AU2009296734B2 - Liquid formulations of bendamustine - Google Patents

Liquid formulations of bendamustine Download PDF

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Publication number
AU2009296734B2
AU2009296734B2 AU2009296734A AU2009296734A AU2009296734B2 AU 2009296734 B2 AU2009296734 B2 AU 2009296734B2 AU 2009296734 A AU2009296734 A AU 2009296734A AU 2009296734 A AU2009296734 A AU 2009296734A AU 2009296734 B2 AU2009296734 B2 AU 2009296734B2
Authority
AU
Australia
Prior art keywords
bendamustine
formulation
pharmaceutically acceptable
formulations
days
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2009296734A
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English (en)
Other versions
AU2009296734A1 (en
Inventor
Anthony S. Drager
Rachel Y. Labell
Piyush R. Patel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cephalon LLC
Original Assignee
Cephalon LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41559533&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2009296734(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cephalon LLC filed Critical Cephalon LLC
Publication of AU2009296734A1 publication Critical patent/AU2009296734A1/en
Priority to AU2015207940A priority Critical patent/AU2015207940B2/en
Application granted granted Critical
Publication of AU2009296734B2 publication Critical patent/AU2009296734B2/en
Priority to AU2016203246A priority patent/AU2016203246B2/en
Assigned to CEPHALON LLC reassignment CEPHALON LLC Request to Amend Deed and Register Assignors: CEPHALON, INC.
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
AU2009296734A 2008-09-25 2009-09-23 Liquid formulations of bendamustine Active AU2009296734B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2015207940A AU2015207940B2 (en) 2008-09-25 2015-07-31 Liquid Formulations of Bendamustine
AU2016203246A AU2016203246B2 (en) 2008-09-25 2016-05-18 Liquid formulations of bendamustine

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10007408P 2008-09-25 2008-09-25
US61/100,074 2008-09-25
PCT/US2009/058023 WO2010036702A1 (en) 2008-09-25 2009-09-23 Liquid formulations of bendamustine

Related Child Applications (2)

Application Number Title Priority Date Filing Date
AU2015207940A Division AU2015207940B2 (en) 2008-09-25 2015-07-31 Liquid Formulations of Bendamustine
AU2016203246A Division AU2016203246B2 (en) 2008-09-25 2016-05-18 Liquid formulations of bendamustine

Publications (2)

Publication Number Publication Date
AU2009296734A1 AU2009296734A1 (en) 2010-04-01
AU2009296734B2 true AU2009296734B2 (en) 2016-02-18

Family

ID=41559533

Family Applications (5)

Application Number Title Priority Date Filing Date
AU2009296734A Active AU2009296734B2 (en) 2008-09-25 2009-09-23 Liquid formulations of bendamustine
AU2015207940A Active AU2015207940B2 (en) 2008-09-25 2015-07-31 Liquid Formulations of Bendamustine
AU2016203246A Active AU2016203246B2 (en) 2008-09-25 2016-05-18 Liquid formulations of bendamustine
AU2016247123A Abandoned AU2016247123A1 (en) 2008-09-25 2016-10-19 Liquid formulations of bendamustine
AU2018202107A Abandoned AU2018202107A1 (en) 2008-09-25 2018-03-23 Liquid formulations of bendamustine

Family Applications After (4)

Application Number Title Priority Date Filing Date
AU2015207940A Active AU2015207940B2 (en) 2008-09-25 2015-07-31 Liquid Formulations of Bendamustine
AU2016203246A Active AU2016203246B2 (en) 2008-09-25 2016-05-18 Liquid formulations of bendamustine
AU2016247123A Abandoned AU2016247123A1 (en) 2008-09-25 2016-10-19 Liquid formulations of bendamustine
AU2018202107A Abandoned AU2018202107A1 (en) 2008-09-25 2018-03-23 Liquid formulations of bendamustine

Country Status (9)

Country Link
US (10) US20110190363A1 (https=)
EP (2) EP2889029A1 (https=)
JP (1) JP5670335B2 (https=)
CN (2) CN102164579B (https=)
AU (5) AU2009296734B2 (https=)
CA (1) CA2735899A1 (https=)
HK (1) HK1211462A1 (https=)
MX (1) MX2011002936A (https=)
WO (1) WO2010036702A1 (https=)

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