AU2013302799B2 - Exosomes and micro-ribonucleic acids for tissue regeneration - Google Patents

Exosomes and micro-ribonucleic acids for tissue regeneration Download PDF

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AU2013302799B2
AU2013302799B2 AU2013302799A AU2013302799A AU2013302799B2 AU 2013302799 B2 AU2013302799 B2 AU 2013302799B2 AU 2013302799 A AU2013302799 A AU 2013302799A AU 2013302799 A AU2013302799 A AU 2013302799A AU 2013302799 B2 AU2013302799 B2 AU 2013302799B2
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exosomes
cells
pct
tissue
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AU2013302799A1 (en
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Ke CHENG
Ahmed Ibrahim
Eduardo Marban
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Cedars Sinai Medical Center
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AU2013302799A 2012-08-13 2013-08-13 Exosomes and micro-ribonucleic acids for tissue regeneration Active AU2013302799B2 (en)

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US201261682666P 2012-08-13 2012-08-13
US61/682,666 2012-08-13
PCT/US2013/054732 WO2014028493A2 (en) 2012-08-13 2013-08-13 Exosomes and micro-ribonucleic acids for tissue regeneration

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AU2013302799A1 AU2013302799A1 (en) 2015-02-26
AU2013302799B2 true AU2013302799B2 (en) 2018-03-01

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US (4) US9828603B2 (https=)
EP (2) EP3563859B1 (https=)
JP (2) JP6433896B2 (https=)
AU (1) AU2013302799B2 (https=)
CA (1) CA2881394C (https=)
WO (1) WO2014028493A2 (https=)

Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11660317B2 (en) 2004-11-08 2023-05-30 The Johns Hopkins University Compositions comprising cardiosphere-derived cells for use in cell therapy
US11286463B2 (en) 2012-03-08 2022-03-29 Advanced ReGen Medical Technologies, LLC Reprogramming of aged adult stem cells
AU2013302799B2 (en) * 2012-08-13 2018-03-01 Cedars-Sinai Medical Center Exosomes and micro-ribonucleic acids for tissue regeneration
US12558316B2 (en) 2013-03-13 2026-02-24 University Of Miami Methods and compositions for the treatment of epidermolysis bullosa
CN105209881B (zh) 2013-03-13 2021-01-22 迈阿密大学 从细胞培养上清液和生物流体分离并纯化微泡的方法
WO2014197421A1 (en) 2013-06-05 2014-12-11 Biotime, Inc. Compositions and methods for induced tissue regeneration in mammalian species
US10772911B2 (en) 2013-12-20 2020-09-15 Advanced ReGen Medical Technologies, LLC Cell free compositions for cellular restoration and methods of making and using same
CR20160307A (es) 2013-12-20 2016-11-08 Advanced Regen Medical Tech Llc Composiciones para la restauración de células y métodos para la preparación y utilización de las mismas
US11078462B2 (en) 2014-02-18 2021-08-03 ReCyte Therapeutics, Inc. Perivascular stromal cells from primate pluripotent stem cells
EP4445915A3 (en) 2014-03-24 2025-01-22 Advanced Regen Medical Technologies, LLC Cell free compositions for cellular restoration and methods of making and using same
EP3733856A1 (en) 2014-04-18 2020-11-04 University of Massachusetts Exosomal loading using hydrophobically modified oligonucleotides
US10568945B2 (en) 2014-04-25 2020-02-25 University Of Cincinnati Compositions and methods for inducing liver regeneration by administering hepatocyte-derived exosomes
US20150328263A1 (en) 2014-05-14 2015-11-19 University Of Maryland, Baltimore Cardiac stem cells for cardiac repair
RU2620069C2 (ru) * 2014-06-26 2017-05-22 Аоварт Гмбх Вещество и способ модуляции пролиферации и дифференцировки регуляторных, стволовых и других соматических клеток
US10240127B2 (en) 2014-07-03 2019-03-26 ReCyte Therapeutics, Inc. Exosomes from clonal progenitor cells
CA2962444C (en) 2014-10-03 2023-09-05 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy
EP3204117A4 (en) * 2014-10-06 2018-05-09 Cedars-Sinai Medical Center Polarization of macrophages to a healing phenotype by cardiosphere-derived cells and by the exosomes secreted by such cells
CN107106615A (zh) * 2014-10-09 2017-08-29 人类起源公司 胎盘来源的贴壁细胞外泌体及其用途
JP6716564B2 (ja) * 2014-12-03 2020-07-01 カプリコール,インコーポレイテッド 安定したエクソソーム製剤の製造方法
WO2016196822A1 (en) * 2015-06-02 2016-12-08 Cedars-Sinai Medical Center Urodele exosomes as therapeutic agents
WO2017091700A1 (en) 2015-11-25 2017-06-01 The Regents Of The University Of Colorado, A Body Corporate Use of microrna-146a and nanoceria conjugate to improve wound healing and promote tissue regeneration
CA3202332A1 (en) 2015-12-07 2017-06-15 Agex Therapeutics, Inc. Methods for the re-derivation of diverse pluripotent stem cell-derived brown fat cells
EP3402543B1 (en) 2016-01-11 2021-09-08 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of heart failure with preserved ejection fraction
WO2017160884A1 (en) 2016-03-14 2017-09-21 Capricor, Inc. Methods of treating ocular inflammation and chemical injuries of the eye with extracellular vesicles
JP7120628B2 (ja) * 2016-03-22 2022-08-17 カプリコール,インコーポレイテッド 細胞外小胞による放射線誘発性皮膚炎を予防するまたは治療する方法
ES3034017T3 (en) * 2016-03-24 2025-08-12 Stemlab Sa Use of umbilical cord blood derived exosomes for tissue repair
EP3436081A4 (en) * 2016-04-29 2019-07-24 Advanced Regen Medical Technologies, LLC Microrna compositions and methods of making and using same
US11697851B2 (en) 2016-05-24 2023-07-11 The Regents Of The University Of California Early ovarian cancer detection diagnostic test based on mRNA isoforms
WO2017210652A1 (en) 2016-06-03 2017-12-07 Cedars-Sinai Medical Center Cdc-derived exosomes for treatment of ventricular tachyarrythmias
CN107557464B (zh) * 2016-07-02 2021-06-04 上海市公共卫生临床中心 用于干扰素治疗慢性乙型肝炎早期病毒学反应的预测模型及检测试剂盒
EA201890841A1 (ru) * 2016-08-17 2018-09-28 Ортоген Аг Фармацевтический препарат против старения
US20210290556A1 (en) * 2016-08-22 2021-09-23 Codiak Biosciences, Inc. Methods of suppressing delivery of exosomes to liver and spleen
FR3055805B1 (fr) * 2016-09-09 2020-05-15 Assistance Publique - Hopitaux De Paris (Ap-Hp) Biomateriau a usage therapeutique
CN109890964A (zh) * 2016-09-09 2019-06-14 康奈尔大学 核酸、蛋白和小分子在玻璃体囊泡体中的递送
US11541078B2 (en) 2016-09-20 2023-01-03 Cedars-Sinai Medical Center Cardiosphere-derived cells and their extracellular vesicles to retard or reverse aging and age-related disorders
WO2018183930A1 (en) * 2017-03-30 2018-10-04 Carson Dennis A Methods for isolating, expanding and administering cancer specific cd8+ t cells
WO2018177583A1 (en) * 2017-03-30 2018-10-04 Lugano Technology Transfer (LTT) SA Device and method for producing and purifying exosomes
IT201700035315A1 (it) * 2017-03-30 2018-09-30 Foundation For Cardiological Res And Education Fcre Dispositivo e metodo di produzione e purificazione di esosomi
EP4699658A2 (en) 2017-04-19 2026-02-25 Cedars-Sinai Medical Center Methods and compositions for treating skeletal muscular dystrophy
JP7083818B2 (ja) * 2017-04-28 2022-06-13 一丸ファルコス株式会社 プラセンタ抽出物
