EA201070667A1 - 8-замещенные пиридо[2,3-в]пиразины и их применение - Google Patents
8-замещенные пиридо[2,3-в]пиразины и их применениеInfo
- Publication number
- EA201070667A1 EA201070667A1 EA201070667A EA201070667A EA201070667A1 EA 201070667 A1 EA201070667 A1 EA 201070667A1 EA 201070667 A EA201070667 A EA 201070667A EA 201070667 A EA201070667 A EA 201070667A EA 201070667 A1 EA201070667 A1 EA 201070667A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- raf
- activity
- compounds
- cancer
- inhibit
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
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- Hospice & Palliative Care (AREA)
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Abstract
Настоящее изобретение относится в целом к области терапевтических соединений для лечения пролиферативных нарушений, рака и т.д. и, в частности, к некоторым 8-замещенным пиридо[2,3-b]пиразинам, охарактеризованным в настоящем описании, которые, в числе прочего, подавляют активность RAF (например, B-RAF). Настоящее изобретение также относится к фармацевтическим композициям, содержащим указанные соединения, и к применению указанных соединений и композиций как, так и, для подавления активности RAF (например, BRAF), подавления активности рецепторных тирозинкиназ (РТК), подавления пролиферации клеток и лечения заболеваний и нарушений, облегчаемых путем подавления RAF, РТК и т.д., пролиферативных нарушений, таких как рак (например, колоректальный рак, меланома) и т.д.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1501907P | 2007-12-19 | 2007-12-19 | |
PCT/GB2008/004208 WO2009077766A1 (en) | 2007-12-19 | 2008-12-19 | Pyrido[2,3-b]pyrazine-8-substituted compounds and their use |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201070667A1 true EA201070667A1 (ru) | 2011-02-28 |
EA019974B1 EA019974B1 (ru) | 2014-07-30 |
Family
ID=40342728
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201070667A EA019974B1 (ru) | 2007-12-19 | 2008-12-19 | 8-ЗАМЕЩЕННЫЕ ПИРИДО[2,3-b]ПИРАЗИНЫ И ИХ ПРИМЕНЕНИЕ |
Country Status (19)
Country | Link |
---|---|
US (5) | US8198279B2 (ru) |
EP (1) | EP2229391B1 (ru) |
JP (1) | JP5511680B2 (ru) |
KR (1) | KR101665143B1 (ru) |
CN (1) | CN101945869B (ru) |
AU (1) | AU2008337286B2 (ru) |
BR (1) | BRPI0821227A2 (ru) |
CA (1) | CA2709257C (ru) |
DK (1) | DK2229391T3 (ru) |
EA (1) | EA019974B1 (ru) |
ES (1) | ES2520940T3 (ru) |
HK (1) | HK1148521A1 (ru) |
IL (1) | IL206330A (ru) |
MX (1) | MX2010006739A (ru) |
NZ (1) | NZ586418A (ru) |
PL (1) | PL2229391T3 (ru) |
UA (1) | UA105763C2 (ru) |
WO (1) | WO2009077766A1 (ru) |
ZA (1) | ZA201004524B (ru) |
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BRPI0821227A2 (pt) | 2007-12-19 | 2015-06-16 | Cancer Rec Tech Ltd | Composto, composição farmacêutica, método para preparar a mesma, uso de um composto, método para tratar uma doença ou distúrbio, para inibir função de raf e para inibir proliferação celular, inibir progressão do ciclo celular, promover apoptose, ou uma combinação de um ou mais dos mesmos |
GB0807609D0 (en) | 2008-04-25 | 2008-06-04 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
GB0905955D0 (en) | 2009-04-06 | 2009-05-20 | Respivert Ltd | Novel compounds |
DK2531502T3 (da) * | 2010-02-01 | 2014-05-19 | Cancer Rec Tech Ltd | 1-(5-tert-butyl-2-phenyl-2h-pyrazol-3-yl)-3-[2-fluoro-4-(1-methyl-2-oxo-2,3-dihydro-1h-imidazo[4,5-b]pyridin-7-yloxy)-phenyl]-urea og associerede forbindelser og ders anvendelse i terapi |
EP2556068B1 (en) | 2010-04-08 | 2019-01-23 | Respivert Limited | P38 map kinase inhibitors |
WO2011158044A2 (en) * | 2010-06-17 | 2011-12-22 | Respivert Limited | Respiratory formulations and compounds for use therein |
CA2841142C (en) | 2010-06-23 | 2020-12-15 | Ryan D. Morin | Biomarkers for non-hodgkin lymphomas and uses thereof |
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EP2508184A1 (en) | 2011-04-06 | 2012-10-10 | Æterna Zentaris GmbH | Pyridopyrazine derivatives and their use |
TWI598336B (zh) | 2011-04-13 | 2017-09-11 | 雅酶股份有限公司 | 經取代之苯化合物 |
JO3438B1 (ar) | 2011-04-13 | 2019-10-20 | Epizyme Inc | مركبات بنزين مستبدلة بأريل أو أريل غير متجانس |
JP6002223B2 (ja) | 2011-08-26 | 2016-10-05 | ニューファーマ, インコーポレイテッド | 特定の化学的実体、組成物、および方法 |
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CN103130686B (zh) * | 2011-12-02 | 2016-09-14 | 天津市国际生物医药联合研究院 | N,n′-不对称二芳基取代脲类化合物及其制备方法和用途 |
US9670180B2 (en) | 2012-01-25 | 2017-06-06 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
HUE060881T2 (hu) | 2012-04-13 | 2023-04-28 | Epizyme Inc | Sóforma az EZH2 gátláshoz |
EP2897618B1 (en) | 2012-09-24 | 2021-11-17 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
MX2015004275A (es) | 2012-10-02 | 2015-08-14 | Bayer Cropscience Ag | Compuestos heterociclicos como plaguicidas. |
EP2906537B1 (en) | 2012-10-15 | 2020-03-11 | Epizyme, Inc. | Substituted benzene compounds |
EP2916838B1 (en) | 2012-11-12 | 2019-03-13 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
PL3057962T3 (pl) | 2013-10-16 | 2024-01-29 | Epizyme, Inc. | Postać soli chlorowodorku do inhibicji ezh2 |
GB201320732D0 (en) | 2013-11-25 | 2014-01-08 | Cancer Rec Tech Ltd | Methods of chemical synthesis |
GB201320729D0 (en) * | 2013-11-25 | 2014-01-08 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
CN106279147A (zh) | 2015-05-21 | 2017-01-04 | 中国科学院上海药物研究所 | 一种吡啶并氮杂环化合物及其制备方法和用途 |
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