AU2008337286B2 - Pyrido[2,3-b]pyrazine-8-substituted compounds and their use - Google Patents

Pyrido[2,3-b]pyrazine-8-substituted compounds and their use Download PDF

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Publication number
AU2008337286B2
AU2008337286B2 AU2008337286A AU2008337286A AU2008337286B2 AU 2008337286 B2 AU2008337286 B2 AU 2008337286B2 AU 2008337286 A AU2008337286 A AU 2008337286A AU 2008337286 A AU2008337286 A AU 2008337286A AU 2008337286 B2 AU2008337286 B2 AU 2008337286B2
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independently
harom
compound according
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AU2008337286A1 (en
Inventor
Richard Marais
Delphine Menard
Dan Niculescu-Duvaz
Ion Niculescu-Duvaz
Arnaud Nourry
Caroline Joy Springer
Bartholomeus Marinus Josephus Marie Suijkerbuijk
Alfonso Zambon
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Institute of Cancer Research Royal Cancer Hospital
Cancer Research Technology Ltd
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Institute of Cancer Research Royal Cancer Hospital
Cancer Research Technology Ltd
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Priority to AU2014253528A priority Critical patent/AU2014253528B2/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

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  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • AIDS & HIV (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Transplantation (AREA)
  • Hematology (AREA)
AU2008337286A 2007-12-19 2008-12-19 Pyrido[2,3-b]pyrazine-8-substituted compounds and their use Ceased AU2008337286B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2014253528A AU2014253528B2 (en) 2007-12-19 2014-10-23 Pyrido[2,3-b]pyrazine-8-substituted compounds and their use

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1501907P 2007-12-19 2007-12-19
US61/015,019 2007-12-19
PCT/GB2008/004208 WO2009077766A1 (en) 2007-12-19 2008-12-19 Pyrido[2,3-b]pyrazine-8-substituted compounds and their use

Related Child Applications (1)

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AU2014253528A Division AU2014253528B2 (en) 2007-12-19 2014-10-23 Pyrido[2,3-b]pyrazine-8-substituted compounds and their use

Publications (2)

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AU2008337286A1 AU2008337286A1 (en) 2009-06-25
AU2008337286B2 true AU2008337286B2 (en) 2014-08-07

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AU2008337286A Ceased AU2008337286B2 (en) 2007-12-19 2008-12-19 Pyrido[2,3-b]pyrazine-8-substituted compounds and their use

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US (5) US8198279B2 (OSRAM)
EP (1) EP2229391B1 (OSRAM)
JP (1) JP5511680B2 (OSRAM)
KR (1) KR101665143B1 (OSRAM)
CN (1) CN101945869B (OSRAM)
AU (1) AU2008337286B2 (OSRAM)
BR (1) BRPI0821227A2 (OSRAM)
CA (1) CA2709257C (OSRAM)
DK (1) DK2229391T3 (OSRAM)
EA (1) EA019974B1 (OSRAM)
ES (1) ES2520940T3 (OSRAM)
IL (1) IL206330A (OSRAM)
MX (1) MX2010006739A (OSRAM)
NZ (1) NZ586418A (OSRAM)
PL (1) PL2229391T3 (OSRAM)
UA (1) UA105763C2 (OSRAM)
WO (1) WO2009077766A1 (OSRAM)
ZA (1) ZA201004524B (OSRAM)

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JP5973426B2 (ja) * 2010-06-17 2016-08-23 レスピバート・リミテツド Ｐ３８ｍａｐｋ阻害剤を含む呼吸器用製剤
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RU2618475C2 (ru) 2010-09-10 2017-05-03 Эпизайм, Инк. Ингибиторы ezh2 человека и способы их применения
US9175331B2 (en) 2010-09-10 2015-11-03 Epizyme, Inc. Inhibitors of human EZH2, and methods of use thereof
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EP2508184A1 (en) 2011-04-06 2012-10-10 Æterna Zentaris GmbH Pyridopyrazine derivatives and their use
TW201733984A (zh) 2011-04-13 2017-10-01 雅酶股份有限公司 經取代之苯化合物
JO3438B1 (ar) 2011-04-13 2019-10-20 Epizyme Inc مركبات بنزين مستبدلة بأريل أو أريل غير متجانس
JP6002223B2 (ja) 2011-08-26 2016-10-05 ニューファーマ， インコーポレイテッド 特定の化学的実体、組成物、および方法
EP3332785B1 (en) 2011-09-14 2020-05-06 Neupharma, Inc. Certain chemical entities, compositions, and methods
CN103130686B (zh) * 2011-12-02 2016-09-14 天津市国际生物医药联合研究院 N，n′-不对称二芳基取代脲类化合物及其制备方法和用途
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WO2014047648A1 (en) 2012-09-24 2014-03-27 Neupharma, Inc. Certain chemical entities, compositions, and methods
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CN106279147A (zh) * 2015-05-21 2017-01-04 中国科学院上海药物研究所 一种吡啶并氮杂环化合物及其制备方法和用途
CN109069462A (zh) 2016-02-23 2018-12-21 癌症研究科技有限公司 缺乏至少两种非必需氨基酸的膳食产品
CN112236135A (zh) 2017-11-13 2021-01-15 癌症研究科技有限公司 膳食产品
GB201809295D0 (en) 2018-06-06 2018-07-25 Institute Of Cancer Res Royal Cancer Hospital Lox inhibitors
GB201818651D0 (en) 2018-11-15 2019-01-02 Univ Sheffield Compounds
GB201818649D0 (en) 2018-11-15 2019-01-02 Univ Sheffield Compounds
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CN114144410A (zh) * 2019-07-19 2022-03-04 阿纳格纳斯生物技术股份有限公司 多芳基脲衍生物及其在治疗肌肉疾病中的用途
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