AU2013302925B2 - Anti-PCSK9 antibodies with pH-dependent binding characteristics - Google Patents

Anti-PCSK9 antibodies with pH-dependent binding characteristics Download PDF

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Publication number
AU2013302925B2
AU2013302925B2 AU2013302925A AU2013302925A AU2013302925B2 AU 2013302925 B2 AU2013302925 B2 AU 2013302925B2 AU 2013302925 A AU2013302925 A AU 2013302925A AU 2013302925 A AU2013302925 A AU 2013302925A AU 2013302925 B2 AU2013302925 B2 AU 2013302925B2
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Australia
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gly
thr
leu
val
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AU2013302925A
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AU2013302925A1 (en
Inventor
Andrew J. Murphy
Nicholas J. Papadopoulos
Neil Stahl
George D. Yancopoulos
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Regeneron Pharmaceuticals Inc
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Regeneron Pharmaceuticals Inc
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Publication of AU2013302925A1 publication Critical patent/AU2013302925A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU2013302925A 2012-08-13 2013-08-12 Anti-PCSK9 antibodies with pH-dependent binding characteristics Ceased AU2013302925B2 (en)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201261682349P 2012-08-13 2012-08-13
US61/682,349 2012-08-13
US201261703342P 2012-09-20 2012-09-20
US61/703,342 2012-09-20
US201261734398P 2012-12-07 2012-12-07
US61/734,398 2012-12-07
US201361761383P 2013-02-06 2013-02-06
US61/761,383 2013-02-06
US201361828258P 2013-05-29 2013-05-29
US61/828,258 2013-05-29
PCT/US2013/054456 WO2014028354A1 (en) 2012-08-13 2013-08-12 Anti-pcsk9 antibodies with ph-dependent binding characteristics

Publications (2)

Publication Number Publication Date
AU2013302925A1 AU2013302925A1 (en) 2015-02-26
AU2013302925B2 true AU2013302925B2 (en) 2018-07-05

Family

ID=50066319

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2013302925A Ceased AU2013302925B2 (en) 2012-08-13 2013-08-12 Anti-PCSK9 antibodies with pH-dependent binding characteristics

Country Status (15)

Country Link
US (1) US9540449B2 (OSRAM)
EP (1) EP2882778B1 (OSRAM)
JP (1) JP6309521B2 (OSRAM)
KR (1) KR20150041662A (OSRAM)
CN (1) CN104540852B (OSRAM)
AR (1) AR092098A1 (OSRAM)
AU (1) AU2013302925B2 (OSRAM)
CA (1) CA2881679C (OSRAM)
EA (1) EA028244B1 (OSRAM)
IL (1) IL236785B (OSRAM)
MX (1) MX363213B (OSRAM)
NZ (1) NZ704771A (OSRAM)
TW (1) TWI596115B (OSRAM)
UY (1) UY34975A (OSRAM)
WO (1) WO2014028354A1 (OSRAM)

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