US11529376B2 (en) * 2017-05-05 2022-12-20 Capricor, Inc. Methods of treating systemic graft-versus-host disease with extracellular vesicles
US20200113943A1 (en) * 2017-06-05 2020-04-16 The Regents Of The University Of California Methods for enhanced production and isolation of cell-derived vesicles and treatment of inflammation and neurological damage
JP2020529477A (ja) * 2017-08-04 2020-10-08 シーダーズ—シナイ メディカル センター がんの治療及び防止のためのカルディオスフィア由来細胞及びその細胞外小胞
EP3675871A4 (en) * 2017-08-31 2021-10-27 Tel HaShomer Medical Research Infrastructure and Services Ltd. COMPOSITIONS AND METHODS OF TREATMENT OF FIBROTIC DISEASES
CA3090593A1 (en) * 2017-09-01 2019-03-07 Orig3N, Inc. Ipsc-derived secretome compositions, and related systems and methods
WO2019055337A1 (en) * 2017-09-13 2019-03-21 Children's Hospital Medical Center ROLE OF EXOSOMES, EXTRACELLULAR VESICLES IN THE REGULATION OF METABOLIC HOMÉOSTASIE
US11660355B2 (en) 2017-12-20 2023-05-30 Cedars-Sinai Medical Center Engineered extracellular vesicles for enhanced tissue delivery
US10717981B2 (en) 2018-01-18 2020-07-21 Advanced ReGen Medical Technologies, LLC Therapeutic compositions and methods of making and using the same
US12146137B2 (en) 2018-02-05 2024-11-19 Cedars-Sinai Medical Center Methods for therapeutic use of exosomes and Y-RNAS
JP2021526556A (ja) 2018-05-30 2021-10-07 ダイレクト バイオロジクス エルエルシー 成長因子および細胞外小胞を凍結または粉状にした、間葉系幹細胞(msc)の調製物を含む助剤、ならびにその使用方法
WO2020069313A2 (en) * 2018-09-28 2020-04-02 Henry Ford Health System Use of extracellular vesicles in combination with tissue plasminogen activator and/or thrombectomy to treat stroke
JP7519698B2 (ja) * 2018-10-04 2024-07-22 エクサオゲンウス セラペウティクス,エスエー 抗炎症及び免疫調節特性を有する臍帯血単核細胞に由来する小型細胞外小胞を含む組成物及びそれらを得るためのプロセス
BR112021015549A2 (pt) 2019-02-07 2021-10-26 Direct Biologics Llc Método para tratar osteoartrite com uma combinação de exossomos de células tronco mesenquimais, células tronco mesenquimais sinoviais e andaimes
JP2022519718A (ja) * 2019-02-08 2022-03-24 ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム 加齢および加齢性臓器不全に関連する疾患の処置のためのテロメラーゼ含有エキソソーム
JP2022525209A (ja) * 2019-03-15 2022-05-11 ユニシテ エーファウ アクチェンゲゼルシャフト 細胞外小胞(ev)の血管新生促進能力の予測方法
WO2020190672A1 (en) * 2019-03-15 2020-09-24 North Carolina State University Cardiomyocyte-derived exosomes inducing regeneration of damaged heart tissue
US20220160786A1 (en) * 2019-04-09 2022-05-26 International Space Medical Co., Ltd. Therapeutic agent for fibrosis, inflammation, and/or aging disease
CA3146433A1 (en) 2019-07-18 2021-01-21 Direct Biologics Llc Preparations comprising mesenchymal stem cells and cannabinoids and methods of their use
KR20220042117A (ko) 2019-08-09 2022-04-04 우베 고산 가부시키가이샤 엑소좀의 생성 방법
WO2021105407A1 (en) * 2019-11-29 2021-06-03 Novadip Biosciences miRNA-BASED PHARMACEUTICAL COMPOSITIONS AND USES THEREOF FOR THE PREVENTION AND THE TREATMENT OF TISSUE DISORDERS
US20210186831A1 (en) * 2019-12-19 2021-06-24 North Carolina State University Therapeutic compositions and methods using exosomes derived from human dermal fibroblasts
WO2021151029A1 (en) * 2020-01-22 2021-07-29 Agex Therapeutics, Inc. Therapeutic exosomes and method of producing them
WO2021178514A1 (en) * 2020-03-04 2021-09-10 Cedars-Sinai Medical Center Cardiosphere-derived cells, exosomes derived therefrom, and methods of using same to treat volumetric muscle loss
US12590310B2 (en) 2020-04-22 2026-03-31 Direct Biologics, Llc Methods and compositions for treating inflammatory conditions associated with infectious disease
WO2021248158A1 (en) * 2020-06-01 2021-12-09 Figene, Llc Fibroblasts as a regenerative cellular source for the treatment of blindness
JP2022058273A (ja) * 2020-09-30 2022-04-11 澁谷工業株式会社 線維化疾患用又は老化疾患用の医薬組成物及び炎症性疾患用の医薬組成物、ないしそれらの製造方法
WO2022109446A1 (en) * 2020-11-23 2022-05-27 The Government Of The United States As Represented By The Secretary Of The Army Extracellular vesicles derived from cardiosphere-derived cells as anti-shock therapeutics
EP4252761A4 (en) * 2020-11-26 2024-06-05 Samsung Life Public Welfare Foundation COMPOSITION FOR THE TREATMENT OF INFECTIOUS DISEASES, COMPRISING EXOSOMES DERIVED FROM THROMBIN-PROCESSED STEM CELLS
CN112852713B (zh) * 2021-02-07 2023-08-18 广州四叶草健康科技有限公司 一种人体皮肤成纤维细胞外泌体制备分离方法
JPWO2022202930A1 (https=) * 2021-03-23 2022-09-29
EP4349347A4 (en) * 2021-05-04 2025-05-14 S&E Bio Co., Ltd. Composition for promoting angiogenesis with extracellular vesicles made from three-dimensional spheroid cell aggregates
JP2024518396A (ja) * 2021-05-04 2024-05-01 エスアンドイー、バイオ、カンパニー、リミテッド 三次元スフェロイド型細胞凝集体に由来の細胞外小胞を含む神経再生促進組成物
CA3243854A1 (en) * 2022-02-08 2023-08-17 Temple University-Of The Commonwealth System Of Higher Education COMPOSITIONS AND PROCESSES FOR REGENERATION OF CARDIAC TISSUE
JP2025508965A (ja) * 2022-03-03 2025-04-10 フィブロバイオロジクス インコーポレイテッド 萎縮した脾臓の再生と修復を刺激する線維芽細胞の治療的使用
JP7773257B2 (ja) 2022-03-28 2025-11-19 合同会社HiRoko Science miR-140を含む医薬組成物及びその製造方法
US12502407B2 (en) 2024-04-25 2025-12-23 Direct Biologics, Llc Treatment of fistula with bone marrow mesenchymal stem cell derived extracellular vesicles

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012020307A2 (en) * 2010-08-13 2012-02-16 The University Court Of The University Of Glasgow Therapeutic uses of microvesicles and related micrornas

Family Cites Families (382)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3470876A (en) 1966-09-28 1969-10-07 John Barchilon Dirigible catheter
US4106488A (en) 1974-08-20 1978-08-15 Robert Thomas Gordon Cancer treatment method
US3964468A (en) 1975-05-30 1976-06-22 The Board Of Trustees Of Leland Stanford Junior University Bioptome
US4659839A (en) 1984-10-10 1987-04-21 Mallinckrodt, Inc. Coupling agents for radiolabeled antibody fragments
GB8711614D0 (en) 1987-05-16 1987-06-24 Medical Res Council Proteins
US4960134A (en) 1988-11-18 1990-10-02 Webster Wilton W Jr Steerable catheter
US5175004A (en) 1988-12-27 1992-12-29 Matsumura Kenneth N Propagatable, new combinant cells for cellular replacement therapy
US4921482A (en) 1989-01-09 1990-05-01 Hammerslag Julius G Steerable angioplasty device
US5052402A (en) 1989-01-31 1991-10-01 C.R. Bard, Inc. Disposable biopsy forceps
US5104787A (en) 1990-03-05 1992-04-14 Lindstrom Richard L Method for apparatus for a defined serumfree medical solution useful for corneal preservation
US6326198B1 (en) 1990-06-14 2001-12-04 Regents Of The University Of Michigan Methods and compositions for the ex vivo replication of stem cells, for the optimization of hematopoietic progenitor cell cultures, and for increasing the metabolism, GM-CSF secretion and/or IL-6 secretion of human stromal cells
US5401629A (en) 1990-08-07 1995-03-28 The Salk Institute Biotechnology/Industrial Associates, Inc. Assay methods and compositions useful for measuring the transduction of an intracellular signal
ES2077007T3 (es) 1990-12-07 1995-11-16 Ruesch Willy Ag Instrumento medico con cabeza orientable.
