的神经炎症中的巨噬细胞/小胶质细胞 |
| GB201614834D0 (en) | 2016-09-01 | 2016-10-19 | Wista Lab Ltd | Treatment of dementia |
| CN111565711B (zh) | 2017-07-20 | 2023-01-03 | 阿茨治疗股份有限公司 | 色甘酸钠和布洛芬的粉末化制剂 |
| EP3817739A4 (en) | 2018-07-02 | 2022-04-13 | The General Hospital Corporation | SODIUM CROMOGLYCATE AND ?-LACTOSE POWDER FORMULATIONS |
| WO2023232764A1 (en) | 2022-05-31 | 2023-12-07 | Wista Laboratories Ltd. | Treatment of neurodegenerative disorders utilising methylthioninium (mt)-containing compounds |
| WO2024061971A1 (en) | 2022-09-21 | 2024-03-28 | Wista Laboratories Ltd. | Novel formulations and vehicles |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9506197D0 (en) | 1995-03-27 | 1995-05-17 | Hoffmann La Roche | Inhibition of tau-tau association. |
| GB0101049D0 (en) | 2001-01-15 | 2001-02-28 | Univ Aberdeen | Materials and methods relating to protein aggregation in neurodegenerative disease |
| GB0322756D0 (en) | 2003-09-29 | 2003-10-29 | Univ Aberdeen | Methods of chemical synthesis |
| CN101084204B (zh) * | 2004-09-23 | 2012-12-05 | 卫思道制药有限公司 | 包括亚甲蓝(mtc)在内的二氨基吩噻嗪鎓化合物的化学合成和纯化方法 |
| DK1799662T3 (da) | 2004-09-23 | 2013-07-15 | Wista Lab Ltd | Fremgangsmåder til kemisk syntese og oprensning af diaminophenothiaziniumforbindelser, herunder methylthioniniumchlorid (MTC) |
| WO2007110629A1 (en) * | 2006-03-29 | 2007-10-04 | Wista Laboratories Ltd | Inhibitors of protein aggregation |
| MY143757A (en) * | 2006-03-29 | 2011-07-15 | Wista Lab Ltd | 3,7-diamond-10h-phenothiazine salts and their use |
| JP2010523591A (ja) * | 2007-04-03 | 2010-07-15 | プロセッタ バイオコンフォーマティクス インコーポレイテッド | 抗ウイルス処置 |
| US7603854B2 (en) | 2007-04-10 | 2009-10-20 | Illinois Tool Works Inc. | Pneumatically self-regulating valve |
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2010
- 2010-09-23 ES ES10771516.1T patent/ES2557318T3/es active Active
- 2010-09-23 CA CA3004822A patent/CA3004822C/en active Active
- 2010-09-23 HR HRP20231201TT patent/HRP20231201T1/hr unknown
- 2010-09-23 US US13/497,686 patent/US8765742B2/en active Active
- 2010-09-23 DK DK10771516.1T patent/DK2480541T3/en active
- 2010-09-23 MY MYPI2012001322A patent/MY159782A/en unknown
- 2010-09-23 PL PL15176967T patent/PL2963024T3/pl unknown
- 2010-09-23 MX MX2012003083A patent/MX2012003083A/es active IP Right Grant
- 2010-09-23 EP EP15176967.6A patent/EP2963024B1/en active Active
- 2010-09-23 DK DK18170358.8T patent/DK3378856T3/da active
- 2010-09-23 JP JP2012530357A patent/JP5806217B2/ja active Active
- 2010-09-23 KR KR1020127009853A patent/KR20120099409A/ko active Application Filing
- 2010-09-23 PL PL20203173.8T patent/PL3792254T3/pl unknown
- 2010-09-23 CA CA2773305A patent/CA2773305C/en active Active
- 2010-09-23 AU AU2010299571A patent/AU2010299571B2/en active Active
- 2010-09-23 BR BR122019022631A patent/BR122019022631B8/pt active IP Right Grant
- 2010-09-23 WO PCT/IB2010/002526 patent/WO2011036558A2/en active Application Filing
- 2010-09-23 CN CN201510501874.XA patent/CN105061358A/zh active Pending
- 2010-09-23 SI SI201032134T patent/SI3792254T1/sl unknown
- 2010-09-23 SG SG10201408584UA patent/SG10201408584UA/en unknown
- 2010-09-23 KR KR1020177013764A patent/KR20170061177A/ko active Search and Examination
- 2010-09-23 SI SI201031765T patent/SI2963024T1/sl unknown
- 2010-09-23 HR HRP20181567TT patent/HRP20181567T2/hr unknown
- 2010-09-23 DK DK20203173.8T patent/DK3792254T3/da active
- 2010-09-23 EP EP20203173.8A patent/EP3792254B1/en active Active
- 2010-09-23 FI FIEP20203173.8T patent/FI3792254T3/fi active
- 2010-09-23 EP EP18170358.8A patent/EP3378856B1/en active Active
- 2010-09-23 PT PT202031738T patent/PT3792254T/pt unknown
- 2010-09-23 CA CA3077911A patent/CA3077911C/en active Active
- 2010-09-23 SI SI201031101T patent/SI2480541T1/sl unknown
- 2010-09-23 EP EP10771516.1A patent/EP2480541B1/en active Active
- 2010-09-23 SI SI201032051T patent/SI3378856T1/sl unknown
- 2010-09-23 BR BR112012006638-2A patent/BR112012006638B1/pt active IP Right Grant
- 2010-09-23 MX MX2015008552A patent/MX355627B/es unknown
- 2010-09-23 ES ES15176967.6T patent/ES2689029T3/es active Active
- 2010-09-23 BR BR122019022628A patent/BR122019022628B8/pt active IP Right Grant
- 2010-09-23 DK DK15176967.6T patent/DK2963024T3/en active
- 2010-09-23 CA CA3141737A patent/CA3141737C/en active Active
- 2010-09-23 ES ES20203173T patent/ES2960761T3/es active Active
- 2010-09-23 CN CN201080053178.2A patent/CN102666511B/zh active Active
- 2010-09-23 PT PT15176967T patent/PT2963024T/pt unknown
- 2010-09-23 PT PT107715161T patent/PT2480541E/pt unknown
- 2010-09-23 BR BR122019022612A patent/BR122019022612B8/pt active IP Right Grant
- 2010-09-23 ES ES18170358T patent/ES2847003T3/es active Active
- 2010-09-23 PL PL10771516T patent/PL2480541T3/pl unknown
- 2010-09-23 PL PL18170358T patent/PL3378856T3/pl unknown
- 2010-09-23 PT PT181703588T patent/PT3378856T/pt unknown
- 2010-09-23 KR KR1020187022958A patent/KR20180094126A/ko not_active Application Discontinuation
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2012
- 2012-08-29 HK HK16101978.6A patent/HK1213897A1/zh unknown
- 2012-08-29 HK HK12108434.3A patent/HK1167653A1/xx unknown
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2021
- 2021-01-19 HR HRP20210086TT patent/HRP20210086T1/hr unknown
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