CA2709257C - Pyrido[2,3-b]pyrazine-8-substituted compounds and their use - Google Patents

Pyrido[2,3-b]pyrazine-8-substituted compounds and their use Download PDF

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Publication number
CA2709257C
CA2709257C CA2709257A CA2709257A CA2709257C CA 2709257 C CA2709257 C CA 2709257C CA 2709257 A CA2709257 A CA 2709257A CA 2709257 A CA2709257 A CA 2709257A CA 2709257 C CA2709257 C CA 2709257C
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Prior art keywords
independently
compound according
piperazino
harom
compound
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Expired - Fee Related
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CA2709257A
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English (en)
French (fr)
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CA2709257A1 (en
Inventor
Caroline Joy Springer
Dan Niculescu-Duvaz
Ion Niculescu-Duvaz
Richard Marais
Bartholomeus Marinus Josephus Marie Suijkerbuijk
Alfonso Zambon
Arnaud Nourry
Delphine Menard
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Institute of Cancer Research Royal Cancer Hospital
Cancer Research Technology Ltd
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Institute of Cancer Research Royal Cancer Hospital
Cancer Research Technology Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/18—Antivirals for RNA viruses for HIV
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    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • A—HUMAN NECESSITIES
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    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

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  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
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  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • AIDS & HIV (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
CA2709257A 2007-12-19 2008-12-19 Pyrido[2,3-b]pyrazine-8-substituted compounds and their use Expired - Fee Related CA2709257C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1501907P 2007-12-19 2007-12-19
US61/015,019 2007-12-19
PCT/GB2008/004208 WO2009077766A1 (en) 2007-12-19 2008-12-19 Pyrido[2,3-b]pyrazine-8-substituted compounds and their use

Publications (2)

Publication Number Publication Date
CA2709257A1 CA2709257A1 (en) 2009-06-25
CA2709257C true CA2709257C (en) 2016-12-13

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CA2709257A Expired - Fee Related CA2709257C (en) 2007-12-19 2008-12-19 Pyrido[2,3-b]pyrazine-8-substituted compounds and their use

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US (5) US8198279B2 (OSRAM)
EP (1) EP2229391B1 (OSRAM)
JP (1) JP5511680B2 (OSRAM)
KR (1) KR101665143B1 (OSRAM)
CN (1) CN101945869B (OSRAM)
AU (1) AU2008337286B2 (OSRAM)
BR (1) BRPI0821227A2 (OSRAM)
CA (1) CA2709257C (OSRAM)
DK (1) DK2229391T3 (OSRAM)
EA (1) EA019974B1 (OSRAM)
ES (1) ES2520940T3 (OSRAM)
IL (1) IL206330A (OSRAM)
MX (1) MX2010006739A (OSRAM)
NZ (1) NZ586418A (OSRAM)
PL (1) PL2229391T3 (OSRAM)
UA (1) UA105763C2 (OSRAM)
WO (1) WO2009077766A1 (OSRAM)
ZA (1) ZA201004524B (OSRAM)

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