US5454787A (en) 1991-02-15 1995-10-03 Lundquist; Ingemar H. Torquable tubular assembly and torquable catheter utilizing the same
US5329923A (en) 1991-02-15 1994-07-19 Lundquist Ingemar H Torquable catheter
US5228441A (en) 1991-02-15 1993-07-20 Lundquist Ingemar H Torquable catheter and method
US5315996A (en) 1991-02-15 1994-05-31 Lundquist Ingemar H Torquable catheter and method
AU660444B2 (en) 1991-02-15 1995-06-29 Ingemar H. Lundquist Torquable catheter and method
US5981165A (en) 1991-07-08 1999-11-09 Neurospheres Holdings Ltd. In vitro induction of dopaminergic cells
US5287857A (en) 1992-06-22 1994-02-22 David Mann Apparatus and method for obtaining an arterial biopsy
US5243167A (en) 1992-09-16 1993-09-07 Ingemar H. Lundquist Apparatus and method for manufacturing a slotted torque tube
US5334145A (en) 1992-09-16 1994-08-02 Lundquist Ingemar H Torquable catheter
US5383852A (en) 1992-12-04 1995-01-24 C. R. Bard, Inc. Catheter with independent proximal and distal control
US5368564A (en) 1992-12-23 1994-11-29 Angeion Corporation Steerable catheter
WO1994028176A2 (en) 1993-05-28 1994-12-08 Mount Sinai School Of Medicine Of The City University Of New York Bc200 rna, probes therefor and use thereof
US5492825A (en) 1993-08-06 1996-02-20 The Regents Of The University Of California Mammalian inward rectifier potassium channel cDNA, IRK1, corresponding vectors, and transformed cells
US5616568A (en) 1993-11-30 1997-04-01 The Research Foundation Of State University Of New York Functionalized derivatives of hyaluronic acid
US5454827A (en) 1994-05-24 1995-10-03 Aust; Gilbert M. Surgical instrument
US5840502A (en) 1994-08-31 1998-11-24 Activated Cell Therapy, Inc. Methods for enriching specific cell-types by density gradient centrifugation
US5702905A (en) 1994-09-28 1997-12-30 Spectral Diagnostics Monoclonal antibody to human ventricular myosin light chains
DE69621528T2 (de) 1995-02-07 2003-01-16 Shiseido Co. Ltd., Tokio/Tokyo Anti-inflamatorische agenzien
US5551427A (en) 1995-02-13 1996-09-03 Altman; Peter A. Implantable device for the effective elimination of cardiac arrhythmogenic sites
US5715832A (en) 1995-02-28 1998-02-10 Boston Scientific Corporation Deflectable biopsy catheter
US5925567A (en) 1995-05-19 1999-07-20 T. Breeders, Inc. Selective expansion of target cell populations
US5702433A (en) 1995-06-27 1997-12-30 Arrow International Investment Corp. Kink-resistant steerable catheter assembly for microwave ablation
BR9610058A (pt) 1995-07-28 1999-07-27 Marie Curie Cancer Care Uso de vp22 ou uma porção ativa fragmento ou homólogo do mesmo proteína de transporte ácido nucleíco vetor de expressão célula hospedeira de mamíferos ou microbiana e processos para transportar uma proteína ou peptídeo desejado para uma população de marcaç o de células e para transportar uma molécula desejada em uma população de células
FR2739621B1 (fr) 1995-10-05 1997-12-05 Centre Nat Rech Scient Peptides utilisables comme vecteurs pour l'adressage intracellulaire de molecules actives
DE69635899T2 (de) 1995-11-17 2006-11-23 Asahi Kasei Kabushiki Kaisha Polypeptid, das die differenzierung unterdrueckt
US5762069A (en) 1995-12-29 1998-06-09 Akos Biomedical, Inc. Multiple sample biopsy forceps
US5856155A (en) 1996-02-23 1999-01-05 The Johns Hopkins University School Of Medicine Compounds and related methods for modulating potassium ion channels and assays for such compounds
US6132390A (en) 1996-02-28 2000-10-17 Eupalamus Llc Handle for manipulation of a stylet used for deflecting a tip of a lead or catheter
US5824031A (en) 1996-02-28 1998-10-20 Cardio Source Apparatus and method for deflecting a tip of a lead or catheter
US5782748A (en) 1996-07-10 1998-07-21 Symbiosis Corporation Endoscopic surgical instruments having detachable proximal and distal portions
GB9615726D0 (en) 1996-07-26 1996-09-04 Medical Res Council Anti-viral agent 11
US5955275A (en) 1997-02-14 1999-09-21 Arcaris, Inc. Methods for identifying nucleic acid sequences encoding agents that affect cellular phenotypes
US6017735A (en) 1997-01-23 2000-01-25 Marie Curie Cancer Care Materials and methods for intracellular transport and their uses
US6086582A (en) 1997-03-13 2000-07-11 Altman; Peter A. Cardiac drug delivery system
US6547787B1 (en) 1997-03-13 2003-04-15 Biocardia, Inc. Drug delivery catheters that attach to tissue and methods for their use
US6511477B2 (en) 1997-03-13 2003-01-28 Biocardia, Inc. Method of drug delivery to interstitial regions of the myocardium
US6443949B2 (en) 1997-03-13 2002-09-03 Biocardia, Inc. Method of drug delivery to interstitial regions of the myocardium
US6416510B1 (en) 1997-03-13 2002-07-09 Biocardia, Inc. Drug delivery catheters that attach to tissue and methods for their use
CA2289702C (en) 1997-05-14 2008-02-19 Inex Pharmaceuticals Corp. High efficiency encapsulation of charged therapeutic agents in lipid vesicles
US6099832A (en) 1997-05-28 2000-08-08 Genzyme Corporation Transplants for myocardial scars
US5899914A (en) 1997-06-11 1999-05-04 Endius Incorporated Surgical instrument
US5851212A (en) 1997-06-11 1998-12-22 Endius Incorporated Surgical instrument
US6004295A (en) 1997-06-26 1999-12-21 An-Go-Gen Inc. Catheters
CA2296704C (en) 1997-07-14 2010-10-19 Osiris Therapeutics, Inc. Cardiac muscle regeneration using mesenchymal stem cells
US7514074B2 (en) 1997-07-14 2009-04-07 Osiris Therapeutics, Inc. Cardiac muscle regeneration using mesenchymal stem cells
GB9718609D0 (en) 1997-09-02 1997-11-05 Imp College Innovations Ltd Fusion protein
US6123699A (en) 1997-09-05 2000-09-26 Cordis Webster, Inc. Omni-directional steerable catheter
US7037648B1 (en) 1997-11-07 2006-05-02 John Hopkins University Somatic transfer of modified genes to predict drug effects
US5938603A (en) 1997-12-01 1999-08-17 Cordis Webster, Inc. Steerable catheter with electromagnetic sensor
US6203487B1 (en) 1997-12-31 2001-03-20 Thomas Jefferson University Use of magnetic particles in the focal delivery of cells
WO1999039624A1 (en) 1998-02-05 1999-08-12 Biosense Inc. Intracardiac drug delivery
EP1064356A2 (en) 1998-03-23 2001-01-03 ZymoGenetics, Inc. Cardiac-derived stem cells
US6296630B1 (en) 1998-04-08 2001-10-02 Biocardia, Inc. Device and method to slow or stop the heart temporarily
US20010044619A1 (en) 1998-04-08 2001-11-22 Peter A. Altman Cardiac drug delivery system and method for use
US6171610B1 (en) 1998-04-24 2001-01-09 University Of Massachusetts Guided development and support of hydrogel-cell compositions
US6165164A (en) 1999-03-29 2000-12-26 Cordis Corporation Catheter for injecting therapeutic and diagnostic agents
US6540725B1 (en) 1998-06-04 2003-04-01 Biosense Webster, Inc. Injection catheter with controllably extendable injection needle
DE19833476B4 (de) 1998-07-24 2005-08-25 Huss, Ralf, Dr. Genetisch modifizierte CD34-Negative, adhärent wachsende hämatopoetische Stammzellen und deren Verwendung in der Gentherapie
US6102887A (en) 1998-08-11 2000-08-15 Biocardia, Inc. Catheter drug delivery system and method for use
US6074408A (en) 1998-10-13 2000-06-13 Freeman; Kenneth V. Modular medical instrument and method of using same
US6153582A (en) 1998-11-05 2000-11-28 Bausch & Lomb Surgical, Inc. Defined serumfree medical solution for ophthalmology
US6572611B1 (en) 1998-11-23 2003-06-03 C. R. Bard, Inc. Intracardiac grasp catheter
US6193763B1 (en) 1998-12-17 2001-02-27 Robert A. Mackin Apparatus and method for contemporaneous treatment and fluoroscopic mapping of body tissue
AUPP785098A0 (en) 1998-12-21 1999-01-21 Victor Chang Cardiac Research Institute, The Treatment of heart disease
US6783510B1 (en) 1999-07-08 2004-08-31 C.R. Bard, Inc. Steerable catheter
US7015037B1 (en) 1999-08-05 2006-03-21 Regents Of The University Of Minnesota Multiponent adult stem cells and methods for isolation
AU6519100A (en) 1999-08-05 2001-03-05 Biocardia, Inc. A system and method for delivering thermally sensitive and reverse-thermal gelation matrials
SE9903185D0 (sv) 1999-09-08 1999-09-08 Europ I Of Science Ab Terapeutisk metod och anordning baserad på magnetism
AU7378600A (en) 1999-09-14 2001-04-17 Children's Medical Center Corporation Methods for treating muscular dystrophy
US20030161817A1 (en) 2001-03-28 2003-08-28 Young Henry E. Pluripotent embryonic-like stem cells, compositions, methods and uses thereof
EP1218489B1 (en) 1999-09-24 2009-03-18 Cybios LLC Pluripotent embryonic-like stem cells, compositions, methods and uses thereof
US6716242B1 (en) 1999-10-13 2004-04-06 Peter A. Altman Pulmonary vein stent and method for use
AU8023200A (en) 1999-10-13 2001-04-23 Biocardia, Inc. Pulmonary vein stent and method for use
AU4305101A (en) 1999-11-22 2001-06-04 Research Foundation Of The State University Of New York, The Magnetic nanoparticles for selective therapy
US6224587B1 (en) 1999-11-22 2001-05-01 C.R. Bard, Inc. Steerable catheter
US20010046489A1 (en) 1999-12-06 2001-11-29 Habener Joel E. Stem cells of the islets of langerhans and their use in treating diabetes mellitus
EP1254952A4 (en) 1999-12-28 2004-09-22 Kyowa Hakko Kogyo Kk CELLS THAT ARE ABLE TO DIFFERENTIZE IN THE HEART MUSCLE CELLS
AU2001234470A1 (en) 2000-01-14 2001-07-24 Beth Israel Deaconess Medical Center Cardiac-cell specific enhancer elements and uses thereof
US6530944B2 (en) 2000-02-08 2003-03-11 Rice University Optically-active nanoparticles for use in therapeutic and diagnostic methods
US6585716B2 (en) 2000-04-05 2003-07-01 Biocardia, Inc. Method of treating the heart
US6478776B1 (en) 2000-04-05 2002-11-12 Biocardia, Inc. Implant delivery catheter system and methods for its use
US20040087016A1 (en) 2000-05-12 2004-05-06 University Of Utah Research Foundation Compositions and methods for cell dedifferentiation and tissue regeneration
WO2002005866A2 (en) 2000-07-13 2002-01-24 Bioheart, Inc. Deployment system for myocardial cellular material
US7862810B2 (en) 2000-07-31 2011-01-04 New York Medical College Methods and compositions for the repair and/or regeneration of damaged myocardium
US20110091428A1 (en) 2000-07-31 2011-04-21 New York Medical College Compositions of adult organ stem cells and uses thereof
WO2002013760A2 (en) 2000-07-31 2002-02-21 New York Medical College Methods and compositions for the repair and/or regeneration of damaged myocardium
AU2001284695A1 (en) 2000-07-31 2002-02-13 New York Medical College Methods and compositions for the repair and/or regeneration of damaged myocardium
US7547674B2 (en) 2001-06-06 2009-06-16 New York Medical College Methods and compositions for the repair and/or regeneration of damaged myocardium
US20040254134A1 (en) 2001-04-27 2004-12-16 Eduardo Marban Biological pacemaker
EP1324780A4 (en) 2000-09-06 2005-06-22 Univ Johns Hopkins METHODS OF TREATING CARDIAC ARRHYTHMIA
US6569105B1 (en) 2000-09-14 2003-05-27 Syntheon, Llc Rotatable and deflectable biopsy forceps
FR2814752A1 (fr) 2000-10-02 2002-04-05 Chru Lille Procede d'obtention in vitro de cellules insulino- secretrices de mammifere et leurs utilisations
US6511471B2 (en) 2000-12-22 2003-01-28 Biocardia, Inc. Drug delivery catheters that attach to tissue and methods for their use
EP2316918B1 (en) 2001-02-14 2015-07-01 Anthrogenesis Corporation Post-partum mammalian placenta, its use and placental stem cells therefrom
EP1372916A2 (en) 2001-03-21 2004-01-02 Vitrox APS Method and housing for performing operations on a material
AU2002306865A1 (en) 2001-03-23 2003-03-03 Warren J. Alilain Generation of multipotent central nervous system stem cells
US7026121B1 (en) 2001-06-08 2006-04-11 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US6905827B2 (en) 2001-06-08 2005-06-14 Expression Diagnostics, Inc. Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
CA2351156A1 (en) 2001-07-04 2003-01-04 Peter W. Zandstra A bioprocess for the generation of pluripotent cell derived cells and tissues
US6796963B2 (en) 2001-07-10 2004-09-28 Myocardial Therapeutics, Inc. Flexible tissue injection catheters with controlled depth penetration
WO2003006950A2 (en) 2001-07-12 2003-01-23 Geron Corporation Cells of the cardiomyocyte lineage produced from human pluripotent stem cells
IL159895A0 (en) 2001-07-20 2004-06-20 Technion Res & Dev Foundation Methods of generating human cardiac cells and tissues and uses thereof
BR0211468A (pt) 2001-07-24 2004-11-23 Univ Yale Métodos de tratar e de prevenir uma doença inflamátoria em um mamìfero e de identificar um composto útil para tratar uma doença inflamatória em um mamìfero, composto, e kits para tratar e para prevenir uma doença inflamatória em um mamìfero
US6997863B2 (en) 2001-07-25 2006-02-14 Triton Biosystems, Inc. Thermotherapy via targeted delivery of nanoscale magnetic particles
US7074175B2 (en) 2001-07-25 2006-07-11 Erik Schroeder Handy Thermotherapy via targeted delivery of nanoscale magnetic particles
US7731648B2 (en) 2001-07-25 2010-06-08 Aduro Biotech Magnetic nanoscale particle compositions, and therapeutic methods related thereto
WO2003018780A1 (en) 2001-08-27 2003-03-06 Advanced Cell Technology, Inc. De-differentiation and re-differentiation of somatic cells and production of cells for cell therapies
US7452532B2 (en) 2001-09-30 2008-11-18 Scicotec Gmbh Transluminal application of adult stem cells for body organ tissue repair
US6805860B1 (en) 2001-09-30 2004-10-19 Eckhard Alt Method of transluminal application of myogenic cells for repair or replacement of heart tissue
US20030082153A1 (en) 2001-10-22 2003-05-01 The Government Of The United States Of America Stem cells that transform to beating cardiomyocytes
WO2003039382A2 (en) 2001-11-05 2003-05-15 Medgenics, Inc. System for processing tissue
DE10162353A1 (de) 2001-12-18 2003-07-03 Roehm Gmbh Extrusionsdüse für Folien oder Platten mit seitlicher Schmelzeeinspeisung
US20040014209A1 (en) 2002-01-23 2004-01-22 Lassar Andrew B. Compositions and methods for modulating cell differentiation
GB0202149D0 (en) 2002-01-30 2002-03-20 Univ Edinburgh Pluripotency determining factors and uses thereof
TWI288779B (en) 2002-03-28 2007-10-21 Blasticon Biotech Forschung Dedifferentiated, programmable stem cells of monocytic origin, and their production and use
US6866117B2 (en) 2002-04-05 2005-03-15 Wing Enterprises, Inc. Light weight ladder systems and methods
US7840261B2 (en) 2002-06-05 2010-11-23 Biocardia, Inc. Catheter systems and methods for placing bi-ventricular pacing leads
AU2003299509A1 (en) 2002-06-21 2004-05-13 University Of Utah Research Foundation Crosslinked compounds and methods of making and using thereof
EP1545219A4 (en) 2002-07-23 2009-09-30 Boston Scient Ltd CELL THERAPY FOR REGENERATION
JP2005534345A (ja) 2002-07-29 2005-11-17 エス セル インターナショナル ピーティーイー リミテッド インスリン陽性、グルコース応答性細胞の分化のための多段階方法
AU2003270051A1 (en) 2002-08-29 2004-03-19 Baylor College Of Medicine Heart derived cells for cardiac repair
US20040258669A1 (en) 2002-11-05 2004-12-23 Dzau Victor J. Mesenchymal stem cells and methods of use thereof
WO2004058939A2 (en) 2002-11-12 2004-07-15 The Research Foundation Of The State University Of New York TRANSLATIONAL CONTROL BY SMALL, NON-TRANSLATABLE RNAs
US7794702B2 (en) 2003-01-15 2010-09-14 The Trustees Of Columbia University In The City Of New York Mesenchymal stem cells as a vehicle for ion channel transfer in syncytial structures
EP1590446A4 (en) 2003-01-31 2006-12-27 Univ California USE OF ISLET 1 AS A MARKER FOR ISOLATING OR GENERATING STEM CELLS
DE10331439B3 (de) 2003-07-10 2005-02-03 Micromod Partikeltechnologie Gmbh Magnetische Nanopartikel mit verbesserten Magneteigenschaften
JP2004248382A (ja) 2003-02-12 2004-09-02 Mitsubishi Motors Corp ハイブリッド車
SI1601770T1 (sl) 2003-03-04 2010-01-29 Intercell Ag Streptococcus pyogenes antigeni
US7837631B2 (en) 2003-03-14 2010-11-23 Boston Scientific Scimed Inc. Biopsy forceps with removable jaw segments
US20060041182A1 (en) 2003-04-16 2006-02-23 Forbes Zachary G Magnetically-controllable delivery system for therapeutic agents
US20040214182A1 (en) 2003-04-25 2004-10-28 Vinod Sharma Genetic modification of targeted regions of the cardiac conduction system
US7329638B2 (en) 2003-04-30 2008-02-12 The Regents Of The University Of Michigan Drug delivery compositions
US20060025713A1 (en) 2003-05-12 2006-02-02 Alex Rosengart Magnetic particle-based therapy
CA2431425A1 (en) 2003-06-05 2004-12-05 Angiogene, Inc. Epas1 gene transfer to improve cell therapy
GB0313259D0 (en) 2003-06-09 2003-07-16 Consejo Superior Investigacion Magnetic nanoparticles
JP2007500756A (ja) 2003-06-12 2007-01-18 リージェンツ オブ ザ ユニバーシティ オブ ミネソタ 組織または器官を標的化するための細胞の指向
ES2265199B1 (es) 2003-06-12 2008-02-01 Cellerix, S.L. Celulas madre adultas multipotentes procedentes de condrocitos desdiferenciados y sus aplicaciones.
EP2399990B1 (en) 2003-06-27 2015-07-22 DePuy Synthes Products, Inc. Cells derived from post-partum umbilical cord for use in treatment of disease of the heart and circulatory system
CN101173250B (zh) 2003-06-30 2011-01-26 卫材R&D管理有限公司 磁性细胞及其使用方法
US20060205071A1 (en) 2003-07-17 2006-09-14 Gamida-Cell Ltd. Methods for ex-vivo expanding stem/progenitor cells
ITRM20030376A1 (it) 2003-07-31 2005-02-01 Univ Roma Procedimento per l'isolamento e l'espansione di cellule staminali cardiache da biopsia.
US20080213812A1 (en) 2003-09-29 2008-09-04 Andrews William H Methods and compositions for modulating telomerase reverse transcriptase (TERT) expression
JP2005110565A (ja) 2003-10-07 2005-04-28 Nobuya Yamanaka 分化多能性維持剤
EP1685252A4 (en) 2003-10-10 2006-11-29 Multicell Technologies Inc USE OF CELL LINES FOR THE MANUFACTURE OF ACTIVE THERAPEUTIC PROTEINS
US7280863B2 (en) 2003-10-20 2007-10-09 Magnetecs, Inc. System and method for radar-assisted catheter guidance and control
CN1537646A (zh) 2003-10-22 2004-10-20 高春平 肿瘤局部综合治疗方法和装置
US20050090732A1 (en) 2003-10-28 2005-04-28 Triton Biosystems, Inc. Therapy via targeted delivery of nanoscale particles
US7951592B2 (en) 2003-11-10 2011-05-31 The Scripps Research Institute Compositions and methods for inducing cell dedifferentiation
GB0329310D0 (en) 2003-12-18 2004-01-21 Univ Keele Method
US7625581B2 (en) 2003-12-19 2009-12-01 Ethicon, Inc. Tissue scaffolds for use in muscoloskeletal repairs
US20070196281A1 (en) 2003-12-31 2007-08-23 Sungho Jin Method and articles for remote magnetically induced treatment of cancer and other diseases, and method for operating such article
JP2007518423A (ja) 2004-01-23 2007-07-12 イントロン、インコーポレイテッド スプライセオソーム仲介型rnaトランススプライシングを使用するアポa−1及びその変異体の発現
WO2005076743A2 (en) 2004-02-17 2005-08-25 Yeda Research And Development Co. Ltd. Disaccharide molecules and derivatives thereof and methods of using same
US7780873B2 (en) 2004-02-23 2010-08-24 Texas A&M University System Bioactive complexes compositions and methods of use thereof
US20050260748A1 (en) 2004-02-27 2005-11-24 Michigan State University Adult stem cells and uses thereof
US20050214938A1 (en) 2004-03-26 2005-09-29 Gold Joseph D Cardiac bodies: clusters of spontaneously contracting cells for regenerating cardiac function
WO2005095652A2 (en) 2004-03-31 2005-10-13 Georgetown University Pnmt as a novel marker for progenitor cells
US20070231393A1 (en) 2004-05-19 2007-10-04 University Of South Carolina System and Device for Magnetic Drug Targeting with Magnetic Drug Carrier Particles
WO2005113754A1 (en) 2004-05-20 2005-12-01 New York Medical College Pluripotent adult stem cells
JP2006006125A (ja) 2004-06-22 2006-01-12 Nipro Corp 骨髄単核細胞の調製方法及び細胞調製装置
US20060018897A1 (en) 2004-06-28 2006-01-26 Transtarget Inc. Bispecific antibodies
KR20070058441A (ko) 2004-07-01 2007-06-08 유니버시티 오브 피츠버그 오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 면역억제성 엑소솜
EP1765980A4 (en) 2004-07-02 2007-12-12 Cytori Therapeutics Inc SYSTEMS AND METHOD FOR THE INSULATION AND USE OF CLINICALLY SAFE, FAT-GUN-GENERATING REGENERATIVE CELLS
US20070196918A1 (en) 2004-07-15 2007-08-23 Sayre Chauncey B Reprogramming of adult human testicular stem cells to pluripotent germ-line stem cells
EP1774334B1 (en) 2004-08-03 2017-10-04 Becton, Dickinson and Company Use of magnetic material to direct isolation of compounds and fractionation of multipart samples
ES2313805B1 (es) 2004-10-04 2009-12-23 Cellerix, S.L. Identificacion y aislamiento de celulas multipotentes de tejido mesenquimal no osteocondral.
US8431397B2 (en) 2004-09-14 2013-04-30 The Trustees Of Columbia University In The City Of New York Differentiation of human mesenchymal stem cells to cardiac progenitor cells that promote cardiac repair
US20060234375A1 (en) 2004-09-30 2006-10-19 Doronin Sergey V Use of human stem cells and/or factors they produce to promote adult mammalian cardiac repair through cardiomyocyte cell division
CA2583473A1 (en) 2004-10-05 2007-04-04 University Of Georgia Research Foundation, Inc. Neuronal progenitors from feeder-free human embryonic stem cell culture
FR2877571B1 (fr) 2004-11-05 2007-04-13 Nanobiotix Sarl Nanoparticules pourvues d'un element de ciblage intracellulaire, preparation et utilisations
WO2006052925A2 (en) 2004-11-08 2006-05-18 The Johns Hopkins University Cardiac stem cells
US11660317B2 (en) 2004-11-08 2023-05-30 The Johns Hopkins University Compositions comprising cardiosphere-derived cells for use in cell therapy
US7402151B2 (en) 2004-12-17 2008-07-22 Biocardia, Inc. Steerable guide catheters and methods for their use
EP1674128A1 (en) 2004-12-22 2006-06-28 Steinbeis-Transferzentrum für Herz-Kreislaufforschung Magnetic pole matrices useful for tissue engineering and treatment of disease
US7850960B2 (en) 2004-12-30 2010-12-14 University Of Washington Methods for regulation of stem cells
WO2006081190A2 (en) 2005-01-25 2006-08-03 Five Prime Therapeutics, Inc. Compositions and methods for treating cardiac conditions
WO2006093276A1 (ja) 2005-03-04 2006-09-08 Kyoto University 心臓組織由来の多能性幹細胞
WO2006108229A1 (en) 2005-04-12 2006-10-19 Angioblast Systems, Inc. Isolation of adult multipotential cells by tissue non-specific alkaline phosphatase
DE102005016873A1 (de) 2005-04-12 2006-10-19 Magforce Nanotechnologies Ag Nanopartikel-Wirstoff-Konjugate
US7846393B2 (en) 2005-04-21 2010-12-07 California Institute Of Technology Membrane filter for capturing circulating tumor cells
GB0508110D0 (en) 2005-04-22 2005-06-01 Univ Keele Gene delivery
WO2006118914A2 (en) 2005-04-29 2006-11-09 Children's Medical Center Corporation Methods of increasing proliferation of adult mammalian cardiomyocytes through p38 map kinase inhibition
US20070003528A1 (en) 2005-06-29 2007-01-04 Paul Consigny Intracoronary device and method of use thereof
US20070014869A1 (en) 2005-07-15 2007-01-18 Cormatrix Cardiovascular, Inc. Compositions for reconstruction, replacement or repair of intracardiac tissue
EP2302034B1 (en) 2005-08-03 2020-10-14 Astellas Institute for Regenerative Medicine Improved methods of reprogramming animal somatic cells
US20070048383A1 (en) 2005-08-25 2007-03-01 Helmus Michael N Self-assembled endovascular structures
US20070054397A1 (en) 2005-08-26 2007-03-08 Harald Ott Adult cardiac uncommitted progenitor cells
WO2007030834A1 (en) 2005-09-09 2007-03-15 The Trustees Of Columbia University In The City Of New York Chimeric hcn channels
ZA200803929B (en) 2005-10-13 2009-08-26 Anthrogenesis Corp Production of oligodendrocytes from placenta-derived stem cells
US7736346B2 (en) 2005-10-18 2010-06-15 Biocardia, Inc. Bio-interventional therapeutic treatments for cardiovascular diseases
AR058135A1 (es) 2005-10-21 2008-01-23 Chugai Pharmaceutical Co Ltd Agentes para el tratamiento de cardiopatias
CN100355454C (zh) 2005-10-25 2007-12-19 南京工业大学 磁热疗用纳米磁粉-抗人肝癌单抗HAb18靶向药物
EP1945256B1 (en) 2005-10-25 2012-07-04 Women's & Children's Health Research Institute Methods and compositions for improving wound repair
CN100509059C (zh) 2005-10-25 2009-07-08 南京工业大学 磁热疗用纳米磁粉-抗cea抗体靶向药物
BRPI0619794B8 (pt) 2005-12-13 2022-06-14 Univ Kyoto Uso de um fator de reprogramação, agente para a preparação de uma célula-tronco pluripotente induzida a partir de uma célula somática e métodos para preparar uma célula- tronco pluripotente induzida método e para preparar uma célula somática e uso de células-tronco pluripotentes induzidas
US20090011004A1 (en) 2005-12-30 2009-01-08 Philadelphia Health & Education Corp., D/B/A/ Drexel University Of College Of Medicine Improved carriers for delivery of nucleic acid agents to cells and tissues
US7875451B2 (en) 2006-01-19 2011-01-25 The University Of Washington Formulation to improve survival of transplanted cells
US7869854B2 (en) 2006-02-23 2011-01-11 Magnetecs, Inc. Apparatus for magnetically deployable catheter with MOSFET sensor and method for mapping and ablation
EP2004237A1 (en) 2006-04-03 2008-12-24 Keele University Targeted therapy
US20080138416A1 (en) 2006-06-13 2008-06-12 Fmc Biopolymer As Method and systems for using biopolymer-based beads and hydrogels
US8568286B2 (en) 2006-06-14 2013-10-29 Cardiac Pacemakers, Inc. Methods to position therapeutic agents using a magnetic field
US9149564B2 (en) 2006-06-23 2015-10-06 The Regents Of The University Of California Articles comprising large-surface-area bio-compatible materials and methods for making and using them
WO2008008857A2 (en) 2006-07-11 2008-01-17 University Of Utah Research Foundation Thiolated macromolecules and methods of making and using thereof
CA2662795A1 (en) 2006-09-05 2008-03-13 Columbus Nanoworks, Inc. Magnetic particles and methods of making and using the same
JP2010510964A (ja) 2006-09-19 2010-04-08 アシュラジェン インコーポレイテッド 治療的介入の標的としての、miR−15、miR−26、miR−31、miR−145、miR−147、miR−188、miR−215、miR−216、miR−331、mmu−miR−292−3pによって調節される遺伝子および経路
US20080089874A1 (en) 2006-09-28 2008-04-17 The Regents Of The University Of California Directed differentiation and maturation of stem cell-derived cardiomyocytes
EP2489742A1 (de) 2006-10-09 2012-08-22 Julius-Maximilians-Universität Würzburg MicroRNA (MIRNA) zur Diagnose und Therapie von Herzerkrankungen
EP2679221B1 (en) 2006-10-20 2020-09-23 Children's Medical Center Corporation Method to enhance tissue regeneration
US8562972B2 (en) 2006-10-23 2013-10-22 Anthrogenesis Corporation Methods and compositions for treatment of bone defects with placental cell populations
US7787949B2 (en) 2006-10-30 2010-08-31 Medtronic, Inc. Biological pacemaker compositions and systems incorporating interstitial cells of Cajal
EP2079831A2 (en) 2006-11-07 2009-07-22 Keck Graduate Institute Enriched stem cell and progenitor cell populations, and methods of producing and using such populations
KR101240487B1 (ko) 2006-11-09 2013-03-08 더 존스 홉킨스 유니버시티 성체 포유동물 심근세포의 심장 줄기 세포로의 역분화
US8076305B2 (en) 2006-11-30 2011-12-13 Medtronic, Inc. Biological pacemakers including mutated hyperpolarization-activated cyclic nucleotide-gated (HCN) channels
KR100830889B1 (ko) 2006-12-18 2008-05-21 주식회사 케이티 세툭시맵이 결합된 나노 입자 및 이의 제조 방법
DE102007008650B4 (de) 2007-02-20 2012-06-06 Charité - Universitätsmedizin Berlin Zellen zur Therapie des Herzens
DK3399025T3 (da) 2007-03-23 2025-06-16 Wisconsin Alumni Res Found Omprogrammering af somatiske celler
EP2626416A3 (en) 2007-04-07 2013-12-18 The Whitehead Institute for Biomedical Research Reprogramming of somatic cells
US8496926B2 (en) 2007-04-16 2013-07-30 Biocardia, Inc. Treatment for chronic myocardial infarction
US9205112B2 (en) 2007-04-23 2015-12-08 Creative Medical Health, Inc. Combination treatment of cardiovascular disease
US20080297287A1 (en) 2007-05-30 2008-12-04 Magnetecs, Inc. Magnetic linear actuator for deployable catheter tools
FI20075417A0 (fi) 2007-06-05 2007-06-05 Marjo-Riitta Suuronen Koostumuksia ja menetelmiä alkion kantasolujen kasvatukseen
WO2009032456A2 (en) 2007-08-01 2009-03-12 Primegen Biotech Llc Non-viral delivery of transcription factors that reprogram human somatic cells into a stem cell-like state
US20090136582A1 (en) 2007-08-03 2009-05-28 Albrecht Ralph M Colloidal magnetic nanobioparticles for cytotoxicity and drug delivery
US8292873B2 (en) 2007-08-09 2012-10-23 Boston Scientific Scimed, Inc. Catheter devices for myocardial injections or other uses
US20090081276A1 (en) 2007-08-13 2009-03-26 Eben Alsberg Bioresorbable implant composition
US20090081170A1 (en) 2007-09-13 2009-03-26 Paul Riley Cardiac progenitor cells
EP2203746B1 (en) 2007-09-24 2013-03-06 Technion Research & Development Foundation Ltd. T cell subpopulations capable of treating cancer
US8414924B2 (en) 2007-10-10 2013-04-09 Kyoto University Preparation for treating heart disease used in cell therapy
EP2209481B1 (en) 2007-10-15 2013-03-13 Fresenius Medical Care Deutschland GmbH Use of microvesicles (mvs) for preparing a medicament having adjuvant activity on endothelial cell transplantation, particularly in the treatment of diabetes by pancreatic islet transplantation, and related method
WO2009058818A2 (en) 2007-10-29 2009-05-07 The Board Of Regents Of The University Of Texas System Compositions comprising a micro-rna and methods of their use in regulating cardiac remodeling
DE102007052114B4 (de) 2007-10-30 2011-01-05 T2Cure Gmbh Verfahren zur Modulation der Funktion, des Wachstums oder der Differenzierung einer Zelle
US8617877B2 (en) 2007-11-02 2013-12-31 The Johns Hopkins University Cardiac stem cell and myocyte secreted paracrine factors
JP5654352B2 (ja) 2007-11-09 2015-01-14 ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム miR−15ファミリーのマイクロRNAによる心筋細胞生存及び心臓修復の調節
US8247374B2 (en) 2007-11-09 2012-08-21 New York Medical College Methods and compositions for the repair and/or regeneration of damaged myocardium using cytokines and variants thereof
US8968699B2 (en) 2007-11-15 2015-03-03 The Regents Of The University Of California Switchable nano-vehicle delivery systems, and methods for making and using them
WO2009067644A1 (en) 2007-11-21 2009-05-28 University Of Miami Compositions, systems and methods for obtaining and expanding insulin-producing cells
WO2009070282A1 (en) 2007-11-26 2009-06-04 Stc.Unm Active nanoparticles and method of using
US8512696B2 (en) 2007-11-30 2013-08-20 Autologous, Llc Methods of isolating non-senescent cardiac stem cells and uses thereof
US8124071B2 (en) 2007-11-30 2012-02-28 New York Medical College Methods of reducing transplant rejection and cardiac allograft vasculopathy by implanting autologous stem cells
WO2009073616A2 (en) 2007-11-30 2009-06-11 New York Medical College Compositions comprising vascular and myocyte progenitor cells and methods of their use
CA2743697A1 (en) 2007-11-30 2009-06-11 New York Medical College Methods of isolating non-senescent cardiac stem cells and uses thereof
AU2008333972A1 (en) 2007-11-30 2009-06-11 New York Medical College Compositions comprising HDAC inhibitors and methods of their use in restoring stem cell function and preventing heart failure
WO2009079592A2 (en) * 2007-12-17 2009-06-25 California Institute Of Technology Modulating immune system development and function through microrna mir-146
US20110110897A1 (en) 2008-01-11 2011-05-12 Schwarz Richard P Adult Human Cardiac-Derived Progenitor Cells
US7750027B2 (en) 2008-01-18 2010-07-06 Oxagen Limited Compounds having CRTH2 antagonist activity
US7999025B2 (en) 2008-01-28 2011-08-16 University Of Utah Research Foundation Asymmetrically-functionalized nanoparticles organized on one-dimensional chains
US9078932B2 (en) 2008-02-04 2015-07-14 Emmetrope, Inc. Magnetic cells for localizing delivery and tissue repair
CN102014934B (zh) 2008-02-22 2014-08-20 新加坡科技研究局 间充质干细胞颗粒
WO2009103818A1 (en) 2008-02-22 2009-08-27 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for obtaining progenitor cells and uses thereof in the treatment of tissue or organ damage
WO2009120702A2 (en) 2008-03-25 2009-10-01 Emory University Elemental iron nanoparticles
CA2723765A1 (en) 2008-05-08 2009-11-12 Coretherapix Slu Multipotent adult stem cell population
EP2294196A1 (en) * 2008-06-06 2011-03-16 Centre National de la Recherche Scientifique - CNRS Use of endo-lysosomal system and secreted vesicles (exosome-like) in treatments and diagnostics based on small rna and experimental study of small rna
AU2009257663B2 (en) 2008-06-09 2014-06-26 New York Medical College Compositions comprising cardiac stem cells overexpressing specific microRNA and methods of their use in repairing damaged myocardium
CN102056591B (zh) 2008-06-11 2013-12-11 刘彦仿 脂质体药剂及其制备方法和用途
WO2009149956A2 (en) 2008-06-13 2009-12-17 Life & Brain Gmbh Fusion protein and use thereof
WO2010033285A2 (en) 2008-06-26 2010-03-25 Spectrum Health Method for treating and preventing radiation damage using genetically modified mesenchymal stem cells
US20130309304A1 (en) 2008-08-05 2013-11-21 Bernardo Nadal-Ginard Compounds and methods
GB0814302D0 (en) 2008-08-05 2008-10-01 Coretherapix Slu Compounds and methods
US20120034155A1 (en) 2010-08-03 2012-02-09 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Artificial cells
US8172831B2 (en) 2008-09-02 2012-05-08 Abbott Cardiovascular Systems Inc. Catheter configured for incremental rotation
WO2010059806A2 (en) 2008-11-20 2010-05-27 Cedars-Sinai Medical Center Generation of induced pluripotent stem cells without the use of viral vectors
US20120046242A1 (en) 2008-12-24 2012-02-23 Massachusetts Institute Of Technology Molecular activators of the wnt/beta-catenin pathway
US20110280834A1 (en) 2009-01-16 2011-11-17 Cedars-Sinai Medical Center Methods and compositions for cardiac tissue regeneration
EP2228444A1 (en) 2009-03-09 2010-09-15 Julius-Maximilians-Universität Würzburg microRNA for diagnostic and therapeutic purposes in cardiovascular diseases
WO2010118059A1 (en) 2009-04-06 2010-10-14 Capricor, Inc. Systems and methods for cardiac tissue repair
US20120201795A1 (en) 2009-04-29 2012-08-09 Guardian Food Technologies, Llc Inhibition Of Pathogenic Growth On Plant Materials Using Lactic Acid Producing Microorganisms
US9072765B2 (en) 2009-05-20 2015-07-07 Board Of Regents, The University Of Texas System Identification of micro-RNAs involved in post-myocardial infarction remodeling and heart failure
JP5667180B2 (ja) 2009-07-01 2015-02-12 イオン メディックス インコーポレイテッド 哺乳類の有核細胞に由来するマイクロベシクル及びその用途
EP3659435A1 (en) 2009-07-15 2020-06-03 Calimmune, Inc. Dual vector for inhibition of human immunodeficiency virus
WO2011020874A1 (en) 2009-08-20 2011-02-24 Inserm (Institut National De La Sante Et De La Recherche Medicale) Vla-4 as a biomarker for prognosis and target for therapy in duchenne muscular dystrophy
US8609617B2 (en) 2009-09-04 2013-12-17 University Of Miami KLF family members regulate intrinsic axon regeneration ability
US9078914B2 (en) 2009-09-10 2015-07-14 Velin-Pharma A/S Method for the preparation of micro-RNA and its therapeutic application
EP2483406A2 (en) 2009-09-30 2012-08-08 President and Fellows of Harvard College Methods for modulation of autophagy through the modulation of autophagy-inhibiting gene products
CN102686264A (zh) 2009-10-27 2012-09-19 雪松-西奈医疗中心 用于具有增强的细胞滞留的靶向细胞递送的外部磁力
US20150010640A1 (en) 2009-10-27 2015-01-08 Cedars-Sinai Medical Center Bi-functional compositions for targeting cells to diseased tissues and methods of using same
US9095629B2 (en) 2009-10-30 2015-08-04 Northwestern University Magnetic nanostructures as theranostic agents
SG2014010698A (en) 2009-11-02 2014-05-29 Agency Science Tech & Res Methods of monitoring cellular states
WO2011057251A2 (en) 2009-11-09 2011-05-12 The Brigham And Women's Hospital, Inc. Treatment of heart disease
DK2498796T3 (en) 2009-11-09 2018-03-05 Aal Scient Inc HEART DISEASE TREATMENT
WO2011062244A1 (ja) 2009-11-18 2011-05-26 Kuroda Masahiko キャリア、その製造方法およびその用途
EP2327781A1 (en) 2009-11-27 2011-06-01 RWTH Aachen Micro-RNA and tissue repair
US20110135577A1 (en) 2009-12-03 2011-06-09 National Taiwan University Superparamagnetic nanoparticles IN MEDICAL THERAPEUTICS and manufacturing method THEREOF
RU2012129900A (ru) 2009-12-15 2014-01-27 Борд Оф Риджентс, Дзе Юниверсити Оф Техас Систем Регуляция микро-рнк при ишемии и ишемически-реперфузионном повреждении
US20130189780A1 (en) 2009-12-31 2013-07-25 Fate Therapeutics, Inc. Reprogramming compositions
EP2371370A1 (en) 2010-04-01 2011-10-05 Johann Wolfgang Goethe-Universität Frankfurt am Main Antagonists of miRNA-29 expression and their use in the prevention and treatment of aortic aneurysms and atherosclerotic plaque destabilization
WO2011127625A1 (zh) 2010-04-13 2011-10-20 江苏命码生物科技有限公司 一种调节生物体内微小核糖核酸含量的方法及其用途
JP5988961B2 (ja) 2010-04-28 2016-09-07 ザ ジェイ. デヴィッド グラッドストーン インスティテューツ 心筋細胞を発生させるための方法
US9249392B2 (en) 2010-04-30 2016-02-02 Cedars-Sinai Medical Center Methods and compositions for maintaining genomic stability in cultured stem cells
US9845457B2 (en) 2010-04-30 2017-12-19 Cedars-Sinai Medical Center Maintenance of genomic stability in cultured stem cells
EP2385120A1 (en) 2010-05-04 2011-11-09 Justus-Liebig- Universitat Giessen Use of anti-miRNA antisense oligonucleotides for the treatment of pulmonary hypertension
TWI762890B (zh) 2010-05-12 2022-05-01 開曼群島商英瑞金公司 生物活性腎細胞
AU2011263546B2 (en) 2010-06-10 2015-01-22 Midatech Limited Peptide-carrying nanoparticles
US8980279B2 (en) 2010-07-26 2015-03-17 Qu Biologics Personalized site-specific immunomodulation
WO2012019103A2 (en) 2010-08-06 2012-02-09 The General Hospital Corporation D/B/A System and apparatus for cell treatment
US20120093885A1 (en) 2010-10-18 2012-04-19 Northwestern University Therapeutic vesicles
EP2446929A1 (en) 2010-10-27 2012-05-02 Johann Wolfgang Goethe-Universität Frankfurt am Main Microvesicles derived from atheroprotective endothelial cells for the treatment and prevention of atherosclerotic diseases
US9248144B2 (en) 2010-11-11 2016-02-02 University Of Miami Compositions, kits and methods for treatment of cardiovascular, immunological and inflammatory diseases
SG183579A1 (en) 2011-02-11 2012-09-27 Agency Science Tech & Res Methods of detecting therapeutic exosomes
CA2829586C (en) 2011-03-11 2021-03-02 Children's Medical Center Corporation Methods and compositions relating to mesenchymal stem cell exosomes
US8871731B2 (en) 2011-03-16 2014-10-28 Migagen Therapeutics, Inc. Micro-RNA for the regulation of cardiac apoptosis and contractile function
US20140329314A1 (en) 2011-03-29 2014-11-06 Christopher O'Sullivan Enriched populations of cardiomyocyte lineage cells from pluripotent stem cells
US9241950B2 (en) 2011-04-28 2016-01-26 New York University MiR-33 inhibitors and uses thereof to decrease inflammation
WO2012162741A1 (en) 2011-06-01 2012-12-06 Monash University Enrichment of cardiomyocytes
EP2535412A1 (en) 2011-06-17 2012-12-19 Universitat Pompeu-Fabra New treatment for muscular dystrophies
EP2549399A1 (en) 2011-07-19 2013-01-23 Koninklijke Philips Electronics N.V. Assessment of Wnt pathway activity using probabilistic modeling of target gene expression
US8802144B2 (en) 2011-08-25 2014-08-12 Wisconsin Alumni Research Foundation 3-dimensional cardiac fibroblast derived extracellular matrix
WO2013048734A1 (en) 2011-09-28 2013-04-04 Tufts Medical Center, Inc. Treatment and prevention of cardiovascular disease with cell derived lipid vesicles, microvesicles and exosomes
US20130280205A1 (en) 2012-01-13 2013-10-24 Georgia Regents University Activators of SGK-1 for Use as Cardioprotective Agents
WO2013165598A1 (en) 2012-04-30 2013-11-07 The Research Foundation For Suny Cancer blood test using bc200 rna isolated from peripheral blood for diagnosis and treatment of invasive breast cancer
KR101389850B1 (ko) 2012-05-04 2014-04-29 이화여자대학교 산학협력단 심장전구세포의 배양방법 및 그 용도
WO2013170170A2 (en) 2012-05-10 2013-11-14 Board Of Regents Of The University Of Nebraska Compositions and methods for gene therapy
WO2013184527A1 (en) 2012-06-05 2013-12-12 Capricor, Inc. Optimized methods for generation of cardiac stem cells from cardiac tissue and their use in cardiac therapy
EP2687219A1 (en) 2012-07-18 2014-01-22 Universität Duisburg-Essen Use of preparations comprising exosomes derived from mesenchymal stem cells (MSCs) in the prevention and therapy of inflammatory conditions
CA2879322A1 (en) 2012-07-19 2014-01-23 Reneuron Limited Stem cell microparticles
AU2013302799B2 (en) * 2012-08-13 2018-03-01 Cedars-Sinai Medical Center Exosomes and micro-ribonucleic acids for tissue regeneration
US9492484B2 (en) 2012-09-27 2016-11-15 The Regents Of The University Of California Cardiosphere derived cell population and methods of use
WO2014066545A1 (en) 2012-10-26 2014-05-01 Cedars-Sinai Medical Center Therapeutic cells depleted of specific subpopulations of cells for use in tissue repair of regeneration
WO2014114465A1 (en) 2013-01-24 2014-07-31 Bernardo Nadal-Ginard Modulation of cardiac stem-progenitor cell differentiation, assays and uses thereof
MX376077B (es) 2013-03-13 2025-03-07 Univ Cincinnati Tratamiento de una disfuncion cardiaca diastolica con un agonista del receptor trpv2.
EP2971010B1 (en) 2013-03-14 2020-06-10 ModernaTX, Inc. Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions
US20140275976A1 (en) 2013-03-15 2014-09-18 Adventist Health System/Sunbelt, Inc. Global Ventricular Cardiac Diastolic Function Evaluation System and Associated Methods
EP3033418B1 (en) 2013-08-14 2019-12-11 Reneuron Limited Stem cell microparticles and mirna
EP3058089B1 (en) 2013-10-18 2018-12-05 Institut National de la Santé et de la Recherche Médicale (INSERM) Rny-derived small rnas as biomarkers for atherosclerosis-related disorders
US11377639B2 (en) 2013-11-15 2022-07-05 Wisconsin Alumni Research Foundation Lineage reprogramming to induced cardiac progenitor cells (iCPC) by defined factors
JP2017501694A (ja) 2013-12-04 2017-01-19 ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム 診断および療法のためのエキソソーム中のゲノムdna、rnaおよびタンパク質の分析
SI3083997T1 (sl) 2013-12-20 2020-12-31 Universite De Lausanne Diagnostične, prognostične in terapevtske uporabe dolgih nekodirajočih RNA-jev za srčno bolezen in regenerativno zdravilo
EP3102191A1 (en) 2014-02-05 2016-12-14 Stc.Unm Exosomes as a therapeutic for cancer
US20150328263A1 (en) 2014-05-14 2015-11-19 University Of Maryland, Baltimore Cardiac stem cells for cardiac repair
EP3161482B1 (en) 2014-06-27 2020-08-26 XY Evergreen Technology Company Method for enriching cns-derived exosomes
CA2962444C (en) 2014-10-03 2023-09-05 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy
WO2016054569A1 (en) 2014-10-03 2016-04-07 Cedars-Sinai Medical Center Cardiosphere-derived cells (cdcs) as therapeutic agents for pulmonary hypertension
EP3204117A4 (en) 2014-10-06 2018-05-09 Cedars-Sinai Medical Center Polarization of macrophages to a healing phenotype by cardiosphere-derived cells and by the exosomes secreted by such cells
EP3209780A4 (en) 2014-10-24 2018-09-19 University of Maryland, Baltimore Short non-coding protein regulatory rnas (sprrnas) and methods of use
JP6716564B2 (ja) 2014-12-03 2020-07-01 カプリコール,インコーポレイテッド 安定したエクソソーム製剤の製造方法
US9885042B2 (en) 2015-01-20 2018-02-06 MiRagen Therapeutics, Inc. miR-92 inhibitors and uses thereof
CN104548136B (zh) 2015-01-27 2018-02-13 青岛大学 一种piRNA药物组合物及其用途
US11083744B2 (en) 2015-03-20 2021-08-10 Mie University Therapeutic agent associated with suppression of proliferation and metastasis of tumor, which comprises exosomes released from cytotoxic T cells and targets cancer stromal/mesenchymal cells
US10131878B2 (en) 2015-04-06 2018-11-20 Wisconsin Alumni Research Foundation Methods for epicardial differentiation of human pluripotent stem cells
KR101818560B1 (ko) 2015-05-18 2018-01-16 가톨릭관동대학교기술지주 주식회사 줄기세포 유래 미세소포체를 포함하는 부정맥 예방 또는 치료용 약제학적 조성물
US10624849B2 (en) 2015-09-28 2020-04-21 Northwestern University Targeted extracellular vesicles comprising membrane proteins with engineered glycosylation sites
EP3402543B1 (en) 2016-01-11 2021-09-08 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of heart failure with preserved ejection fraction
WO2017136652A1 (en) 2016-02-04 2017-08-10 Tarveda Therapeutics, Inc. Stapled peptide conjugates and particles
EP3420086A1 (en) 2016-02-26 2019-01-02 Yale University COMPOSITIONS AND METHODS OF USING piRNAS IN CANCER DIAGNOSTICS AND THERAPEUTICS
WO2017160884A1 (en) 2016-03-14 2017-09-21 Capricor, Inc. Methods of treating ocular inflammation and chemical injuries of the eye with extracellular vesicles
WO2017173034A1 (en) 2016-03-30 2017-10-05 The University Of North Carolina At Chapel Hill Biological agent-exosome compositions and uses thereof
AU2017250295B2 (en) 2016-04-14 2022-08-25 Fred Hutchinson Cancer Center Compositions and methods to program therapeutic cells using targeted nucleic acid nanocarriers
US11859234B2 (en) 2016-05-06 2024-01-02 The Trustees Of Princeton University Method of monitoring RNase L activity
WO2017210652A1 (en) 2016-06-03 2017-12-07 Cedars-Sinai Medical Center Cdc-derived exosomes for treatment of ventricular tachyarrythmias
US11541078B2 (en) 2016-09-20 2023-01-03 Cedars-Sinai Medical Center Cardiosphere-derived cells and their extracellular vesicles to retard or reverse aging and age-related disorders
US11147249B2 (en) 2016-12-08 2021-10-19 Alector Llc Siglec transgenic mice and methods of use thereof
EP4699658A2 (en) 2017-04-19 2026-02-25 Cedars-Sinai Medical Center Methods and compositions for treating skeletal muscular dystrophy
ES2785682T3 (es) 2017-07-17 2020-10-07 Univ Masarykova Método de diagnóstico de cáncer colorrectal
JP2020529477A (ja) 2017-08-04 2020-10-08 シーダーズ—シナイ メディカル センター がんの治療及び防止のためのカルディオスフィア由来細胞及びその細胞外小胞
WO2019050071A1 (ko) 2017-09-08 2019-03-14 고려대학교 산학협력단 엑소좀 또는 엑소좀 유래 리보핵산을 포함하는 간섬유증 예방 또는 치료용 조성물
US11786551B2 (en) 2017-09-26 2023-10-17 The Trustees Of The University Of Pennsylvania Methods for treating heart disease via redirected T cell immunotherapies
WO2019117270A1 (ja) 2017-12-13 2019-06-20 国立大学法人広島大学 頭頸部がんの検出を補助する方法
US11660355B2 (en) 2017-12-20 2023-05-30 Cedars-Sinai Medical Center Engineered extracellular vesicles for enhanced tissue delivery
EP3746137A4 (en) 2018-01-30 2021-11-24 Capricor, Inc. ACTIVATION-INDUCED TISSUE EFFECTOR CELLS SUITABLE FOR CELL THERAPY AND DERIVED EXTRACELLULAR VESICLES FROM THEM
US12146137B2 (en) 2018-02-05 2024-11-19 Cedars-Sinai Medical Center Methods for therapeutic use of exosomes and Y-RNAS
US12258594B2 (en) 2018-12-05 2025-03-25 The Broad Institute, Inc. Cas proteins with reduced immunogenicity and methods of screening thereof
WO2020131986A1 (en) 2018-12-21 2020-06-25 Pioneer Hi-Bred International, Inc. Multiplex genome targeting
US20220218757A1 (en) 2019-05-08 2022-07-14 Cedars-Sinai Medical Center Therapeutically active cells and exosomes
WO2021178514A1 (en) 2020-03-04 2021-09-10 Cedars-Sinai Medical Center Cardiosphere-derived cells, exosomes derived therefrom, and methods of using same to treat volumetric muscle loss
WO2021188899A1 (en) 2020-03-20 2021-09-23 Cedars-Sinai Medical Center Cardiosphere-derived cell (cdc) therapy for the treatment of viral infections
CN115698286A (zh) 2020-05-19 2023-02-03 西达-赛奈医疗中心 外泌体衍生的piwi-相互作用rna及使用其的方法
WO2023278802A1 (en) 2021-07-01 2023-01-05 Cedars-Sinai Medical Center Formulations for oral delivery of nucleic acids
CA3259099A1 (en) 2022-06-15 2023-12-21 Cedars-Sinai Medical Center Non-coding RNA agents (BCYRN1 and their derivatives) for treating immune disorders
JP2025534332A (ja) 2022-09-30 2025-10-15 セダーズ-シナイ メディカル センター 治療用核酸及びその使用方法
WO2025171122A1 (en) 2024-02-08 2025-08-14 Cedars-Sinai Medical Center Enhanced regulatory t cells and methods of use thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012020307A2 (en) * 2010-08-13 2012-02-16 The University Court Of The University Of Glasgow Therapeutic uses of microvesicles and related micrornas

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Chimenti, I. et al. 2010 Circ. Res. Vol. 106, pp. 971-980 *
Vrijsen, K. et al. 2010 J. Cell. Mol. Med. Vol. 14, No. 5, pp. 1064-1070 *

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